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The map label for this gene is sucD

Identifier: 16078673

GI number: 16078673

Start: 1681617

End: 1682519

Strand: Direct

Name: sucD

Synonym: BSU16100

Alternate gene names: 16078673

Gene position: 1681617-1682519 (Clockwise)

Preceding gene: 16078672

Following gene: 16078674

Centisome position: 39.89

GC content: 46.4

Gene sequence:

>903_bases
ATGAGTGTTTTCATTAATAAAGATACAAGAGTTATTGTGCAAGGGATTACAGGTTCTACCGCTTTATTTCATACGAAGCA
GATGCTTGAATACGGCACAAATATCGTTGGCGGTGTAACACCTGGAAAAGGCGGAACAGAAGCGGAAGGTGTTCCTGTAT
TTAATACAGTGGCTGAAGCAGTTCAAACAACCGGCGCTAACGCGTCTGTTATATATGTGCCCGCACCGTTTGCAGCTGAT
GCGATTATGGAAGCGGTAGATGCGGAGCTTGATCTCGTGATTTGTATCACAGAACATATCCCGGTTTTGGATATGGTGAA
GGTCAAACGCTTCATGGAAGGCAAGAAAACGAGACTGATAGGGCCGAACTGTCCTGGTGTCATTACGCCTGAAGAATGTA
AAATCGGCATTATGCCCGGATACATCCATAAAAAGGGTCATGTAGGCGTTGTATCACGTTCAGGAACATTAACATACGAA
GCGGTGCACCAGCTCTCAGAAGCGGGTGTAGGGCAATCTACAGCTGTTGGAATCGGCGGCGACCCTGTAAATGGAACAAA
CTTTATTGACGTTTTAAAAGCGTTTAACGAAGATCCTGACACACACGCAGTCATCATGATTGGCGAAATCGGCGGTACGG
CCGAAGAGGAAGCGGCAGAGTGGGTAAAAGCCAACATGACAAAACCGGTAGTCGGTTTTATTGGCGGTAAAACAGCACCT
CCTGGGAAGCGCATGGGGCATGCAGGCGCCATTATTTCCGGCGGGAAAGGGACAGCTGATGAAAAAATCAAAACCCTTAA
TGCATGCGGAATCGAAGTTGCAGAGACACCTTCTGTCATGGGTGAAACCTTAATCAAGGTGCTGAAAGAGAAGAACTTGT
TCGAAACTTGTAAAACGCATTAA

Upstream 100 bases:

>100_bases
GAATCAGGATTAAACATTACATCTGCGGAATCAATGGCTGACGGCGCGCAGAAAATCGTATCCTTAGTTTAAGAAAGAAT
GAAAGGCAGGGGACCAAATA

Downstream 100 bases:

>100_bases
TAAAAAAGGGACAGCCGTCAAGGCTGTTCCTGCTTTTTCTAACAAAAGGAGGTCAATCTATTGGATCAGGCCGCTGTCTG
CCTAACGATTTGCAGAATCA

Product: succinyl-CoA synthetase subunit alpha

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha; Vegetative protein 239; VEG239

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MSVFINKDTRVIVQGITGSTALFHTKQMLEYGTNIVGGVTPGKGGTEAEGVPVFNTVAEAVQTTGANASVIYVPAPFAAD
AIMEAVDAELDLVICITEHIPVLDMVKVKRFMEGKKTRLIGPNCPGVITPEECKIGIMPGYIHKKGHVGVVSRSGTLTYE
AVHQLSEAGVGQSTAVGIGGDPVNGTNFIDVLKAFNEDPDTHAVIMIGEIGGTAEEEAAEWVKANMTKPVVGFIGGKTAP
PGKRMGHAGAIISGGKGTADEKIKTLNACGIEVAETPSVMGETLIKVLKEKNLFETCKTH

Sequences:

>Translated_300_residues
MSVFINKDTRVIVQGITGSTALFHTKQMLEYGTNIVGGVTPGKGGTEAEGVPVFNTVAEAVQTTGANASVIYVPAPFAAD
AIMEAVDAELDLVICITEHIPVLDMVKVKRFMEGKKTRLIGPNCPGVITPEECKIGIMPGYIHKKGHVGVVSRSGTLTYE
AVHQLSEAGVGQSTAVGIGGDPVNGTNFIDVLKAFNEDPDTHAVIMIGEIGGTAEEEAAEWVKANMTKPVVGFIGGKTAP
PGKRMGHAGAIISGGKGTADEKIKTLNACGIEVAETPSVMGETLIKVLKEKNLFETCKTH
>Mature_299_residues
SVFINKDTRVIVQGITGSTALFHTKQMLEYGTNIVGGVTPGKGGTEAEGVPVFNTVAEAVQTTGANASVIYVPAPFAADA
IMEAVDAELDLVICITEHIPVLDMVKVKRFMEGKKTRLIGPNCPGVITPEECKIGIMPGYIHKKGHVGVVSRSGTLTYEA
VHQLSEAGVGQSTAVGIGGDPVNGTNFIDVLKAFNEDPDTHAVIMIGEIGGTAEEEAAEWVKANMTKPVVGFIGGKTAPP
GKRMGHAGAIISGGKGTADEKIKTLNACGIEVAETPSVMGETLIKVLKEKNLFETCKTH

