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The map label for this gene is fabHB

Identifier: 16078081

GI number: 16078081

Start: 1092770

End: 1093747

Strand: Reverse

Name: fabHB

Synonym: BSU10170

Alternate gene names: 16078081

Gene position: 1093747-1092770 (Counterclockwise)

Preceding gene: 16078086

Following gene: 16078074

Centisome position: 25.95

GC content: 47.96

Gene sequence:

>978_bases
ATGTCAAAAGCAAAAATTACAGCTATCGGCACCTATGCGCCGAGCAGACGTTTAACCAATGCAGATTTAGAAAAGATCGT
TGATACCTCTGATGAATGGATCGTTCAGCGCACAGGAATGAGAGAACGCCGGATTGCGGATGAACATCAATTTACCTCTG
ATTTATGCATAGAAGCGGTGAAGAATCTCAAGAGCCGTTATAAAGGAACGCTTGATGATGTCGATATGATCCTCGTTGCC
ACAACCACATCCGATTACGCCTTTCCGAGTACGGCATGCCGCGTACAGGAATATTTCGGCTGGGAAAGCACCGGCGCGCT
GGATATTAATGCGACATGCGCCGGGCTGACATACGGCCTCCATTTGGCAAATGGATTGATCACATCTGGCCTTCATCAAA
AAATTCTCGTCATCGCCGGAGAGACGTTATCAAAGGTAACCGATTATACCGATCGAACGACATGCGTACTGTTCGGCGAT
GCCGCGGGTGCGCTGTTAGTAGAACGAGATGAAGAGACGCCGGGATTTCTTGCGTCTGTACAAGGAACAAGCGGGAACGG
CGGCGATATTTTGTATCGTGCCGGACTGCGAAATGAAATAAACGGTGTGCAGCTTGTCGGTTCCGGAAAAATGGTGCAAA
ACGGACGCGAGGTATATAAATGGGCCGCAAGAACCGTCCCTGGCGAATTTGAACGGCTTTTACATAAAGCAGGACTCAGC
TCCGATGATCTCGATTGGTTTGTTCCTCACAGCGCCAACTTGCGCATGATCGAGTCAATTTGTGAAAAAACACCGTTCCC
GATTGAAAAAACGCTCACTAGTGTTGAGCACTACGGAAACACGTCTTCGGTTTCAATTGTTTTGGCGCTCGATCTCGCAG
TGAAAGCCGGGAAGCTGAAAAAAGATCAAATCGTTTTGCTTTTCGGGTTTGGCGGCGGATTAACCTATACAGGATTGCTT
ATTAAATGGGGGATGTAA

Upstream 100 bases:

>100_bases
AGATTCCTATCTACACTTCTCTTTTTTTGTAAAAAAACCTTCTTTTTAGTACCAGATACTAATATCTAGTGTTATAATCT
GACCATAAGGAGTGATTCAT

Downstream 100 bases:

>100_bases
CAAAAAAAGAACTTGTTTCCAAGGAAACAAGTTCTTTTTCTTTATGAAGCCGGCTGTTCTTCTGATGTTTCTTCCTTCCG
GCTTAACATTGTAAAGTAAG

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III protein 2; Beta-ketoacyl-ACP synthase III 2; KAS III 2; bFabH2

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MSKAKITAIGTYAPSRRLTNADLEKIVDTSDEWIVQRTGMRERRIADEHQFTSDLCIEAVKNLKSRYKGTLDDVDMILVA
TTTSDYAFPSTACRVQEYFGWESTGALDINATCAGLTYGLHLANGLITSGLHQKILVIAGETLSKVTDYTDRTTCVLFGD
AAGALLVERDEETPGFLASVQGTSGNGGDILYRAGLRNEINGVQLVGSGKMVQNGREVYKWAARTVPGEFERLLHKAGLS
SDDLDWFVPHSANLRMIESICEKTPFPIEKTLTSVEHYGNTSSVSIVLALDLAVKAGKLKKDQIVLLFGFGGGLTYTGLL
IKWGM

Sequences:

>Translated_325_residues
MSKAKITAIGTYAPSRRLTNADLEKIVDTSDEWIVQRTGMRERRIADEHQFTSDLCIEAVKNLKSRYKGTLDDVDMILVA
TTTSDYAFPSTACRVQEYFGWESTGALDINATCAGLTYGLHLANGLITSGLHQKILVIAGETLSKVTDYTDRTTCVLFGD
AAGALLVERDEETPGFLASVQGTSGNGGDILYRAGLRNEINGVQLVGSGKMVQNGREVYKWAARTVPGEFERLLHKAGLS
SDDLDWFVPHSANLRMIESICEKTPFPIEKTLTSVEHYGNTSSVSIVLALDLAVKAGKLKKDQIVLLFGFGGGLTYTGLL
IKWGM
>Mature_324_residues
SKAKITAIGTYAPSRRLTNADLEKIVDTSDEWIVQRTGMRERRIADEHQFTSDLCIEAVKNLKSRYKGTLDDVDMILVAT
TTSDYAFPSTACRVQEYFGWESTGALDINATCAGLTYGLHLANGLITSGLHQKILVIAGETLSKVTDYTDRTTCVLFGDA
AGALLVERDEETPGFLASVQGTSGNGGDILYRAGLRNEINGVQLVGSGKMVQNGREVYKWAARTVPGEFERLLHKAGLSS
DDLDWFVPHSANLRMIESICEKTPFPIEKTLTSVEHYGNTSSVSIVLALDLAVKAGKLKKDQIVLLFGFGGGLTYTGLLI
KWGM

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=321, Percent_Identity=38.6292834890966, Blast_Score=226, Evalue=2e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH2_BACSU (O07600)

Other databases:

- EMBL:   Y14083
- EMBL:   AL009126
- PIR:   H69829
- RefSeq:   NP_388898.1
- ProteinModelPortal:   O07600
- SMR:   O07600
- EnsemblBacteria:   EBBACT00000002452
- GeneID:   939306
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU10170
- NMPDR:   fig|224308.1.peg.1017
- GenoList:   BSU10170
- GeneTree:   EBGT00050000001269
- HOGENOM:   HBG649927
- OMA:   REVYKWA
- ProtClustDB:   PRK12879
- BioCyc:   BSUB:BSU10170-MONOMER
- BRENDA:   2.3.1.180
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.180

Molecular weight: Translated: 35425; Mature: 35294

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: NA

Important sites: ACT_SITE 113-113 ACT_SITE 250-250 ACT_SITE 280-280

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKAKITAIGTYAPSRRLTNADLEKIVDTSDEWIVQRTGMRERRIADEHQFTSDLCIEAV
CCCCEEEEEECCCCCCCCCHHHHHHHHCCCCHHEEECCCCHHHHHHHHHHHHHHHHHHHH
KNLKSRYKGTLDDVDMILVATTTSDYAFPSTACRVQEYFGWESTGALDINATCAGLTYGL
HHHHHHCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHCCCCCCCEEEECCCHHHHHHHH
HLANGLITSGLHQKILVIAGETLSKVTDYTDRTTCVLFGDAAGALLVERDEETPGFLASV
HHHHHHHHHCCCCEEEEEECCHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCCEEEEE
QGTSGNGGDILYRAGLRNEINGVQLVGSGKMVQNGREVYKWAARTVPGEFERLLHKAGLS
CCCCCCCCCEEEECCCCCCCCCEEEEECCCHHHCCHHHHHHHHHCCCHHHHHHHHHCCCC
SDDLDWFVPHSANLRMIESICEKTPFPIEKTLTSVEHYGNTSSVSIVLALDLAVKAGKLK
CCCCCEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEEEEEEHHHCCCCC
KDQIVLLFGFGGGLTYTGLLIKWGM
CCCEEEEEECCCCCEEEEEEEEECC
>Mature Secondary Structure 
SKAKITAIGTYAPSRRLTNADLEKIVDTSDEWIVQRTGMRERRIADEHQFTSDLCIEAV
CCCEEEEEECCCCCCCCCHHHHHHHHCCCCHHEEECCCCHHHHHHHHHHHHHHHHHHHH
KNLKSRYKGTLDDVDMILVATTTSDYAFPSTACRVQEYFGWESTGALDINATCAGLTYGL
HHHHHHCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHCCCCCCCEEEECCCHHHHHHHH
HLANGLITSGLHQKILVIAGETLSKVTDYTDRTTCVLFGDAAGALLVERDEETPGFLASV
HHHHHHHHHCCCCEEEEEECCHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCCEEEEE
QGTSGNGGDILYRAGLRNEINGVQLVGSGKMVQNGREVYKWAARTVPGEFERLLHKAGLS
CCCCCCCCCEEEECCCCCCCCCEEEEECCCHHHCCHHHHHHHHHCCCHHHHHHHHHCCCC
SDDLDWFVPHSANLRMIESICEKTPFPIEKTLTSVEHYGNTSSVSIVLALDLAVKAGKLK
CCCCCEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEEEEEEHHHCCCCC
KDQIVLLFGFGGGLTYTGLLIKWGM
CCCEEEEEECCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 10629181; 12737802