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The map label for this gene is serA [H]

Identifier: 15606928

GI number: 15606928

Start: 1340752

End: 1342353

Strand: Direct

Name: serA [H]

Synonym: aq_1905

Alternate gene names: 15606928

Gene position: 1340752-1342353 (Clockwise)

Preceding gene: 15606927

Following gene: 15606929

Centisome position: 86.43

GC content: 47.32

Gene sequence:

>1602_bases
TTGTACAAGGTACTGATTACTGACCCGATAGCTCCCGAAGGGATTGAACTGCTTCAAAAGGACCCGGAAGTTGAAGTTTA
CAACGAGCCAGACATTTCCTACGAGGAACTCCTTGAGATTATAAAGGACTTTGACGCAATAATTACGAGGAGCAGAACGC
CCGTAACCAAGGAGCTTCTGGAAAGGGCGGAAAAATTGAAAGTCGTCGGAAGGGCGGGCGTAGGTGTTGACAACGTAGAC
ATAGAGGAGGCGACAAAGAGGGGAATACTCGTCGTAAACACGCCCGGGGCAAACACGATAGGTGCAACGGAACTCACGAT
GATGCACATGCTCACGATAATGAGGAACGGACACAAGGCCCACGAGAGTATGCTCAACTACAAGTGGGACAGAAAGAAGT
TCATGGGAGAAGAACTCTACGGAAGAATCCTTGGGATTATAGGGCTCGGAAACATAGGCTCTCAGGTTGCGATAAGGGCA
AAGGCCTTCGGTATGAAGGTGATGGCCTACGACCCTTACATTCCCAGAGAAAAAGCGGAAAAACTGGGAGTAAAACTCGT
GGACAACCTCCACGACATGTTAAGGGAAATAGACGTCCTCACCATTCACGCACCACTCACCCACGAAACAAAGAACATGA
TAGACGAGAAAGAGTTTGAAATAATGAAGGACGGCGTTTACATAGTCAACTGCGCGAGAGGAGGGATAATAAACGAGAAG
GCTCTCATAAAGTACATGGAGAGCGGAAAGATAAAGGGAGTGGCTCTGGACGTTTACTCAAAGGAACCCCCACCTCCCGA
ATTTATAGACGAACTCAAGAGATTAGCGGACAAGGTTAACATATCCCTCAGTCCCCACATAGGTGCGAACACTTACGAGT
CCCAGAGGAACGTTGCGGTAATCGTAGCACAGCAGGTTTTAAAGGCTTTAAAAGGTCAAACCGTGGAGTATGCAGTAAAC
GCACCCTTCCCCGACCTTTCGGTTCTCACACTCATAAAGCCCTACCTAGACCTTGCGGAAAAACTCGGGAAGTTCCTCGT
TCAGTGGACGGAAGAGGGAATAAGGGAAGTTCACATAGAGGTAAGGGGAGACATAGCGGAATACTTCCAGCCCATATCCT
CCGCGGTTTTAAAGGGCATACTGGAAGAAGTCGTGGACTTTCCCGTAAACATCATTAACGCCTTCTACGTTGCCAAGGAC
AGGGGAATAAAAGTTGAAGAACTCTCCTCTGAAGAAACTCCCGACTTCAAGCACTACATAAAAGTAGTGGTAAAGGCTGA
CGGAAAAGAAAAGGTTGTAGCGGGAACCGTCCTGGAGGGGCAAATCCCAAGGATAACCGAGATTGACAGATACAAGGTAG
ACATAGAACCCGAAGGAATACTTCTCGTTTTTGAAAATAAAGACGTTCCGGGAGTTATAGGAAAGATAGGCTCAATACTC
GGAGAGGCTAACATAAACATAGCGGGCTTCAGACTCGGCAGGGAAAAGAAAGGCGGTATAGCCATAGGAATTCTCAACTT
AGACGAACCAGCTTCGGAGGAAGTTCTCAGCAGAATAAAAGAAATACCCGAAATACTCTTCGTCAAACACATCGTCCTTT
GA

Upstream 100 bases:

>100_bases
ACCCGTGAGGAGGATAAAGGAGGCAGAAGCCAACAGGAACTTAATCTTGAAGTTTAAAGATATAAAGGAATAGAATTTAA
ATTTCTCGGAGGTAAAGACC

Downstream 100 bases:

>100_bases
GCTTCCTCCCTTATAATTTTGCTTATGCTCGAAAGGGAAAAGCTCGCACGCCTCATAAAAAAACGCTCCCTGAAAGTAGC
GGATGAACCCGTGTTTAAAC

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 533; Mature: 533

Protein sequence:

>533_residues
MYKVLITDPIAPEGIELLQKDPEVEVYNEPDISYEELLEIIKDFDAIITRSRTPVTKELLERAEKLKVVGRAGVGVDNVD
IEEATKRGILVVNTPGANTIGATELTMMHMLTIMRNGHKAHESMLNYKWDRKKFMGEELYGRILGIIGLGNIGSQVAIRA
KAFGMKVMAYDPYIPREKAEKLGVKLVDNLHDMLREIDVLTIHAPLTHETKNMIDEKEFEIMKDGVYIVNCARGGIINEK
ALIKYMESGKIKGVALDVYSKEPPPPEFIDELKRLADKVNISLSPHIGANTYESQRNVAVIVAQQVLKALKGQTVEYAVN
APFPDLSVLTLIKPYLDLAEKLGKFLVQWTEEGIREVHIEVRGDIAEYFQPISSAVLKGILEEVVDFPVNIINAFYVAKD
RGIKVEELSSEETPDFKHYIKVVVKADGKEKVVAGTVLEGQIPRITEIDRYKVDIEPEGILLVFENKDVPGVIGKIGSIL
GEANINIAGFRLGREKKGGIAIGILNLDEPASEEVLSRIKEIPEILFVKHIVL

Sequences:

>Translated_533_residues
MYKVLITDPIAPEGIELLQKDPEVEVYNEPDISYEELLEIIKDFDAIITRSRTPVTKELLERAEKLKVVGRAGVGVDNVD
IEEATKRGILVVNTPGANTIGATELTMMHMLTIMRNGHKAHESMLNYKWDRKKFMGEELYGRILGIIGLGNIGSQVAIRA
KAFGMKVMAYDPYIPREKAEKLGVKLVDNLHDMLREIDVLTIHAPLTHETKNMIDEKEFEIMKDGVYIVNCARGGIINEK
ALIKYMESGKIKGVALDVYSKEPPPPEFIDELKRLADKVNISLSPHIGANTYESQRNVAVIVAQQVLKALKGQTVEYAVN
APFPDLSVLTLIKPYLDLAEKLGKFLVQWTEEGIREVHIEVRGDIAEYFQPISSAVLKGILEEVVDFPVNIINAFYVAKD
RGIKVEELSSEETPDFKHYIKVVVKADGKEKVVAGTVLEGQIPRITEIDRYKVDIEPEGILLVFENKDVPGVIGKIGSIL
GEANINIAGFRLGREKKGGIAIGILNLDEPASEEVLSRIKEIPEILFVKHIVL
>Mature_533_residues
MYKVLITDPIAPEGIELLQKDPEVEVYNEPDISYEELLEIIKDFDAIITRSRTPVTKELLERAEKLKVVGRAGVGVDNVD
IEEATKRGILVVNTPGANTIGATELTMMHMLTIMRNGHKAHESMLNYKWDRKKFMGEELYGRILGIIGLGNIGSQVAIRA
KAFGMKVMAYDPYIPREKAEKLGVKLVDNLHDMLREIDVLTIHAPLTHETKNMIDEKEFEIMKDGVYIVNCARGGIINEK
ALIKYMESGKIKGVALDVYSKEPPPPEFIDELKRLADKVNISLSPHIGANTYESQRNVAVIVAQQVLKALKGQTVEYAVN
APFPDLSVLTLIKPYLDLAEKLGKFLVQWTEEGIREVHIEVRGDIAEYFQPISSAVLKGILEEVVDFPVNIINAFYVAKD
RGIKVEELSSEETPDFKHYIKVVVKADGKEKVVAGTVLEGQIPRITEIDRYKVDIEPEGILLVFENKDVPGVIGKIGSIL
GEANINIAGFRLGREKKGGIAIGILNLDEPASEEVLSRIKEIPEILFVKHIVL

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=421, Percent_Identity=38.479809976247, Blast_Score=296, Evalue=3e-80,
Organism=Homo sapiens, GI61743967, Length=268, Percent_Identity=34.3283582089552, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI4557497, Length=268, Percent_Identity=34.3283582089552, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI145580578, Length=274, Percent_Identity=32.8467153284672, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI4557499, Length=274, Percent_Identity=32.8467153284672, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI145580575, Length=274, Percent_Identity=32.8467153284672, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI6912396, Length=322, Percent_Identity=31.055900621118, Blast_Score=129, Evalue=5e-30,
Organism=Escherichia coli, GI1789279, Length=330, Percent_Identity=33.030303030303, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI1787645, Length=270, Percent_Identity=31.8518518518519, Blast_Score=138, Evalue=9e-34,
Organism=Escherichia coli, GI87082289, Length=279, Percent_Identity=29.0322580645161, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1788660, Length=300, Percent_Identity=29.6666666666667, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI87081824, Length=151, Percent_Identity=31.7880794701987, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=311, Percent_Identity=42.7652733118971, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI25147481, Length=277, Percent_Identity=30.3249097472924, Blast_Score=142, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6320925, Length=339, Percent_Identity=33.9233038348083, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6322116, Length=339, Percent_Identity=33.0383480825959, Blast_Score=177, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6324964, Length=313, Percent_Identity=30.6709265175719, Blast_Score=138, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6324055, Length=244, Percent_Identity=29.0983606557377, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6324980, Length=176, Percent_Identity=30.6818181818182, Blast_Score=87, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6321253, Length=209, Percent_Identity=25.3588516746411, Blast_Score=74, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6325144, Length=171, Percent_Identity=32.1637426900585, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI19921140, Length=316, Percent_Identity=41.7721518987342, Blast_Score=241, Evalue=8e-64,
Organism=Drosophila melanogaster, GI28574286, Length=321, Percent_Identity=33.3333333333333, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI62472511, Length=270, Percent_Identity=32.962962962963, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI24646446, Length=270, Percent_Identity=33.7037037037037, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI24646448, Length=270, Percent_Identity=33.7037037037037, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI24646452, Length=270, Percent_Identity=33.7037037037037, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI24646450, Length=270, Percent_Identity=33.7037037037037, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI28571528, Length=318, Percent_Identity=33.3333333333333, Blast_Score=145, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24585514, Length=319, Percent_Identity=30.0940438871473, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI28574282, Length=319, Percent_Identity=30.0940438871473, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI28574284, Length=319, Percent_Identity=30.0940438871473, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI45552429, Length=319, Percent_Identity=30.0940438871473, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI45551003, Length=319, Percent_Identity=30.0940438871473, Blast_Score=142, Evalue=7e-34,
Organism=Drosophila melanogaster, GI24585516, Length=318, Percent_Identity=28.6163522012579, Blast_Score=134, Evalue=2e-31,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 59449; Mature: 59449

