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The map label for this gene is tktB_2

Identifier: 15618968

GI number: 15618968

Start: 1215724

End: 1217658

Strand: Reverse

Name: tktB_2

Synonym: CPn1060

Alternate gene names: 15618968

Gene position: 1217658-1215724 (Counterclockwise)

Preceding gene: 15618969

Following gene: 15618954

Centisome position: 98.98

GC content: 43.15

Gene sequence:

>1935_bases
ATGACTTCGTCTTCTTGCCCCCTTTTAGACCTGATATTGTCTCCTGCAGATTTAAAGAAACTCTCTATTTCTCAGCTTCC
TGGTTTAGCTGAAGAAATCCGTTATCGCATCATCTCTGTATTATCACAAACAGGAGGCCACTTATCTTCAAATCTTGGAA
TCGTAGAGCTTACTATAGCCTTACATTACGTGTTCTCTTCCCCAAAAGATAAATTTATTTTTGATGTAGGACATCAGACC
TATCCTCATAAACTACTGACAGGAAGAAATAATGAAGGATTTGACCATATACGCAATGACAACGGCCTCAGTGGTTTTAC
CAACCCTACGGAGAGTGACCACGATTTATTTTTCTCTGGACATGCAGGGACGGCATTGTCTTTAGCTCTAGGAATGGCTC
AAACAACCCCTTTAGAATCACGCACACACGTCATTCCCATCCTTGGAGATGCTGCATTCTCTTGTGGTCTTACCTTAGAA
GCGTTGAACAATATTTCAACAGATTTATCGAAGTTTGTTGTTATTTTGAATGACAACAATATGTCGATCTCTAAAAACGT
AGGAGCCATGTCTCGAATCTTTTCCCGATGGCTACACCACCCTGCAACCAATAAACTCACTAAGCAAGTGGAAAAATGGC
TCGCTAAAATTCCACGCTATGGGGATAGCTTAGCAAAGCACAGTCGGAGACTTTCACAATGTGTTAAAAATCTCTTCTGT
CCCACTCCTTTATTTGAACAATTCGGATTAGCGTATGTCGGCCCTATAGACGGTCATAATGTTAAAAAACTGATCCCCAT
CCTTCAGTCCGTTCGTAACCTCCCTTTTCCTATTCTTGTCCACGTCTGTACAACTAAGGGGAAGGGCCTAGACCAAGCCC
AAAATAACCCTGCAAAGTATCACGGAGTCAGAGCAAACTTCAATAAGCGAGAATCCGCAAAACATCTTCCTGCGATTAAG
CCTAAGCCTTCTTTCCCTGATATATTTGGCCAAACGCTATGTGAACTTGGAGAGGTTTCCTCACGTCTCCATGTGGTGAC
TCCTGCAATGTCTATAGGATCTCGTTTGGAAGGTTTCAAACAGAAGTTCCCAGAACGCTTCTTTGATGTAGGGATTGCTG
AAGGCCATGCAGTGACTTTCAGTGCAGGCATTGCAAAAGCCGGCAATCCTGTGATCTGTTCTATATATTCTACATTTTTA
CACCGTGCTCTCGATAATGTTTTCCACGATGTTTGCATGCAAGATCTTCCCGTGATTTTTGCTATAGATCGTGCAGGACT
TGCCTATGGTGATGGACGTAGTCATCACGGCATCTATGATATGAGTTTCCTACGTGCGATGCCCCAGATGATTATCTGTC
AGCCACGTAGCCAGGTGGTATTCCAACAGCTACTGTATTCTTCTCTACACTGGTCCTCTCCTTCTGCTATCCGCTACCCC
AATATCCCAGCTCCTCATGGAGACCCACTCACTGGAGATCCAAATTTCCTAAGATCCCCAGGCAATGCTGAGACCCTCTC
ACAAGGTGAGGACGTTCTCATCATAGCTCTTGGAACCCTCTGCTTCACGGCCCTATCTATAAAACATCAGTTGCTTGCTT
ATGGCATCTCCGCAACTGTTGTAGACCCGATCTTTATAAAACCTTTTGATAACGATCTTTTCAGTCTTTTACTGATGAGT
CACTCTAAGGTGATTACCATAGAAGAGCACTCCATTCGAGGAGGATTAGCGTCCGAGTTTAATAATTTTGTAGCTACGTT
CAATTTTAAGGTCGATATCTTAAATTTTGCAATCCCCGATACATTCCTATCCCATGGGAGTAAGGAAGCCCTCACAAAAT
CTATAGGCCTTGATGAGAGTAGTATGACCAACCGCATTCTCACTCATTTCAACTTCAGATCAAAAAAGCAGACTGTTGGA
GACGTCAGAGTTTAA

