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The map label for this gene is uxaB

Identifier: 16078303

GI number: 16078303

Start: 1309880

End: 1311322

Strand: Direct

Name: uxaB

Synonym: BSU12380

Alternate gene names: 16078303

Gene position: 1309880-1311322 (Clockwise)

Preceding gene: 16078302

Following gene: 255767278

Centisome position: 31.07

GC content: 42.9

Gene sequence:

>1443_bases
GTGCAGAAGCTGAATAAAAATGTGTACGATCACTATACTCAGTATCCAGAAAAAATTCTCCAATTCGGAGAAGGAAACTT
TCTTCGGGGATTTATCGATTGGCAGATTGATCAATTGAATCAACACACTGATTTTAATGGGAGCGTGGCAGTTGTCCAGC
CAAGAGGCTCAGAAAAAATCAAACGATTAAATGAGCAAGATGGATTATATACACTTTTTTTACAAGGAATGAAAGACGGA
GAAGCGGTAAACGAGCATATGATTATCAACTCAATCAGCCGGGGAATTGACCTGTTTTCTGATTATGAAGCATACAAAGA
ATTGGCATCAAGCGAAAGGCTTCGGTTTATTATCTCCAACACCACTGAGGCTGGGATTGTATGTGATGAAAAAGATCGTT
TAGAGGATAGGCCGCAAAAAACATTCCCTGGGAAATTAACTGCATTTCTTTACTTTCGCTATCAGGCTTTTAAAGGAGAT
CAGACAAAAGGGTGTGTCCTGATCCCATGTGAACTGATCGAGAATAACGGTGAAAAGCTGAGGGAAACGGTTCTTCATTA
TGCACATCTGTGGAAGCTGGAGGAAGGATTTACACAGTGGATTCATGAGGCCAATACATTTTGTAATAGTTTAGTAGACC
GGATTGTTCCGGGTTTTCCCGTCGACAGCATTGATGAGATCACGGCAGATCTTGGCTATCAGGATGATTTGATAGTTGTG
GGAGAGCAATATTATTTGTGGGTTATCGAGGGGCCTGATTGGATTGGAAAAGAACTTCCCTTTGCGGCTGCAGGGCTGCA
TACAAAGATCGTCAGCGACCTCACCCCATACCGGACTAAAAAAGTAAGAATTTTAAATGGCGCTCATACAGCAATGACGC
CAGTGGCTTTATTATACGGCTTGAAGACTGTTAGGGATGCAGTCGAGCATCCGGAAGTGGGGCGATTTATAAGAGAGCTG
ATTGATGACGAAATTCTTCCTGTTTTAAAAATGGAAGGTCTTTCTCAGTATGCTGACGATGTGCTGAACCGTTTTAAAAA
CCCGTATATTAAGCATTACCTGGAAAGCATTGCATTGAACGCCATTTCCAAATTCAAAACGAGAAACCTGCCGACTCTTA
AGGAATATGCTGAACAAAAGGGACAGCTTCCTGAACGCTTGGTGTTTTCTTTCAGCGCTCTTCTGTATTTTTATCATGAT
AACGAGACATTGCAGGATGATCCGGCAGTTCTTCAATTTTTCAAAGAGGTTTGGTGTCAGGAGGATGGCGACATGCTTCG
GATTGCATCAAGAGTGTTAGGCGAACAGCGGCTGTGGGGGGCAGATCTCAATGAGATACCGAAGCTGACTGATAGAGTCG
CTGTTTACTTGAATCATATTCATGAGCTGGGCATGCAGAGGGCTCTTGAACAATACTGCATACAAGGGGGAGAGGTACGT
TGA

Upstream 100 bases:

>100_bases
TCAGTCAGACGATTGACGACGTGATGTCCCGTTTTTCAGCGGGCATTCTTTATACAGAAAAATGTTAACGTGTGCATAAA
GTGAGAGGGAGGCAATAAGG

Downstream 100 bases:

