| Definition | Chlamydophila pneumoniae CWL029, complete genome. |
|---|---|
| Accession | NC_000922 |
| Length | 1,230,230 |
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The map label for this gene is topA
Identifier: 15618678
GI number: 15618678
Start: 865118
End: 867733
Strand: Reverse
Name: topA
Synonym: CPn0769
Alternate gene names: 15618678
Gene position: 867733-865118 (Counterclockwise)
Preceding gene: 15618680
Following gene: 15618675
Centisome position: 70.53
GC content: 40.56
Gene sequence:
>2616_bases ATGAAAAAGTCCTTAATTATAGTAGAATCACCTGCAAAAATTAAAACGCTACAAAAATTATTAGGGAGTGAATTTGTTTT TGCCTCATCTATAGGACATATTGTAGATCTCCCTGCTAAGGAATTTGGCATTGATGTGGATCATGATTTCGAACCACAAT ACCAAGTGCTTCCCGATAAACAAGAGGTCATCAATCACATCCGCAAGCTAGCCGCGAAGTGTGAAAAAGTCTATCTTTCC CCTGACCCTGATAGAGAAGGAGAGGCAATTGCCTGGCACATCGCGAATCAGCTTCCTGACTCTCCTCTGATCCAGAGGGT ATCGTTTAATGCCATTACCAAAAATGCGGTTACAGAGGCCTTAAAACACCCTCGAACCATCGATATGGCTTTAGTCAACG CACAACAAGCGCGGAGACTTCTTGACCGCATTGTGGGATATAAAATTTCTCCTATCCTAAGTCGAAAGTTACAACAACGC TCAGGGATATCTGCAGGGCGTGTGCAATCTGTAGCTTTGAAGCTTGTCGTAGATCGAGAAAAGGCTATTGATGCTTTTGT TCCTGTTGAATACTGGAATTTACGCGTTTTAATGCAAGATCCCAAAACGACAAAAACGTTTTGGGCGCATTTATACGCTG TGCAAGGAAAAAAGTGGGAGAAAGAAATCCCTGAAGGGAAAACCGAAAATGATGTCCTTCTTATTAACTCTGAAGAGAAA GCCCGTCACTATGCCGAGCTGTTAGAGAAATCCTCGTATACAATCACTCGTGTAGAAGCTAAGGCAAAACGACGTTTTGC TCCTCCTCCTTTCATTACATCCACTCTCCAGCAGGAAGCAAGCCGGCATTTTCGTTTTTCTGCTTCTAGAACCATGTCTA TAGCGCAAACCCTCTATGAGGGCGTCGATTTAGATAGTGAAGATTCTACAGGTTTGATTACCTACATGCGTACGGATTCC GTACGTGTAGATCCCGAAGCATTAACTACAGTTAGAGAGTACATCCAACAGACTTTCGGTAAAGAATATCTCCCTGAGAA AGCAAACGTATATACTACAAAAAAGATGACGCAAGATGCTCACGAAGCCATACGTCCCACTGATATTAATCTGACTCCTG ACAAATTAAAGAATAAGCTTTCTGATGATCAATTTAAAGTATACAACTTAATCTGGAAACGCTTCGTAGCCTCACAGATT ACCCCTGCAATTTATGATACTTTAGCTGTTCAAATTACTACGGATACAGAAATAGACCTCCGAGCTTCAGGATCCTTACT AAAATTTAAAGGGTTTCTCGCTGTCTATGAAGAGAAGCAAGATGATGAAAATGATCAAGAAGAAGACCATCCTCTCCCCC CCCTACATGCCCAAGATGCCTTAATCAAAGAGGAAGTATCCCAAGAACAGGCATTTACAAAACCCCTTCCTAGATTCACA GAAGCTTCTCTAGTCAAAGAGTTAGAAAAATCTGGGATCGGCCGTCCTTCAACGTATGCCACGATAATGAACAAAATTCA AAGTCGTGAATATACGACTAAAGAAAATCAACGGTTACGTCCTACAGAATTAGGAAAGATTATCTCACAGTTCTTAGAAA CAAACTTTCCAAGAATTATGGATATCGGGTTCACAGCTCTCATGGAAGACGAGCTTGAACTCATTGCAGATAATAAAAAA CCTTGGAAACTCTTACTTCAAGAATTCTGGACTACATTCCTTCCTGTAGTGATTACAGCAGAAAAAGAAGCTGTCATTCC TAGAATTCTCACAAATATAGAATGTTCTAAGTGCCATAAAGGAAAACTAGTAAAAATCTGGTCTAAAAACAGTTATTTCT ATGGCTGCTCAGAATATCCTGAATGCGATTACCGCACTTCTGAAGAAGAGCTCGCTTTCAACAAAGAAGACTATGCTGAA