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The map label for this gene is obgE

Identifier: 15607036

GI number: 15607036

Start: 1456740

End: 1457771

Strand: Direct

Name: obgE

Synonym: aq_2069

Alternate gene names: 15607036

Gene position: 1456740-1457771 (Clockwise)

Preceding gene: 15607035

Following gene: 15607037

Centisome position: 93.9

GC content: 47.97

Gene sequence:

>1032_bases
ATGGAGAAGTTCGTAGACAGAGTAAAAATCTTCGTGAAAGGGGGAAAGGGCGGAGACGGAGCAGTAGCCTTTTTGAGGGA
AAAGTACAGACCGAAAGGAGGACCTGCGGGAGGAGACGGAGGAAAGGGTGGAGACGTTATCTTAGTTGCTACGAGTTCAA
AGCACACACTCCTTGACTTTAAGTATAAAAAGCATTACATAGCCCAAAACGGAGAACCCGGAAAGGGCAAGAAAATGCAT
GGAAAGGACGGAGAGGACCTCATAATCTACGTTCCCGTGGGAACTGTCGTGAAGGACGCACAAACAGGGGAAGTTATTTG
CGACCTAGTAAAGGAAGGACAGAAGTGTATCGTTGCTAAAGGCGGAAAAGGCGGAAGGGGAAACGCAAGGTTTGCAACTC
CTACAAATCAAGCACCTACCTACGCGGAAAAGGGTCAGAAGGGCGAGGAGAGGTGGATAATCCTTGAACTGAAGCTCATA
GCGGACGTGGGACTCGTCGGTTTTCCAAACGCAGGAAAGTCTACGCTCCTTTCAAGGCTCACGAGAGCAAAACCAAAAAT
TGCGGACTACCCTTTCACAACCTTGAGTCCGAACTTAGGAGTGATGGAACTCGATTGGGAAAGGAGACTCGTTATAGCGG
ACATTCCGGGACTGATAGAGGACGCCCACAAGGGGGCAGGACTGGGACACGAGTTCTTAAGACACATAGAGAGAACCAAG
TTCTTAGCCCACGTGATAGACGTATCTGACTTCAGGGAAAGAGAACCGGTGCAAGCTTTTGAAGCCATAAACAGAGAACT
GGAACTATACAGTCCGAAACTCGCCCAAAAACCACAAATCGTCGTGGCCAACAAAATAGACGCTTTGAGTGACAGGAGTT
TGCTTTCAGAGCTTGAAAAGTACTTCAAGGAAAAAGGTTACGAATTTTACGCGGTTTCCGCACTCACAGGAGAGGGAATA
GAAGAATTAAAGGAGGGTCTCTGGAAGAAGTACGAGGAAATAAGAGACAAAGAATCCGCGCAAGTAACCTGA

Upstream 100 bases:

>100_bases
TCACATAATAGACGGGAGGGTGAAGCACTCTATACTCCTTGAGGTTTTCACAAAGGAGGGGGTGGGAACTGAGATTACTC
TGGAATAAATTAAAAAATTT

Downstream 100 bases:

>100_bases
ACCTTTTGATGTAGTTTATATAAATATGCTTCAAGTAAGAGTAAAACCCGGAGTAGAAGACAGGATTAGAGGATTTTTCC
CTTGGGTTTACAGGTCGGAA

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MEKFVDRVKIFVKGGKGGDGAVAFLREKYRPKGGPAGGDGGKGGDVILVATSSKHTLLDFKYKKHYIAQNGEPGKGKKMH
GKDGEDLIIYVPVGTVVKDAQTGEVICDLVKEGQKCIVAKGGKGGRGNARFATPTNQAPTYAEKGQKGEERWIILELKLI
ADVGLVGFPNAGKSTLLSRLTRAKPKIADYPFTTLSPNLGVMELDWERRLVIADIPGLIEDAHKGAGLGHEFLRHIERTK
FLAHVIDVSDFREREPVQAFEAINRELELYSPKLAQKPQIVVANKIDALSDRSLLSELEKYFKEKGYEFYAVSALTGEGI
EELKEGLWKKYEEIRDKESAQVT

Sequences:

>Translated_343_residues
MEKFVDRVKIFVKGGKGGDGAVAFLREKYRPKGGPAGGDGGKGGDVILVATSSKHTLLDFKYKKHYIAQNGEPGKGKKMH
GKDGEDLIIYVPVGTVVKDAQTGEVICDLVKEGQKCIVAKGGKGGRGNARFATPTNQAPTYAEKGQKGEERWIILELKLI
ADVGLVGFPNAGKSTLLSRLTRAKPKIADYPFTTLSPNLGVMELDWERRLVIADIPGLIEDAHKGAGLGHEFLRHIERTK
FLAHVIDVSDFREREPVQAFEAINRELELYSPKLAQKPQIVVANKIDALSDRSLLSELEKYFKEKGYEFYAVSALTGEGI
EELKEGLWKKYEEIRDKESAQVT
>Mature_343_residues
MEKFVDRVKIFVKGGKGGDGAVAFLREKYRPKGGPAGGDGGKGGDVILVATSSKHTLLDFKYKKHYIAQNGEPGKGKKMH
GKDGEDLIIYVPVGTVVKDAQTGEVICDLVKEGQKCIVAKGGKGGRGNARFATPTNQAPTYAEKGQKGEERWIILELKLI
ADVGLVGFPNAGKSTLLSRLTRAKPKIADYPFTTLSPNLGVMELDWERRLVIADIPGLIEDAHKGAGLGHEFLRHIERTK
FLAHVIDVSDFREREPVQAFEAINRELELYSPKLAQKPQIVVANKIDALSDRSLLSELEKYFKEKGYEFYAVSALTGEGI
EELKEGLWKKYEEIRDKESAQVT