>100_bases
AGTCGTTTATAAAGATTCATAAGCAAGATAATGTCCTTCTTGCTCTGCGGGATATTCAAAAGGGAGAGAGGCTGCATGCT
TACGGCGTGTCGATTGAAGT

Product: altronate oxidoreductase

Products: NA

Alternate protein names: Tagaturonate dehydrogenase; Tagaturonate reductase

Number of amino acids: Translated: 480; Mature: 480

Protein sequence:

>480_residues
MQKLNKNVYDHYTQYPEKILQFGEGNFLRGFIDWQIDQLNQHTDFNGSVAVVQPRGSEKIKRLNEQDGLYTLFLQGMKDG
EAVNEHMIINSISRGIDLFSDYEAYKELASSERLRFIISNTTEAGIVCDEKDRLEDRPQKTFPGKLTAFLYFRYQAFKGD
QTKGCVLIPCELIENNGEKLRETVLHYAHLWKLEEGFTQWIHEANTFCNSLVDRIVPGFPVDSIDEITADLGYQDDLIVV
GEQYYLWVIEGPDWIGKELPFAAAGLHTKIVSDLTPYRTKKVRILNGAHTAMTPVALLYGLKTVRDAVEHPEVGRFIREL
IDDEILPVLKMEGLSQYADDVLNRFKNPYIKHYLESIALNAISKFKTRNLPTLKEYAEQKGQLPERLVFSFSALLYFYHD
NETLQDDPAVLQFFKEVWCQEDGDMLRIASRVLGEQRLWGADLNEIPKLTDRVAVYLNHIHELGMQRALEQYCIQGGEVR

Sequences:

>Translated_480_residues
MQKLNKNVYDHYTQYPEKILQFGEGNFLRGFIDWQIDQLNQHTDFNGSVAVVQPRGSEKIKRLNEQDGLYTLFLQGMKDG
EAVNEHMIINSISRGIDLFSDYEAYKELASSERLRFIISNTTEAGIVCDEKDRLEDRPQKTFPGKLTAFLYFRYQAFKGD
QTKGCVLIPCELIENNGEKLRETVLHYAHLWKLEEGFTQWIHEANTFCNSLVDRIVPGFPVDSIDEITADLGYQDDLIVV
GEQYYLWVIEGPDWIGKELPFAAAGLHTKIVSDLTPYRTKKVRILNGAHTAMTPVALLYGLKTVRDAVEHPEVGRFIREL
IDDEILPVLKMEGLSQYADDVLNRFKNPYIKHYLESIALNAISKFKTRNLPTLKEYAEQKGQLPERLVFSFSALLYFYHD
NETLQDDPAVLQFFKEVWCQEDGDMLRIASRVLGEQRLWGADLNEIPKLTDRVAVYLNHIHELGMQRALEQYCIQGGEVR
>Mature_480_residues
MQKLNKNVYDHYTQYPEKILQFGEGNFLRGFIDWQIDQLNQHTDFNGSVAVVQPRGSEKIKRLNEQDGLYTLFLQGMKDG
EAVNEHMIINSISRGIDLFSDYEAYKELASSERLRFIISNTTEAGIVCDEKDRLEDRPQKTFPGKLTAFLYFRYQAFKGD
QTKGCVLIPCELIENNGEKLRETVLHYAHLWKLEEGFTQWIHEANTFCNSLVDRIVPGFPVDSIDEITADLGYQDDLIVV
GEQYYLWVIEGPDWIGKELPFAAAGLHTKIVSDLTPYRTKKVRILNGAHTAMTPVALLYGLKTVRDAVEHPEVGRFIREL
IDDEILPVLKMEGLSQYADDVLNRFKNPYIKHYLESIALNAISKFKTRNLPTLKEYAEQKGQLPERLVFSFSALLYFYHD
NETLQDDPAVLQFFKEVWCQEDGDMLRIASRVLGEQRLWGADLNEIPKLTDRVAVYLNHIHELGMQRALEQYCIQGGEVR

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family. UxaB subfamily

Homologues:

Organism=Escherichia coli, GI48994885, Length=484, Percent_Identity=44.2148760330579, Blast_Score=415, Evalue=1e-117,
Organism=Escherichia coli, GI1788497, Length=374, Percent_Identity=26.2032085561497, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1787823, Length=487, Percent_Identity=24.6406570841889, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1790779, Length=395, Percent_Identity=25.3164556962025, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6324401, Length=376, Percent_Identity=27.6595744680851, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6320765, Length=376, Percent_Identity=27.6595744680851, Blast_Score=119, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UXAB_BACSU (O34354)

Other databases:

- EMBL:   AF015825
- EMBL:   AL009126
- PIR:   C69853
- RefSeq:   NP_389120.1
- ProteinModelPortal:   O34354
- SMR:   O34354
- EnsemblBacteria:   EBBACT00000001461
- GeneID:   936468
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU12380
- NMPDR:   fig|224308.1.peg.1239
- GenoList:   BSU12380
- GeneTree:   EBGT00050000001215
- HOGENOM:   HBG297101
- OMA:   MTKYRTR
- PhylomeDB:   O34354
- ProtClustDB:   PRK03643
- BioCyc:   BSUB:BSU12380-MONOMER
- BRENDA:   1.1.1.58
- HAMAP:   MF_00670
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR013131
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PRINTS:   PR00084

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C; SSF48179 6DGDH_C_like

EC number: =1.1.1.58

Molecular weight: Translated: 55362; Mature: 55362

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKLNKNVYDHYTQYPEKILQFGEGNFLRGFIDWQIDQLNQHTDFNGSVAVVQPRGSEKI
CCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHCCCCCCCCCCEEEECCCCHHHH
KRLNEQDGLYTLFLQGMKDGEAVNEHMIINSISRGIDLFSDYEAYKELASSERLRFIISN
HHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
TTEAGIVCDEKDRLEDRPQKTFPGKLTAFLYFRYQAFKGDQTKGCVLIPCELIENNGEKL
CCCCCEEECCHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHCCCHHH
RETVLHYAHLWKLEEGFTQWIHEANTFCNSLVDRIVPGFPVDSIDEITADLGYQDDLIVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCEEEE
GEQYYLWVIEGPDWIGKELPFAAAGLHTKIVSDLTPYRTKKVRILNGAHTAMTPVALLYG
CCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHH
LKTVRDAVEHPEVGRFIRELIDDEILPVLKMEGLSQYADDVLNRFKNPYIKHYLESIALN
HHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
AISKFKTRNLPTLKEYAEQKGQLPERLVFSFSALLYFYHDNETLQDDPAVLQFFKEVWCQ
HHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHCC
EDGDMLRIASRVLGEQRLWGADLNEIPKLTDRVAVYLNHIHELGMQRALEQYCIQGGEVR
CCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MQKLNKNVYDHYTQYPEKILQFGEGNFLRGFIDWQIDQLNQHTDFNGSVAVVQPRGSEKI
CCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHCCCCCCCCCCEEEECCCCHHHH
KRLNEQDGLYTLFLQGMKDGEAVNEHMIINSISRGIDLFSDYEAYKELASSERLRFIISN
HHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
TTEAGIVCDEKDRLEDRPQKTFPGKLTAFLYFRYQAFKGDQTKGCVLIPCELIENNGEKL
CCCCCEEECCHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHCCCHHH
RETVLHYAHLWKLEEGFTQWIHEANTFCNSLVDRIVPGFPVDSIDEITADLGYQDDLIVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCEEEE
GEQYYLWVIEGPDWIGKELPFAAAGLHTKIVSDLTPYRTKKVRILNGAHTAMTPVALLYG
CCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHH
LKTVRDAVEHPEVGRFIRELIDDEILPVLKMEGLSQYADDVLNRFKNPYIKHYLESIALN
HHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
AISKFKTRNLPTLKEYAEQKGQLPERLVFSFSALLYFYHDNETLQDDPAVLQFFKEVWCQ
HHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHCC
EDGDMLRIASRVLGEQRLWGADLNEIPKLTDRVAVYLNHIHELGMQRALEQYCIQGGEVR
CCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579062; 9384377