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The map label for this gene is hemN_2

Identifier: 15618798

GI number: 15618798

Start: 1015459

End: 1016835

Strand: Reverse

Name: hemN_2

Synonym: CPn0889

Alternate gene names: 15618798

Gene position: 1016835-1015459 (Counterclockwise)

Preceding gene: 15618799

Following gene: 15618797

Centisome position: 82.65

GC content: 40.38

Gene sequence:

>1377_bases
ATGTTCAACGTCAACTTTAAATTCTTAGAAGGACTTCATCAACCCGCGCCCAGATACACAAGCTACCCTACAGCTTTAGA
ATGGGAACCTTCCGATGCGGCTCCAGCTCTTCTAGCGTTCCAAAGAATTAGAGAAAATCCTCAGCCTCTCTCTCTTTATT
TTCATATCCCCTTCTGCCAATCCATGTGTTTGTATTGCGGTTGTTCTGTTGTTTTGAATCGTCGTGAAGATATTGTAGAA
GCTTATATCAACACCCTAATCCAAGAGATGAAACTTGTCGTTGAGACCATAGGATTCCGGCCTCAGGTATCCAGGATTCA
TTTTGGAGGAGGCACCCCTAGCAGACTCTCCAGGGAGTTGTTTACCCTGCTTTTTGACCACATCCATAAGCTTTTTGATC
TTTCACATGCTGAAGAAATTGCTATTGAAGTGGATCCTCGTTCTTTAAGAAACGACATGGAAAAAGCAGATTTCTTTCAG
AACGTAGGTTTTAATAGGGTTAGCTTAGGCGTTCAAGATACCCAAGCTGATGTTCAAGAAGCTGTACGACGACGCCAATC
GCATGAGGAATCTTTAAAGGCATACGAAAAATTTAAGGAACTCGCCTTCCAAAGTATCAATATAGACTTAATTTATGGTC
TTCCCAAACAAACCAAGGAGTCCTTTTCTAAAACAATTCAAGATATCTTAGCGATGTATCCAGATCGTCTTGCTTTATTT
TCTTTTGCCTCAGTTCCATGGATCAAGCCGCACCAAAAAGCCATGAAAGCTTCGGATATGCCTTCTATGGAAGAGAAATT
CGCGATTTATTCTCAATCCCGGCATTTACTTACAAAAGCAGGATATCAGGCCATCGGTATGGATCATTTCTCTCTTCCCC
ATGATCCTCTTACCCTCGCTTTCAAAAACAAAACTCTAATCCGCAACTTTCAGGGGTATTCTCTACCCCCAGAAGAAGAT
CTGCTCGGGTTAGGAATGACTTCTACAAGCTTCATTCGTGGAATTTATCTACAAAATGCAAAAACCCTTGAGGAATATCA
CAATACGGTGCTTCGAGGAACATTTGCCACTGTGAAAAGTAAAATTCTTACCGAGGATGATCGGATTAGAAAATGGGCAA
TCCATAAGCTGATGTGCACGTTTACGATCAATAAGGAAGAGTTTTTCAACCTTTTTGGATATGAGTTTGATACTTATTTT
ATAGAAAGTCGTGATCGCTTGATAAGTATGGAAACTACAGGTCTCATCCATAACAGTCCTGGCTCTTTGAAAGTAACTCC
TCTTGGAGAATTGTTTGTCAGAGTCATTGCCACAGCTTTCGATCACTATTTTCTCAATAAGGTATCTAAAAAAGAATGTT
TCTCAGCTTCTATATAA

Upstream 100 bases:

>100_bases
TTCCTTGTTCCTTTAAGAACATATCCTAACTTCATTTTTAATTCTGGACATGGGATTCTTCCTGAAACACCTTTAGAAAA
CGTCCAATTGGTAGTTTCTT

Downstream 100 bases:

>100_bases
AAATGTTGAGAAACTGAGCAGAGAGGAGGTTTTGTGTGAAGAGAGCAATCATTATAGGCGCAGGAATTTCTGGTCTTGCT
GCAGGTTGGTGGCTTCATAA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MFNVNFKFLEGLHQPAPRYTSYPTALEWEPSDAAPALLAFQRIRENPQPLSLYFHIPFCQSMCLYCGCSVVLNRREDIVE
AYINTLIQEMKLVVETIGFRPQVSRIHFGGGTPSRLSRELFTLLFDHIHKLFDLSHAEEIAIEVDPRSLRNDMEKADFFQ
NVGFNRVSLGVQDTQADVQEAVRRRQSHEESLKAYEKFKELAFQSINIDLIYGLPKQTKESFSKTIQDILAMYPDRLALF
SFASVPWIKPHQKAMKASDMPSMEEKFAIYSQSRHLLTKAGYQAIGMDHFSLPHDPLTLAFKNKTLIRNFQGYSLPPEED
LLGLGMTSTSFIRGIYLQNAKTLEEYHNTVLRGTFATVKSKILTEDDRIRKWAIHKLMCTFTINKEEFFNLFGYEFDTYF
IESRDRLISMETTGLIHNSPGSLKVTPLGELFVRVIATAFDHYFLNKVSKKECFSASI

Sequences:

>Translated_458_residues
MFNVNFKFLEGLHQPAPRYTSYPTALEWEPSDAAPALLAFQRIRENPQPLSLYFHIPFCQSMCLYCGCSVVLNRREDIVE
AYINTLIQEMKLVVETIGFRPQVSRIHFGGGTPSRLSRELFTLLFDHIHKLFDLSHAEEIAIEVDPRSLRNDMEKADFFQ
NVGFNRVSLGVQDTQADVQEAVRRRQSHEESLKAYEKFKELAFQSINIDLIYGLPKQTKESFSKTIQDILAMYPDRLALF
SFASVPWIKPHQKAMKASDMPSMEEKFAIYSQSRHLLTKAGYQAIGMDHFSLPHDPLTLAFKNKTLIRNFQGYSLPPEED
LLGLGMTSTSFIRGIYLQNAKTLEEYHNTVLRGTFATVKSKILTEDDRIRKWAIHKLMCTFTINKEEFFNLFGYEFDTYF
IESRDRLISMETTGLIHNSPGSLKVTPLGELFVRVIATAFDHYFLNKVSKKECFSASI
>Mature_458_residues
MFNVNFKFLEGLHQPAPRYTSYPTALEWEPSDAAPALLAFQRIRENPQPLSLYFHIPFCQSMCLYCGCSVVLNRREDIVE
AYINTLIQEMKLVVETIGFRPQVSRIHFGGGTPSRLSRELFTLLFDHIHKLFDLSHAEEIAIEVDPRSLRNDMEKADFFQ
NVGFNRVSLGVQDTQADVQEAVRRRQSHEESLKAYEKFKELAFQSINIDLIYGLPKQTKESFSKTIQDILAMYPDRLALF
SFASVPWIKPHQKAMKASDMPSMEEKFAIYSQSRHLLTKAGYQAIGMDHFSLPHDPLTLAFKNKTLIRNFQGYSLPPEED
LLGLGMTSTSFIRGIYLQNAKTLEEYHNTVLRGTFATVKSKILTEDDRIRKWAIHKLMCTFTINKEEFFNLFGYEFDTYF
IESRDRLISMETTGLIHNSPGSLKVTPLGELFVRVIATAFDHYFLNKVSKKECFSASI

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=254, Percent_Identity=24.4094488188976, Blast_Score=83, Evalue=6e-16,
Organism=Escherichia coli, GI87082341, Length=449, Percent_Identity=37.6391982182628, Blast_Score=311, Evalue=7e-86,
Organism=Escherichia coli, GI1789325, Length=246, Percent_Identity=28.8617886178862, Blast_Score=107, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 52744; Mature: 52744

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNVNFKFLEGLHQPAPRYTSYPTALEWEPSDAAPALLAFQRIRENPQPLSLYFHIPFCQ
CCCCCHHHHHHHCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHCCCCCEEEEEECHHHH
SMCLYCGCSVVLNRREDIVEAYINTLIQEMKLVVETIGFRPQVSRIHFGGGTPSRLSREL
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHH
FTLLFDHIHKLFDLSHAEEIAIEVDPRSLRNDMEKADFFQNVGFNRVSLGVQDTQADVQE
HHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHH
AVRRRQSHEESLKAYEKFKELAFQSINIDLIYGLPKQTKESFSKTIQDILAMYPDRLALF
HHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHH
SFASVPWIKPHQKAMKASDMPSMEEKFAIYSQSRHLLTKAGYQAIGMDHFSLPHDPLTLA
HHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCEEEE
FKNKTLIRNFQGYSLPPEEDLLGLGMTSTSFIRGIYLQNAKTLEEYHNTVLRGTFATVKS
ECCCHHHHCCCCCCCCCCHHHEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
KILTEDDRIRKWAIHKLMCTFTINKEEFFNLFGYEFDTYFIESRDRLISMETTGLIHNSP
HHCCCHHHHHHHHHHHHHEEEEECHHHHHHHHCCCHHHEEEECCCCEEEEEECCEEECCC
GSLKVTPLGELFVRVIATAFDHYFLNKVSKKECFSASI
CCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFNVNFKFLEGLHQPAPRYTSYPTALEWEPSDAAPALLAFQRIRENPQPLSLYFHIPFCQ
CCCCCHHHHHHHCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHCCCCCEEEEEECHHHH
SMCLYCGCSVVLNRREDIVEAYINTLIQEMKLVVETIGFRPQVSRIHFGGGTPSRLSREL
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHH
FTLLFDHIHKLFDLSHAEEIAIEVDPRSLRNDMEKADFFQNVGFNRVSLGVQDTQADVQE
HHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHH
AVRRRQSHEESLKAYEKFKELAFQSINIDLIYGLPKQTKESFSKTIQDILAMYPDRLALF
HHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHH
SFASVPWIKPHQKAMKASDMPSMEEKFAIYSQSRHLLTKAGYQAIGMDHFSLPHDPLTLA
HHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCEEEE
FKNKTLIRNFQGYSLPPEEDLLGLGMTSTSFIRGIYLQNAKTLEEYHNTVLRGTFATVKS
ECCCHHHHCCCCCCCCCCHHHEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
KILTEDDRIRKWAIHKLMCTFTINKEEFFNLFGYEFDTYFIESRDRLISMETTGLIHNSP
HHCCCHHHHHHHHHHHHHEEEEECHHHHHHHHCCCHHHEEEECCCCEEEEEECCEEECCC
GSLKVTPLGELFVRVIATAFDHYFLNKVSKKECFSASI
CCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]