GACACCCCCTGGGACAGTCCTTGTCCTCTTTGTGGAGGCGTTATGAAAGTACGTCACGGCCGCTATGGAACATTTTTAGG GTGTGAGAAGTATCCTGAATGCCGTGGCACTATATCAATCCATAAAAAGGGAGAGGAAATCGAACAGGAAGAGCCTATCC CCTGCCCTGCAATAGGCTGTAATGGGAAAATTTTCAAAAAACGCTCCCGTTACAACAAGATTTTCTATTCCTGTTCAGAG TATCCTGAATGTAGTGTGATTGGAAATTCTATAGATGCTGTAATCACAAAGTACTCAGGAACAGAAAAAATTCCCTATAA GAAAAAAACTCCGACCAAGAAAAAATCTTCAGCAAAAACAACAAAAGCAGCCAAAACACCTTCTAAAAAGGGAAAAGCAA AAAGCTCGGTTAAAAAATCTTCAGAAAAGAAAACAGGTCCTTTATTCCTTCCCTCTCCAGATCTAGCAAAAATGATCGGA AACGAACCCGTATCTCGGGGAGAAGCAACCAAAAAAATCTGGGATTACATCAAGGAACATCAATTACAGGCACCAGAAAA TAAAAAACTTTTAGTTCCTGATAACAATTTAGCTACGATCATTGGTCCGAATCCTATCGATATGTTCCAACTTTCGAAAC ACCTAAGTCAGCATTTAACAAAGGTCTCTAATGACGAGTCGTCGGCTTCTTCGTAA
Upstream 100 bases:
>100_bases TGCATGAAAACAAAGTTTTAGGAATTAGAAAATTAAATTAATAAAAGGGAGTCGCGTTTTCTCTCGGTAAAGTATCCAGG GTCCTCACGCAATTAGATTA
Downstream 100 bases:
>100_bases TCATTCACAAGCTGGTAGACTTCTTGGTAGGATGTCGCTTTTGCTAGAGACGAACGAAGAAAACGCACCTTAGCCGCGGA AATTAGGTAGTGGCCACATA
Product: DNA topoisomerase I/SWI domain fusion protein
Products: NA
Alternate protein names: DNA topoisomerase I; Omega-protein; Relaxing enzyme; Swivelase; Untwisting enzyme [H]
Number of amino acids: Translated: 871; Mature: 871
Protein sequence:
>871_residues MKKSLIIVESPAKIKTLQKLLGSEFVFASSIGHIVDLPAKEFGIDVDHDFEPQYQVLPDKQEVINHIRKLAAKCEKVYLS PDPDREGEAIAWHIANQLPDSPLIQRVSFNAITKNAVTEALKHPRTIDMALVNAQQARRLLDRIVGYKISPILSRKLQQR SGISAGRVQSVALKLVVDREKAIDAFVPVEYWNLRVLMQDPKTTKTFWAHLYAVQGKKWEKEIPEGKTENDVLLINSEEK ARHYAELLEKSSYTITRVEAKAKRRFAPPPFITSTLQQEASRHFRFSASRTMSIAQTLYEGVDLDSEDSTGLITYMRTDS VRVDPEALTTVREYIQQTFGKEYLPEKANVYTTKKMTQDAHEAIRPTDINLTPDKLKNKLSDDQFKVYNLIWKRFVASQI TPAIYDTLAVQITTDTEIDLRASGSLLKFKGFLAVYEEKQDDENDQEEDHPLPPLHAQDALIKEEVSQEQAFTKPLPRFT EASLVKELEKSGIGRPSTYATIMNKIQSREYTTKENQRLRPTELGKIISQFLETNFPRIMDIGFTALMEDELELIADNKK PWKLLLQEFWTTFLPVVITAEKEAVIPRILTNIECSKCHKGKLVKIWSKNSYFYGCSEYPECDYRTSEEELAFNKEDYAE DTPWDSPCPLCGGVMKVRHGRYGTFLGCEKYPECRGTISIHKKGEEIEQEEPIPCPAIGCNGKIFKKRSRYNKIFYSCSE YPECSVIGNSIDAVITKYSGTEKIPYKKKTPTKKKSSAKTTKAAKTPSKKGKAKSSVKKSSEKKTGPLFLPSPDLAKMIG NEPVSRGEATKKIWDYIKEHQLQAPENKKLLVPDNNLATIIGPNPIDMFQLSKHLSQHLTKVSNDESSASS
Sequences:
