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The map label for this gene is kinC

Identifier: 16078513

GI number: 16078513

Start: 1518333

End: 1519619

Strand: Direct

Name: kinC

Synonym: BSU14490

Alternate gene names: 16078513

Gene position: 1518333-1519619 (Clockwise)

Preceding gene: 16078512

Following gene: 16078514

Centisome position: 36.02

GC content: 39.63

Gene sequence:

>1287_bases
ATGAGAAAATATCAAGCTCGTATCATTTCCATCATTTTGGCAATGATTTTTATAATGTTTTGGGATTATTTATTTTATTT
TATAGGCAAAAACCCGATTAATTGGCCTGTTGATATTGTGTATACTGCAGTCACGCTGGTAAGTGTCTGGATGTTGGCTT
ATTATATTGATGAGAAACAGCAGCTGGTTAAGAAAATGAAGGATAACGAATGGAAGTATAAACAGCTTTCTGAAGAAAAA
AACCGCATCATGGATAATTTGCAGGAAATCGTATTTCAAACGAATGCAAAAGGTGAAATTACATATTTAAACCAAGCGTG
GGCATCTATAACCGGGTTTTCAATCAGTGAATGTATGGGAACAATGTATAACGATTACTTCATAAAAGAAAAGCACGTAG
CCGACCACATTAACACCCAAATCCAAAACAAAGCGTCTTCTGGCATGTTTACGGCAAAATACGTGACAAAAAACGGCACG
ATTTTTTGGGGAGAAGTTCATTATAAACTTTACTATGACCGGGATGACCAATTTACAGGCAGCCTGGGTACAATGTCAGA
TATCACTGAGCGGAAAGAGGCTGAAGATGAGCTCATTGAGATTAATGAACGGCTGGCGAGGGAATCCCAGAAACTATCAA
TCACAAGTGAACTTGCCGCAGGTATTGCTCATGAGGTCAGAAACCCTTTAACATCTGTCAGCGGTTTCCTCCAGATTATG
AAAACACAATATCCGGACAGAAAAGACTATTTTGACATCATCTTTTCAGAGATTAAAAGAATCGATTTAGTGCTCAGCGA
GCTGCTGCTGCTTGCAAAACCGCAGGCAATCACATTTAAAACACACCAGCTTAATGAGATCTTGAAACAAGTCACGACAT
TGCTTGATACCAATGCAATTCTGTCCAATATCGTCATAGAGAAAAATTTCAAAGAGACAGATGGCTGTATGATTAATGGA
GACGAAAATCAGCTGAAGCAGGTCTTTATCAACATCATTAAAAACGGAATTGAGGCAATGCCAAAGGGCGGTGTCGTAAC
CATTTCAACTGCTAAAACCGCCTCTCATGCAGTGATAAGCGTAAAGGATGAAGGAAACGGCATGCCGCAGGAAAAGCTGA
AGCAGATTGGCAAACCTTTTTATTCAACAAAAGAAAAGGGCACTGGACTGGGACTTCCCATTTGTTTGAGAATCCTGAAG
GAACATGACGGGGAATTGAAAATCGAAAGTGAAGCTGGAAAAGGCAGCGTCTTTCAAGTGGTTTTGCCTTTAAAATCAGA
CAGCTGA

Upstream 100 bases:

>100_bases
TATTTGGTAATGAATGATTTGGGATACTTTACATATTTTACTCAATTATTTGTCGAAGAATGGTACAATAAGTAGAGAAA
CACAAGCGGCAGGTGGTCAT

Downstream 100 bases:

>100_bases
GAGGAGAAAAATAAAGTGAACTCGCTTCTGTTTGTATACGGGACATTAAGAAAGCATGAAAAAAACCATCATTTGCTGGC
ACAATCGGCATGTATCAATG

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MRKYQARIISIILAMIFIMFWDYLFYFIGKNPINWPVDIVYTAVTLVSVWMLAYYIDEKQQLVKKMKDNEWKYKQLSEEK
NRIMDNLQEIVFQTNAKGEITYLNQAWASITGFSISECMGTMYNDYFIKEKHVADHINTQIQNKASSGMFTAKYVTKNGT
IFWGEVHYKLYYDRDDQFTGSLGTMSDITERKEAEDELIEINERLARESQKLSITSELAAGIAHEVRNPLTSVSGFLQIM
KTQYPDRKDYFDIIFSEIKRIDLVLSELLLLAKPQAITFKTHQLNEILKQVTTLLDTNAILSNIVIEKNFKETDGCMING
DENQLKQVFINIIKNGIEAMPKGGVVTISTAKTASHAVISVKDEGNGMPQEKLKQIGKPFYSTKEKGTGLGLPICLRILK
EHDGELKIESEAGKGSVFQVVLPLKSDS

Sequences:

>Translated_428_residues
MRKYQARIISIILAMIFIMFWDYLFYFIGKNPINWPVDIVYTAVTLVSVWMLAYYIDEKQQLVKKMKDNEWKYKQLSEEK
NRIMDNLQEIVFQTNAKGEITYLNQAWASITGFSISECMGTMYNDYFIKEKHVADHINTQIQNKASSGMFTAKYVTKNGT
IFWGEVHYKLYYDRDDQFTGSLGTMSDITERKEAEDELIEINERLARESQKLSITSELAAGIAHEVRNPLTSVSGFLQIM
KTQYPDRKDYFDIIFSEIKRIDLVLSELLLLAKPQAITFKTHQLNEILKQVTTLLDTNAILSNIVIEKNFKETDGCMING
DENQLKQVFINIIKNGIEAMPKGGVVTISTAKTASHAVISVKDEGNGMPQEKLKQIGKPFYSTKEKGTGLGLPICLRILK
EHDGELKIESEAGKGSVFQVVLPLKSDS
>Mature_428_residues
MRKYQARIISIILAMIFIMFWDYLFYFIGKNPINWPVDIVYTAVTLVSVWMLAYYIDEKQQLVKKMKDNEWKYKQLSEEK
NRIMDNLQEIVFQTNAKGEITYLNQAWASITGFSISECMGTMYNDYFIKEKHVADHINTQIQNKASSGMFTAKYVTKNGT
IFWGEVHYKLYYDRDDQFTGSLGTMSDITERKEAEDELIEINERLARESQKLSITSELAAGIAHEVRNPLTSVSGFLQIM
KTQYPDRKDYFDIIFSEIKRIDLVLSELLLLAKPQAITFKTHQLNEILKQVTTLLDTNAILSNIVIEKNFKETDGCMING
DENQLKQVFINIIKNGIEAMPKGGVVTISTAKTASHAVISVKDEGNGMPQEKLKQIGKPFYSTKEKGTGLGLPICLRILK
EHDGELKIESEAGKGSVFQVVLPLKSDS

Specific function: Phosphorylates the sporulation-regulatory protein spo0A

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain

Homologues:

Organism=Escherichia coli, GI1788549, Length=350, Percent_Identity=30, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1790436, Length=222, Percent_Identity=32.4324324324324, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1786600, Length=217, Percent_Identity=29.4930875576037, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790300, Length=223, Percent_Identity=28.2511210762332, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI145693157, Length=258, Percent_Identity=26.7441860465116, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI48994928, Length=378, Percent_Identity=24.0740740740741, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1788713, Length=258, Percent_Identity=26.7441860465116, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1786783, Length=245, Percent_Identity=26.530612244898, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1789149, Length=262, Percent_Identity=25.1908396946565, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI87081816, Length=246, Percent_Identity=25.609756097561, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1790346, Length=219, Percent_Identity=27.3972602739726, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1788393, Length=263, Percent_Identity=24.7148288973384, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI87082128, Length=261, Percent_Identity=23.3716475095785, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1790551, Length=228, Percent_Identity=25.8771929824561, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790861, Length=199, Percent_Identity=22.1105527638191, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KINC_BACSU (P39764)