Upstream 100 bases:

>100_bases
TGTTATCTTCTTTCTGTTAACTCCAAAGGAGAACTCCTCAAAAGTCCTTCTGGAGACCCTATAGTACAAACGTTTCCTAT
ACATCCACATCACTAAGGTC

Downstream 100 bases:

>100_bases
TTATCCCTAGAGATTGTAATTTCCTTAGAAGGGAAAGTACCTTTAACCCGCTTGCATCTTATGGAAGAGAGCAAGATAAT
CATTAAGACTCAATACTTCA

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 644; Mature: 643

Protein sequence:

>644_residues
MTSSSCPLLDLILSPADLKKLSISQLPGLAEEIRYRIISVLSQTGGHLSSNLGIVELTIALHYVFSSPKDKFIFDVGHQT
YPHKLLTGRNNEGFDHIRNDNGLSGFTNPTESDHDLFFSGHAGTALSLALGMAQTTPLESRTHVIPILGDAAFSCGLTLE
ALNNISTDLSKFVVILNDNNMSISKNVGAMSRIFSRWLHHPATNKLTKQVEKWLAKIPRYGDSLAKHSRRLSQCVKNLFC
PTPLFEQFGLAYVGPIDGHNVKKLIPILQSVRNLPFPILVHVCTTKGKGLDQAQNNPAKYHGVRANFNKRESAKHLPAIK
PKPSFPDIFGQTLCELGEVSSRLHVVTPAMSIGSRLEGFKQKFPERFFDVGIAEGHAVTFSAGIAKAGNPVICSIYSTFL
HRALDNVFHDVCMQDLPVIFAIDRAGLAYGDGRSHHGIYDMSFLRAMPQMIICQPRSQVVFQQLLYSSLHWSSPSAIRYP
NIPAPHGDPLTGDPNFLRSPGNAETLSQGEDVLIIALGTLCFTALSIKHQLLAYGISATVVDPIFIKPFDNDLFSLLLMS
HSKVITIEEHSIRGGLASEFNNFVATFNFKVDILNFAIPDTFLSHGSKEALTKSIGLDESSMTNRILTHFNFRSKKQTVG
DVRV

Sequences:

>Translated_644_residues
MTSSSCPLLDLILSPADLKKLSISQLPGLAEEIRYRIISVLSQTGGHLSSNLGIVELTIALHYVFSSPKDKFIFDVGHQT
YPHKLLTGRNNEGFDHIRNDNGLSGFTNPTESDHDLFFSGHAGTALSLALGMAQTTPLESRTHVIPILGDAAFSCGLTLE
ALNNISTDLSKFVVILNDNNMSISKNVGAMSRIFSRWLHHPATNKLTKQVEKWLAKIPRYGDSLAKHSRRLSQCVKNLFC
PTPLFEQFGLAYVGPIDGHNVKKLIPILQSVRNLPFPILVHVCTTKGKGLDQAQNNPAKYHGVRANFNKRESAKHLPAIK
PKPSFPDIFGQTLCELGEVSSRLHVVTPAMSIGSRLEGFKQKFPERFFDVGIAEGHAVTFSAGIAKAGNPVICSIYSTFL
HRALDNVFHDVCMQDLPVIFAIDRAGLAYGDGRSHHGIYDMSFLRAMPQMIICQPRSQVVFQQLLYSSLHWSSPSAIRYP
NIPAPHGDPLTGDPNFLRSPGNAETLSQGEDVLIIALGTLCFTALSIKHQLLAYGISATVVDPIFIKPFDNDLFSLLLMS
HSKVITIEEHSIRGGLASEFNNFVATFNFKVDILNFAIPDTFLSHGSKEALTKSIGLDESSMTNRILTHFNFRSKKQTVG
DVRV
>Mature_643_residues
TSSSCPLLDLILSPADLKKLSISQLPGLAEEIRYRIISVLSQTGGHLSSNLGIVELTIALHYVFSSPKDKFIFDVGHQTY
PHKLLTGRNNEGFDHIRNDNGLSGFTNPTESDHDLFFSGHAGTALSLALGMAQTTPLESRTHVIPILGDAAFSCGLTLEA
LNNISTDLSKFVVILNDNNMSISKNVGAMSRIFSRWLHHPATNKLTKQVEKWLAKIPRYGDSLAKHSRRLSQCVKNLFCP
TPLFEQFGLAYVGPIDGHNVKKLIPILQSVRNLPFPILVHVCTTKGKGLDQAQNNPAKYHGVRANFNKRESAKHLPAIKP
KPSFPDIFGQTLCELGEVSSRLHVVTPAMSIGSRLEGFKQKFPERFFDVGIAEGHAVTFSAGIAKAGNPVICSIYSTFLH
RALDNVFHDVCMQDLPVIFAIDRAGLAYGDGRSHHGIYDMSFLRAMPQMIICQPRSQVVFQQLLYSSLHWSSPSAIRYPN
IPAPHGDPLTGDPNFLRSPGNAETLSQGEDVLIIALGTLCFTALSIKHQLLAYGISATVVDPIFIKPFDNDLFSLLLMSH
SKVITIEEHSIRGGLASEFNNFVATFNFKVDILNFAIPDTFLSHGSKEALTKSIGLDESSMTNRILTHFNFRSKKQTVGD
VRV

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=610, Percent_Identity=21.8032786885246, Blast_Score=91, Evalue=5e-18,
Organism=Homo sapiens, GI4507521, Length=610, Percent_Identity=21.8032786885246, Blast_Score=91, Evalue=5e-18,
Organism=Homo sapiens, GI133778974, Length=365, Percent_Identity=22.4657534246575, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI1786622, Length=625, Percent_Identity=38.88, Blast_Score=444, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24666278, Length=272, Percent_Identity=23.8970588235294, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45551847, Length=383, Percent_Identity=23.4986945169713, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI45550715, Length=383, Percent_Identity=23.4986945169713, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24645119, Length=383, Percent_Identity=23.4986945169713, Blast_Score=73, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_CHLPN (Q9Z6J9)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   A72002
- PIR:   A86623
- RefSeq:   NP_225254.1
- RefSeq:   NP_301115.1
- RefSeq:   NP_445329.1
- RefSeq:   NP_877373.1
- ProteinModelPortal:   Q9Z6J9
- SMR:   Q9Z6J9
- GeneID:   1467781
- GeneID:   894783
- GeneID:   919827
- GeneID:   963116
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0790
- KEGG:   cpn:CPn1060
- KEGG:   cpt:CpB1102
- TIGR:   CP_0790
- HOGENOM:   HBG571647
- OMA:   ILITIEE
- PhylomeDB:   Q9Z6J9
- ProtClustDB:   PRK05444
- BioCyc:   CPNE115711:CP_0790-MONOMER
- BioCyc:   CPNE115713:CPN1060-MONOMER
- BioCyc:   CPNE138677:CPJ1060-MONOMER
- BioCyc:   CPNE182082:CPB1102-MONOMER
- BRENDA:   2.2.1.7
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 70892; Mature: 70761

