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The map label for this gene is ctrA

Identifier: 16078011

GI number: 16078011

Start: 1023350

End: 1024747

Strand: Direct

Name: ctrA

Synonym: BSU09460

Alternate gene names: 16078011

Gene position: 1023350-1024747 (Clockwise)

Preceding gene: 16078010

Following gene: 16078012

Centisome position: 24.28

GC content: 47.28

Gene sequence:

>1398_bases
ATGAAAGGGAGCGTTTTTAGGAAGAAAAGCATTCAGGATTTAATCGCTGCGACGAGCGGGGAAAAGTCTTTAAAAAGAGA
ATTAGGGGCATTTGATTTAACGTTGCTTGGAATCGGCGCCATTATTGGCACAGGGATTTTTGTTCTGACGGGAACAGGCG
CAGTCACGGCCGGTCCCGGGCTGACGATTTCATTTGTTGTGGCGGCGTTGGCTTGTTTATTCGCCGCCCTGTCTTACGCG
GAATTTGCGTCAAGTGTGCCTGTTTCAGGTTCGGTGTATACATTCACTTATGCGACATTGGGAGAGCTTATGGCCTTTAT
TATCGGGTGGGATTTAATTTTAGAATACATGCTGGCGGTAAGTGCAGTGTCGGTCGGCTGGTCTGGTTATTTCCAATCGT
TTTTATCAGGGCTTGGCATTCATCTTCCGGTTGCTTTAACAGCGGCACCGGGCGCAGTGAAAGGCACCTTTACCCTGTTT
AATCTTCCTGCATTCGTCATTGTAATGGCGATCACATATTTGCTTTATTTAGGCATCAAAGAATCAAAAAGAGTCAACAA
TATCATGGTTATCTTGAAGATACTGGTTGTTCTGCTGTTTATCGCGGTGGCAGCCGTTTACGTGAAGCCGCACAACTGGC
AGCCGTTTATGCCAATGGGCTTTGGCGGCGTGTTCAGTGCAGCGGCGCTCGTATTCTTTGCTTTTATCGGATTTGACGCT
GTATCCTCTGCTGCGGAAGAAACGAAAAATCCCGCGAAGGATCTGCCTAAAGGCATTATTTTCTCTTTACTGGTCTGCAC
GATTTTATATGTCACCGTATCAGCCATCATGACTGGGGTTATCCCGTTTGCTCAATTTGCGGGTGTGGATCATCCGGTTT
CTCTTGTTCTTCAAAGCGCAGGGCAAAATTGGGTGGCAGGCATCATTGATATTGGCGCCGTGTTGGGAATGACAACAGTT
ATGCTCGTGATGCTTTACGGGCAGACCCGCGTCATGTTTGCCATGTCGCGTGACGGACTTGTGCCGGGTTCACTTTCTAA
AGTGCATCCAAAGCACAAAACACCTTATGTAGCCACTTGGTTTTTCGGAACGATGTCGGCGCTTCTCGGCTCACTTGTTC
CGCTGGATGAACTTGCAAAGCTGGTGAACATCGGGACGTTGTCGGCATTTGTCCTGATTTCTGTGGCAGTTATCGTTTTG
AGAAAGAAACAGCCTGATCTTCCGAGAGCTTTTAAATGCCCGGGAGTTCCCGTGATCCCAGGCCTGGCGATTCTGTTCTG
CCTGTTCTTGATTTTAAATCTGGGATGGGTGACGATTGTCCGCTTCCTAGTGTGGCTGTTAATCGGCTTGGTAATCTATT
TCCTGTATTCAAGAAAGCATTCAAAATTAAATCAATAA

Upstream 100 bases:

>100_bases
CAAATATAGTAGAAAAAAAAGAATAATGACCATTGTTACTCATGAATTCAGAAAATTCAAATAAAATATATAAAAATAGA
TGATCGGGAGTTGAAGGGGA

Downstream 100 bases:

>100_bases
CCTTTTGATAAAGAGAGCGGCCATACAGGCCGCCTCTTTTCTGTTCTTGGCAAATGAATCTATAGAAATGAAGACAAAAA
TAAGAGATAATATAGGCTGG

Product: branched-chain amino acid transporter

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MKGSVFRKKSIQDLIAATSGEKSLKRELGAFDLTLLGIGAIIGTGIFVLTGTGAVTAGPGLTISFVVAALACLFAALSYA
EFASSVPVSGSVYTFTYATLGELMAFIIGWDLILEYMLAVSAVSVGWSGYFQSFLSGLGIHLPVALTAAPGAVKGTFTLF
NLPAFVIVMAITYLLYLGIKESKRVNNIMVILKILVVLLFIAVAAVYVKPHNWQPFMPMGFGGVFSAAALVFFAFIGFDA
VSSAAEETKNPAKDLPKGIIFSLLVCTILYVTVSAIMTGVIPFAQFAGVDHPVSLVLQSAGQNWVAGIIDIGAVLGMTTV
MLVMLYGQTRVMFAMSRDGLVPGSLSKVHPKHKTPYVATWFFGTMSALLGSLVPLDELAKLVNIGTLSAFVLISVAVIVL
RKKQPDLPRAFKCPGVPVIPGLAILFCLFLILNLGWVTIVRFLVWLLIGLVIYFLYSRKHSKLNQ

