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The map label for this gene is ykkD

Identifier: 16078375

GI number: 16078375

Start: 1376855

End: 1377172

Strand: Direct

Name: ykkD

Synonym: BSU13100

Alternate gene names: 16078375

Gene position: 1376855-1377172 (Clockwise)

Preceding gene: 16078374

Following gene: 255767307

Centisome position: 32.66

GC content: 48.11

Gene sequence:

>318_bases
ATGCTGCACTGGATCAGTTTATTGTGCGCGGGCTGTTTAGAAATGGCCGGCGTGGCCCTTATGAATCAATATGCGAAAGA
AAAAAGCGTGAAATGGGTGCTGTTGATCATTGTTGGTTTTGCCGCTTCATTTTCCTTGCTGTCGTACGCAATGGAAACCA
CTCCGATGGGAACGGCTTACGCGGTCTGGACAGGAATTGGCACCGCCGGCGGGGCGCTTATCGGCATCCTCTTTTACAAG
GAGCAGAAAGACGCCAAACGGATCTTCTTTATCGCGTTGATTTTATGCTCAGCAGTTGGTTTAAAAATTCTGTCATAA

Upstream 100 bases:

>100_bases
GATGGCCGAAGCTATTGTTAATTGGCGTGCTCTTAATCGGTGTAATCGGGTTGAAGCTTGTGACACAGGATGAGACAGAG
GAAAAAGGAGGCGAGGCATA

Downstream 100 bases:

>100_bases
ATTGATTTTTATCAAATCTTCAGTATAATGGATAAATAGTTTAGACTTACAAAGATAAGAGGGATTATTCATGAAATCAT
ATATGACTCAGCGGTTGGAC

Product: efflux transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 105; Mature: 105

Protein sequence:

>105_residues
MLHWISLLCAGCLEMAGVALMNQYAKEKSVKWVLLIIVGFAASFSLLSYAMETTPMGTAYAVWTGIGTAGGALIGILFYK
EQKDAKRIFFIALILCSAVGLKILS

Sequences:

>Translated_105_residues
MLHWISLLCAGCLEMAGVALMNQYAKEKSVKWVLLIIVGFAASFSLLSYAMETTPMGTAYAVWTGIGTAGGALIGILFYK
EQKDAKRIFFIALILCSAVGLKILS
>Mature_105_residues
MLHWISLLCAGCLEMAGVALMNQYAKEKSVKWVLLIIVGFAASFSLLSYAMETTPMGTAYAVWTGIGTAGGALIGILFYK
EQKDAKRIFFIALILCSAVGLKILS

Specific function: Part of a multidrug efflux pump. Confers resistance to a broad range of toxic compounds such as cationic dyes, neutral and anionic antimicrobials

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family. YkkC/ykkD (TC 2.A.7.1.5) subfamily

Homologues:

Organism=Escherichia coli, GI87082378, Length=106, Percent_Identity=39.622641509434, Blast_Score=66, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): YKKD_BACSU (P49857)

Other databases:

- EMBL:   D78189
- EMBL:   AJ002571
- EMBL:   AL009126
- PIR:   B69857
- RefSeq:   NP_389193.1
- ProteinModelPortal:   P49857
- EnsemblBacteria:   EBBACT00000000617
- GeneID:   938109
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU13100
- NMPDR:   fig|224308.1.peg.1312
- GenoList:   BSU13100
- GeneTree:   EBGT00050000001579
- HOGENOM:   HBG740972
- OMA:   GVAMINQ
- ProtClustDB:   CLSK887164
- BioCyc:   BSUB:BSU13100-MONOMER
- GO:   GO:0006810
- InterPro:   IPR000390

Pfam domain/function: PF00893 Multi_Drug_Res

EC number: NA

Molecular weight: Translated: 11325; Mature: 11325

Theoretical pI: Translated: 8.85; Mature: 8.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xe99f16c)-; HASH(0xe619068)-; HASH(0xe98d9e8)-; HASH(0xc8e2a0c)-;

Cys/Met content:

2.9 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
7.6 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
7.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHWISLLCAGCLEMAGVALMNQYAKEKSVKWVLLIIVGFAASFSLLSYAMETTPMGTAY
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
AVWTGIGTAGGALIGILFYKEQKDAKRIFFIALILCSAVGLKILS
HHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure
MLHWISLLCAGCLEMAGVALMNQYAKEKSVKWVLLIIVGFAASFSLLSYAMETTPMGTAY
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
AVWTGIGTAGGALIGILFYKEQKDAKRIFFIALILCSAVGLKILS
HHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8682784; 9384377