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKVLITDPIAPEGIELLQKDPEVEVYNEPDISYEELLEIIKDFDAIITRSRTPVTKELL
CEEEEEECCCCCCHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
ERAEKLKVVGRAGVGVDNVDIEEATKRGILVVNTPGANTIGATELTMMHMLTIMRNGHKA
HHHHHHHHHHCCCCCCCCCCHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCHH
HESMLNYKWDRKKFMGEELYGRILGIIGLGNIGSQVAIRAKAFGMKVMAYDPYIPREKAE
HHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHEEEEHHHCEEEEEECCCCCHHHHH
KLGVKLVDNLHDMLREIDVLTIHAPLTHETKNMIDEKEFEIMKDGVYIVNCARGGIINEK
HHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHCCHHHHHHHHCCEEEEEECCCCCCCHH
ALIKYMESGKIKGVALDVYSKEPPPPEFIDELKRLADKVNISLSPHIGANTYESQRNVAV
HHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCEEE
IVAQQVLKALKGQTVEYAVNAPFPDLSVLTLIKPYLDLAEKLGKFLVQWTEEGIREVHIE
HHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEE
VRGDIAEYFQPISSAVLKGILEEVVDFPVNIINAFYVAKDRGIKVEELSSEETPDFKHYI
EECCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHEECCCCCCHHHCCCCCCCCHHHHE
KVVVKADGKEKVVAGTVLEGQIPRITEIDRYKVDIEPEGILLVFENKDVPGVIGKIGSIL
EEEEECCCCCEEEEEEEECCCCCCCCCCCCEEEEECCCCEEEEECCCCCCHHHHHHHHHH
GEANINIAGFRLGREKKGGIAIGILNLDEPASEEVLSRIKEIPEILFVKHIVL
CCCCCEEEEEEECCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MYKVLITDPIAPEGIELLQKDPEVEVYNEPDISYEELLEIIKDFDAIITRSRTPVTKELL
CEEEEEECCCCCCHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
ERAEKLKVVGRAGVGVDNVDIEEATKRGILVVNTPGANTIGATELTMMHMLTIMRNGHKA
HHHHHHHHHHCCCCCCCCCCHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCHH
HESMLNYKWDRKKFMGEELYGRILGIIGLGNIGSQVAIRAKAFGMKVMAYDPYIPREKAE
HHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHEEEEHHHCEEEEEECCCCCHHHHH
KLGVKLVDNLHDMLREIDVLTIHAPLTHETKNMIDEKEFEIMKDGVYIVNCARGGIINEK
HHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHCCHHHHHHHHCCEEEEEECCCCCCCHH
ALIKYMESGKIKGVALDVYSKEPPPPEFIDELKRLADKVNISLSPHIGANTYESQRNVAV
HHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCEEE
IVAQQVLKALKGQTVEYAVNAPFPDLSVLTLIKPYLDLAEKLGKFLVQWTEEGIREVHIE
HHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEE
VRGDIAEYFQPISSAVLKGILEEVVDFPVNIINAFYVAKDRGIKVEELSSEETPDFKHYI
EECCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHEECCCCCCHHHCCCCCCCCHHHHE
KVVVKADGKEKVVAGTVLEGQIPRITEIDRYKVDIEPEGILLVFENKDVPGVIGKIGSIL
EEEEECCCCCEEEEEEEECCCCCCCCCCCCEEEEECCCCEEEEECCCCCCHHHHHHHHHH
GEANINIAGFRLGREKKGGIAIGILNLDEPASEEVLSRIKEIPEILFVKHIVL
CCCCCEEEEEEECCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]