Click here to switch to the map view.

The map label for this gene is phhA

Identifier: 15618954

GI number: 15618954

Start: 1199587

End: 1200675

Strand: Reverse

Name: phhA

Synonym: CPn1046

Alternate gene names: NA

Gene position: 1200675-1199587 (Counterclockwise)

Preceding gene: 15618968

Following gene: 15618953

Centisome position: 97.6

GC content: 38.57

Gene sequence:

>1089_bases
GTGCACTACTGCGAGAGAACCCTGGACCCAAAGTATATTCTGAAGATTGCTCTAAAGCTGAGACAATCACTTTCCCTGTT
CTTCCAGAACAGCCAATCACTCCAACGTGCATACTCGACCCCATATTCCTACTACCGAATCATTCTACAAAAGGAAAATA
AAGAGAAGCAAGCTTTAGCTCGACACAAATGCATTTCTATTTTAGAATTTTTCAAAAACTTACTCTTTGTTCATCTTCTG
TCATTATCAAAGAATCAAAGGGAAGGTTGCTCCACTGATATGGCTGTTGTAAGCACTCCCTTTTTTAATCGGAATTTATG
GTATCGACTCCTTTCCTCACGGTTTTCTCTATGGAAAAGCTATTGTCCAAGATTTTTTCTTGATTACTTAGAAGCTTTCG
GTCTCCTTTCTGATTTCTTAGACCATCAAGCAGTCATTAAATTCTTCGAATTAGAAACACATTTTTCCTATTATCCCGTT
TCAGGATTTGTAGCTCCCCATCAATACTTGTCTCTGTTGCAGGACCGTTACTTTCCCATTGCCTCTGTAATGCGAACTCT
CGATAAAGATAATTTCTCCTTAACTCCTGATCTCATCCATGACCTTTTAGGGCACGTGCCTTGGCTTCTACATCCCTCAT
TTTCTGAATTTTTCATAAACATGGGAAGACTCTTCACTAAAGTCATAGAAAAAGTACAAGCTCTTCCTAGTAAAAAACAA
CGCATACAAACCCTACAAAGCAATCTGATCGCTATTGTACGCTGCTTTTGGTTTACTGTTGAAAGCGGACTTATTGAAAA
CCATGAAGGAAGAAAAGCATATGGAGCCGTTCTTATCAGTTCTCCTCAGGAACTTGGACACGCTTTCATTGATAACGTAC
GTGTTCTCCCTTTAGAATTGGATCAGATTATTCGTCTTCCCTTCAATACATCAACTCCACAAGAGACTTTATTTTCAATA
AGACATTTTGATGAACTGGTAGAACTCACTTCAAAATTAGAATGGATGCTCGACCAAGGTCTGTTAGAATCAATTCCCCT
TTACAATCAAGAGAAATATCTTTCTGGTTTTGAGGTACTTTGCCAATGA

Upstream 100 bases:

>100_bases
TTAGGAGAGATTAAGAGATGGGCAACGACTTCTTTAGTTAGTAAGGGGTGGGAAAAATCAACAAGAACATCGTTATGTGC
AATCACTTGAAAAAGAGTGA

Downstream 100 bases:

>100_bases
ATACATCCCACAGAAAAACATTAGTATTTTCCTACTTGTCTTCAACCTTTACTTTGCTTCTTGTTCTCTCCAATCTTGTC
CTCTCTTCGAAGCTCATTCC

Product: aromatic amino acid hydroxylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MHYCERTLDPKYILKIALKLRQSLSLFFQNSQSLQRAYSTPYSYYRIILQKENKEKQALARHKCISILEFFKNLLFVHLL
SLSKNQREGCSTDMAVVSTPFFNRNLWYRLLSSRFSLWKSYCPRFFLDYLEAFGLLSDFLDHQAVIKFFELETHFSYYPV
SGFVAPHQYLSLLQDRYFPIASVMRTLDKDNFSLTPDLIHDLLGHVPWLLHPSFSEFFINMGRLFTKVIEKVQALPSKKQ
RIQTLQSNLIAIVRCFWFTVESGLIENHEGRKAYGAVLISSPQELGHAFIDNVRVLPLELDQIIRLPFNTSTPQETLFSI
RHFDELVELTSKLEWMLDQGLLESIPLYNQEKYLSGFEVLCQ

Sequences:

>Translated_362_residues
MHYCERTLDPKYILKIALKLRQSLSLFFQNSQSLQRAYSTPYSYYRIILQKENKEKQALARHKCISILEFFKNLLFVHLL
SLSKNQREGCSTDMAVVSTPFFNRNLWYRLLSSRFSLWKSYCPRFFLDYLEAFGLLSDFLDHQAVIKFFELETHFSYYPV
SGFVAPHQYLSLLQDRYFPIASVMRTLDKDNFSLTPDLIHDLLGHVPWLLHPSFSEFFINMGRLFTKVIEKVQALPSKKQ
RIQTLQSNLIAIVRCFWFTVESGLIENHEGRKAYGAVLISSPQELGHAFIDNVRVLPLELDQIIRLPFNTSTPQETLFSI
RHFDELVELTSKLEWMLDQGLLESIPLYNQEKYLSGFEVLCQ
>Mature_362_residues
MHYCERTLDPKYILKIALKLRQSLSLFFQNSQSLQRAYSTPYSYYRIILQKENKEKQALARHKCISILEFFKNLLFVHLL
SLSKNQREGCSTDMAVVSTPFFNRNLWYRLLSSRFSLWKSYCPRFFLDYLEAFGLLSDFLDHQAVIKFFELETHFSYYPV
SGFVAPHQYLSLLQDRYFPIASVMRTLDKDNFSLTPDLIHDLLGHVPWLLHPSFSEFFINMGRLFTKVIEKVQALPSKKQ
RIQTLQSNLIAIVRCFWFTVESGLIENHEGRKAYGAVLISSPQELGHAFIDNVRVLPLELDQIIRLPFNTSTPQETLFSI
RHFDELVELTSKLEWMLDQGLLESIPLYNQEKYLSGFEVLCQ

