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The map label for this gene is exuM

Identifier: 16078296

GI number: 16078296

Start: 1301939

End: 1303318

Strand: Direct

Name: exuM

Synonym: BSU12310

Alternate gene names: 16078296

Gene position: 1301939-1303318 (Clockwise)

Preceding gene: 16078295

Following gene: 16078297

Centisome position: 30.88

GC content: 44.64

Gene sequence:

>1380_bases
ATGCGAACTGAACTGGCAAATAAGGTTGTGTCGGTCGAAACGGAAAAAAGGCTTTCATTGAAAGAGAAAATGTCCTATGG
CTTTGGTGATTTTGGCAACGGTTTTATGTTTGATCTCGGCCAGATTTATTTATTGAAGTATTTCACTGATGTAGCGGGAA
TCCCCGCTGCGATGGCCGGCGGCATTTTTTTAGTCAGTAAGCTGTTTGCAGCGATAACAGATCCAATTGTCGGCTCATCA
ATCGATTATCGCAAAAACATCGGCAAACGGGGGAAATTCAGGCCTTATCTATTAATCGGCAGCATCGTGCTTGCGGTGCT
TACTGTTCTTATTTTTCTGTCTCCCAATGTATCAACGACCGGAAAACTGATATATGCATATGCATCCTATATGATTTGGG
GCATCGGCTATTCGTTTGTGAATATTCCGTACGGCTCATTAGGGGCAGCGATGACTCAAAATTCTGAGGACCGGACCTCC
ATTTCGACGTTCCGCCAAATCGGATCACTTGGCGCCTTGTTTATCACAAGTGTGGCCGTGATGCCGCTGCTCGTCAAGTT
TGATAATCCGAAGGTCGGCTACCCGGTGGTCATGGGCTTGTTCGCCGCGCTCGGTGTGTTTTGGTTTTATATTTGCTACC
GCAACTGCAAAGAGCGCATTATCATATCGGAAGCACCCAAAGAAAAATTAACACTCTCATCTGTCGTCAAAACATTTATT
ACAAATAAACCGCTGTTAACCCTTGTCCTGATGACGATTTTTTCAATTTCCGCATACAACATTAAATCCGCCATGCTCGT
CTATTTCGCACAATATAACTTGGGCAATGTTGAATTAATGGCTTATATGAACTTCATCATTATTGGTTCTTCCTTTTTGG
GCGTCGTATTCCTTCCAAAGCTCGTCAAGATGTTTGGAAAGAAACGAACGGCAATGATCGGCTTTGGCATCAGTGTGGCC
GCGGATCTGATCAACTTTATGCTTCCATCTAACGTTTATGTGTTTACAATTCTCGCCAGTATCGCCTTTATCGGAATCAG
TATCCCAAATGGCATCACGTGGGCTCTTGTCTCCGATATTATCGACTATGGCGAATGGAAATCCGGTGAACGGAAGGAAG
CAACGACATATTCACTTTTCAATTTCTCAAGAAAGCTTGCTCAATCTTTGTCTGGCTTTCTCTCGGGGATCGGTTTGGGG
ATTATCGGCTATGTGCCGAATGCAGTCCAGACAGCACAGGCGCTGATTGGCATCAAAGCGCTGCTTCTTCTGTATCCGGC
CATTGCTTTGGCATTAGCGATGTTCATTATCGGCTTTCTTTATAAACTCACAGACCAGCAGCATGCTCAGATCGTTCAGG
ATCTTCATCAAAAGAGCTGA

Upstream 100 bases:

>100_bases
TTTCAATTTCAAGAAGAGAAAGCAAACGTGTAACAAAGTGTCCGCTCAGTATCGCTGAGCGGATCACTATCCGAAAATTC
TTAAGACACAGAGGTGGAAC

Downstream 100 bases:

>100_bases
CAATATAATATAAAGAATATTTAAAATAATTTGTAAATAAAATGTGTTTGTAGGGGTTTCGCTTGGAGAGTGCCCAAAAA
ACTGAAAAGGAAGGAGGCAC

Product: Na+:altronate/mannonate symporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MRTELANKVVSVETEKRLSLKEKMSYGFGDFGNGFMFDLGQIYLLKYFTDVAGIPAAMAGGIFLVSKLFAAITDPIVGSS
IDYRKNIGKRGKFRPYLLIGSIVLAVLTVLIFLSPNVSTTGKLIYAYASYMIWGIGYSFVNIPYGSLGAAMTQNSEDRTS
ISTFRQIGSLGALFITSVAVMPLLVKFDNPKVGYPVVMGLFAALGVFWFYICYRNCKERIIISEAPKEKLTLSSVVKTFI
TNKPLLTLVLMTIFSISAYNIKSAMLVYFAQYNLGNVELMAYMNFIIIGSSFLGVVFLPKLVKMFGKKRTAMIGFGISVA
ADLINFMLPSNVYVFTILASIAFIGISIPNGITWALVSDIIDYGEWKSGERKEATTYSLFNFSRKLAQSLSGFLSGIGLG
IIGYVPNAVQTAQALIGIKALLLLYPAIALALAMFIIGFLYKLTDQQHAQIVQDLHQKS

