Click here to switch to the map view.

The map label for this gene is Not Available

Identifier: 15618518

GI number: 15618518

Start: 699013

End: 699645

Strand: Reverse

Name: Not Available

Synonym: CPn0608

Alternate gene names: 15618518

Gene position: 699645-699013 (Counterclockwise)

Preceding gene: 15618520

Following gene: 15618517

Centisome position: 56.87

GC content: 41.55

Gene sequence:

>633_bases
ATGATGAACTACGAAGATGCAAAATTACGCGGTCAAGCTGTAGCAATTCTATACCAAATCGGAGCTATAAAGTTCGGAAA
ACATATTCTCGCTAGCGGAGAAGAAACTCCTCTGTATGTAGATATGCGTCTTGTGATCTCCTCTCCAGAAGTTCTCCAGA
CAGTGGCAACTCTTATTTGGCGCCTCCGCCCCTCATTCAATAGTAGCTTACTCTGCGGAGTCCCTTATACTGCTCTAACC
CTAGCAACCTCGATCTCTTTAAAATATAACATCCCTATGGTATTGCGAAGGAAGGAATTACAGAATGTAGACCCCTCGGA
CGCTATTAAAGTAGAAGGGTTATTTACTCCAGGACAAACTTGTTTAGTCATCAATGATATGGTTTCCTCAGGAAAATCTA
TAATAGAGACAGCAGTCGCACTGGAAGAAAATGGTCTGGTAGTTCGTGAAGCATTGGTATTCTTAGATCGTAGAAAAGAA
GCGTGTCAACCACTTGGTCCACAGGGAATAAAAGTCAGTTCGGTATTTACTGTACCCACTCTGATAAAAGCTTTGATCGC
TTATGGGAAGCTAAGCAGTGGTGATCTAACCCTGGCAAACAAAATTTCCGAAATTCTAGAAATTGAATCTTAA

Upstream 100 bases:

>100_bases
CCTTTGGGAAGAGAAATTCCAAGAAACAGGCGTATTAGCATGTTTTCCCTTATAAGTGAGTTTTTTGTATTTTGTCAAAA
ACGGTCGGAGGCTCTGGAGA

Downstream 100 bases:

>100_bases
TTTCTAGAACATATTTATTAAAAAGAATTTAATTATTTAACAAAATTTATTTGTTTTGTTGTGTTGGCCTTTTTATTTGT
TTCTAATTTAAAATTAAATT

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MMNYEDAKLRGQAVAILYQIGAIKFGKHILASGEETPLYVDMRLVISSPEVLQTVATLIWRLRPSFNSSLLCGVPYTALT
LATSISLKYNIPMVLRRKELQNVDPSDAIKVEGLFTPGQTCLVINDMVSSGKSIIETAVALEENGLVVREALVFLDRRKE
ACQPLGPQGIKVSSVFTVPTLIKALIAYGKLSSGDLTLANKISEILEIES

Sequences:

>Translated_210_residues
MMNYEDAKLRGQAVAILYQIGAIKFGKHILASGEETPLYVDMRLVISSPEVLQTVATLIWRLRPSFNSSLLCGVPYTALT
LATSISLKYNIPMVLRRKELQNVDPSDAIKVEGLFTPGQTCLVINDMVSSGKSIIETAVALEENGLVVREALVFLDRRKE
ACQPLGPQGIKVSSVFTVPTLIKALIAYGKLSSGDLTLANKISEILEIES
>Mature_210_residues
MMNYEDAKLRGQAVAILYQIGAIKFGKHILASGEETPLYVDMRLVISSPEVLQTVATLIWRLRPSFNSSLLCGVPYTALT
LATSISLKYNIPMVLRRKELQNVDPSDAIKVEGLFTPGQTCLVINDMVSSGKSIIETAVALEENGLVVREALVFLDRRKE
ACQPLGPQGIKVSSVFTVPTLIKALIAYGKLSSGDLTLANKISEILEIES

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily

Homologues:

Organism=Homo sapiens, GI4507835, Length=177, Percent_Identity=41.2429378531073, Blast_Score=134, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17508631, Length=178, Percent_Identity=35.3932584269663, Blast_Score=113, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17554964, Length=172, Percent_Identity=27.906976744186, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17933654, Length=212, Percent_Identity=34.4339622641509, Blast_Score=120, Evalue=5e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRE_CHLPN (Q9Z7U6)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   B72058
- PIR:   E86566
- RefSeq:   NP_224804.1
- RefSeq:   NP_300664.1
- RefSeq:   NP_444691.1
- RefSeq:   NP_876904.1
- ProteinModelPortal:   Q9Z7U6
- SMR:   Q9Z7U6
- PHCI-2DPAGE:   Q9Z7U6
- GeneID:   1467311
- GeneID:   895475
- GeneID:   919370
- GeneID:   962980
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0139
- KEGG:   cpj:CPj0608
- KEGG:   cpn:CPn0608
- KEGG:   cpt:CpB0632
- TIGR:   CP_0139
- HOGENOM:   HBG402662
- OMA:   GVIERTK
- ProtClustDB:   PRK13809
- BioCyc:   CPNE115711:CP_0139-MONOMER
- BioCyc:   CPNE115713:CPN0608-MONOMER
- BioCyc:   CPNE138677:CPJ0608-MONOMER
- BioCyc:   CPNE182082:CPB0632-MONOMER
- BRENDA:   2.4.2.10
- HAMAP:   MF_01208
- InterPro:   IPR000836

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.10

Molecular weight: Translated: 22895; Mature: 22895

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: BINDING 97-97 BINDING 98-98 BINDING 129-129 BINDING 157-157

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMNYEDAKLRGQAVAILYQIGAIKFGKHILASGEETPLYVDMRLVISSPEVLQTVATLIW
CCCCCCHHHCCHHEEEEHHHHHHHHCCHHHCCCCCCCEEEEEEEEECCHHHHHHHHHHHH
RLRPSFNSSLLCGVPYTALTLATSISLKYNIPMVLRRKELQNVDPSDAIKVEGLFTPGQT
HHCCCCCCCEEECCCHHHHHHHHHEEEEECCHHEEEHHHHCCCCCCCCEEEEEEECCCCE
CLVINDMVSSGKSIIETAVALEENGLVVREALVFLDRRKEACQPLGPQGIKVSSVFTVPT
EEEEEHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEHEECHHH
LIKALIAYGKLSSGDLTLANKISEILEIES
HHHHHHHHCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MMNYEDAKLRGQAVAILYQIGAIKFGKHILASGEETPLYVDMRLVISSPEVLQTVATLIW
CCCCCCHHHCCHHEEEEHHHHHHHHCCHHHCCCCCCCEEEEEEEEECCHHHHHHHHHHHH
RLRPSFNSSLLCGVPYTALTLATSISLKYNIPMVLRRKELQNVDPSDAIKVEGLFTPGQT
HHCCCCCCCEEECCCHHHHHHHHHEEEEECCHHEEEHHHHCCCCCCCCEEEEEEECCCCE
CLVINDMVSSGKSIIETAVALEENGLVVREALVFLDRRKEACQPLGPQGIKVSSVFTVPT
EEEEEHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEHEECHHH
LIKALIAYGKLSSGDLTLANKISEILEIES
HHHHHHHHCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362