Theoretical pI: Translated: 8.55; Mature: 8.55

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSSSCPLLDLILSPADLKKLSISQLPGLAEEIRYRIISVLSQTGGHLSSNLGIVELTIA
CCCCCCCHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEHHHH
LHYVFSSPKDKFIFDVGHQTYPHKLLTGRNNEGFDHIRNDNGLSGFTNPTESDHDLFFSG
HHHHHCCCCCCEEEECCCCCCCCHHHCCCCCCCCHHHCCCCCCCCCCCCCCCCCCEEEEC
HAGTALSLALGMAQTTPLESRTHVIPILGDAAFSCGLTLEALNNISTDLSKFVVILNDNN
CCCHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHCCCHHHHHHHHHHCCEEEEEEECCCC
MSISKNVGAMSRIFSRWLHHPATNKLTKQVEKWLAKIPRYGDSLAKHSRRLSQCVKNLFC
CEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC
PTPLFEQFGLAYVGPIDGHNVKKLIPILQSVRNLPFPILVHVCTTKGKGLDQAQNNPAKY
CCHHHHHCCCEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHCCCCCCC
HGVRANFNKRESAKHLPAIKPKPSFPDIFGQTLCELGEVSSRLHVVTPAMSIGSRLEGFK
CCEECCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHH
QKFPERFFDVGIAEGHAVTFSAGIAKAGNPVICSIYSTFLHRALDNVFHDVCMQDLPVIF
HHCCHHHHHCCCCCCCEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCEEE
AIDRAGLAYGDGRSHHGIYDMSFLRAMPQMIICQPRSQVVFQQLLYSSLHWSSPSAIRYP
EEECCCCEECCCCCCCCCHHHHHHHHCCHHEEECCHHHHHHHHHHHHHHCCCCCCCEECC
NIPAPHGDPLTGDPNFLRSPGNAETLSQGEDVLIIALGTLCFTALSIKHQLLAYGISATV
CCCCCCCCCCCCCCHHHCCCCCCHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCHHHE
VDPIFIKPFDNDLFSLLLMSHSKVITIEEHSIRGGLASEFNNFVATFNFKVDILNFAIPD
ECCEEEECCCHHHHHHHHHCCCCEEEEECCCCCCCHHHHHCCEEEEEEEEEEEEEHHCCH
TFLSHGSKEALTKSIGLDESSMTNRILTHFNFRSKKQTVGDVRV
HHHHCCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TSSSCPLLDLILSPADLKKLSISQLPGLAEEIRYRIISVLSQTGGHLSSNLGIVELTIA
CCCCCCHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEHHHH
LHYVFSSPKDKFIFDVGHQTYPHKLLTGRNNEGFDHIRNDNGLSGFTNPTESDHDLFFSG
HHHHHCCCCCCEEEECCCCCCCCHHHCCCCCCCCHHHCCCCCCCCCCCCCCCCCCEEEEC
HAGTALSLALGMAQTTPLESRTHVIPILGDAAFSCGLTLEALNNISTDLSKFVVILNDNN
CCCHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHCCCHHHHHHHHHHCCEEEEEEECCCC
MSISKNVGAMSRIFSRWLHHPATNKLTKQVEKWLAKIPRYGDSLAKHSRRLSQCVKNLFC
CEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC
PTPLFEQFGLAYVGPIDGHNVKKLIPILQSVRNLPFPILVHVCTTKGKGLDQAQNNPAKY
CCHHHHHCCCEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHCCCCCCC
HGVRANFNKRESAKHLPAIKPKPSFPDIFGQTLCELGEVSSRLHVVTPAMSIGSRLEGFK
CCEECCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHH
QKFPERFFDVGIAEGHAVTFSAGIAKAGNPVICSIYSTFLHRALDNVFHDVCMQDLPVIF
HHCCHHHHHCCCCCCCEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCEEE
AIDRAGLAYGDGRSHHGIYDMSFLRAMPQMIICQPRSQVVFQQLLYSSLHWSSPSAIRYP
EEECCCCEECCCCCCCCCHHHHHHHHCCHHEEECCHHHHHHHHHHHHHHCCCCCCCEECC
NIPAPHGDPLTGDPNFLRSPGNAETLSQGEDVLIIALGTLCFTALSIKHQLLAYGISATV
CCCCCCCCCCCCCCHHHCCCCCCHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCHHHE
VDPIFIKPFDNDLFSLLLMSHSKVITIEEHSIRGGLASEFNNFVATFNFKVDILNFAIPD
ECCEEEECCCHHHHHHHHHCCCCEEEEECCCCCCCHHHHHCCEEEEEEEEEEEEEHHCCH
TFLSHGSKEALTKSIGLDESSMTNRILTHFNFRSKKQTVGDVRV
HHHHCCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362