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The map label for this gene is uxaC

Identifier: 16078295

GI number: 16078295

Start: 1300450

End: 1301871

Strand: Direct

Name: uxaC

Synonym: BSU12300

Alternate gene names: 16078295

Gene position: 1300450-1301871 (Clockwise)

Preceding gene: 16078294

Following gene: 16078296

Centisome position: 30.85

GC content: 43.25

Gene sequence:

>1422_bases
ATGGAACCCTTCATGGGCAAAAACTTTTTATTGAAAAATGAAACCGCTGTCAGCCTCTATCACAATTATGCGAAAGACAT
GCCAATTATTGATTACCACTGCCACTTAAGTCCGAAAGAAATCTATGAAAATAAGACATTTCAAAACATCACGGAAGCCT
GGCTGTATGGTGACCATTATAAATGGCGCATCATGAGAGCCAATGGAATTGAGGAGACATACATTACCGGAGATGCGCCT
GATGAGGAGAAATTTATGGCTTGGGCGAAAACCGTGCCGATGGCGATTGGCAACCCGCTCTACAACTGGACTCACTTAGA
ATTGCAGCGTTTTTTTGGCATTTACGAGATTTTAAACGAGAAGTCCGGGTCGGCTATATGGAAACAGACAAATAAACTGC
TCAAAGGGGAAGGCTTCGGGGCAAGGGATTTAATCGTGAAATCAAATGTAAAGGTCGTGTGCACCACAGATGACCCTGTT
GATTCTCTTGAATACCATTTATTGTTAAAAGAAGACAAAGACTTTCCTGTCAGTGTGCTGCCTGGATTTCGGCCGGATAA
AGGACTTGAGATCAATCGTGAAGGCTTTCCTGAGTGGGTGCAGGCGCTTGAAGATGCCGCTGCCATATCGATTACAACCT
ATGATGAGTTTTTAAAGGCGTTGGAAAAACGAGTGCGATTCTTCCACTCAGCCGGCGGCAGAGTTTCTGATCACGCGATA
GATACAATGGTATTTGCCGAAACAACAAAAGAAGAAGCTGGACGGATTTTTTCTGACAGATTACAAGGAACAGAGGTTTC
TTGTGAAGATGAGAAGAAATTTAAGACATATACGCTTCAGTTTCTTTGCGGTTTGTATGCGGAGCTCGATTGGGCGATGC
AGTTTCATATCAACGCTTTAAGAAACACGAATACAAAAATGATGAAAAGGCTCGGACCTGATACAGGGTATGATTCAATG
AACGATGAAGAAATTGCTAAGCCTTTATACAAGCTGCTGAACTCAGTTGAGATGAAGAACCAGCTGCCGAAAACGATTTT
ATATTCACTGAATCCAAATGATAACTATGTCATCGCCAGCATGATCAACAGTTTTCAGGACGGTATTACCCCGGGAAAAA
TACAATTCGGCACAGCCTGGTGGTTTAACGATACTAAAGACGGAATGCTCGACCAAATGAAAGCGTTATCAAATGTTGGC
CTTTTCAGCCGTTTTATCGGCATGCTCACCGATTCCAGAAGCTTTCTTTCGTATACGCGCCACGAATATTTCAGGCGGAT
CGTCTGCAATTTGATTGGAGAATGGGTGGAAAACGGCGAAGTGCCGCGCGATATGGAGCTTCTGGGAAGCATCGTTCAGG
GGATTTGCTATGACAATGCGAAACACTACTTTCAATTTCAAGAAGAGAAAGCAAACGTGTAA

Upstream 100 bases:

>100_bases
TCAAAAAAGAGATTGATCCCAAAGGAATATAAAGGTAAAATAAAAACAAATCAAAATGTTAACGTTAACATTTTGAAATA
GAATGAAAGACGGTGAGGAC

Downstream 100 bases:

>100_bases
CAAAGTGTCCGCTCAGTATCGCTGAGCGGATCACTATCCGAAAATTCTTAAGACACAGAGGTGGAACATGCGAACTGAAC
TGGCAAATAAGGTTGTGTCG

Product: glucuronate isomerase

Products: NA

Alternate protein names: Glucuronate isomerase; Uronic isomerase

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MEPFMGKNFLLKNETAVSLYHNYAKDMPIIDYHCHLSPKEIYENKTFQNITEAWLYGDHYKWRIMRANGIEETYITGDAP
DEEKFMAWAKTVPMAIGNPLYNWTHLELQRFFGIYEILNEKSGSAIWKQTNKLLKGEGFGARDLIVKSNVKVVCTTDDPV
DSLEYHLLLKEDKDFPVSVLPGFRPDKGLEINREGFPEWVQALEDAAAISITTYDEFLKALEKRVRFFHSAGGRVSDHAI
DTMVFAETTKEEAGRIFSDRLQGTEVSCEDEKKFKTYTLQFLCGLYAELDWAMQFHINALRNTNTKMMKRLGPDTGYDSM
NDEEIAKPLYKLLNSVEMKNQLPKTILYSLNPNDNYVIASMINSFQDGITPGKIQFGTAWWFNDTKDGMLDQMKALSNVG
LFSRFIGMLTDSRSFLSYTRHEYFRRIVCNLIGEWVENGEVPRDMELLGSIVQGICYDNAKHYFQFQEEKANV

Sequences:

>Translated_473_residues
MEPFMGKNFLLKNETAVSLYHNYAKDMPIIDYHCHLSPKEIYENKTFQNITEAWLYGDHYKWRIMRANGIEETYITGDAP
DEEKFMAWAKTVPMAIGNPLYNWTHLELQRFFGIYEILNEKSGSAIWKQTNKLLKGEGFGARDLIVKSNVKVVCTTDDPV
DSLEYHLLLKEDKDFPVSVLPGFRPDKGLEINREGFPEWVQALEDAAAISITTYDEFLKALEKRVRFFHSAGGRVSDHAI
DTMVFAETTKEEAGRIFSDRLQGTEVSCEDEKKFKTYTLQFLCGLYAELDWAMQFHINALRNTNTKMMKRLGPDTGYDSM
NDEEIAKPLYKLLNSVEMKNQLPKTILYSLNPNDNYVIASMINSFQDGITPGKIQFGTAWWFNDTKDGMLDQMKALSNVG
LFSRFIGMLTDSRSFLSYTRHEYFRRIVCNLIGEWVENGEVPRDMELLGSIVQGICYDNAKHYFQFQEEKANV
>Mature_473_residues
MEPFMGKNFLLKNETAVSLYHNYAKDMPIIDYHCHLSPKEIYENKTFQNITEAWLYGDHYKWRIMRANGIEETYITGDAP
DEEKFMAWAKTVPMAIGNPLYNWTHLELQRFFGIYEILNEKSGSAIWKQTNKLLKGEGFGARDLIVKSNVKVVCTTDDPV
DSLEYHLLLKEDKDFPVSVLPGFRPDKGLEINREGFPEWVQALEDAAAISITTYDEFLKALEKRVRFFHSAGGRVSDHAI
DTMVFAETTKEEAGRIFSDRLQGTEVSCEDEKKFKTYTLQFLCGLYAELDWAMQFHINALRNTNTKMMKRLGPDTGYDSM
NDEEIAKPLYKLLNSVEMKNQLPKTILYSLNPNDNYVIASMINSFQDGITPGKIQFGTAWWFNDTKDGMLDQMKALSNVG
LFSRFIGMLTDSRSFLSYTRHEYFRRIVCNLIGEWVENGEVPRDMELLGSIVQGICYDNAKHYFQFQEEKANV

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG1904

COG function: function code G; Glucuronate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uronate isomerase family

Homologues:

Organism=Escherichia coli, GI2367192, Length=468, Percent_Identity=52.1367521367521, Blast_Score=515, Evalue=1e-147,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UXAC_BACSU (O34808)

Other databases:

- EMBL:   AF015825
- EMBL:   AL009126
- PIR:   C69852
- RefSeq:   NP_389112.1
- ProteinModelPortal:   O34808
- SMR:   O34808
- EnsemblBacteria:   EBBACT00000003502
- GeneID:   936461
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU12300
- NMPDR:   fig|224308.1.peg.1231
- GenoList:   BSU12300
- GeneTree:   EBGT00050000002347
- HOGENOM:   HBG297087
- OMA:   AWAKTVP
- PhylomeDB:   O34808
- ProtClustDB:   PRK02925
- BioCyc:   BSUB:BSU12300-MONOMER
- BRENDA:   5.3.1.12
- HAMAP:   MF_00675
- InterPro:   IPR003766
- InterPro:   IPR023177
- Gene3D:   G3DSA:1.10.2020.10

Pfam domain/function: PF02614 UxaC

EC number: =5.3.1.12

Molecular weight: Translated: 54613; Mature: 54613

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPFMGKNFLLKNETAVSLYHNYAKDMPIIDYHCHLSPKEIYENKTFQNITEAWLYGDHY
CCCCCCCCEEEECCHHHHHHHHHHCCCCEEEEEECCCHHHHHCCCHHHHHHHHHHCCCCE
KWRIMRANGIEETYITGDAPDEEKFMAWAKTVPMAIGNPLYNWTHLELQRFFGIYEILNE
EEEEEECCCCCEEEECCCCCCHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHHC
KSGSAIWKQTNKLLKGEGFGARDLIVKSNVKVVCTTDDPVDSLEYHLLLKEDKDFPVSVL
CCCCHHHHHHHHHHCCCCCCCCCEEEECCCEEEECCCCCCCCCEEEEEEECCCCCCEEEC
PGFRPDKGLEINREGFPEWVQALEDAAAISITTYDEFLKALEKRVRFFHSAGGRVSDHAI
CCCCCCCCCEECCCCCHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHCCCCCCHHHH
DTMVFAETTKEEAGRIFSDRLQGTEVSCEDEKKFKTYTLQFLCGLYAELDWAMQFHINAL
HHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RNTNTKMMKRLGPDTGYDSMNDEEIAKPLYKLLNSVEMKNQLPKTILYSLNPNDNYVIAS
HCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEHHH
MINSFQDGITPGKIQFGTAWWFNDTKDGMLDQMKALSNVGLFSRFIGMLTDSRSFLSYTR
HHHHHHHCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
HEYFRRIVCNLIGEWVENGEVPRDMELLGSIVQGICYDNAKHYFQFQEEKANV
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHEEHHHCCCC
>Mature Secondary Structure
MEPFMGKNFLLKNETAVSLYHNYAKDMPIIDYHCHLSPKEIYENKTFQNITEAWLYGDHY
CCCCCCCCEEEECCHHHHHHHHHHCCCCEEEEEECCCHHHHHCCCHHHHHHHHHHCCCCE
KWRIMRANGIEETYITGDAPDEEKFMAWAKTVPMAIGNPLYNWTHLELQRFFGIYEILNE
EEEEEECCCCCEEEECCCCCCHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHHC
KSGSAIWKQTNKLLKGEGFGARDLIVKSNVKVVCTTDDPVDSLEYHLLLKEDKDFPVSVL
CCCCHHHHHHHHHHCCCCCCCCCEEEECCCEEEECCCCCCCCCEEEEEEECCCCCCEEEC
PGFRPDKGLEINREGFPEWVQALEDAAAISITTYDEFLKALEKRVRFFHSAGGRVSDHAI
CCCCCCCCCEECCCCCHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHCCCCCCHHHH
DTMVFAETTKEEAGRIFSDRLQGTEVSCEDEKKFKTYTLQFLCGLYAELDWAMQFHINAL
HHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RNTNTKMMKRLGPDTGYDSMNDEEIAKPLYKLLNSVEMKNQLPKTILYSLNPNDNYVIAS
HCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEHHH
MINSFQDGITPGKIQFGTAWWFNDTKDGMLDQMKALSNVGLFSRFIGMLTDSRSFLSYTR
HHHHHHHCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
HEYFRRIVCNLIGEWVENGEVPRDMELLGSIVQGICYDNAKHYFQFQEEKANV
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHEEHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579062; 9384377