Specific function: Unknown

COG id: COG3186

COG function: function code E; Phenylalanine-4-hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family

Homologues:

Organism=Homo sapiens, GI4759248, Length=230, Percent_Identity=27.8260869565217, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI31795563, Length=209, Percent_Identity=28.7081339712919, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI4557819, Length=233, Percent_Identity=26.6094420600858, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI88900503, Length=219, Percent_Identity=28.310502283105, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI88900501, Length=219, Percent_Identity=28.310502283105, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI88900505, Length=219, Percent_Identity=28.310502283105, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI115532103, Length=240, Percent_Identity=23.75, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI115533973, Length=240, Percent_Identity=23.75, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71980736, Length=147, Percent_Identity=31.9727891156463, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17136774, Length=149, Percent_Identity=34.2281879194631, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17136776, Length=149, Percent_Identity=34.2281879194631, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24660393, Length=157, Percent_Identity=29.9363057324841, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI62472054, Length=157, Percent_Identity=29.9363057324841, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24654994, Length=154, Percent_Identity=30.5194805194805, Blast_Score=68, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AAAH_CHLPN (Q9Z6L3)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   C86621
- PIR:   E72002
- RefSeq:   NP_225240.1
- RefSeq:   NP_301101.1
- RefSeq:   NP_445345.1
- RefSeq:   NP_877358.1
- ProteinModelPortal:   Q9Z6L3
- SMR:   Q9Z6L3
- GeneID:   1467765
- GeneID:   894768
- GeneID:   919820
- GeneID:   962721
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0806
- KEGG:   cpj:CPj1046
- KEGG:   cpn:CPn1046
- KEGG:   cpt:CpB1086
- TIGR:   CP_0806
- OMA:   RCFWFTV
- ProtClustDB:   PRK14055
- BioCyc:   CPNE115711:CP_0806-MONOMER
- BioCyc:   CPNE115713:CPN1046-MONOMER
- BioCyc:   CPNE138677:CPJ1046-MONOMER
- BioCyc:   CPNE182082:CPB1086-MONOMER
- InterPro:   IPR001273
- InterPro:   IPR018301
- InterPro:   IPR019774
- Gene3D:   G3DSA:1.10.800.10
- PANTHER:   PTHR11473
- PRINTS:   PR00372

Pfam domain/function: PF00351 Biopterin_H; SSF56534 Aaa_hydroxylase

EC number: 1.14.16.-

Molecular weight: Translated: 42514; Mature: 42514

Theoretical pI: Translated: 8.13; Mature: 8.13

Prosite motif: PS00367 BH4_AAA_HYDROXYL_1; PS51410 BH4_AAA_HYDROXYL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHYCERTLDPKYILKIALKLRQSLSLFFQNSQSLQRAYSTPYSYYRIILQKENKEKQALA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCHHHHHHHHHCCCHHHHHHH
RHKCISILEFFKNLLFVHLLSLSKNQREGCSTDMAVVSTPFFNRNLWYRLLSSRFSLWKS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHH
YCPRFFLDYLEAFGLLSDFLDHQAVIKFFELETHFSYYPVSGFVAPHQYLSLLQDRYFPI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHCCCCH
ASVMRTLDKDNFSLTPDLIHDLLGHVPWLLHPSFSEFFINMGRLFTKVIEKVQALPSKKQ
HHHHHHHCCCCCCCCHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHH
RIQTLQSNLIAIVRCFWFTVESGLIENHEGRKAYGAVLISSPQELGHAFIDNVRVLPLEL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHEECCHHHHHHHHHCCCEEEEECH
DQIIRLPFNTSTPQETLFSIRHFDELVELTSKLEWMLDQGLLESIPLYNQEKYLSGFEVL
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
CQ
CC
>Mature Secondary Structure
MHYCERTLDPKYILKIALKLRQSLSLFFQNSQSLQRAYSTPYSYYRIILQKENKEKQALA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCHHHHHHHHHCCCHHHHHHH
RHKCISILEFFKNLLFVHLLSLSKNQREGCSTDMAVVSTPFFNRNLWYRLLSSRFSLWKS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHH
YCPRFFLDYLEAFGLLSDFLDHQAVIKFFELETHFSYYPVSGFVAPHQYLSLLQDRYFPI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHCCCCH
ASVMRTLDKDNFSLTPDLIHDLLGHVPWLLHPSFSEFFINMGRLFTKVIEKVQALPSKKQ
HHHHHHHCCCCCCCCHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHH
RIQTLQSNLIAIVRCFWFTVESGLIENHEGRKAYGAVLISSPQELGHAFIDNVRVLPLEL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHEECCHHHHHHHHHCCCEEEEECH
DQIIRLPFNTSTPQETLFSIRHFDELVELTSKLEWMLDQGLLESIPLYNQEKYLSGFEVL
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
CQ
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362