>Translated_871_residues MKKSLIIVESPAKIKTLQKLLGSEFVFASSIGHIVDLPAKEFGIDVDHDFEPQYQVLPDKQEVINHIRKLAAKCEKVYLS PDPDREGEAIAWHIANQLPDSPLIQRVSFNAITKNAVTEALKHPRTIDMALVNAQQARRLLDRIVGYKISPILSRKLQQR SGISAGRVQSVALKLVVDREKAIDAFVPVEYWNLRVLMQDPKTTKTFWAHLYAVQGKKWEKEIPEGKTENDVLLINSEEK ARHYAELLEKSSYTITRVEAKAKRRFAPPPFITSTLQQEASRHFRFSASRTMSIAQTLYEGVDLDSEDSTGLITYMRTDS VRVDPEALTTVREYIQQTFGKEYLPEKANVYTTKKMTQDAHEAIRPTDINLTPDKLKNKLSDDQFKVYNLIWKRFVASQI TPAIYDTLAVQITTDTEIDLRASGSLLKFKGFLAVYEEKQDDENDQEEDHPLPPLHAQDALIKEEVSQEQAFTKPLPRFT EASLVKELEKSGIGRPSTYATIMNKIQSREYTTKENQRLRPTELGKIISQFLETNFPRIMDIGFTALMEDELELIADNKK PWKLLLQEFWTTFLPVVITAEKEAVIPRILTNIECSKCHKGKLVKIWSKNSYFYGCSEYPECDYRTSEEELAFNKEDYAE DTPWDSPCPLCGGVMKVRHGRYGTFLGCEKYPECRGTISIHKKGEEIEQEEPIPCPAIGCNGKIFKKRSRYNKIFYSCSE YPECSVIGNSIDAVITKYSGTEKIPYKKKTPTKKKSSAKTTKAAKTPSKKGKAKSSVKKSSEKKTGPLFLPSPDLAKMIG NEPVSRGEATKKIWDYIKEHQLQAPENKKLLVPDNNLATIIGPNPIDMFQLSKHLSQHLTKVSNDESSASS >Mature_871_residues MKKSLIIVESPAKIKTLQKLLGSEFVFASSIGHIVDLPAKEFGIDVDHDFEPQYQVLPDKQEVINHIRKLAAKCEKVYLS PDPDREGEAIAWHIANQLPDSPLIQRVSFNAITKNAVTEALKHPRTIDMALVNAQQARRLLDRIVGYKISPILSRKLQQR SGISAGRVQSVALKLVVDREKAIDAFVPVEYWNLRVLMQDPKTTKTFWAHLYAVQGKKWEKEIPEGKTENDVLLINSEEK ARHYAELLEKSSYTITRVEAKAKRRFAPPPFITSTLQQEASRHFRFSASRTMSIAQTLYEGVDLDSEDSTGLITYMRTDS VRVDPEALTTVREYIQQTFGKEYLPEKANVYTTKKMTQDAHEAIRPTDINLTPDKLKNKLSDDQFKVYNLIWKRFVASQI TPAIYDTLAVQITTDTEIDLRASGSLLKFKGFLAVYEEKQDDENDQEEDHPLPPLHAQDALIKEEVSQEQAFTKPLPRFT EASLVKELEKSGIGRPSTYATIMNKIQSREYTTKENQRLRPTELGKIISQFLETNFPRIMDIGFTALMEDELELIADNKK PWKLLLQEFWTTFLPVVITAEKEAVIPRILTNIECSKCHKGKLVKIWSKNSYFYGCSEYPECDYRTSEEELAFNKEDYAE DTPWDSPCPLCGGVMKVRHGRYGTFLGCEKYPECRGTISIHKKGEEIEQEEPIPCPAIGCNGKIFKKRSRYNKIFYSCSE YPECSVIGNSIDAVITKYSGTEKIPYKKKTPTKKKSSAKTTKAAKTPSKKGKAKSSVKKSSEKKTGPLFLPSPDLAKMIG NEPVSRGEATKKIWDYIKEHQLQAPENKKLLVPDNNLATIIGPNPIDMFQLSKHLSQHLTKVSNDESSASS
Specific function: The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another [H]
COG id: COG0550
COG function: function code L; Topoisomerase IA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 Toprim domain [H]
Homologues:
Organism=Homo sapiens, GI10835218, Length=620, Percent_Identity=24.6774193548387, Blast_Score=134, Evalue=4e-31, Organism=Homo sapiens, GI4507635, Length=683, Percent_Identity=22.2547584187408, Blast_Score=91, Evalue=4e-18, Organism=Escherichia coli, GI1787529, Length=824, Percent_Identity=36.7718446601942, Blast_Score=475, Evalue=1e-135, Organism=Escherichia coli, GI1788061, Length=582, Percent_Identity=25.6013745704467, Blast_Score=119, Evalue=9e-28, Organism=Escherichia coli, GI48994931, Length=136, Percent_Identity=38.2352941176471, Blast_Score=94, Evalue=4e-20, Organism=Caenorhabditis elegans, GI17555378, Length=560, Percent_Identity=26.25, Blast_Score=120, Evalue=3e-27, Organism=Saccharomyces