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The map label for this gene is tdh

Identifier: 16078762

GI number: 16078762

Start: 1770461

End: 1771504

Strand: Direct

Name: tdh

Synonym: BSU16990

Alternate gene names: 16078762

Gene position: 1770461-1771504 (Clockwise)

Preceding gene: 16078761

Following gene: 16078763

Centisome position: 42.0

GC content: 45.88

Gene sequence:

>1044_bases
ATGCAGAGTGGAAAGATGAAAGCTCTAATGAAAAAGGACGGGGCGTTCGGTGCTGTGCTGACTGAAGTTCCCATTCCTGA
GATTGATAAACATGAAGTCCTCATAAAAGTGAAAGCCGCTTCCATATGCGGCACGGATGTCCACATTTATAATTGGGATC
AATGGGCACGTCAGAGAATCAAAACACCCTATGTTTTCGGCCATGAGTTCAGCGGCATCGTAGAGGGCGTGGGAGAGAAT
GTCAGCAGTGTAAAAGTGGGAGAGTATGTGTCTGCGGAAACACACATTGTCTGTGGTGAATGTGTCCCTTGCCTAACAGG
AAAATCTCATGTGTGTACCAATACTGCTATAATCGGAGTGGACACGGCAGGCTGTTTTGCGGAGTATGTAAAAGTTCCAG
CTGATAACATTTGGAGAAATCCCGCTGATATGGACCCGTCGATTGCTTCCATTCAAGAGCCTTTAGGAAATGCAGTTCAT
ACCGTACTCGAGAGCCAGCCTGCAGGAGGAACGACTGCAGTCATTGGATGCGGACCGATTGGTCTTATGGCTGTTGCGGT
TGCAAAAGCAGCAGGAGCTTCTCAGGTGATAGCGATTGATAAGAATGAATACAGGCTGAGGCTTGCAAAACAAATGGGAG
CGACTTGTACTGTTTCTATTGAAAAAGAAGACCCGCTCAAAATTGTAAGCGCTTTAACGAGTGGAGAAGGAGCAGATCTT
GTTTGTGAGATGTCGGGCCATCCCTCAGCGATTGCCCAAGGTCTTGCGATGGCTGCGAATGGCGGAAGATTTCATATTCT
CAGCTTGCCGGAACATCCGGTGACAATTGATTTGACGAATAAAGTGGTATTTAAAGGGCTTACCATCCAAGGAATCACAG
GAAGAAAAATGTTTTCAACATGGCGCCAGGTGTCTCAGTTGATCAGTTCAAACATGATCGATCTTGCACCTGTTATTACC
CATCAGTTTCCATTAGAGGAGTTTGAAAAAGGTTTCGAACTGATGAGAAGCGGGCAGTGCGGAAAAGTAATTTTAATTCC
ATAA

Upstream 100 bases:

>100_bases
CAGATACTTTTGTCCTTCTGGAAAAGACAGTTCTGTTTACGCTTATTCCATATCATGGTACAATCCGAATATAACAAGAA
TTTTTCAAGGAGGATTGTAC

Downstream 100 bases:

>100_bases
AGGGGGATAAACATGACGAAGGAATTTGAGTTTTTAAAAGCAGAGCTTAATAGTATGAAAGAAAACCATACATGGCAAGA
CATAAAACAGCTTGAATCTA

Product: L-threonine 3-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MQSGKMKALMKKDGAFGAVLTEVPIPEIDKHEVLIKVKAASICGTDVHIYNWDQWARQRIKTPYVFGHEFSGIVEGVGEN
VSSVKVGEYVSAETHIVCGECVPCLTGKSHVCTNTAIIGVDTAGCFAEYVKVPADNIWRNPADMDPSIASIQEPLGNAVH
TVLESQPAGGTTAVIGCGPIGLMAVAVAKAAGASQVIAIDKNEYRLRLAKQMGATCTVSIEKEDPLKIVSALTSGEGADL
VCEMSGHPSAIAQGLAMAANGGRFHILSLPEHPVTIDLTNKVVFKGLTIQGITGRKMFSTWRQVSQLISSNMIDLAPVIT
HQFPLEEFEKGFELMRSGQCGKVILIP

Sequences:

>Translated_347_residues
MQSGKMKALMKKDGAFGAVLTEVPIPEIDKHEVLIKVKAASICGTDVHIYNWDQWARQRIKTPYVFGHEFSGIVEGVGEN
VSSVKVGEYVSAETHIVCGECVPCLTGKSHVCTNTAIIGVDTAGCFAEYVKVPADNIWRNPADMDPSIASIQEPLGNAVH
TVLESQPAGGTTAVIGCGPIGLMAVAVAKAAGASQVIAIDKNEYRLRLAKQMGATCTVSIEKEDPLKIVSALTSGEGADL
VCEMSGHPSAIAQGLAMAANGGRFHILSLPEHPVTIDLTNKVVFKGLTIQGITGRKMFSTWRQVSQLISSNMIDLAPVIT
HQFPLEEFEKGFELMRSGQCGKVILIP
>Mature_347_residues
MQSGKMKALMKKDGAFGAVLTEVPIPEIDKHEVLIKVKAASICGTDVHIYNWDQWARQRIKTPYVFGHEFSGIVEGVGEN
VSSVKVGEYVSAETHIVCGECVPCLTGKSHVCTNTAIIGVDTAGCFAEYVKVPADNIWRNPADMDPSIASIQEPLGNAVH
TVLESQPAGGTTAVIGCGPIGLMAVAVAKAAGASQVIAIDKNEYRLRLAKQMGATCTVSIEKEDPLKIVSALTSGEGADL
VCEMSGHPSAIAQGLAMAANGGRFHILSLPEHPVTIDLTNKVVFKGLTIQGITGRKMFSTWRQVSQLISSNMIDLAPVIT
HQFPLEEFEKGFELMRSGQCGKVILIP

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family

Homologues:

Organism=Homo sapiens, GI156627571, Length=330, Percent_Identity=28.7878787878788, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI156523966, Length=360, Percent_Identity=26.9444444444444, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI4501929, Length=362, Percent_Identity=29.0055248618785, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI4501939, Length=353, Percent_Identity=26.3456090651558, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI4501933, Length=361, Percent_Identity=28.808864265928, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI71743840, Length=355, Percent_Identity=27.0422535211268, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI262073058, Length=355, Percent_Identity=27.0422535211268, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI34577061, Length=349, Percent_Identity=28.080229226361, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI71565154, Length=361, Percent_Identity=27.7008310249307, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI71565152, Length=371, Percent_Identity=25.6064690026954, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI194239674, Length=337, Percent_Identity=25.2225519287834, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI13236495, Length=337, Percent_Identity=25.2225519287834, Blast_Score=72, Evalue=8e-13,
Organism=Escherichia coli, GI1790045, Length=340, Percent_Identity=48.2352941176471, Blast_Score=335, Evalue=2e-93,
Organism=Escherichia coli, GI1787863, Length=349, Percent_Identity=32.6647564469914, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1788075, Length=359, Percent_Identity=30.08356545961, Blast_Score=151, Evalue=8e-38,
Organism=Escherichia coli, GI1788073, Length=331, Percent_Identity=28.3987915407855, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1788407, Length=348, Percent_Identity=29.0229885057471, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI226510992, Length=314, Percent_Identity=28.343949044586, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1786825, Length=401, Percent_Identity=27.431421446384, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI87082125, Length=345, Percent_Identity=30.7246376811594, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1790718, Length=327, Percent_Identity=25.0764525993884, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1786552, Length=362, Percent_Identity=30.1104972375691, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI87081918, Length=266, Percent_Identity=31.5789473684211, Blast_Score=83, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17562876, Length=336, Percent_Identity=28.8690476190476, Blast_Score=138, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17562878, Length=335, Percent_Identity=27.1641791044776, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI25146526, Length=351, Percent_Identity=26.2108262108262, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71997431, Length=353, Percent_Identity=26.0623229461756, Blast_Score=71, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17562582, Length=284, Percent_Identity=26.7605633802817, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71988145, Length=185, Percent_Identity=29.7297297297297, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323099, Length=326, Percent_Identity=31.2883435582822, Blast_Score=140, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6322619, Length=338, Percent_Identity=29.585798816568, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6319955, Length=338, Percent_Identity=29.585798816568, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6319258, Length=367, Percent_Identity=29.4277929155313, Blast_Score=106, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6320033, Length=363, Percent_Identity=29.2011019283747, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6324486, Length=276, Percent_Identity=30.4347826086957, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6323961, Length=276, Percent_Identity=30.4347826086957, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6319257, Length=243, Percent_Identity=27.5720164609054, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319621, Length=276, Percent_Identity=27.536231884058, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323729, Length=325, Percent_Identity=27.0769230769231, Blast_Score=79, Evalue=7e-16,
Organism=Drosophila melanogaster, GI17137530, Length=329, Percent_Identity=27.355623100304, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI17737897, Length=330, Percent_Identity=27.5757575757576, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI17737895, Length=364, Percent_Identity=27.1978021978022, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TDH_BACSU (O31776)

