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The map label for this gene is yjbV

Identifier: 16078236

GI number: 16078236

Start: 1246837

End: 1247652

Strand: Direct

Name: yjbV

Synonym: BSU11710

Alternate gene names: 16078236

Gene position: 1246837-1247652 (Clockwise)

Preceding gene: 16078235

Following gene: 50812220

Centisome position: 29.58

GC content: 49.51

Gene sequence:

>816_bases
ATGAGTATATATAAAGCATTGACAATCGCCGGATCAGATTCAGGCGGCGGCGCAGGGATACAGGCTGATATTAAAACCTT
TCAAGAGCTTGATGTATTCGGAATGTCTGCGATTACGGCGGTAACCGCTCAAAATACGCTTGGCGTTCACGGGGTGCATC
CGCTGACTGTAGAGACGTTGAGACAGCAAATTGACGCTGTTGCTGAGGATTTGAGACCGGATGCAGTTAAGACGGGAATG
CTCTGGAATGCCGACATGATTGAAGAAGTGGCAAGAAAAATTGACGAGTACGGATTCAATCGTGTAATTGTTGATCCGGT
TATGATCGCAAAGGGCGGGGCATCCTTGCTGCGTGATGAGTCAGTTGCCACCTTAAAGGAGTTGCTCATTCCAAGAAGCT
ACGCGATTACGCCGAATGTCCCGGAAGCAGAAACGCTGACAGGAATGACAATCAGCTCGCTGGATGACCGGAAAAAAGCA
GCGGAGCAGCTCGTCAAGATGGGTGCGCAGCATGTCATTATCAAAGGCGGGCACCAGCCTGAGGACAATCACATTACTGA
CCTTCTTTTTGATGGCAGCATGTTTATGCAAATCACCCATCCTTATATCAATACGAAGCATACGCATGGCACAGGCTGCA
CCTTTGCTGCGGCTTTAACGGCCCAAACGGCTAAAGGAGACAGCATCCATCAGGCATTTGAGGTTGCGGCCAACTTTGTC
CGTGAAGCGGTGGAAAATACGCTCGGCATCGGATCGGGACACGGGCCGACAAACCATTTCGCTTTTAAACGAAACAGCTT
AAATACAAGCCGATGA

Upstream 100 bases:

>100_bases
GTTCCGGGACGGCAGAGCTTTGATCCATGGAACAAATGATATTGCCCGGGCAAAATCCATTTATCATAAATGGATTGGGT
AATAAAAGGAGTGTAGTGTA

Downstream 100 bases:

>100_bases
GATCACCAGCTGATGGTGATCTCTTTTGCGTTTGCTACGGTATGCGCTTTTCATCTGGACAAGGTTATGATATGATAGGA
ATTAAGATCAGGTACTAATA

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MSIYKALTIAGSDSGGGAGIQADIKTFQELDVFGMSAITAVTAQNTLGVHGVHPLTVETLRQQIDAVAEDLRPDAVKTGM
LWNADMIEEVARKIDEYGFNRVIVDPVMIAKGGASLLRDESVATLKELLIPRSYAITPNVPEAETLTGMTISSLDDRKKA
AEQLVKMGAQHVIIKGGHQPEDNHITDLLFDGSMFMQITHPYINTKHTHGTGCTFAAALTAQTAKGDSIHQAFEVAANFV
REAVENTLGIGSGHGPTNHFAFKRNSLNTSR

Sequences:

