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The map label for this gene is uxuA

Identifier: 16078299

GI number: 16078299

Start: 1305486

End: 1306565

Strand: Direct

Name: uxuA

Synonym: BSU12340

Alternate gene names: 16078299

Gene position: 1305486-1306565 (Clockwise)

Preceding gene: 16078298

Following gene: 16078300

Centisome position: 30.97

GC content: 47.22

Gene sequence:

>1080_bases
ATGAATATGACATTCCGATGGTATGGACGAGGCAACGATACAGTCACACTTGAATACGTGAAGCAAATTCCCGGTGTCAA
AGGCATCGTTTGGGCTCTCCATCAAAAGCCCGTCGGCGACGTGTGGGAAAAAGAAGAAATCAGAGCCGAAACTGAATATA
TTCAATCCTATGGTTTTCATGCTGAAGTTGTAGAAAGCGTGAATGTTCACGAAGCGATTAAACTTGGGAACGAAGAACGC
GGCCGGTATATTGAAAACTACAAGCAAACGATCCGCAACCTTGCCGGATTTGGCGTGAAAGTGATCTGCTATAATTTTAT
GCCGGTTTTTGATTGGACACGCACGGACATGTTCCGGCCGCTAGAAGATGGATCGACCGCTCTGTTTTTTGAAAAGGCCA
AGGTGGAAAGCCTTGATCCTCAAGAGCTGATTCGGACGGTGGAGGAAGCATCCGACATGACACTGCCGGGGTGGGAGCCC
GAAAAATTGGCTCGGATCAAAGAGCTTTTTGCTGCCTACAGAACGGTCGATGAAGAAAAGCTATGGGACAATTTATCATT
CTTTTTGCAGGAAATTCTTCCTGTTGCTGAGGCCTATGGTGTTCAAATGGCCATTCATCCGGATGACCCGCCGTGGCCGA
TTTTCGGACTGCCGCGCATTATCACAGGAGAGGCAAGCTATAAGAAACTGCGGGCGATATCAGATTCACCGTCTAATTGT
ATCACCCTTTGTACAGGTTCAATGGGAGCCAATCCCGCTAACGACATGGTGGAGATCGCTAAAACGTATGCCGGCATCGC
TCCATTTTCACATATTCGCAATGTGAAAATTTATGAGAATGGCGATTTTATTGAAACATCTCATTTAACAAAGGATGGTT
CGATCAACATTCAAGGCGTGATGGAAGAACTGCATAAGCAGGATTACGAAGGATATGTCAGACCGGATCATGGGCGCCAT
CTTTGGGGCGAGCAATGCCGCCCGGGATATGGCTTATACGATCGGGCACTTGGCATCATGTATTTGAACGGGCTGTGGGA
CGCTTATGAAGCAATGGCAAAAAAAGAGGTGGGCATATGA

Upstream 100 bases:

>100_bases
TGACGTTCATCATGCATTTCAGTTTATTAAGGAGCATCCAGATCAGGTGCGGAAAGCCGTCATCACGTTTGATTAAATGA
CTGAATCCGGAGGTGCGAGC

Downstream 100 bases:

>100_bases
TCCCGCTGCATGAGAACCTGGCTGGTAAAACGGCTGTCATCACTGGCGGCAGCGGCGTGCTTTGCTCTGCGATGGCCCGG
GAGCTAGCCCGTCATGGCAT

Product: mannonate dehydratase

Products: NA

Alternate protein names: D-mannonate hydrolase

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MNMTFRWYGRGNDTVTLEYVKQIPGVKGIVWALHQKPVGDVWEKEEIRAETEYIQSYGFHAEVVESVNVHEAIKLGNEER
GRYIENYKQTIRNLAGFGVKVICYNFMPVFDWTRTDMFRPLEDGSTALFFEKAKVESLDPQELIRTVEEASDMTLPGWEP
EKLARIKELFAAYRTVDEEKLWDNLSFFLQEILPVAEAYGVQMAIHPDDPPWPIFGLPRIITGEASYKKLRAISDSPSNC
ITLCTGSMGANPANDMVEIAKTYAGIAPFSHIRNVKIYENGDFIETSHLTKDGSINIQGVMEELHKQDYEGYVRPDHGRH
LWGEQCRPGYGLYDRALGIMYLNGLWDAYEAMAKKEVGI

Sequences:

>Translated_359_residues
MNMTFRWYGRGNDTVTLEYVKQIPGVKGIVWALHQKPVGDVWEKEEIRAETEYIQSYGFHAEVVESVNVHEAIKLGNEER
GRYIENYKQTIRNLAGFGVKVICYNFMPVFDWTRTDMFRPLEDGSTALFFEKAKVESLDPQELIRTVEEASDMTLPGWEP
EKLARIKELFAAYRTVDEEKLWDNLSFFLQEILPVAEAYGVQMAIHPDDPPWPIFGLPRIITGEASYKKLRAISDSPSNC
ITLCTGSMGANPANDMVEIAKTYAGIAPFSHIRNVKIYENGDFIETSHLTKDGSINIQGVMEELHKQDYEGYVRPDHGRH
LWGEQCRPGYGLYDRALGIMYLNGLWDAYEAMAKKEVGI
>Mature_359_residues
MNMTFRWYGRGNDTVTLEYVKQIPGVKGIVWALHQKPVGDVWEKEEIRAETEYIQSYGFHAEVVESVNVHEAIKLGNEER
GRYIENYKQTIRNLAGFGVKVICYNFMPVFDWTRTDMFRPLEDGSTALFFEKAKVESLDPQELIRTVEEASDMTLPGWEP
EKLARIKELFAAYRTVDEEKLWDNLSFFLQEILPVAEAYGVQMAIHPDDPPWPIFGLPRIITGEASYKKLRAISDSPSNC
ITLCTGSMGANPANDMVEIAKTYAGIAPFSHIRNVKIYENGDFIETSHLTKDGSINIQGVMEELHKQDYEGYVRPDHGRH
LWGEQCRPGYGLYDRALGIMYLNGLWDAYEAMAKKEVGI

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG1312

COG function: function code G; D-mannonate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannonate dehydratase family

Homologues:

Organism=Escherichia coli, GI1790778, Length=385, Percent_Identity=36.3636363636364, Blast_Score=232, Evalue=3e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UXUA_BACSU (O34346)

Other databases:

- EMBL:   AF015825
- EMBL:   AL009126
- PIR:   G69852
- RefSeq:   NP_389116.1
- ProteinModelPortal:   O34346
- SMR:   O34346
- EnsemblBacteria:   EBBACT00000002778
- GeneID:   939409
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU12340
- NMPDR:   fig|224308.1.peg.1235
- GenoList:   BSU12340
- GeneTree:   EBGT00050000001836
- HOGENOM:   HBG585927
- OMA:   GIVWALH
- PhylomeDB:   O34346
- ProtClustDB:   PRK03906
- BioCyc:   BSUB:BSU12340-MONOMER
- BRENDA:   4.2.1.8
- HAMAP:   MF_00106
- InterPro:   IPR004628
- InterPro:   IPR013022
- Gene3D:   G3DSA:3.20.20.150
- PIRSF:   PIRSF016049
- TIGRFAMs:   TIGR00695

Pfam domain/function: PF03786 UxuA; SSF51658 Xyl_isomerase-like_TIM-brl

EC number: =4.2.1.8

Molecular weight: Translated: 41024; Mature: 41024

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMTFRWYGRGNDTVTLEYVKQIPGVKGIVWALHQKPVGDVWEKEEIRAETEYIQSYGFH
CCCEEEEECCCCCEEEHHHHHHCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCH
AEVVESVNVHEAIKLGNEERGRYIENYKQTIRNLAGFGVKVICYNFMPVFDWTRTDMFRP
HHHHHHCCHHHHHHCCCHHCCHHHHHHHHHHHHHHCCCEEEEEECCCHHCCCCHHHHCCC
LEDGSTALFFEKAKVESLDPQELIRTVEEASDMTLPGWEPEKLARIKELFAAYRTVDEEK
CCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHH
LWDNLSFFLQEILPVAEAYGVQMAIHPDDPPWPIFGLPRIITGEASYKKLRAISDSPSNC
HHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCEEEECCHHHHHHHHHCCCCCCE
ITLCTGSMGANPANDMVEIAKTYAGIAPFSHIRNVKIYENGDFIETSHLTKDGSINIQGV
EEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHCCEEEEECCCEEECCCCCCCCCEEHHHH
MEELHKQDYEGYVRPDHGRHLWGEQCRPGYGLYDRALGIMYLNGLWDAYEAMAKKEVGI
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNMTFRWYGRGNDTVTLEYVKQIPGVKGIVWALHQKPVGDVWEKEEIRAETEYIQSYGFH
CCCEEEEECCCCCEEEHHHHHHCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCH
AEVVESVNVHEAIKLGNEERGRYIENYKQTIRNLAGFGVKVICYNFMPVFDWTRTDMFRP
HHHHHHCCHHHHHHCCCHHCCHHHHHHHHHHHHHHCCCEEEEEECCCHHCCCCHHHHCCC
LEDGSTALFFEKAKVESLDPQELIRTVEEASDMTLPGWEPEKLARIKELFAAYRTVDEEK
CCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHH
LWDNLSFFLQEILPVAEAYGVQMAIHPDDPPWPIFGLPRIITGEASYKKLRAISDSPSNC
HHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCEEEECCHHHHHHHHHCCCCCCE
ITLCTGSMGANPANDMVEIAKTYAGIAPFSHIRNVKIYENGDFIETSHLTKDGSINIQGV
EEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHCCEEEEECCCEEECCCCCCCCCEEHHHH
MEELHKQDYEGYVRPDHGRHLWGEQCRPGYGLYDRALGIMYLNGLWDAYEAMAKKEVGI
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579062; 9384377