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The map label for this gene is hxlA

Identifier: 16077415

GI number: 16077415

Start: 375166

End: 375798

Strand: Reverse

Name: hxlA

Synonym: BSU03460

Alternate gene names: 16077415

Gene position: 375798-375166 (Counterclockwise)

Preceding gene: 16077423

Following gene: 16077414

Centisome position: 8.91

GC content: 44.55

Gene sequence:

>633_bases
ATGGAATTACAGCTTGCATTAGACCTCGTCAACATCCCGGAAGCCATTGAGCTTGTCAAAGAGGTAGAACAATACATCGA
CGTAGTTGAAATCGGAACACCGGTCGTCATCAATGAAGGCCTAAGAGCCGTTAAAGAAATAAAAGAAGCATTTCCTCAAT
TGAAGGTTCTTGCAGACCTGAAAATCATGGATGCCGGAGGCTACGAAATTATGAAAGCGTCGGAAGCAGGCGCTGACATC
ATCACCGTTTTAGGGGCTACAGACGATGCAACGATTAAAGGCGCAGTAGAAGAAGCCAAAAAACAAAAGAAGAAAATCTT
AGTGGACATGATTAACGTGAAAGATATCGAATCCCGTGCGAAAGAAATTGACGCACTCGGTGTTGACTACATCTGCGTCC
ACACTGGCTATGATCTTCAAGCAGAGGGCAAAAACTCTTTCGAAGAATTAACGACAATCAAAAATACCGTAAAAAACGCA
AAAACCGCAATCGCGGGCGGCATCAAACTTGATACACTGCCAGAAGTGATCCAGCAAAAGCCTGACCTTGTCATTGTCGG
GGGCGGAATTACAAGCGCAGCTGATAAGGCGGAAACAGCTTCAAAAATGAAGCAGCTGATTGTCCAAGGATAA

Upstream 100 bases:

>100_bases
GTATCCTCCAAGTAACTTGTTGACTTCAAAGTGCCTACTTCTCAACAAAAGAAGGAACCTATAGAATGAACAATAATTCG
AAAAAGGGAGTGGATCAACA

Downstream 100 bases:

>100_bases
CTCCGATGAAAACGACTGAATACGTAGCGGAAATTCTCAATGAGTTACACAATTCAGCAGCTTATATTTCTAATGAAGAA
GCTGACCAGCTTGCCGATCA

Product: 3-hexulose-6-phosphate synthase

Products: NA

Alternate protein names: HPS; D-arabino-3-hexulose-6-phosphate formaldehyde lyase; HUMPS

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MELQLALDLVNIPEAIELVKEVEQYIDVVEIGTPVVINEGLRAVKEIKEAFPQLKVLADLKIMDAGGYEIMKASEAGADI
ITVLGATDDATIKGAVEEAKKQKKKILVDMINVKDIESRAKEIDALGVDYICVHTGYDLQAEGKNSFEELTTIKNTVKNA
KTAIAGGIKLDTLPEVIQQKPDLVIVGGGITSAADKAETASKMKQLIVQG

Sequences:

>Translated_210_residues
MELQLALDLVNIPEAIELVKEVEQYIDVVEIGTPVVINEGLRAVKEIKEAFPQLKVLADLKIMDAGGYEIMKASEAGADI
ITVLGATDDATIKGAVEEAKKQKKKILVDMINVKDIESRAKEIDALGVDYICVHTGYDLQAEGKNSFEELTTIKNTVKNA
KTAIAGGIKLDTLPEVIQQKPDLVIVGGGITSAADKAETASKMKQLIVQG
>Mature_210_residues
MELQLALDLVNIPEAIELVKEVEQYIDVVEIGTPVVINEGLRAVKEIKEAFPQLKVLADLKIMDAGGYEIMKASEAGADI
ITVLGATDDATIKGAVEEAKKQKKKILVDMINVKDIESRAKEIDALGVDYICVHTGYDLQAEGKNSFEELTTIKNTVKNA
KTAIAGGIKLDTLPEVIQQKPDLVIVGGGITSAADKAETASKMKQLIVQG

Specific function: Catalyzes the condensation of ribulose 5-phosphate with formaldehyde to form 3-hexulose 6-phosphate. Together with hxlB, may act as a formaldehyde detoxification system

COG id: COG0269

COG function: function code G; 3-hexulose-6-phosphate synthase and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPS/KGPDC family. HPS subfamily

Homologues:

Organism=Escherichia coli, GI1790640, Length=209, Percent_Identity=32.5358851674641, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1790006, Length=207, Percent_Identity=30.4347826086957, Blast_Score=79, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HPS_BACSU (P42405)

Other databases:

- EMBL:   D30762
- EMBL:   D50453
- EMBL:   AL009126
- PIR:   A69761
- RefSeq:   NP_388228.1
- ProteinModelPortal:   P42405
- SMR:   P42405
- EnsemblBacteria:   EBBACT00000000193
- GeneID:   938314
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU03460
- NMPDR:   fig|224308.1.peg.347
- GenoList:   BSU03460
- GeneTree:   EBGT00050000002581
- HOGENOM:   HBG417610
- OMA:   PVVINEG
- PhylomeDB:   P42405
- ProtClustDB:   CLSK884731
- BioCyc:   BSUB:BSU03460-MONOMER
- InterPro:   IPR017553
- InterPro:   IPR013785
- InterPro:   IPR001754
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- SMART:   SM00934
- TIGRFAMs:   TIGR03128

Pfam domain/function: PF00215 OMPdecase; SSF51366 RibP_bind_barrel

EC number: =4.1.2.43

Molecular weight: Translated: 22572; Mature: 22572

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELQLALDLVNIPEAIELVKEVEQYIDVVEIGTPVVINEGLRAVKEIKEAFPQLKVLADL
CCEEEEEEHHCCHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHCE
KIMDAGGYEIMKASEAGADIITVLGATDDATIKGAVEEAKKQKKKILVDMINVKDIESRA
EEEECCCCCEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHH
KEIDALGVDYICVHTGYDLQAEGKNSFEELTTIKNTVKNAKTAIAGGIKLDTLPEVIQQK
HHHHHCCCCEEEEECCCCCEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
PDLVIVGGGITSAADKAETASKMKQLIVQG
CCEEEECCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MELQLALDLVNIPEAIELVKEVEQYIDVVEIGTPVVINEGLRAVKEIKEAFPQLKVLADL
CCEEEEEEHHCCHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHCE
KIMDAGGYEIMKASEAGADIITVLGATDDATIKGAVEEAKKQKKKILVDMINVKDIESRA
EEEECCCCCEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHH
KEIDALGVDYICVHTGYDLQAEGKNSFEELTTIKNTVKNAKTAIAGGIKLDTLPEVIQQK
HHHHHCCCCEEEEECCCCCEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
PDLVIVGGGITSAADKAETASKMKQLIVQG
CCEEEECCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7704255; 8969502; 9384377