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family

Homologues:

Organism=Homo sapiens, GI109452591, Length=297, Percent_Identity=60.6060606060606, Blast_Score=308, Evalue=3e-84,
Organism=Homo sapiens, GI38569423, Length=254, Percent_Identity=28.740157480315, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI38569421, Length=254, Percent_Identity=28.740157480315, Blast_Score=88, Evalue=9e-18,
Organism=Escherichia coli, GI1786949, Length=289, Percent_Identity=64.3598615916955, Blast_Score=377, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17550194, Length=285, Percent_Identity=62.8070175438596, Blast_Score=344, Evalue=4e-95,
Organism=Caenorhabditis elegans, GI17553126, Length=292, Percent_Identity=59.9315068493151, Blast_Score=333, Evalue=9e-92,
Organism=Caenorhabditis elegans, GI17557344, Length=254, Percent_Identity=26.3779527559055, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17551266, Length=255, Percent_Identity=26.2745098039216, Blast_Score=78, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6324716, Length=293, Percent_Identity=47.7815699658703, Blast_Score=265, Evalue=5e-72,
Organism=Drosophila melanogaster, GI21356559, Length=287, Percent_Identity=56.794425087108, Blast_Score=339, Evalue=1e-93,
Organism=Drosophila melanogaster, GI28574296, Length=294, Percent_Identity=58.843537414966, Blast_Score=315, Evalue=3e-86,
Organism=Drosophila melanogaster, GI281363477, Length=254, Percent_Identity=27.9527559055118, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI281363475, Length=254, Percent_Identity=27.9527559055118, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI281363473, Length=254, Percent_Identity=27.9527559055118, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SUCD_BACSU (P80865)

Other databases:

- EMBL:   AJ000975
- EMBL:   AL009126
- PIR:   F69719
- RefSeq:   NP_389492.1
- ProteinModelPortal:   P80865
- SMR:   P80865
- PhosSite:   P80865
- EnsemblBacteria:   EBBACT00000004047
- GeneID:   937797
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU16100
- NMPDR:   fig|224308.1.peg.1612
- GenoList:   BSU16100
- GeneTree:   EBGT00050000000622
- HOGENOM:   HBG615372
- OMA:   ADAICEA
- PhylomeDB:   P80865
- ProtClustDB:   PRK05678
- BioCyc:   BSUB:BSU16100-MONOMER
- BRENDA:   6.2.1.5
- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:3.40.50.261
- PIRSF:   PIRSF001553
- PRINTS:   PR01798
- SMART:   SM00881
- TIGRFAMs:   TIGR01019

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA; SSF52210 CoA_ligase

EC number: =6.2.1.5

Molecular weight: Translated: 31383; Mature: 31251

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS01216 SUCCINYL_COA_LIG_1; PS00399 SUCCINYL_COA_LIG_2

Important sites: ACT_SITE 247-247

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVFINKDTRVIVQGITGSTALFHTKQMLEYGTNIVGGVTPGKGGTEAEGVPVFNTVAEA
CEEEEECCCEEEEEECCCCHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCHHHHHHHH
VQTTGANASVIYVPAPFAADAIMEAVDAELDLVICITEHIPVLDMVKVKRFMEGKKTRLI
HHHCCCCCEEEEECCCHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHCCCCEEEE
GPNCPGVITPEECKIGIMPGYIHKKGHVGVVSRSGTLTYEAVHQLSEAGVGQSTAVGIGG
CCCCCCCCCCCCCEEECCCCCEECCCCEEEEECCCCCHHHHHHHHHHCCCCCCEEEECCC
DPVNGTNFIDVLKAFNEDPDTHAVIMIGEIGGTAEEEAAEWVKANMTKPVVGFIGGKTAP
CCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCEEEECCCCCCC
PGKRMGHAGAIISGGKGTADEKIKTLNACGIEVAETPSVMGETLIKVLKEKNLFETCKTH
CCCCCCCCCEEEECCCCCHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHCCHHHHHCCC
>Mature Secondary Structure 
SVFINKDTRVIVQGITGSTALFHTKQMLEYGTNIVGGVTPGKGGTEAEGVPVFNTVAEA
EEEEECCCEEEEEECCCCHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCHHHHHHHH
VQTTGANASVIYVPAPFAADAIMEAVDAELDLVICITEHIPVLDMVKVKRFMEGKKTRLI
HHHCCCCCEEEEECCCHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHCCCCEEEE
GPNCPGVITPEECKIGIMPGYIHKKGHVGVVSRSGTLTYEAVHQLSEAGVGQSTAVGIGG
CCCCCCCCCCCCCEEECCCCCEECCCCEEEEECCCCCHHHHHHHHHHCCCCCCEEEECCC
DPVNGTNFIDVLKAFNEDPDTHAVIMIGEIGGTAEEEAAEWVKANMTKPVVGFIGGKTAP
CCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCEEEECCCCCCC
PGKRMGHAGAIISGGKGTADEKIKTLNACGIEVAETPSVMGETLIKVLKEKNLFETCKTH
CCCCCCCCCEEEECCCCCHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 9298659