Sequences:

>Translated_465_residues
MKGSVFRKKSIQDLIAATSGEKSLKRELGAFDLTLLGIGAIIGTGIFVLTGTGAVTAGPGLTISFVVAALACLFAALSYA
EFASSVPVSGSVYTFTYATLGELMAFIIGWDLILEYMLAVSAVSVGWSGYFQSFLSGLGIHLPVALTAAPGAVKGTFTLF
NLPAFVIVMAITYLLYLGIKESKRVNNIMVILKILVVLLFIAVAAVYVKPHNWQPFMPMGFGGVFSAAALVFFAFIGFDA
VSSAAEETKNPAKDLPKGIIFSLLVCTILYVTVSAIMTGVIPFAQFAGVDHPVSLVLQSAGQNWVAGIIDIGAVLGMTTV
MLVMLYGQTRVMFAMSRDGLVPGSLSKVHPKHKTPYVATWFFGTMSALLGSLVPLDELAKLVNIGTLSAFVLISVAVIVL
RKKQPDLPRAFKCPGVPVIPGLAILFCLFLILNLGWVTIVRFLVWLLIGLVIYFLYSRKHSKLNQ
>Mature_465_residues
MKGSVFRKKSIQDLIAATSGEKSLKRELGAFDLTLLGIGAIIGTGIFVLTGTGAVTAGPGLTISFVVAALACLFAALSYA
EFASSVPVSGSVYTFTYATLGELMAFIIGWDLILEYMLAVSAVSVGWSGYFQSFLSGLGIHLPVALTAAPGAVKGTFTLF
NLPAFVIVMAITYLLYLGIKESKRVNNIMVILKILVVLLFIAVAAVYVKPHNWQPFMPMGFGGVFSAAALVFFAFIGFDA
VSSAAEETKNPAKDLPKGIIFSLLVCTILYVTVSAIMTGVIPFAQFAGVDHPVSLVLQSAGQNWVAGIIDIGAVLGMTTV
MLVMLYGQTRVMFAMSRDGLVPGSLSKVHPKHKTPYVATWFFGTMSALLGSLVPLDELAKLVNIGTLSAFVLISVAVIVL
RKKQPDLPRAFKCPGVPVIPGLAILFCLFLILNLGWVTIVRFLVWLLIGLVIYFLYSRKHSKLNQ

Specific function: Transporter For Gaba. [C]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily

Homologues:

Organism=Homo sapiens, GI4507047, Length=428, Percent_Identity=35.7476635514019, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI258614005, Length=423, Percent_Identity=36.4066193853428, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI258614003, Length=423, Percent_Identity=36.4066193853428, Blast_Score=226, Evalue=4e-59,
Organism=Homo sapiens, GI258645169, Length=423, Percent_Identity=36.6430260047281, Blast_Score=222, Evalue=4e-58,
Organism=Homo sapiens, GI110347453, Length=406, Percent_Identity=35.4679802955665, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI114326544, Length=429, Percent_Identity=33.5664335664336, Blast_Score=216, Evalue=5e-56,
Organism=Homo sapiens, GI114326550, Length=429, Percent_Identity=33.5664335664336, Blast_Score=216, Evalue=5e-56,
Organism=Homo sapiens, GI181337167, Length=416, Percent_Identity=35.3365384615385, Blast_Score=215, Evalue=5e-56,
Organism=Homo sapiens, GI115648063, Length=422, Percent_Identity=24.1706161137441, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI115648022, Length=422, Percent_Identity=24.1706161137441, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI186910308, Length=408, Percent_Identity=25, Blast_Score=93, Evalue=7e-19,
Organism=Homo sapiens, GI186910306, Length=408, Percent_Identity=25, Blast_Score=93, Evalue=7e-19,
Organism=Homo sapiens, GI186910304, Length=408, Percent_Identity=25, Blast_Score=93, Evalue=7e-19,
Organism=Homo sapiens, GI33286428, Length=459, Percent_Identity=26.3616557734205, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI187423910, Length=478, Percent_Identity=24.8953974895398, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI7657591, Length=478, Percent_Identity=24.8953974895398, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI7657683, Length=397, Percent_Identity=25.4408060453401, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI71979932, Length=470, Percent_Identity=27.0212765957447, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1789017, Length=409, Percent_Identity=25.4278728606357, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI87081869, Length=466, Percent_Identity=22.7467811158798, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1786302, Length=470, Percent_Identity=24.2553191489362, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI87082250, Length=466, Percent_Identity=24.0343347639485, Blast_Score=96, Evalue=7e-21,
Organism=Escherichia coli, GI87082023, Length=416, Percent_Identity=24.5192307692308, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788480, Length=358, Percent_Identity=24.5810055865922, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI87081915, Length=422, Percent_Identity=23.696682464455, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1786602, Length=472, Percent_Identity=20.7627118644068, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1790653, Length=417, Percent_Identity=23.021582733813, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1786694, Length=343, Percent_Identity=23.0320699708455, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI87081708, Length=483, Percent_Identity=21.1180124223602, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1790584, Length=258, Percent_Identity=25.968992248062, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI2367353, Length=454, Percent_Identity=22.2466960352423, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17532491, Length=418, Percent_Identity=36.8421052631579, Blast_Score=248, Evalue=6e-66,
Organism=Caenorhabditis elegans, GI17533459, Length=410, Percent_Identity=33.4146341463415, Blast_Score=211, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI17531343, Length=411, Percent_Identity=32.8467153284672, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17568033, Length=418, Percent_Identity=24.8803827751196, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17540018, Length=435, Percent_Identity=24.367816091954, Blast_Score=81, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17537453, Length=354, Percent_Identity=24.8587570621469, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71982612, Length=427, Percent_Identity=21.3114754098361, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71982608, Length=427, Percent_Identity=21.3114754098361, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI32566695, Length=441, Percent_Identity=21.3151927437642, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6321629, Length=442, Percent_Identity=21.7194570135747, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24667468, Length=419, Percent_Identity=37.2315035799523, Blast_Score=261, Evalue=1e-69,
Organism=Drosophila melanogaster, GI221512776, Length=419, Percent_Identity=35.799522673031, Blast_Score=255, Evalue=4e-68,
Organism=Drosophila melanogaster, GI24666159, Length=419, Percent_Identity=35.799522673031, Blast_Score=255, Evalue=6e-68,
Organism=Drosophila melanogaster, GI24668806, Length=428, Percent_Identity=34.1121495327103, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI21356285, Length=428, Percent_Identity=34.1121495327103, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI24668802, Length=428, Percent_Identity=34.1121495327103, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI161077963, Length=429, Percent_Identity=36.1305361305361, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI281366235, Length=411, Percent_Identity=33.0900243309002, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI116007820, Length=411, Percent_Identity=33.0900243309002, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI116007818, Length=411, Percent_Identity=32.6034063260341, Blast_Score=188, Evalue=5e-48,
Organism=Drosophila melanogaster, GI85725152, Length=411, Percent_Identity=32.6034063260341, Blast_Score=188, Evalue=5e-48,
Organism=Drosophila melanogaster, GI24651635, Length=418, Percent_Identity=24.4019138755981, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24651633, Length=418, Percent_Identity=24.4019138755981, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21357367, Length=434, Percent_Identity=23.2718894009217, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI45550968, Length=422, Percent_Identity=26.0663507109005, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI19921172, Length=422, Percent_Identity=26.0663507109005, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI221331183, Length=447, Percent_Identity=24.1610738255034, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17647653, Length=447, Percent_Identity=24.1610738255034, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24664379, Length=447, Percent_Identity=24.1610738255034, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24641993, Length=433, Percent_Identity=24.2494226327945, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24641995, Length=433, Percent_Identity=24.0184757505774, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): YHDG_BACSU (O07576)

Other databases:

- EMBL:   Y14082
- EMBL:   AL009126
- PIR:   E69825
- RefSeq:   NP_388827.1
- ProteinModelPortal:   O07576
- EnsemblBacteria:   EBBACT00000000444
- GeneID:   939746
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU09460
- NMPDR:   fig|224308.1.peg.946
- GenoList:   BSU09460
- GeneTree:   EBGT00070000031899
- HOGENOM:   HBG727793
- OMA:   TWIISIG
- ProtClustDB:   CLSK2301444
- BioCyc:   BSUB:BSU09460-MONOMER
- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004758
- InterPro:   IPR015606
- PANTHER:   PTHR11785
- PANTHER:   PTHR11785:SF53
- PIRSF:   PIRSF006060
- TIGRFAMs:   TIGR00909

Pfam domain/function: PF00324 AA_permease

EC number: NA

Molecular weight: Translated: 49711; Mature: 49711

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xdfa40e4)-; HASH(0xdbdc814)-; HASH(0xdcb911c)-; HASH(0xd590730)-; HASH(0xde24cb4)-; HASH(0xdb7db08)-; HASH(0xd973634)-; HASH(0xc39c654)-; HASH(0xde63bb8)-; HASH(0xdb4ff88)-; HASH(0xcd01f44)-; HASH(0xc436c00)-;

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
>Mature Secondary Structure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HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377