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The map label for this gene is hpr

Identifier: 16078063

GI number: 16078063

Start: 1073106

End: 1073717

Strand: Reverse

Name: hpr

Synonym: BSU09990

Alternate gene names: 16078063

Gene position: 1073717-1073106 (Counterclockwise)

Preceding gene: 16078064

Following gene: 255767232

Centisome position: 25.47

GC content: 41.83

Gene sequence:

>612_bases
ATGAATCGAGTGGAACCGCCCTATGATGTGAAAGAAGCTCTGGTTTTCACCCAGAAAATGGCTCAGCTTAGCAAGGCTCT
TTGGAAATCGATCGAGAAGGATTGGCAGCAATGGCTCAAACCGTATGACCTGAATATTAATGAGCATCATATTTTATGGA
TTGCGTATCAATTGAATGGAGCTTCCATTTCTGAAATCGCGAAATTCGGGGTCATGCACGTATCAACCGCATTCAACTTT
TCAAAAAAGCTGGAAGAACGGGGATATTTAAGGTTCTCCAAACGGCTGAATGATAAACGGAACACATATGTCCAATTGAC
TGAGGAAGGTACCGAGGTATTCTGGAGCTTGCTTGAGGAATTTGATCCGACACGCAACGCTGTTTTTAAAGGGTCACAGC
CTTTATATCATTTATTCGGAAAATTTCCTGAAGTGGCAGAAATGATGTGTATGATACGCCATATCTACGGCGATGATTTT
ATGGAAATTTTCGAAACGTCACTCACCAATATTGACAATGACTTTGAAAGCGTAAACGGAAAATTGAAGAAAAAAGCAAA
GGACAGTGCGGCGGATGAACCGGCTGAAGAGCTCGAACCTGTAAACAGTTAA

Upstream 100 bases:

>100_bases
TGGTTTGTGAATTTATTAAAAAATTCTTACATTTTCATCTTTATTAATCTTTATTTTATTGGCATAATAGAGAAAAAGAA
AAAGAGAAGCAGGTGACGTA

Downstream 100 bases:

>100_bases
TCAAAATGCTTCATGATGTCGATAAAGACTTCCATCAGCTCTTGATAAAGCCCCTGCTCATACAGGGCAAAAATTGTTTC
ATGAACATCTAATTTTTCAT

Product: transcriptional regulator Hpr

Products: NA

Alternate protein names: Protease production regulatory protein hpr

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MNRVEPPYDVKEALVFTQKMAQLSKALWKSIEKDWQQWLKPYDLNINEHHILWIAYQLNGASISEIAKFGVMHVSTAFNF
SKKLEERGYLRFSKRLNDKRNTYVQLTEEGTEVFWSLLEEFDPTRNAVFKGSQPLYHLFGKFPEVAEMMCMIRHIYGDDF
MEIFETSLTNIDNDFESVNGKLKKKAKDSAADEPAEELEPVNS

Sequences:

>Translated_203_residues
MNRVEPPYDVKEALVFTQKMAQLSKALWKSIEKDWQQWLKPYDLNINEHHILWIAYQLNGASISEIAKFGVMHVSTAFNF
SKKLEERGYLRFSKRLNDKRNTYVQLTEEGTEVFWSLLEEFDPTRNAVFKGSQPLYHLFGKFPEVAEMMCMIRHIYGDDF
MEIFETSLTNIDNDFESVNGKLKKKAKDSAADEPAEELEPVNS
>Mature_203_residues
MNRVEPPYDVKEALVFTQKMAQLSKALWKSIEKDWQQWLKPYDLNINEHHILWIAYQLNGASISEIAKFGVMHVSTAFNF
SKKLEERGYLRFSKRLNDKRNTYVQLTEEGTEVFWSLLEEFDPTRNAVFKGSQPLYHLFGKFPEVAEMMCMIRHIYGDDF
MEIFETSLTNIDNDFESVNGKLKKKAKDSAADEPAEELEPVNS

Specific function: Negative regulator of protease production and sporulation. Acts by binding directly to the promoter of protease genes (aprE and nprE), and by repressing oligopeptide permease operons (appABCDF and oppABCDF), thereby preventing uptake of oligopeptides requ

COG id: COG1846

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH marR-type DNA-binding domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HPR_BACSU (P11065)

Other databases:

- EMBL:   M20237
- EMBL:   Y14077
- EMBL:   AL009126
- PIR:   A32009
- RefSeq:   NP_388880.1
- PDB:   2FXA
- PDBsum:   2FXA
- ProteinModelPortal:   P11065
- SMR:   P11065
- IntAct:   P11065
- EnsemblBacteria:   EBBACT00000000672
- GeneID:   939765
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU09990
- NMPDR:   fig|224308.1.peg.999
- GenoList:   BSU09990
- GeneTree:   EBGT00050000001224
- HOGENOM:   HBG313781
- OMA:   NEHHILW
- ProtClustDB:   PRK13777
- BioCyc:   BSUB:BSU09990-MONOMER
- GO:   GO:0005622
- HAMAP:   MF_01911
- InterPro:   IPR000835
- InterPro:   IPR023187
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- SMART:   SM00347

Pfam domain/function: PF01047 MarR

EC number: NA

Molecular weight: Translated: 23713; Mature: 23713

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS01117 HTH_MARR_1; PS50995 HTH_MARR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRVEPPYDVKEALVFTQKMAQLSKALWKSIEKDWQQWLKPYDLNINEHHILWIAYQLNG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECC
ASISEIAKFGVMHVSTAFNFSKKLEERGYLRFSKRLNDKRNTYVQLTEEGTEVFWSLLEE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHH
FDPTRNAVFKGSQPLYHLFGKFPEVAEMMCMIRHIYGDDFMEIFETSLTNIDNDFESVNG
HCCHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHH
KLKKKAKDSAADEPAEELEPVNS
HHHHHHHHCCCCCCHHHCCCCCC
>Mature Secondary Structure
MNRVEPPYDVKEALVFTQKMAQLSKALWKSIEKDWQQWLKPYDLNINEHHILWIAYQLNG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECC
ASISEIAKFGVMHVSTAFNFSKKLEERGYLRFSKRLNDKRNTYVQLTEEGTEVFWSLLEE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHH
FDPTRNAVFKGSQPLYHLFGKFPEVAEMMCMIRHIYGDDFMEIFETSLTNIDNDFESVNG
HCCHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHH
KLKKKAKDSAADEPAEELEPVNS
HHHHHHHHCCCCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3131303; 9579061; 9384377