cerevisiae, GI6323263, Length=574, Percent_Identity=23.6933797909408, Blast_Score=105, Evalue=5e-23, Organism=Drosophila melanogaster, GI24585251, Length=706, Percent_Identity=25.4957507082153, Blast_Score=127, Evalue=2e-29, Organism=Drosophila melanogaster, GI24640096, Length=533, Percent_Identity=24.577861163227, Blast_Score=111, Evalue=2e-24,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003601 - InterPro: IPR013497 - InterPro: IPR013824 - InterPro: IPR013825 - InterPro: IPR000380 - InterPro: IPR003602 - InterPro: IPR013498 - InterPro: IPR005733 - InterPro: IPR006171 [H]
Pfam domain/function: PF01131 Topoisom_bac; PF01751 Toprim; PF01396 zf-C4_Topoisom [H]
EC number: =5.99.1.2 [H]
Molecular weight: Translated: 98893; Mature: 98893
Theoretical pI: Translated: 8.68; Mature: 8.68
Prosite motif: PS00396 TOPOISOMERASE_I_PROK
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.5 %Cys (Translated Protein) 1.4 %Met (Translated Protein) 2.9 %Cys+Met (Translated Protein) 1.5 %Cys (Mature Protein) 1.4 %Met (Mature Protein) 2.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKKSLIIVESPAKIKTLQKLLGSEFVFASSIGHIVDLPAKEFGIDVDHDFEPQYQVLPDK CCCCEEEEECCHHHHHHHHHHCCCEEHHHCCCHHEECCHHHHCCCCCCCCCCCCEECCCH QEVINHIRKLAAKCEKVYLSPDPDREGEAIAWHIANQLPDSPLIQRVSFNAITKNAVTEA HHHHHHHHHHHHHHHEEECCCCCCCCCCEEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHH LKHPRTIDMALVNAQQARRLLDRIVGYKISPILSRKLQQRSGISAGRVQSVALKLVVDRE HHCCCEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHEECHH KAIDAFVPVEYWNLRVLMQDPKTTKTFWAHLYAVQGKKWEKEIPEGKTENDVLLINSEEK HHHHHCCCEEEEEEEEEEECCCCHHHHHHHHHHHCCCCHHHHCCCCCCCCCEEEEECHHH ARHYAELLEKSSYTITRVEAKAKRRFAPPPFITSTLQQEASRHFRFSASRTMSIAQTLYE HHHHHHHHHCCCCEEEEEHHHHHHCCCCCCHHHHHHHHHHHHHEECCHHHHHHHHHHHHH GVDLDSEDSTGLITYMRTDSVRVDPEALTTVREYIQQTFGKEYLPEKANVYTTKKMTQDA CCCCCCCCCCCEEEEEECCCEEECHHHHHHHHHHHHHHHCHHHCCCCCCEEEHHHHHHHH HEAIRPTDINLTPDKLKNKLSDDQFKVYNLIWKRFVASQITPAIYDTLAVQITTDTEIDL HHCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHEEEEEEECCCCEEE RASGSLLKFKGFLAVYEEKQDDENDQEEDHPLPPLHAQDALIKEEVSQEQAFTKPLPRFT ECCCCEEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHH EASLVKELEKSGIGRPSTYATIMNKIQSREYTTKENQRLRPTELGKIISQFLETNFPRIM HHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEE DIGFTALMEDELELIADNKKPWKLLLQEFWTTFLPVVITAEKEAVIPRILTNIECSKCHK HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCEEEECCCHHHHHHHHCCCCHHHCCC GKLVKIWSKNSYFYGCSEYPECDYRTSEEELAFNKEDYAEDTPWDSPCPLCGGVMKVRHG