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The map label for this gene is yhdZ

Identifier: 16078030

GI number: 16078030

Start: 1040094

End: 1040837

Strand: Direct

Name: yhdZ

Synonym: BSU09650

Alternate gene names: 16078030

Gene position: 1040094-1040837 (Clockwise)

Preceding gene: 16078029

Following gene: 16078032

Centisome position: 24.67

GC content: 48.12

Gene sequence:

>744_bases
TTGGAAACATTCAAAAGTATTCTACATGAAGCACAGAGAATTGTTGTGCTGACCGGAGCGGGAATGAGCACAGAATCAGG
GATCCCCGACTTTCGTTCAGCAGGGGGCATTTGGACGGAGGATGCCTCAAGAATGGAAGCGATGAGCCTTGATTATTTTT
TAAGTTATCCGCGTCTGTTTTGGCCCAAATTCAAAGAATTGTTCCAGATGAAAATGAGCGGCAGCTTTGAACCGAATGAA
GGCCATTTGCTTTTAGCTGAGCTGGAGAAGCAAGGGAAGCAGGTCGATATTTTCACGCAAAACATTGACGGTCTTCATAA
AAAAGCGGGGAGCAGGCATGTGTACGAACTGCATGGTTCTATCCAGACAGCAGCTTGTCCGGCATGCGGCGCCCGATATG
ATCTTCCCCATTTGCTGGAGCGGGAGGTGCCGGAGTGCACGGCGGCCGGAAACAATGGGGACATTTGCGGAACGGTATTA
AAAACCGATGTTGTTCTCTTTGGCGATGCCGTCATGCACTTTGACACCCTTTATGAAAAGCTGGATCAAGCAGATCTTTT
ATTGGTTATCGGCACGTCTCTCGAAGTGGCTCCGGCTAGATTTGTGCCTGAGGATGCAAGCCTGATTCCCGGCATGAAGA
AAGTCATCATAAACCTTGAACCAACGTATTGCGACAGCTTGTTTGACATGGTCATCCATCAAAAAATCGGCGAGTTTGCC
CGAAGTTTGGGCATGAAAAAGTGA

Upstream 100 bases:

>100_bases
TCTAAATAAAGAGGAAAAGGAACGGGCTTAAAAGAGAGACTTCGTCTGACAGAGGCGGAGTCTTTTTCATGGTAAAATAA
GAGAAAAAGGCGGTGTTGAG

Downstream 100 bases:

>100_bases
GCCGCTTTATGCGCCTCACTTTTTTATTCATGAACAGGAACCATTGTGTCCTCTAACACTCCGAAGGAATAGCCTTTTTC
TTTTAATTTATTGATTAGTA

Product: NAD-dependent deacetylase

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
METFKSILHEAQRIVVLTGAGMSTESGIPDFRSAGGIWTEDASRMEAMSLDYFLSYPRLFWPKFKELFQMKMSGSFEPNE
GHLLLAELEKQGKQVDIFTQNIDGLHKKAGSRHVYELHGSIQTAACPACGARYDLPHLLEREVPECTAAGNNGDICGTVL
KTDVVLFGDAVMHFDTLYEKLDQADLLLVIGTSLEVAPARFVPEDASLIPGMKKVIINLEPTYCDSLFDMVIHQKIGEFA
RSLGMKK

Sequences:

>Translated_247_residues
METFKSILHEAQRIVVLTGAGMSTESGIPDFRSAGGIWTEDASRMEAMSLDYFLSYPRLFWPKFKELFQMKMSGSFEPNE
GHLLLAELEKQGKQVDIFTQNIDGLHKKAGSRHVYELHGSIQTAACPACGARYDLPHLLEREVPECTAAGNNGDICGTVL
KTDVVLFGDAVMHFDTLYEKLDQADLLLVIGTSLEVAPARFVPEDASLIPGMKKVIINLEPTYCDSLFDMVIHQKIGEFA
RSLGMKK
>Mature_247_residues
METFKSILHEAQRIVVLTGAGMSTESGIPDFRSAGGIWTEDASRMEAMSLDYFLSYPRLFWPKFKELFQMKMSGSFEPNE
GHLLLAELEKQGKQVDIFTQNIDGLHKKAGSRHVYELHGSIQTAACPACGARYDLPHLLEREVPECTAAGNNGDICGTVL
KTDVVLFGDAVMHFDTLYEKLDQADLLLVIGTSLEVAPARFVPEDASLIPGMKKVIINLEPTYCDSLFDMVIHQKIGEFA
RSLGMKK

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain

Homologues:

Organism=Homo sapiens, GI7657575, Length=266, Percent_Identity=32.7067669172932, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI300795542, Length=238, Percent_Identity=36.1344537815126, Blast_Score=128, Evalue=5e-30,
Organism=Homo sapiens, GI13787215, Length=257, Percent_Identity=33.852140077821, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI6912664, Length=256, Percent_Identity=33.984375, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI6912662, Length=268, Percent_Identity=35.0746268656716, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI6912660, Length=200, Percent_Identity=36.5, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI63054862, Length=195, Percent_Identity=35.3846153846154, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI13775602, Length=222, Percent_Identity=31.981981981982, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI300797577, Length=247, Percent_Identity=31.5789473684211, Blast_Score=98, Evalue=6e-21,
Organism=Homo sapiens, GI13775600, Length=225, Percent_Identity=30.6666666666667, Blast_Score=98, Evalue=7e-21,
Organism=Homo sapiens, GI215982798, Length=210, Percent_Identity=30.4761904761905, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI300797705, Length=198, Percent_Identity=32.3232323232323, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI300797597, Length=239, Percent_Identity=30.9623430962343, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI7706712, Length=256, Percent_Identity=27.34375, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI308199517, Length=226, Percent_Identity=33.6283185840708, Blast_Score=103, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17541892, Length=238, Percent_Identity=32.7731092436975, Blast_Score=114, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI71990482, Length=286, Percent_Identity=31.8181818181818, Blast_Score=111, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17567771, Length=290, Percent_Identity=27.9310344827586, Blast_Score=107, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI71990487, Length=288, Percent_Identity=31.5972222222222, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17505510, Length=240, Percent_Identity=29.5833333333333, Blast_Score=87, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6325242, Length=266, Percent_Identity=31.203007518797, Blast_Score=105, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6320163, Length=296, Percent_Identity=29.7297297297297, Blast_Score=98, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6324504, Length=272, Percent_Identity=30.5147058823529, Blast_Score=97, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6320397, Length=231, Percent_Identity=26.4069264069264, Blast_Score=69, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17137536, Length=245, Percent_Identity=31.8367346938775, Blast_Score=120, Evalue=9e-28,
Organism=Drosophila melanogaster, GI24648389, Length=205, Percent_Identity=33.6585365853659, Blast_Score=103, Evalue=9e-23,
Organism=Drosophila melanogaster, GI28571445, Length=198, Percent_Identity=32.3232323232323, Blast_Score=94, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24645650, Length=244, Percent_Identity=27.8688524590164, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NPD_BACSU (O07595)

Other databases:

- EMBL:   Y14082
- EMBL:   AL009126
- PIR:   H69827
- RefSeq:   NP_388846.1
- ProteinModelPortal:   O07595
- SMR:   O07595
- EnsemblBacteria:   EBBACT00000003653
- GeneID:   936271
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU09650
- NMPDR:   fig|224308.1.peg.965
- GenoList:   BSU09650
- GeneTree:   EBGT00050000002097
- HOGENOM:   HBG641281
- OMA:   AGLINYF
- PhylomeDB:   O07595
- ProtClustDB:   PRK00481
- BioCyc:   BSUB:BSU09650-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01121
- InterPro:   IPR003000
- PANTHER:   PTHR11085

Pfam domain/function: PF02146 SIR2

EC number: 3.5.1.- [C]

Molecular weight: Translated: 27418; Mature: 27418

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS50305 SIRTUIN

Important sites: ACT_SITE 118-118

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METFKSILHEAQRIVVLTGAGMSTESGIPDFRSAGGIWTEDASRMEAMSLDYFLSYPRLF
CHHHHHHHHHCCEEEEEECCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHCCHHH
WPKFKELFQMKMSGSFEPNEGHLLLAELEKQGKQVDIFTQNIDGLHKKAGSRHVYELHGS
HHHHHHHHHHHHCCCCCCCCCCEEEEEHHHCCCEEEEEECCHHHHHHHCCCCEEEEECCC
IQTAACPACGARYDLPHLLEREVPECTAAGNNGDICGTVLKTDVVLFGDAVMHFDTLYEK
CHHHCCCCCCCCCCCHHHHHHCCCCHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
LDQADLLLVIGTSLEVAPARFVPEDASLIPGMKKVIINLEPTYCDSLFDMVIHQKIGEFA
HCCCCEEEEECCCCEECCCCCCCCCHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHH
RSLGMKK
HHHCCCC
>Mature Secondary Structure
METFKSILHEAQRIVVLTGAGMSTESGIPDFRSAGGIWTEDASRMEAMSLDYFLSYPRLF
CHHHHHHHHHCCEEEEEECCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHCCHHH
WPKFKELFQMKMSGSFEPNEGHLLLAELEKQGKQVDIFTQNIDGLHKKAGSRHVYELHGS
HHHHHHHHHHHHCCCCCCCCCCEEEEEHHHCCCEEEEEECCHHHHHHHCCCCEEEEECCC
IQTAACPACGARYDLPHLLEREVPECTAAGNNGDICGTVLKTDVVLFGDAVMHFDTLYEK
CHHHCCCCCCCCCCCHHHHHHCCCCHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
LDQADLLLVIGTSLEVAPARFVPEDASLIPGMKKVIINLEPTYCDSLFDMVIHQKIGEFA
HCCCCEEEEECCCCEECCCCCCCCCHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHH
RSLGMKK
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377