Other databases:

- EMBL:   D37798
- EMBL:   D37799
- EMBL:   L34803
- EMBL:   AF012285
- EMBL:   AL009126
- PIR:   I39871
- RefSeq:   NP_389332.1
- ProteinModelPortal:   P39764
- SMR:   P39764
- EnsemblBacteria:   EBBACT00000000408
- GeneID:   938742
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU14490
- NMPDR:   fig|224308.1.peg.1451
- GenoList:   BSU14490
- GeneTree:   EBGT00070000031987
- HOGENOM:   HBG337968
- OMA:   NRIMDNL
- PhylomeDB:   P39764
- ProtClustDB:   CLSK887239
- BioCyc:   BSUB:BSU14490-MONOMER
- BRENDA:   2.7.13.3
- InterPro:   IPR003594
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- Gene3D:   G3DSA:3.30.565.10
- PRINTS:   PR00344
- SMART:   SM00387
- SMART:   SM00388
- SMART:   SM00086
- SMART:   SM00091
- TIGRFAMs:   TIGR00229

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS; SSF55874 ATP_bd_ATPase; SSF47384 His_kin_homodim

EC number: =2.7.13.3

Molecular weight: Translated: 48847; Mature: 48847

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS50109 HIS_KIN; PS50113 PAC; PS50112 PAS

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xeb082ec)-; HASH(0xed26360)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKYQARIISIILAMIFIMFWDYLFYFIGKNPINWPVDIVYTAVTLVSVWMLAYYIDEKQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
QLVKKMKDNEWKYKQLSEEKNRIMDNLQEIVFQTNAKGEITYLNQAWASITGFSISECMG
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHCCCCHHHHHH
TMYNDYFIKEKHVADHINTQIQNKASSGMFTAKYVTKNGTIFWGEVHYKLYYDRDDQFTG
HHHHHHHEEHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEEEEEEECCCCCCCC
SLGTMSDITERKEAEDELIEINERLARESQKLSITSELAAGIAHEVRNPLTSVSGFLQIM
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KTQYPDRKDYFDIIFSEIKRIDLVLSELLLLAKPQAITFKTHQLNEILKQVTTLLDTNAI
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHH
LSNIVIEKNFKETDGCMINGDENQLKQVFINIIKNGIEAMPKGGVVTISTAKTASHAVIS
HHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEE
VKDEGNGMPQEKLKQIGKPFYSTKEKGTGLGLPICLRILKEHDGELKIESEAGKGSVFQV
EECCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCEEEE
VLPLKSDS
EEECCCCH
>Mature Secondary Structure
MRKYQARIISIILAMIFIMFWDYLFYFIGKNPINWPVDIVYTAVTLVSVWMLAYYIDEKQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
QLVKKMKDNEWKYKQLSEEKNRIMDNLQEIVFQTNAKGEITYLNQAWASITGFSISECMG
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHCCCCHHHHHH
TMYNDYFIKEKHVADHINTQIQNKASSGMFTAKYVTKNGTIFWGEVHYKLYYDRDDQFTG
HHHHHHHEEHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEEEEEEECCCCCCCC
SLGTMSDITERKEAEDELIEINERLARESQKLSITSELAAGIAHEVRNPLTSVSGFLQIM
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KTQYPDRKDYFDIIFSEIKRIDLVLSELLLLAKPQAITFKTHQLNEILKQVTTLLDTNAI
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHH
LSNIVIEKNFKETDGCMINGDENQLKQVFINIIKNGIEAMPKGGVVTISTAKTASHAVIS
HHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEE
VKDEGNGMPQEKLKQIGKPFYSTKEKGTGLGLPICLRILKEHDGELKIESEAGKGSVFQV
EECCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCEEEE
VLPLKSDS
EEECCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8002615; 8002614; 8969500; 9384377