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The map label for this gene is umpS

Identifier: 15606929

GI number: 15606929

Start: 1342372

End: 1342923

Strand: Direct

Name: umpS

Synonym: aq_1907

Alternate gene names: 15606929

Gene position: 1342372-1342923 (Clockwise)

Preceding gene: 15606928

Following gene: 15606931

Centisome position: 86.53

GC content: 47.28

Gene sequence:

>552_bases
TTGCTTATGCTCGAAAGGGAAAAGCTCGCACGCCTCATAAAAAAACGCTCCCTGAAAGTAGCGGATGAACCCGTGTTTAA
ACTCTCCTCGGGAAAACTCAGCAGGTACTACGTGGATTTAAAACAGATAACCTTTGATCCCGAAGGGGATTACTTAATCG
GAAAAGCTATGTACGAACTCGTCAAAGAATTCAACCCTGACGCCTGCGGTGGACTCACTCTCGGTGCAGACCCCATAGCC
TACGCAATTGCCTTCGTTTCCCTTATGGACTCAAACCCTATAAAACCTTTCGTGGTAAGAAAAGAACCCAAAGGTCACGG
TATGAAGAGGCAGATAGAGGGTCTTTTAAATCCGGGAGAAAGGGTTGCCGTTCTGGAAGACGTGGTAACCACGGGCTCTT
CAGCTCTAAAAGCTGTAAAGGCATGTAGAGAATACGGCCTTGAGGTTATAGGCGTTTTTGCGGTGGTTGACAGGGAAGAG
GGAGGCAGGGAAAACATAGAAAAGGAGGGAATACCCCTTTACTCCCTCTTTAAACTCTCGGAACTCCTTTAG

Upstream 100 bases:

>100_bases
AGACGAACCAGCTTCGGAGGAAGTTCTCAGCAGAATAAAAGAAATACCCGAAATACTCTTCGTCAAACACATCGTCCTTT
GAGCTTCCTCCCTTATAATT

Downstream 100 bases:

>100_bases
ATGTAGACCTCTTCCCTCTTTGCGACTTCCACTATTTTGTCGAGGAGTTTTCCAAGTCCCCAGCGTTTTTCTGCGGAAAT
CAGTACCGCATCCCCTTCAA

Product: uridine 5-monophosphate synthase

Products: NA

Alternate protein names: OPRT; OPRTase

Number of amino acids: Translated: 183; Mature: 183

Protein sequence:

>183_residues
MLMLEREKLARLIKKRSLKVADEPVFKLSSGKLSRYYVDLKQITFDPEGDYLIGKAMYELVKEFNPDACGGLTLGADPIA
YAIAFVSLMDSNPIKPFVVRKEPKGHGMKRQIEGLLNPGERVAVLEDVVTTGSSALKAVKACREYGLEVIGVFAVVDREE
GGRENIEKEGIPLYSLFKLSELL

Sequences:

>Translated_183_residues
MLMLEREKLARLIKKRSLKVADEPVFKLSSGKLSRYYVDLKQITFDPEGDYLIGKAMYELVKEFNPDACGGLTLGADPIA
YAIAFVSLMDSNPIKPFVVRKEPKGHGMKRQIEGLLNPGERVAVLEDVVTTGSSALKAVKACREYGLEVIGVFAVVDREE
GGRENIEKEGIPLYSLFKLSELL
>Mature_183_residues
MLMLEREKLARLIKKRSLKVADEPVFKLSSGKLSRYYVDLKQITFDPEGDYLIGKAMYELVKEFNPDACGGLTLGADPIA
YAIAFVSLMDSNPIKPFVVRKEPKGHGMKRQIEGLLNPGERVAVLEDVVTTGSSALKAVKACREYGLEVIGVFAVVDREE
GGRENIEKEGIPLYSLFKLSELL

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily

Homologues:

Organism=Homo sapiens, GI4507835, Length=160, Percent_Identity=35, Blast_Score=97, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17554964, Length=182, Percent_Identity=35.1648351648352, Blast_Score=98, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17508631, Length=160, Percent_Identity=32.5, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17933654, Length=175, Percent_Identity=35.4285714285714, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRE_AQUAE (O67742)

Other databases:

- EMBL:   AE000657
- PIR:   B70464
- RefSeq:   NP_214310.1
- ProteinModelPortal:   O67742
- SMR:   O67742
- GeneID:   1193547
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_1907
- NMPDR:   fig|224324.1.peg.1325
- HOGENOM:   HBG404341
- OMA:   GKEADYY
- ProtClustDB:   CLSK2299868
- BioCyc:   AAEO224324:AQ_1907-MONOMER
- BRENDA:   2.4.2.10
- HAMAP:   MF_01208
- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836
- TIGRFAMs:   TIGR00336

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.10

Molecular weight: Translated: 20310; Mature: 20310

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: BINDING 100-100 BINDING 101-101 BINDING 104-104 BINDING 106-106 BINDING 130-130 BINDING 158-158

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLMLEREKLARLIKKRSLKVADEPVFKLSSGKLSRYYVDLKQITFDPEGDYLIGKAMYEL
CCEECHHHHHHHHHHHCCCCCCCCCEEECCCCCCCEEEEHHHEEECCCCCEEHHHHHHHH
VKEFNPDACGGLTLGADPIAYAIAFVSLMDSNPIKPFVVRKEPKGHGMKRQIEGLLNPGE
HHHCCCCCCCCCEECCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHCCCCC
RVAVLEDVVTTGSSALKAVKACREYGLEVIGVFAVVDREEGGRENIEKEGIPLYSLFKLS
HHHHHHHHHHCCHHHHHHHHHHHHCCHHHEEHHHEEECCCCCCCCHHHCCCCHHHHHHHH
ELL
HCC
>Mature Secondary Structure
MLMLEREKLARLIKKRSLKVADEPVFKLSSGKLSRYYVDLKQITFDPEGDYLIGKAMYEL
CCEECHHHHHHHHHHHCCCCCCCCCEEECCCCCCCEEEEHHHEEECCCCCEEHHHHHHHH
VKEFNPDACGGLTLGADPIAYAIAFVSLMDSNPIKPFVVRKEPKGHGMKRQIEGLLNPGE
HHHCCCCCCCCCEECCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHCCCCC
RVAVLEDVVTTGSSALKAVKACREYGLEVIGVFAVVDREEGGRENIEKEGIPLYSLFKLS
HHHHHHHHHHCCHHHHHHHHHHHHCCHHHEEHHHEEECCCCCCCCHHHCCCCHHHHHHHH
ELL
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320