Sequences:

>Translated_459_residues
MRTELANKVVSVETEKRLSLKEKMSYGFGDFGNGFMFDLGQIYLLKYFTDVAGIPAAMAGGIFLVSKLFAAITDPIVGSS
IDYRKNIGKRGKFRPYLLIGSIVLAVLTVLIFLSPNVSTTGKLIYAYASYMIWGIGYSFVNIPYGSLGAAMTQNSEDRTS
ISTFRQIGSLGALFITSVAVMPLLVKFDNPKVGYPVVMGLFAALGVFWFYICYRNCKERIIISEAPKEKLTLSSVVKTFI
TNKPLLTLVLMTIFSISAYNIKSAMLVYFAQYNLGNVELMAYMNFIIIGSSFLGVVFLPKLVKMFGKKRTAMIGFGISVA
ADLINFMLPSNVYVFTILASIAFIGISIPNGITWALVSDIIDYGEWKSGERKEATTYSLFNFSRKLAQSLSGFLSGIGLG
IIGYVPNAVQTAQALIGIKALLLLYPAIALALAMFIIGFLYKLTDQQHAQIVQDLHQKS
>Mature_459_residues
MRTELANKVVSVETEKRLSLKEKMSYGFGDFGNGFMFDLGQIYLLKYFTDVAGIPAAMAGGIFLVSKLFAAITDPIVGSS
IDYRKNIGKRGKFRPYLLIGSIVLAVLTVLIFLSPNVSTTGKLIYAYASYMIWGIGYSFVNIPYGSLGAAMTQNSEDRTS
ISTFRQIGSLGALFITSVAVMPLLVKFDNPKVGYPVVMGLFAALGVFWFYICYRNCKERIIISEAPKEKLTLSSVVKTFI
TNKPLLTLVLMTIFSISAYNIKSAMLVYFAQYNLGNVELMAYMNFIIIGSSFLGVVFLPKLVKMFGKKRTAMIGFGISVA
ADLINFMLPSNVYVFTILASIAFIGISIPNGITWALVSDIIDYGEWKSGERKEATTYSLFNFSRKLAQSLSGFLSGIGLG
IIGYVPNAVQTAQALIGIKALLLLYPAIALALAMFIIGFLYKLTDQQHAQIVQDLHQKS

Specific function: Unknown

COG id: COG2211

COG function: function code G; Na+/melibiose symporter and related transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:galactoside symporter (TC 2.A.2) family

Homologues:

Organism=Homo sapiens, GI122937339, Length=428, Percent_Identity=23.8317757009346, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI48994989, Length=445, Percent_Identity=37.3033707865169, Blast_Score=333, Evalue=1e-92,
Organism=Escherichia coli, GI145693206, Length=445, Percent_Identity=35.9550561797753, Blast_Score=318, Evalue=5e-88,
Organism=Escherichia coli, GI1787902, Length=460, Percent_Identity=32.3913043478261, Blast_Score=205, Evalue=4e-54,
Organism=Escherichia coli, GI1786466, Length=451, Percent_Identity=29.7117516629712, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI87082306, Length=448, Percent_Identity=29.6875, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI1790561, Length=451, Percent_Identity=27.4944567627494, Blast_Score=178, Evalue=7e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): YJMB_BACSU (O34961)

Other databases:

- EMBL:   AF015825
- EMBL:   AL009126
- PIR:   D69852
- RefSeq:   NP_389113.1
- ProteinModelPortal:   O34961
- EnsemblBacteria:   EBBACT00000003735
- GeneID:   939410
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU12310
- NMPDR:   fig|224308.1.peg.1232
- GenoList:   BSU12310
- GeneTree:   EBGT00050000000688
- HOGENOM:   HBG518114
- OMA:   VETQPTN
- PhylomeDB:   O34961
- ProtClustDB:   CLSK882529
- BioCyc:   BSUB:BSU12310-MONOMER
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001927
- InterPro:   IPR018043
- TIGRFAMs:   TIGR00792

Pfam domain/function: PF07690 MFS_1; SSF103473 MFS_gen_substrate_transporter

EC number: NA

Molecular weight: Translated: 50421; Mature: 50421

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: PS50850 MFS; PS00872 NA_GALACTOSIDE_SYMP

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xe2954a0)-; HASH(0xe5523cc)-; HASH(0xe701274)-; HASH(0xe808808)-; HASH(0xde89d3c)-; HASH(0xd9a1ec0)-; HASH(0xda0af70)-; HASH(0xe703aa0)-; HASH(0xe8039f0)-; HASH(0xe6d72ac)-; HASH(0xd182044)-; HASH(0xe80ab4c)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCH
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579062; 9384377