Other databases:

- EMBL:   AL009126
- PIR:   C69721
- RefSeq:   NP_389581.1
- ProteinModelPortal:   O31776
- SMR:   O31776
- EnsemblBacteria:   EBBACT00000002866
- GeneID:   939462
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU16990
- NMPDR:   fig|224308.1.peg.1702
- GenoList:   BSU16990
- GeneTree:   EBGT00050000000383
- HOGENOM:   HBG753318
- OMA:   CFAEYVK
- PhylomeDB:   O31776
- ProtClustDB:   PRK05396
- BioCyc:   BSUB:BSU16990-MONOMER
- BRENDA:   1.1.1.103
- GO:   GO:0005737
- HAMAP:   MF_00627
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR11695
- TIGRFAMs:   TIGR00692

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N; SSF50129 GroES_like

EC number: =1.1.1.103

Molecular weight: Translated: 36997; Mature: 36997

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSGKMKALMKKDGAFGAVLTEVPIPEIDKHEVLIKVKAASICGTDVHIYNWDQWARQRI
CCCCCHHHHHHCCCCCEEEEECCCCCCCCCCEEEEEEEEEEECCCEEEEEECHHHHHHHC
KTPYVFGHEFSGIVEGVGENVSSVKVGEYVSAETHIVCGECVPCLTGKSHVCTNTAIIGV
CCCEEECCCHHHHHHHHCCCCCEEEECCEECCCCEEEECCCCCCCCCCCCEECCEEEEEE
DTAGCFAEYVKVPADNIWRNPADMDPSIASIQEPLGNAVHTVLESQPAGGTTAVIGCGPI
CCHHHHHHHHHCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCHH
GLMAVAVAKAAGASQVIAIDKNEYRLRLAKQMGATCTVSIEKEDPLKIVSALTSGEGADL
HHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCEEEEEECCCCHHHHHHHHHCCCCCEE
VCEMSGHPSAIAQGLAMAANGGRFHILSLPEHPVTIDLTNKVVFKGLTIQGITGRKMFST
EEEECCCHHHHHHHHHEEECCCEEEEEECCCCCEEEEECCEEEEECEEEECCCCHHHHHH
WRQVSQLISSNMIDLAPVITHQFPLEEFEKGFELMRSGQCGKVILIP
HHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEC
>Mature Secondary Structure
MQSGKMKALMKKDGAFGAVLTEVPIPEIDKHEVLIKVKAASICGTDVHIYNWDQWARQRI
CCCCCHHHHHHCCCCCEEEEECCCCCCCCCCEEEEEEEEEEECCCEEEEEECHHHHHHHC
KTPYVFGHEFSGIVEGVGENVSSVKVGEYVSAETHIVCGECVPCLTGKSHVCTNTAIIGV
CCCEEECCCHHHHHHHHCCCCCEEEECCEECCCCEEEECCCCCCCCCCCCEECCEEEEEE
DTAGCFAEYVKVPADNIWRNPADMDPSIASIQEPLGNAVHTVLESQPAGGTTAVIGCGPI
CCHHHHHHHHHCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCHH
GLMAVAVAKAAGASQVIAIDKNEYRLRLAKQMGATCTVSIEKEDPLKIVSALTSGEGADL
HHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCEEEEEECCCCHHHHHHHHHCCCCCEE
VCEMSGHPSAIAQGLAMAANGGRFHILSLPEHPVTIDLTNKVVFKGLTIQGITGRKMFST
EEEECCCHHHHHHHHHEEECCCEEEEEECCCCCEEEEECCEEEEECEEEECCCCHHHHHH
WRQVSQLISSNMIDLAPVITHQFPLEEFEKGFELMRSGQCGKVILIP
HHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377