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The map label for this gene is xerC

Identifier: 16078677

GI number: 16078677

Start: 1687187

End: 1688101

Strand: Direct

Name: xerC

Synonym: BSU16140

Alternate gene names: 16078677

Gene position: 1687187-1688101 (Clockwise)

Preceding gene: 16078676

Following gene: 16078678

Centisome position: 40.02

GC content: 39.67

Gene sequence:

>915_bases
ATGGAGAATGTTAAGAATTTCGTAAAGTTATTCGTTGAATATTTACAAATTGAAAAAAATTATTCACAATATACTATTGT
GAATTATGTGGATTCAATTGAAGAATTCGAGACTTTCCTGCGCGTTCAAGGTATAAATGGATTTGAAGAAGCTGCATATC
AAGATACTAGGATTTTTTTGACAGAAGCCTATGAAAAAGGTTTATCGAGAAGAACAATAAGCAAAAAGATATCTGCATTA
AGAAGCTTTTATAAGTTTCTGATGCGGGAAAAGCTTATTGAAGAAAATCCGTTTCAGCTTGTTCATCTGCCAAAACAGGA
GAAACGGATACCGAAGTTTCTATATCAAAAAGAGCTTGAGGAGCTGTTTGAAGTTTCAGATATAAGCCAGCCGGCCGGAA
TGAGGGATCAAGCGCTGTTAGAGCTGCTCTATGCCACTGGAATGAGGGTCAGTGAATGCTGTTCCATAACTATTAACGAC
GTTGATTTATTTATGGACACTGTGCTTGTTCACGGTAAAGGCAAGAAGCAGCGCTATATCCCCTTTGGGTCTTATGCCCG
CGAAGCGTTGAAGGTATACATGAATAGCGGAAGACAGTGCTTGCTGATGAAGGCAAAAGAACCTCATGATCTATTATTCG
TAAATCAAAGAGGCGGACCGCTTACAGCCCGTGGCATCAGACATATTTTAAGCGGGCTTGTTCAAAAAGCGTCAAGCACT
TTACATATCCATCCGCATATGCTTCGACATACGTTCGCCACGCATCTGTTAAATGAAGGAGCGGATTTGAGAAGCGTTCA
AGAACTGCTCGGGCATTCCAATCTGTCTTCTACACAGATATACACGCACGTTTCGAAGGAAATGTTGAGAAACACATATA
TGTCTCACCATCCAAGAGCATTTAAGAAAAATTAA

Upstream 100 bases:

>100_bases
GAAACAATTCAAACAATTTCGAAAACAATATAGGTATTGATTGCAACCTGAGCGCGATTTGTGATACCATTTAAAAGCCC
TTCCTGGGGAGGTATTAGGC

Downstream 100 bases:

>100_bases
AGGAGGCCCTTTATGTCATCTTTTCATGCGACCACAATATTTGCCGTACAGCATAAAGGACGAAGCGCTATGTCCGGAGA
CGGCCAAGTAACATTTGGTC

Product: site-specific tyrosine recombinase XerC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MENVKNFVKLFVEYLQIEKNYSQYTIVNYVDSIEEFETFLRVQGINGFEEAAYQDTRIFLTEAYEKGLSRRTISKKISAL
RSFYKFLMREKLIEENPFQLVHLPKQEKRIPKFLYQKELEELFEVSDISQPAGMRDQALLELLYATGMRVSECCSITIND
VDLFMDTVLVHGKGKKQRYIPFGSYAREALKVYMNSGRQCLLMKAKEPHDLLFVNQRGGPLTARGIRHILSGLVQKASST
LHIHPHMLRHTFATHLLNEGADLRSVQELLGHSNLSSTQIYTHVSKEMLRNTYMSHHPRAFKKN

Sequences:

>Translated_304_residues
MENVKNFVKLFVEYLQIEKNYSQYTIVNYVDSIEEFETFLRVQGINGFEEAAYQDTRIFLTEAYEKGLSRRTISKKISAL
RSFYKFLMREKLIEENPFQLVHLPKQEKRIPKFLYQKELEELFEVSDISQPAGMRDQALLELLYATGMRVSECCSITIND
VDLFMDTVLVHGKGKKQRYIPFGSYAREALKVYMNSGRQCLLMKAKEPHDLLFVNQRGGPLTARGIRHILSGLVQKASST
LHIHPHMLRHTFATHLLNEGADLRSVQELLGHSNLSSTQIYTHVSKEMLRNTYMSHHPRAFKKN
>Mature_304_residues
MENVKNFVKLFVEYLQIEKNYSQYTIVNYVDSIEEFETFLRVQGINGFEEAAYQDTRIFLTEAYEKGLSRRTISKKISAL
RSFYKFLMREKLIEENPFQLVHLPKQEKRIPKFLYQKELEELFEVSDISQPAGMRDQALLELLYATGMRVSECCSITIND
VDLFMDTVLVHGKGKKQRYIPFGSYAREALKVYMNSGRQCLLMKAKEPHDLLFVNQRGGPLTARGIRHILSGLVQKASST
LHIHPHMLRHTFATHLLNEGADLRSVQELLGHSNLSSTQIYTHVSKEMLRNTYMSHHPRAFKKN

