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The map label for this gene is hemG

Identifier: 15618797

GI number: 15618797

Start: 1014116

End: 1015423

Strand: Reverse

Name: hemG

Synonym: CPn0888

Alternate gene names: 15618797

Gene position: 1015423-1014116 (Counterclockwise)

Preceding gene: 15618798

Following gene: 15618795

Centisome position: 82.54

GC content: 43.81

Gene sequence:

>1308_bases
GTGAAGAGAGCAATCATTATAGGCGCAGGAATTTCTGGTCTTGCTGCAGGTTGGTGGCTTCATAAGAAATTCCCCCAAGC
GGAAATCCTTGTTTTAGATAAAGAAGCCTACGCAGGAGGCTTCGTCCGCACGGAATCCCCTCAAGGGTTTTCTTTTGACC
TCGGACCTAAAGGATTCCTCACCCGGGGAGACGGAGAGTATACTCTAAAACTTATCCATGAACTTGGTCTCCAAAATTCC
TTGATCTTCAGTGATCGTGCAGCAAAAAACCGCTTTGTCTACTACAGAGGGAAGGCCCATAAAATATCCACCTGGACTCT
CCTAAGAAAGGGCCTGCTTCCTTCTTTAATTAAGGACTTCCGTGCACCTTGCTATACTCAAGATAGTTCCGTTCAGGATT
TCTTAAAGCGACATAGTTCACAAAATTTTACAAGCTATATATTAGATCCACTAATCACAGCCATACGCGCAGGCCATAGC
AGCATTCTCTCCACACACATGGCATTTCCTGAACTAGCAAAGAGAGAAGCTTCCAGCGGGTCTCTATTACGCAGTTATCT
TAAAAATAGATCCCCCAAAAAGTCTAAGACCGACAGATATCTTGCATCTCTATCTCCTTCCATGGGGACTTTGATTACTA
CTATCCAAGAAAAACTCCCCGCAACATGGAAGTTTTCTACTAGTGTGACTCACATCGATTGTTCACCAAAAGAAGCTTGT
GTAACCACACCTTCAGAGACGTTTTTTGCCGATATGGTAATTTATACAGGACCTCTCCAGCAGCTTCCTGTATTGCTTCC
TAACTATGGAATTGAAAATTTATCTAAAAGAGTTCTCCCTTGGAATTTATCTAGCATCAGCTTAGGTTGGCATCACGCCA
ACTTTTCGCTTCCCAAAGGTTATGGCATGCTATTTGCAGACGAGCTTCCCCTCTTGGGAATCGTTTGGAATTCTCAAATC
TTCCCGCAAGCTACGCCAGGGAAAACAGTGCTCTCCCTTCTCATTGAAGGCAAATGGCGGGAATCAGAAGCTCATGCCTT
TGCGATAGCAGCTCTCTCAGAATACCTGAATATCAATCAAAAACCAGATGCTTTTGCTTTATTTTCATCTCAGGATGGCA
TGCCACAACATGCTGTTGGCTTTCTAGAAAGGAAAGAGCGTATCCTACCTCACTTACCAGGAAATTTAAAAATTGTAGGT
CAAAATATTGCAGGCCCAGGACTGAATCGATGTATAGCTTCTGCATATCATGCTATCTGTGATTTACACACCGAGGAAAC
GCTGGCACAACCCCAGAGTTCTCTGTAG

Upstream 100 bases:

>100_bases
CAGCTTTCGATCACTATTTTCTCAATAAGGTATCTAAAAAAGAATGTTTCTCAGCTTCTATATAAAAATGTTGAGAAACT
GAGCAGAGAGGAGGTTTTGT

Downstream 100 bases:

>100_bases
AGACTCGCCATAATAGTCTCTGTAAGAACGTGGGGAAATTAAATTCTTTTCTACATGCTCAAGAAGATGATTGGACAAGT
GTGCGGTCTCATGTAACTGA

Product: protoporphyrinogen oxidase

Products: NA

Alternate protein names: PPO [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MKRAIIIGAGISGLAAGWWLHKKFPQAEILVLDKEAYAGGFVRTESPQGFSFDLGPKGFLTRGDGEYTLKLIHELGLQNS
LIFSDRAAKNRFVYYRGKAHKISTWTLLRKGLLPSLIKDFRAPCYTQDSSVQDFLKRHSSQNFTSYILDPLITAIRAGHS
SILSTHMAFPELAKREASSGSLLRSYLKNRSPKKSKTDRYLASLSPSMGTLITTIQEKLPATWKFSTSVTHIDCSPKEAC
VTTPSETFFADMVIYTGPLQQLPVLLPNYGIENLSKRVLPWNLSSISLGWHHANFSLPKGYGMLFADELPLLGIVWNSQI
FPQATPGKTVLSLLIEGKWRESEAHAFAIAALSEYLNINQKPDAFALFSSQDGMPQHAVGFLERKERILPHLPGNLKIVG
QNIAGPGLNRCIASAYHAICDLHTEETLAQPQSSL

Sequences:

>Translated_435_residues
MKRAIIIGAGISGLAAGWWLHKKFPQAEILVLDKEAYAGGFVRTESPQGFSFDLGPKGFLTRGDGEYTLKLIHELGLQNS
LIFSDRAAKNRFVYYRGKAHKISTWTLLRKGLLPSLIKDFRAPCYTQDSSVQDFLKRHSSQNFTSYILDPLITAIRAGHS
SILSTHMAFPELAKREASSGSLLRSYLKNRSPKKSKTDRYLASLSPSMGTLITTIQEKLPATWKFSTSVTHIDCSPKEAC
VTTPSETFFADMVIYTGPLQQLPVLLPNYGIENLSKRVLPWNLSSISLGWHHANFSLPKGYGMLFADELPLLGIVWNSQI
FPQATPGKTVLSLLIEGKWRESEAHAFAIAALSEYLNINQKPDAFALFSSQDGMPQHAVGFLERKERILPHLPGNLKIVG
QNIAGPGLNRCIASAYHAICDLHTEETLAQPQSSL
>Mature_435_residues
MKRAIIIGAGISGLAAGWWLHKKFPQAEILVLDKEAYAGGFVRTESPQGFSFDLGPKGFLTRGDGEYTLKLIHELGLQNS
LIFSDRAAKNRFVYYRGKAHKISTWTLLRKGLLPSLIKDFRAPCYTQDSSVQDFLKRHSSQNFTSYILDPLITAIRAGHS
SILSTHMAFPELAKREASSGSLLRSYLKNRSPKKSKTDRYLASLSPSMGTLITTIQEKLPATWKFSTSVTHIDCSPKEAC
VTTPSETFFADMVIYTGPLQQLPVLLPNYGIENLSKRVLPWNLSSISLGWHHANFSLPKGYGMLFADELPLLGIVWNSQI
FPQATPGKTVLSLLIEGKWRESEAHAFAIAALSEYLNINQKPDAFALFSSQDGMPQHAVGFLERKERILPHLPGNLKIVG
QNIAGPGLNRCIASAYHAICDLHTEETLAQPQSSL

Specific function: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. Also oxidizes the pathway intermediate coproporphyrinogen-III [H]

COG id: COG1232

COG function: function code H; Protoporphyrinogen oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protoporphyrinogen oxidase family [H]

Homologues:

Organism=Homo sapiens, GI170650615, Length=489, Percent_Identity=23.721881390593, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI4506001, Length=489, Percent_Identity=23.721881390593, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24649745, Length=461, Percent_Identity=23.644251626898, Blast_Score=88, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002937
- InterPro:   IPR016040
- InterPro:   IPR004572 [H]

Pfam domain/function: PF01593 Amino_oxidase [H]

EC number: =1.3.3.4 [H]

Molecular weight: Translated: 48186; Mature: 48186

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRAIIIGAGISGLAAGWWLHKKFPQAEILVLDKEAYAGGFVRTESPQGFSFDLGPKGFL
CCCEEEEECCCHHHHHHHHHHCCCCCCEEEEEECHHHCCCEEECCCCCCCEECCCCCCCE
TRGDGEYTLKLIHELGLQNSLIFSDRAAKNRFVYYRGKAHKISTWTLLRKGLLPSLIKDF
ECCCCHHHHHHHHHHCCCCCEEECCCCCCCCEEEEECCCCEEHHHHHHHHHHHHHHHHHH
RAPCYTQDSSVQDFLKRHSSQNFTSYILDPLITAIRAGHSSILSTHMAFPELAKREASSG
CCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCH
SLLRSYLKNRSPKKSKTDRYLASLSPSMGTLITTIQEKLPATWKFSTSVTHIDCSPKEAC
HHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEECCCEEEEECCCCCCE
VTTPSETFFADMVIYTGPLQQLPVLLPNYGIENLSKRVLPWNLSSISLGWHHANFSLPKG
ECCCCHHHHHHHHHCCCCHHHCCHHCCCCCHHHHHHCCCCCCCCEEEEEEEECCCCCCCC
YGMLFADELPLLGIVWNSQIFPQATPGKTVLSLLIEGKWRESEAHAFAIAALSEYLNINQ
CCEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCC
KPDAFALFSSQDGMPQHAVGFLERKERILPHLPGNLKIVGQNIAGPGLNRCIASAYHAIC
CCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHH
DLHTEETLAQPQSSL
HCCCHHHHCCCCCCC
>Mature Secondary Structure
MKRAIIIGAGISGLAAGWWLHKKFPQAEILVLDKEAYAGGFVRTESPQGFSFDLGPKGFL
CCCEEEEECCCHHHHHHHHHHCCCCCCEEEEEECHHHCCCEEECCCCCCCEECCCCCCCE
TRGDGEYTLKLIHELGLQNSLIFSDRAAKNRFVYYRGKAHKISTWTLLRKGLLPSLIKDF
ECCCCHHHHHHHHHHCCCCCEEECCCCCCCCEEEEECCCCEEHHHHHHHHHHHHHHHHHH
RAPCYTQDSSVQDFLKRHSSQNFTSYILDPLITAIRAGHSSILSTHMAFPELAKREASSG
CCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCH
SLLRSYLKNRSPKKSKTDRYLASLSPSMGTLITTIQEKLPATWKFSTSVTHIDCSPKEAC
HHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEECCCEEEEECCCCCCE
VTTPSETFFADMVIYTGPLQQLPVLLPNYGIENLSKRVLPWNLSSISLGWHHANFSLPKG
ECCCCHHHHHHHHHCCCCHHHCCHHCCCCCHHHHHHCCCCCCCCEEEEEEEECCCCCCCC
YGMLFADELPLLGIVWNSQIFPQATPGKTVLSLLIEGKWRESEAHAFAIAALSEYLNINQ
CCEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCC
KPDAFALFSSQDGMPQHAVGFLERKERILPHLPGNLKIVGQNIAGPGLNRCIASAYHAIC
CCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHH
DLHTEETLAQPQSSL
HCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1459957; 9579061; 9384377; 8288631 [H]