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain

Homologues:

Organism=Homo sapiens, GI24308117, Length=338, Percent_Identity=42.8994082840237, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI111955139, Length=365, Percent_Identity=40.5479452054795, Blast_Score=208, Evalue=7e-54,
Organism=Homo sapiens, GI111955063, Length=257, Percent_Identity=39.2996108949416, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI58761500, Length=130, Percent_Identity=31.5384615384615, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI55953087, Length=170, Percent_Identity=32.3529411764706, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1789574, Length=324, Percent_Identity=49.3827160493827, Blast_Score=262, Evalue=3e-71,
Organism=Escherichia coli, GI1790615, Length=172, Percent_Identity=31.9767441860465, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1787454, Length=130, Percent_Identity=36.1538461538462, Blast_Score=75, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17508313, Length=335, Percent_Identity=41.7910447761194, Blast_Score=178, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI17552324, Length=325, Percent_Identity=33.5384615384615, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17509631, Length=128, Percent_Identity=33.59375, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6321962, Length=193, Percent_Identity=37.3056994818653, Blast_Score=127, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6319281, Length=126, Percent_Identity=34.1269841269841, Blast_Score=66, Evalue=7e-12,
Organism=Drosophila melanogaster, GI20129375, Length=337, Percent_Identity=41.2462908011869, Blast_Score=214, Evalue=7e-56,
Organism=Drosophila melanogaster, GI24585318, Length=344, Percent_Identity=37.7906976744186, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI21356473, Length=160, Percent_Identity=32.5, Blast_Score=68, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24640873, Length=130, Percent_Identity=33.0769230769231, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24640877, Length=130, Percent_Identity=33.0769230769231, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24640875, Length=130, Percent_Identity=33.0769230769231, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OBG_AQUAE (O67849)

Other databases:

- EMBL:   AE000657
- PIR:   E70477
- RefSeq:   NP_214418.1
- HSSP:   P44681
- ProteinModelPortal:   O67849
- SMR:   O67849
- GeneID:   1193838
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_2069
- NMPDR:   fig|224324.1.peg.1433
- HOGENOM:   HBG716038
- OMA:   LIDYRFN
- PhylomeDB:   O67849
- ProtClustDB:   PRK12299
- BioCyc:   AAEO224324:AQ_2069-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01454
- InterPro:   IPR014100
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:2.70.210.12
- PANTHER:   PTHR11702:SF3
- PIRSF:   PIRSF002401
- PRINTS:   PR00326
- TIGRFAMs:   TIGR02729
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF01018 GTP1_OBG; PF01926 MMR_HSR1; SSF82051 GTP1_OBG_sub

EC number: NA

Molecular weight: Translated: 37797; Mature: 37797

Theoretical pI: Translated: 9.26; Mature: 9.26

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKFVDRVKIFVKGGKGGDGAVAFLREKYRPKGGPAGGDGGKGGDVILVATSSKHTLLDF
CHHHHEEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEE
KYKKHYIAQNGEPGKGKKMHGKDGEDLIIYVPVGTVVKDAQTGEVICDLVKEGQKCIVAK
HHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCHHHCCCCCHHHHHHHHHCCCEEEEEE
GGKGGRGNARFATPTNQAPTYAEKGQKGEERWIILELKLIADVGLVGFPNAGKSTLLSRL
CCCCCCCCCEECCCCCCCCCHHHCCCCCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHH
TRAKPKIADYPFTTLSPNLGVMELDWERRLVIADIPGLIEDAHKGAGLGHEFLRHIERTK
HHCCCCCCCCCCCCCCCCCCEEEECCCCEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHH
FLAHVIDVSDFREREPVQAFEAINRELELYSPKLAQKPQIVVANKIDALSDRSLLSELEK
HHHHHHHHHHHHCCCHHHHHHHHCCHHHHCCCCCCCCCCEEEECCCCHHHHHHHHHHHHH
YFKEKGYEFYAVSALTGEGIEELKEGLWKKYEEIRDKESAQVT
HHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MEKFVDRVKIFVKGGKGGDGAVAFLREKYRPKGGPAGGDGGKGGDVILVATSSKHTLLDF
CHHHHEEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEE
KYKKHYIAQNGEPGKGKKMHGKDGEDLIIYVPVGTVVKDAQTGEVICDLVKEGQKCIVAK
HHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCHHHCCCCCHHHHHHHHHCCCEEEEEE
GGKGGRGNARFATPTNQAPTYAEKGQKGEERWIILELKLIADVGLVGFPNAGKSTLLSRL
CCCCCCCCCEECCCCCCCCCHHHCCCCCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHH
TRAKPKIADYPFTTLSPNLGVMELDWERRLVIADIPGLIEDAHKGAGLGHEFLRHIERTK
HHCCCCCCCCCCCCCCCCCCEEEECCCCEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHH
FLAHVIDVSDFREREPVQAFEAINRELELYSPKLAQKPQIVVANKIDALSDRSLLSELEK
HHHHHHHHHHHHCCCHHHHHHHHCCHHHHCCCCCCCCCCEEEECCCCHHHHHHHHHHHHH
YFKEKGYEFYAVSALTGEGIEELKEGLWKKYEEIRDKESAQVT
HHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320