>Translated_271_residues
MSIYKALTIAGSDSGGGAGIQADIKTFQELDVFGMSAITAVTAQNTLGVHGVHPLTVETLRQQIDAVAEDLRPDAVKTGM
LWNADMIEEVARKIDEYGFNRVIVDPVMIAKGGASLLRDESVATLKELLIPRSYAITPNVPEAETLTGMTISSLDDRKKA
AEQLVKMGAQHVIIKGGHQPEDNHITDLLFDGSMFMQITHPYINTKHTHGTGCTFAAALTAQTAKGDSIHQAFEVAANFV
REAVENTLGIGSGHGPTNHFAFKRNSLNTSR
>Mature_270_residues
SIYKALTIAGSDSGGGAGIQADIKTFQELDVFGMSAITAVTAQNTLGVHGVHPLTVETLRQQIDAVAEDLRPDAVKTGML
WNADMIEEVARKIDEYGFNRVIVDPVMIAKGGASLLRDESVATLKELLIPRSYAITPNVPEAETLTGMTISSLDDRKKAA
EQLVKMGAQHVIIKGGHQPEDNHITDLLFDGSMFMQITHPYINTKHTHGTGCTFAAALTAQTAKGDSIHQAFEVAANFVR
EAVENTLGIGSGHGPTNHFAFKRNSLNTSR

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Shows no activity with pyridoxal, pyridoxamine or pyridoxine

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family

Homologues:

Organism=Escherichia coli, GI1788420, Length=272, Percent_Identity=41.9117647058824, Blast_Score=188, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6325378, Length=271, Percent_Identity=34.3173431734317, Blast_Score=150, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6324997, Length=268, Percent_Identity=36.5671641791045, Blast_Score=134, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6324517, Length=268, Percent_Identity=35.4477611940299, Blast_Score=130, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): THID_BACSU (O31620)

Other databases:

- EMBL:   AL009126
- PIR:   F69845
- RefSeq:   NP_389053.1
- HSSP:   P55882
- ProteinModelPortal:   O31620
- SMR:   O31620
- EnsemblBacteria:   EBBACT00000002265
- GeneID:   936415
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU11710
- NMPDR:   fig|224308.1.peg.1172
- GenoList:   BSU11710
- GeneTree:   EBGT00050000001225
- HOGENOM:   HBG476673
- OMA:   LNIGHGH
- PhylomeDB:   O31620
- ProtClustDB:   PRK06427
- BioCyc:   BSUB:BSU11710-MONOMER
- InterPro:   IPR013749
- InterPro:   IPR004399
- TIGRFAMs:   TIGR00097

Pfam domain/function: PF08543 Phos_pyr_kin

EC number: =2.7.1.49; =2.7.4.7

Molecular weight: Translated: 29124; Mature: 28993

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: NA

Important sites: BINDING 44-44

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIYKALTIAGSDSGGGAGIQADIKTFQELDVFGMSAITAVTAQNTLGVHGVHPLTVETL
CCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
RQQIDAVAEDLRPDAVKTGMLWNADMIEEVARKIDEYGFNRVIVDPVMIAKGGASLLRDE
HHHHHHHHHHCCCCHHHHCCEECHHHHHHHHHHHHHHCCCEEEECCEEEECCCHHHHHHH
SVATLKELLIPRSYAITPNVPEAETLTGMTISSLDDRKKAAEQLVKMGAQHVIIKGGHQP
HHHHHHHHHCCCCEECCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
EDNHITDLLFDGSMFMQITHPYINTKHTHGTGCTFAAALTAQTAKGDSIHQAFEVAANFV
CCCCHHHEEECCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHH
REAVENTLGIGSGHGPTNHFAFKRNSLNTSR
HHHHHHHCCCCCCCCCCCCEEEECCCCCCCC
>Mature Secondary Structure 
SIYKALTIAGSDSGGGAGIQADIKTFQELDVFGMSAITAVTAQNTLGVHGVHPLTVETL
CCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
RQQIDAVAEDLRPDAVKTGMLWNADMIEEVARKIDEYGFNRVIVDPVMIAKGGASLLRDE
HHHHHHHHHHCCCCHHHHCCEECHHHHHHHHHHHHHHCCCEEEECCEEEECCCHHHHHHH
SVATLKELLIPRSYAITPNVPEAETLTGMTISSLDDRKKAAEQLVKMGAQHVIIKGGHQP
HHHHHHHHHCCCCEECCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
EDNHITDLLFDGSMFMQITHPYINTKHTHGTGCTFAAALTAQTAKGDSIHQAFEVAANFV
CCCCHHHEEECCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHH
REAVENTLGIGSGHGPTNHFAFKRNSLNTSR
HHHHHHHCCCCCCCCCCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377