Specific function: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The xerC-xerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell div

COG id: COG4974

COG function: function code L; Site-specific recombinase XerD

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'phage' integrase family. XerC subfamily

Homologues:

Organism=Escherichia coli, GI1789261, Length=299, Percent_Identity=39.7993311036789, Blast_Score=209, Evalue=1e-55,
Organism=Escherichia coli, GI1790244, Length=300, Percent_Identity=34.3333333333333, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI1790767, Length=183, Percent_Identity=31.6939890710383, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1790768, Length=172, Percent_Identity=29.0697674418605, Blast_Score=71, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): XERC_BACSU (P39776)

Other databases:

- EMBL:   U13634
- EMBL:   AL009126
- EMBL:   AJ000975
- PIR:   G69601
- RefSeq:   NP_389496.1
- ProteinModelPortal:   P39776
- SMR:   P39776
- EnsemblBacteria:   EBBACT00000002304
- GeneID:   938003
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU16140
- NMPDR:   fig|224308.1.peg.1616
- GenoList:   BSU16140
- GeneTree:   EBGT00070000031883
- HOGENOM:   HBG727654
- OMA:   YSQYTIV
- PhylomeDB:   P39776
- ProtClustDB:   PRK00236
- BioCyc:   BSUB:BSU16140-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01808
- InterPro:   IPR011010
- InterPro:   IPR013762
- InterPro:   IPR002104
- InterPro:   IPR010998
- InterPro:   IPR023109
- InterPro:   IPR004107
- InterPro:   IPR011931
- Gene3D:   G3DSA:1.10.150.130
- Gene3D:   G3DSA:1.10.443.10
- TIGRFAMs:   TIGR02224

Pfam domain/function: PF02899 Phage_integr_N; PF00589 Phage_integrase; SSF56349 DNA_brk_join_enz; SSF47823 L_intgrse_like_N

EC number: NA

Molecular weight: Translated: 35342; Mature: 35342

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: NA

Important sites: ACT_SITE 149-149 ACT_SITE 173-173 ACT_SITE 246-246 ACT_SITE 249-249 ACT_SITE 272-272 ACT_SITE 281-281

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENVKNFVKLFVEYLQIEKNYSQYTIVNYVDSIEEFETFLRVQGINGFEEAAYQDTRIFL
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHH
TEAYEKGLSRRTISKKISALRSFYKFLMREKLIEENPFQLVHLPKQEKRIPKFLYQKELE
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHH
ELFEVSDISQPAGMRDQALLELLYATGMRVSECCSITINDVDLFMDTVLVHGKGKKQRYI
HHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHEEEEHHHHHHHHHHHHCCCCCCCCCC
PFGSYAREALKVYMNSGRQCLLMKAKEPHDLLFVNQRGGPLTARGIRHILSGLVQKASST
CCHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCE
LHIHPHMLRHTFATHLLNEGADLRSVQELLGHSNLSSTQIYTHVSKEMLRNTYMSHHPRA
EEECHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCH
FKKN
HCCC
>Mature Secondary Structure
MENVKNFVKLFVEYLQIEKNYSQYTIVNYVDSIEEFETFLRVQGINGFEEAAYQDTRIFL
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHH
TEAYEKGLSRRTISKKISALRSFYKFLMREKLIEENPFQLVHLPKQEKRIPKFLYQKELE
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHH
ELFEVSDISQPAGMRDQALLELLYATGMRVSECCSITINDVDLFMDTVLVHGKGKKQRYI
HHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHEEEEHHHHHHHHHHHHCCCCCCCCCC
PFGSYAREALKVYMNSGRQCLLMKAKEPHDLLFVNQRGGPLTARGIRHILSGLVQKASST
CCHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCE
LHIHPHMLRHTFATHLLNEGADLRSVQELLGHSNLSSTQIYTHVSKEMLRNTYMSHHPRA
EEECHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCH
FKKN
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7783641; 9384377; 10498718