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The map label for this gene is penP

Identifier: 16078940

GI number: 16078940

Start: 2048533

End: 2049453

Strand: Direct

Name: penP

Synonym: BSU18800

Alternate gene names: 16078940

Gene position: 2048533-2049453 (Clockwise)

Preceding gene: 16078937

Following gene: 16078942

Centisome position: 48.59

GC content: 42.67

Gene sequence:

>921_bases
ATGAAGTTGAAAACTAAAGCGTCAATAAAATTCGGAATATGTGTTGGGCTTTTATGTTTAAGCATTACTGGTTTCACACC
TTTTTTCAACTCAACACATGCCGAAGCAAAATCCATAGAAGACACAAACATGGCAAGCTGTATAACGAATAAAAAATTTG
TTCAACTTGAGAAAAAATTTGATGCCAGGCTTGGTGTTTATGCAATTGATATAGGTTCAAACAAGACAATCGCCTATCGG
CCGAATGAACGATTTGCTTACGCATCAACCTATAAAGTTCTAGCCGCAGCTGCTGTCCTGAAGAAAAACTCAATTGAAAA
ACTTAATGAAGTCATCCACTACAGCAAGGACGATCTTGTTACATATTCTCCAATCACAGAGAAACACCTAGATACAGGCA
TGAGCCTAAAAGAAATCTCGGAAGCGGCTATCCGTTACAGCGATAATACCGCTGGGAACATCTTGTTGCAACAGCTTGGC
GGCCCTAAAGGTTTTGAAAAGTCACTGAAACAGATTGGGGATCATGTAACGAAAGCTAAACGATTCGAGACGGATCTAAA
CTCTGCGATTCCTGGTGATATTCGTGACACCAGCACCGCAAAAGCACTGGCAACCGATCTTAAAGCCTTCACTTTAGATA
ACACTCTCACGACTGACAAACGCATGATCTTAACCGATTGGATGCGAGGCAATGCTACTGGTGACGAACTGATTCGGGCA
GGCGCTCCAATAGGATGGGAAGTCGGCGATAAATCCGGAGCCGGAAGTTACGGGACACGAAACGACATTGCTATCGTTTG
GCCGCCAAACAGAGCTCCTATTGTTGTGGCAATTCTGTCAAACCGCTTTACGAAAGATGCTAATTATGATAATGCTCTTA
TCGCTGAGGCTGCAAAAGTCGTCCTTAACGATCTCAAATAA

Upstream 100 bases:

>100_bases
CAATTGATTCTATGTTTACTAGCGCAAAGGGGTTTGTTACACTAACTGTCATGGGAAACATTTCAAAGGTAATACAAAAT
CATTTGAATGAGGAGGCCTG

Downstream 100 bases:

>100_bases
TATGTTTAGCCTTTTGCCACAAAGGAAAAGACATTACTTTTTTAACTTCTACCGTTCATTTTTTGATGAACGGTTCTTTC
ATAAGACCTCTAGAATCATA

Product: beta-lactamase precursor

Products: NA

Alternate protein names: Penicillinase

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MKLKTKASIKFGICVGLLCLSITGFTPFFNSTHAEAKSIEDTNMASCITNKKFVQLEKKFDARLGVYAIDIGSNKTIAYR
PNERFAYASTYKVLAAAAVLKKNSIEKLNEVIHYSKDDLVTYSPITEKHLDTGMSLKEISEAAIRYSDNTAGNILLQQLG
GPKGFEKSLKQIGDHVTKAKRFETDLNSAIPGDIRDTSTAKALATDLKAFTLDNTLTTDKRMILTDWMRGNATGDELIRA
GAPIGWEVGDKSGAGSYGTRNDIAIVWPPNRAPIVVAILSNRFTKDANYDNALIAEAAKVVLNDLK

Sequences:

>Translated_306_residues
MKLKTKASIKFGICVGLLCLSITGFTPFFNSTHAEAKSIEDTNMASCITNKKFVQLEKKFDARLGVYAIDIGSNKTIAYR
PNERFAYASTYKVLAAAAVLKKNSIEKLNEVIHYSKDDLVTYSPITEKHLDTGMSLKEISEAAIRYSDNTAGNILLQQLG
GPKGFEKSLKQIGDHVTKAKRFETDLNSAIPGDIRDTSTAKALATDLKAFTLDNTLTTDKRMILTDWMRGNATGDELIRA
GAPIGWEVGDKSGAGSYGTRNDIAIVWPPNRAPIVVAILSNRFTKDANYDNALIAEAAKVVLNDLK
>Mature_306_residues
MKLKTKASIKFGICVGLLCLSITGFTPFFNSTHAEAKSIEDTNMASCITNKKFVQLEKKFDARLGVYAIDIGSNKTIAYR
PNERFAYASTYKVLAAAAVLKKNSIEKLNEVIHYSKDDLVTYSPITEKHLDTGMSLKEISEAAIRYSDNTAGNILLQQLG
GPKGFEKSLKQIGDHVTKAKRFETDLNSAIPGDIRDTSTAKALATDLKAFTLDNTLTTDKRMILTDWMRGNATGDELIRA
GAPIGWEVGDKSGAGSYGTRNDIAIVWPPNRAPIVVAILSNRFTKDANYDNALIAEAAKVVLNDLK

Specific function: This protein is a beta-lactamase with a substrate specificity for penicillins

COG id: COG2367

COG function: function code V; Beta-lactamase class A

Gene ontology:

Cell location: Secreted

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-A beta-lactamase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BLAC_BACSU (P39824)

Other databases:

- EMBL:   Z35652
- EMBL:   AF027868
- EMBL:   AL009126
- PIR:   G69674
- RefSeq:   NP_389761.1
- ProteinModelPortal:   P39824
- SMR:   P39824
- EnsemblBacteria:   EBBACT00000003740
- GeneID:   940129
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU18800
- NMPDR:   fig|224308.1.peg.1883
- GenoList:   BSU18800
- GeneTree:   EBGT00050000002772
- HOGENOM:   HBG535713
- OMA:   NDIAIVW
- ProtClustDB:   CLSK2393383
- BioCyc:   BSUB:BSU18800-MONOMER
- BRENDA:   3.5.2.6
- InterPro:   IPR012338
- InterPro:   IPR001466
- InterPro:   IPR000871
- PRINTS:   PR00118

Pfam domain/function: PF00144 Beta-lactamase; SSF56601 PBP_transp_fold

EC number: =3.5.2.6

Molecular weight: Translated: 33447; Mature: 33447

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: PS00146 BETA_LACTAMASE_A

Important sites: ACT_SITE 89-89

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLKTKASIKFGICVGLLCLSITGFTPFFNSTHAEAKSIEDTNMASCITNKKFVQLEKKF
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCHHHHHHCCHHHHHHHHHH
DARLGVYAIDIGSNKTIAYRPNERFAYASTYKVLAAAAVLKKNSIEKLNEVIHYSKDDLV
CCCCCEEEEEECCCCEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
TYSPITEKHLDTGMSLKEISEAAIRYSDNTAGNILLQQLGGPKGFEKSLKQIGDHVTKAK
EECCCHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
RFETDLNSAIPGDIRDTSTAKALATDLKAFTLDNTLTTDKRMILTDWMRGNATGDELIRA
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHEEECCCCCCCCEEEEEHHHCCCCCHHHHHHC
GAPIGWEVGDKSGAGSYGTRNDIAIVWPPNRAPIVVAILSNRFTKDANYDNALIAEAAKV
CCCCCEECCCCCCCCCCCCCCCEEEEECCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHH
VLNDLK
HHHCCC
>Mature Secondary Structure
MKLKTKASIKFGICVGLLCLSITGFTPFFNSTHAEAKSIEDTNMASCITNKKFVQLEKKF
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCHHHHHHCCHHHHHHHHHH
DARLGVYAIDIGSNKTIAYRPNERFAYASTYKVLAAAAVLKKNSIEKLNEVIHYSKDDLV
CCCCCEEEEEECCCCEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
TYSPITEKHLDTGMSLKEISEAAIRYSDNTAGNILLQQLGGPKGFEKSLKQIGDHVTKAK
EECCCHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
RFETDLNSAIPGDIRDTSTAKALATDLKAFTLDNTLTTDKRMILTDWMRGNATGDELIRA
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHEEECCCCCCCCEEEEEHHHCCCCCHHHHHHC
GAPIGWEVGDKSGAGSYGTRNDIAIVWPPNRAPIVVAILSNRFTKDANYDNALIAEAAKV
CCCCCEECCCCCCCCCCCCCCCEEEEECCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHH
VLNDLK
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 10658653