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The map label for this gene is uxaA

Identifier: 255767278

GI number: 255767278

Start: 1311319

End: 1312812

Strand: Direct

Name: uxaA

Synonym: BSU12390

Alternate gene names: 255767278

Gene position: 1311319-1312812 (Clockwise)

Preceding gene: 16078303

Following gene: 16078307

Centisome position: 31.11

GC content: 46.18

Gene sequence:

>1494_bases
TTGAAGTCGTTTATAAAGATTCATAAGCAAGATAATGTCCTTCTTGCTCTGCGGGATATTCAAAAGGGAGAGAGGCTGCA
TGCTTACGGCGTGTCGATTGAAGTAAAGGATGATATAAAAAGAGGCCATAAGATTGCATTGCAGTCTATCAAAGAAAACG
ACAGCATCGTCAAGTACGGGTTTCCAATCGGTCATGCATCACAAGATATCTCGATCGGAGAGCATATTCATGTCCATAAT
ACGAAAACAAACCTGTCTGATATCCAATTATACAGCTATACACCGAGATTTGATGAAAATCCGTATTCTAATGAGAACCG
GACGTTTAAAGGTTTTAGAAGAGAAAACGGAGATGCGGGTGTACGGAATGAATTGTGGATTGTCCCAACTGTCGGCTGTG
TCAATGGAATAGCAGAAAAAATGCTGCAGCGTTTTGTCAGAGAAACAGGGGATATCGCTCCATTTGATAACGTACTGGTG
TTAAAGCATCAATACGGATGCTCGCAGCTTGGCGACGATCATGAAAATACGAAGCAGATCCTGCTGAATGCCATTCGCCA
TCCAAATGCCGGCGGCGTCTTGGTGTTAGGGCTTGGCTGTGAAAACAATGAGCTGGCAAGAATGAAGGAAGCACTGCAAG
ATGTGAACTTGAAGCGGGTGAAGTTTCTGGAATCCCAGTCGGTGACCGACGAAATGGAGGCAGGCGTTGCTTTGCTGAAG
GAAATTCATGAAGCGGCCAAAGGAGATAAGAGAGAAGACATTCCGCTGTCTGAACTGAAGATCGGGCTGAAATGCGGAGG
TTCGGACGGTTTTTCCGGCATAACCGCAAACCCGCTGCTTGGACGTTTTTCAGATTATCTCATTGCACAGGGAGGGAGTA
CTGTGCTGACGGAAGTACCGGAAATGTTCGGCGCAGAAACCATCCTGATGCAGCGGGCTGCCAATGAAGAAGTGTTTCAT
AAGATAGTCGATTTAATCAATGATTTCAAACAATACTTTATTAAACATGATCAGCCGGTGTACGAAAATCCTTCACCGGG
CAACAAAGCGGGCGGCATTTCTACACTTGAGGATAAATCGCTGGGCTGTACGCAAAAAGCGGGGATTTCTCCTGTCACGG
ATGTCTTGAAATACGGTGAAGTACTCAAGACAAAAGGGCTGACTCTTTTGAGCGCACCGGGCAATGATTTGATCGCCTCC
TCCGCATTGGCGGCTGCCGGCTGCCAAATTGTCCTCTTTACAACGGGAAGAGGCACGCCGTTTGGCACCTTTGTCCCGAC
GGTGAAAGTAGCGACAAACACCGAGCTGTATGAGGCGAAGCCGCATTGGATTGATTTTAACGCAGGCCTTTTAGCAGAGG
ATGATGTTCATGAGGAATATGTGCTGCGTGAGTTTATCCACTATATGATTGAGGTGGCAAGCGGCCAGCTTGTGAACCAT
GAAAAAAATGATTTCAAAGAACTCGCCATTTTTAAATCGGGTGTGACGTTATAA

Upstream 100 bases:

>100_bases
CGAAGCTGACTGATAGAGTCGCTGTTTACTTGAATCATATTCATGAGCTGGGCATGCAGAGGGCTCTTGAACAATACTGC
ATACAAGGGGGAGAGGTACG

Downstream 100 bases:

>100_bases
TAAGAAAAGGCTATCCTTCAAGCGGATAGCCTTCTTCATTAAATCAATTTTAAACCGCTGACTAAAATAATGGAAGCCAT
AATAAATTGCAGTGGACGCG

Product: altronate hydrolase

Products: NA

Alternate protein names: Altronic acid hydratase

Number of amino acids: Translated: 497; Mature: 497

Protein sequence:

>497_residues
MKSFIKIHKQDNVLLALRDIQKGERLHAYGVSIEVKDDIKRGHKIALQSIKENDSIVKYGFPIGHASQDISIGEHIHVHN
TKTNLSDIQLYSYTPRFDENPYSNENRTFKGFRRENGDAGVRNELWIVPTVGCVNGIAEKMLQRFVRETGDIAPFDNVLV
LKHQYGCSQLGDDHENTKQILLNAIRHPNAGGVLVLGLGCENNELARMKEALQDVNLKRVKFLESQSVTDEMEAGVALLK
EIHEAAKGDKREDIPLSELKIGLKCGGSDGFSGITANPLLGRFSDYLIAQGGSTVLTEVPEMFGAETILMQRAANEEVFH
KIVDLINDFKQYFIKHDQPVYENPSPGNKAGGISTLEDKSLGCTQKAGISPVTDVLKYGEVLKTKGLTLLSAPGNDLIAS
SALAAAGCQIVLFTTGRGTPFGTFVPTVKVATNTELYEAKPHWIDFNAGLLAEDDVHEEYVLREFIHYMIEVASGQLVNH
EKNDFKELAIFKSGVTL

Sequences:

>Translated_497_residues
MKSFIKIHKQDNVLLALRDIQKGERLHAYGVSIEVKDDIKRGHKIALQSIKENDSIVKYGFPIGHASQDISIGEHIHVHN
TKTNLSDIQLYSYTPRFDENPYSNENRTFKGFRRENGDAGVRNELWIVPTVGCVNGIAEKMLQRFVRETGDIAPFDNVLV
LKHQYGCSQLGDDHENTKQILLNAIRHPNAGGVLVLGLGCENNELARMKEALQDVNLKRVKFLESQSVTDEMEAGVALLK
EIHEAAKGDKREDIPLSELKIGLKCGGSDGFSGITANPLLGRFSDYLIAQGGSTVLTEVPEMFGAETILMQRAANEEVFH
KIVDLINDFKQYFIKHDQPVYENPSPGNKAGGISTLEDKSLGCTQKAGISPVTDVLKYGEVLKTKGLTLLSAPGNDLIAS
SALAAAGCQIVLFTTGRGTPFGTFVPTVKVATNTELYEAKPHWIDFNAGLLAEDDVHEEYVLREFIHYMIEVASGQLVNH
EKNDFKELAIFKSGVTL
>Mature_497_residues
MKSFIKIHKQDNVLLALRDIQKGERLHAYGVSIEVKDDIKRGHKIALQSIKENDSIVKYGFPIGHASQDISIGEHIHVHN
TKTNLSDIQLYSYTPRFDENPYSNENRTFKGFRRENGDAGVRNELWIVPTVGCVNGIAEKMLQRFVRETGDIAPFDNVLV
LKHQYGCSQLGDDHENTKQILLNAIRHPNAGGVLVLGLGCENNELARMKEALQDVNLKRVKFLESQSVTDEMEAGVALLK
EIHEAAKGDKREDIPLSELKIGLKCGGSDGFSGITANPLLGRFSDYLIAQGGSTVLTEVPEMFGAETILMQRAANEEVFH
KIVDLINDFKQYFIKHDQPVYENPSPGNKAGGISTLEDKSLGCTQKAGISPVTDVLKYGEVLKTKGLTLLSAPGNDLIAS
SALAAAGCQIVLFTTGRGTPFGTFVPTVKVATNTELYEAKPHWIDFNAGLLAEDDVHEEYVLREFIHYMIEVASGQLVNH
EKNDFKELAIFKSGVTL

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG2721

COG function: function code G; Altronate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uxaA family

Homologues:

Organism=Escherichia coli, GI1789475, Length=494, Percent_Identity=59.3117408906883, Blast_Score=622, Evalue=1e-179,
Organism=Escherichia coli, GI1789516, Length=492, Percent_Identity=33.9430894308943, Blast_Score=250, Evalue=2e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UXAA_BACSU (O34673)

Other databases:

- EMBL:   AF015825
- EMBL:   AL009126
- PIR:   D69853
- RefSeq:   NP_389121.2
- ProteinModelPortal:   O34673
- SMR:   O34673
- EnsemblBacteria:   EBBACT00000000865
- GeneID:   939837
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU12390
- NMPDR:   fig|224308.1.peg.1240
- GenoList:   BSU12390
- GeneTree:   EBGT00050000000845
- HOGENOM:   HBG373182
- ProtClustDB:   CLSK2748849
- BioCyc:   BSUB:BSU12390-MONOMER
- BRENDA:   4.2.1.7
- InterPro:   IPR007392
- InterPro:   IPR013974
- SMART:   SM00858

Pfam domain/function: PF04295 GD_AH_C; PF08666 SAF

EC number: =4.2.1.7

Molecular weight: Translated: 54873; Mature: 54873

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSFIKIHKQDNVLLALRDIQKGERLHAYGVSIEVKDDIKRGHKIALQSIKENDSIVKYG
CCCCEEEECCCCEEEEEECCCCCCEEEEEEEEEEEHHHHHCCHHHHHHHHCCCCCEEEEC
FPIGHASQDISIGEHIHVHNTKTNLSDIQLYSYTPRFDENPYSNENRTFKGFRRENGDAG
CCCCCCCCCCCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHCCCCCCC
VRNELWIVPTVGCVNGIAEKMLQRFVRETGDIAPFDNVLVLKHQYGCSQLGDDHENTKQI
CCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHCCCCCHHHHHH
LLNAIRHPNAGGVLVLGLGCENNELARMKEALQDVNLKRVKFLESQSVTDEMEAGVALLK
HHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHH
EIHEAAKGDKREDIPLSELKIGLKCGGSDGFSGITANPLLGRFSDYLIAQGGSTVLTEVP
HHHHHHCCCCCCCCCHHHEEEEEEECCCCCCCCCCCCCHHHHHHHHHEECCCCHHHHHHH
EMFGAETILMQRAANEEVFHKIVDLINDFKQYFIKHDQPVYENPSPGNKAGGISTLEDKS
HHHCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
LGCTQKAGISPVTDVLKYGEVLKTKGLTLLSAPGNDLIASSALAAAGCQIVLFTTGRGTP
CCCCHHCCCCHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCCEEEEEECCCCCC
FGTFVPTVKVATNTELYEAKPHWIDFNAGLLAEDDVHEEYVLREFIHYMIEVASGQLVNH
CCCCCCEEEEECCCEEEECCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEECC
EKNDFKELAIFKSGVTL
CHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKSFIKIHKQDNVLLALRDIQKGERLHAYGVSIEVKDDIKRGHKIALQSIKENDSIVKYG
CCCCEEEECCCCEEEEEECCCCCCEEEEEEEEEEEHHHHHCCHHHHHHHHCCCCCEEEEC
FPIGHASQDISIGEHIHVHNTKTNLSDIQLYSYTPRFDENPYSNENRTFKGFRRENGDAG
CCCCCCCCCCCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHCCCCCCC
VRNELWIVPTVGCVNGIAEKMLQRFVRETGDIAPFDNVLVLKHQYGCSQLGDDHENTKQI
CCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHCCCCCHHHHHH
LLNAIRHPNAGGVLVLGLGCENNELARMKEALQDVNLKRVKFLESQSVTDEMEAGVALLK
HHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHH
EIHEAAKGDKREDIPLSELKIGLKCGGSDGFSGITANPLLGRFSDYLIAQGGSTVLTEVP
HHHHHHCCCCCCCCCHHHEEEEEEECCCCCCCCCCCCCHHHHHHHHHEECCCCHHHHHHH
EMFGAETILMQRAANEEVFHKIVDLINDFKQYFIKHDQPVYENPSPGNKAGGISTLEDKS
HHHCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
LGCTQKAGISPVTDVLKYGEVLKTKGLTLLSAPGNDLIASSALAAAGCQIVLFTTGRGTP
CCCCHHCCCCHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCCEEEEEECCCCCC
FGTFVPTVKVATNTELYEAKPHWIDFNAGLLAEDDVHEEYVLREFIHYMIEVASGQLVNH
CCCCCCEEEEECCCEEEECCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEECC
EKNDFKELAIFKSGVTL
CHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579062; 9384377