Click here to switch to the map view.

The map label for this gene is ykkC

Identifier: 16078374

GI number: 16078374

Start: 1376517

End: 1376855

Strand: Direct

Name: ykkC

Synonym: BSU13090

Alternate gene names: 16078374

Gene position: 1376517-1376855 (Clockwise)

Preceding gene: 16078373

Following gene: 16078375

Centisome position: 32.65

GC content: 49.26

Gene sequence:

>339_bases
ATGAAATGGGGATTGGTCGTGCTTGCCGCTGTTTTCGAGGTTGTTTGGGTGATAGGCTTAAAGCACGCTGACTCAGCCTT
AACATGGAGCGGCACTGCCATCGGCATCATATTCAGCTTTTACCTTCTAATGAAGGCGACTCACAGTCTGCCTGTTGGTA
CCGTGTATGCCGTCTTTACCGGGCTCGGCACAGCGGGAACAGTACTTAGTGAAATCGTTCTTTTTCATGAACCGGTTGGA
TGGCCGAAGCTATTGTTAATTGGCGTGCTCTTAATCGGTGTAATCGGGTTGAAGCTTGTGACACAGGATGAGACAGAGGA
AAAAGGAGGCGAGGCATAA

Upstream 100 bases:

>100_bases
GGAGGGAAAAAAGCCCGGGAGAGTCAATCTCATGTGAGACGACTGTCCGGGGTTTTTTTGTTTTCGGAGAATCTTAATAG
ATAGAAAGGAATGACTCAAA

Downstream 100 bases:

>100_bases
TGCTGCACTGGATCAGTTTATTGTGCGCGGGCTGTTTAGAAATGGCCGGCGTGGCCCTTATGAATCAATATGCGAAAGAA
AAAAGCGTGAAATGGGTGCT

Product: efflux transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 112; Mature: 112

Protein sequence:

>112_residues
MKWGLVVLAAVFEVVWVIGLKHADSALTWSGTAIGIIFSFYLLMKATHSLPVGTVYAVFTGLGTAGTVLSEIVLFHEPVG
WPKLLLIGVLLIGVIGLKLVTQDETEEKGGEA

Sequences:

>Translated_112_residues
MKWGLVVLAAVFEVVWVIGLKHADSALTWSGTAIGIIFSFYLLMKATHSLPVGTVYAVFTGLGTAGTVLSEIVLFHEPVG
WPKLLLIGVLLIGVIGLKLVTQDETEEKGGEA
>Mature_112_residues
MKWGLVVLAAVFEVVWVIGLKHADSALTWSGTAIGIIFSFYLLMKATHSLPVGTVYAVFTGLGTAGTVLSEIVLFHEPVG
WPKLLLIGVLLIGVIGLKLVTQDETEEKGGEA

Specific function: Part of a multidrug efflux pump. Confers resistance to a broad range of toxic compounds such as cationic dyes, neutral and anionic antimicrobials

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family. YkkC/ykkD (TC 2.A.7.1.5) subfamily

Homologues:

Organism=Escherichia coli, GI87082378, Length=105, Percent_Identity=44.7619047619048, Blast_Score=70, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): YKKC_BACSU (P49856)

Other databases:

- EMBL:   D78189
- EMBL:   AJ002571
- EMBL:   AL009126
- PIR:   A69857
- RefSeq:   NP_389192.1
- ProteinModelPortal:   P49856
- EnsemblBacteria:   EBBACT00000001526
- GeneID:   936835
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU13090
- NMPDR:   fig|224308.1.peg.1311
- GenoList:   BSU13090
- GeneTree:   EBGT00050000001579
- HOGENOM:   HBG740972
- OMA:   ISACKYL
- ProtClustDB:   CLSK887163
- BioCyc:   BSUB:BSU13090-MONOMER
- GO:   GO:0006810
- InterPro:   IPR000390

Pfam domain/function: PF00893 Multi_Drug_Res

EC number: NA

Molecular weight: Translated: 11921; Mature: 11921

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xe64771c)-; HASH(0xe51691c)-; HASH(0xe9d3e18)-; HASH(0xe988788)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKWGLVVLAAVFEVVWVIGLKHADSALTWSGTAIGIIFSFYLLMKATHSLPVGTVYAVFT
CCHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
GLGTAGTVLSEIVLFHEPVGWPKLLLIGVLLIGVIGLKLVTQDETEEKGGEA
CCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
>Mature Secondary Structure
MKWGLVVLAAVFEVVWVIGLKHADSALTWSGTAIGIIFSFYLLMKATHSLPVGTVYAVFT
CCHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
GLGTAGTVLSEIVLFHEPVGWPKLLLIGVLLIGVIGLKLVTQDETEEKGGEA
CCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8682784; 9384377