CCEEEEEECCCEEECCCCCCCCCCCCCHHHHCCCCHHCCCCCCCCCCCCHHHHHHHHHCC RYGTFLGCEKYPECRGTISIHKKGEEIEQEEPIPCPAIGCNGKIFKKRSRYNKIFYSCSE CCCCEECCCCCCCCCCEEEEECCCCHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC YPECSVIGNSIDAVITKYSGTEKIPYKKKTPTKKKSSAKTTKAAKTPSKKGKAKSSVKKS CCCCEEECCCHHHHEEECCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHH SEKKTGPLFLPSPDLAKMIGNEPVSRGEATKKIWDYIKEHQLQAPENKKLLVPDNNLATI CCCCCCCEECCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEE IGPNPIDMFQLSKHLSQHLTKVSNDESSASS ECCCCHHHHHHHHHHHHHHHHHCCCCCCCCC >Mature Secondary Structure MKKSLIIVESPAKIKTLQKLLGSEFVFASSIGHIVDLPAKEFGIDVDHDFEPQYQVLPDK CCCCEEEEECCHHHHHHHHHHCCCEEHHHCCCHHEECCHHHHCCCCCCCCCCCCEECCCH QEVINHIRKLAAKCEKVYLSPDPDREGEAIAWHIANQLPDSPLIQRVSFNAITKNAVTEA HHHHHHHHHHHHHHHEEECCCCCCCCCCEEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHH LKHPRTIDMALVNAQQARRLLDRIVGYKISPILSRKLQQRSGISAGRVQSVALKLVVDRE HHCCCEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHEECHH KAIDAFVPVEYWNLRVLMQDPKTTKTFWAHLYAVQGKKWEKEIPEGKTENDVLLINSEEK HHHHHCCCEEEEEEEEEEECCCCHHHHHHHHHHHCCCCHHHHCCCCCCCCCEEEEECHHH ARHYAELLEKSSYTITRVEAKAKRRFAPPPFITSTLQQEASRHFRFSASRTMSIAQTLYE HHHHHHHHHCCCCEEEEEHHHHHHCCCCCCHHHHHHHHHHHHHEECCHHHHHHHHHHHHH GVDLDSEDSTGLITYMRTDSVRVDPEALTTVREYIQQTFGKEYLPEKANVYTTKKMTQDA CCCCCCCCCCCEEEEEECCCEEECHHHHHHHHHHHHHHHCHHHCCCCCCEEEHHHHHHHH HEAIRPTDINLTPDKLKNKLSDDQFKVYNLIWKRFVASQITPAIYDTLAVQITTDTEIDL HHCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHEEEEEEECCCCEEE RASGSLLKFKGFLAVYEEKQDDENDQEEDHPLPPLHAQDALIKEEVSQEQAFTKPLPRFT ECCCCEEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHH EASLVKELEKSGIGRPSTYATIMNKIQSREYTTKENQRLRPTELGKIISQFLETNFPRIM HHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEE DIGFTALMEDELELIADNKKPWKLLLQEFWTTFLPVVITAEKEAVIPRILTNIECSKCHK HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCEEEECCCHHHHHHHHCCCCHHHCCC GKLVKIWSKNSYFYGCSEYPECDYRTSEEELAFNKEDYAEDTPWDSPCPLCGGVMKVRHG CCEEEEEECCCEEECCCCCCCCCCCCCHHHHCCCCHHCCCCCCCCCCCCHHHHHHHHHCC RYGTFLGCEKYPECRGTISIHKKGEEIEQEEPIPCPAIGCNGKIFKKRSRYNKIFYSCSE CCCCEECCCCCCCCCCEEEEECCCCHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC YPECSVIGNSIDAVITKYSGTEKIPYKKKTPTKKKSSAKTTKAAKTPSKKGKAKSSVKKS CCCCEEECCCHHHHEEECCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHH SEKKTGPLFLPSPDLAKMIGNEPVSRGEATKKIWDYIKEHQLQAPENKKLLVPDNNLATI CCCCCCCEECCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEE IGPNPIDMFQLSKHLSQHLTKVSNDESSASS ECCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11058132 [H]