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The map label for this gene is thrA [H]

Identifier: 15606863

GI number: 15606863

Start: 1277001

End: 1278308

Strand: Direct

Name: thrA [H]

Synonym: aq_1812

Alternate gene names: 15606863

Gene position: 1277001-1278308 (Clockwise)

Preceding gene: 15606851

Following gene: 15606864

Centisome position: 82.32

GC content: 46.94

Gene sequence:

>1308_bases
ATGGGCTTTGTAAGGGTCGGAATAATCGGTTGCGGTACGGTTGGAACGGGAACCGCCAAACTCCTCATACAGAATGCAGA
CCTAATAAAGAAGAAAACGGGTATAGAGTTCAAACTCGTGAAAGTTGCGGACATAGACTGGGAGAGAAAGAGGGAGTTTG
AAGTTCCGAAAGAACTGAGAACCACAGATTATAAAGAAGTTATAGATAATTCGGACGTGGTCGTTGAACTCGTAGGCGGT
AAAACTTTCGCTAAGAAGGTAATACTGGAAGCTCTGGAAGCGGGAAAGTGCGTTGTTACAGCAAATAAACACCTCCTCGC
AGAGGAAGGGAAGGAGATTTTTGAAGAGGCCAAGAAGAGAAACTTATTTATAGGTTTTGAAGCCTCGGTGGGAGGAGGGA
TTCCCGTGATAAAAGCGTTAAGGGAAGGACTTGCGGGGAATAAAATTCTCAACATCCTCGGTATCCTCAACGGAACGACA
AATTACATACTCACGAGGATGTTTGAGGAAAATCTTGACTTTGAAACGGCTTTAAAGGAAGCAAAAGAAAAAGGGTATGC
GGAGGCAGATCCAAGTCTTGACATAGACGGGTGGGATGCGGCTCACAAGATTGCTATTCTCGCCATGCTCGCCTACGGTG
GGTATCTAGACTTTAACGACGTTTACGTAGAGGGTATAAGGAACGTTGATAAGCTCGACGTAGAACTGGGAAAGGAACTG
GGATACACACTGAAACTCCTCGCAATCGCGAAAAAAGTTGACTCGGAGGTTGAGGTGAGGGTTCATCCCACCTTTATACA
CTCCGAGGAAGCCCTTGCAAAGGTCTCCGGAGTTTACAACGCAGTCATGATAGAGGGAGATTTTGTAGGGAAAACCATGT
TCTATGGTCAGGGGGCGGGTTCACATCCGACCGCTTCTGCGGTGGTGGCGGACGTGATAGACGCGGGGAGGTTCTTACTC
TGTAGCTCTAAGGTTCTTCCTCCCGTGAACTGGGAAGAAGGAGAACTGAAGGTCAGGAAGAACTTTTACTCCAGGTACTA
CCTTAGGTTTGACGTTCCTGACAAGCCCGGAGTTCTGGCAAAGATAGCGAATGTACTTGCGGATTACAATATAAGCATAG
CCTCGGTTCTCCAGAAGGAAATGGTTTGTAAAATCGCGGGCAGGGAGGGTGAAACTATAGTTCCTCTGGTTATCCTGACT
CACAAAGCTTTTGAAGAGGATATACAGAACGCTTTAAAGGAGATACAGAAGCTCCCCGTAGTTGTTGATAAGCCCGTGCT
GATACGTGTGGAAGAGGAGGCTTACTGA

Upstream 100 bases:

>100_bases
CTTAATTTTCAAAAATGATAAAATGGTAAATTAAACATATAAAAATTAGTTTAAGTCTTAAGTCCTTGTCCCCCTTTTAA
AAATAAAGGATAATTCTCTT

Downstream 100 bases:

>100_bases
AAAAGTGGAAATACTTCTAATCGCTTCTCTTCTGAGTTTAGGTACTTTCCTTGGCAGTTTTCTTTCTCTGTTTTTCAGGA
GTGTGAACGTAGGTGTGAGT

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MGFVRVGIIGCGTVGTGTAKLLIQNADLIKKKTGIEFKLVKVADIDWERKREFEVPKELRTTDYKEVIDNSDVVVELVGG
KTFAKKVILEALEAGKCVVTANKHLLAEEGKEIFEEAKKRNLFIGFEASVGGGIPVIKALREGLAGNKILNILGILNGTT
NYILTRMFEENLDFETALKEAKEKGYAEADPSLDIDGWDAAHKIAILAMLAYGGYLDFNDVYVEGIRNVDKLDVELGKEL
GYTLKLLAIAKKVDSEVEVRVHPTFIHSEEALAKVSGVYNAVMIEGDFVGKTMFYGQGAGSHPTASAVVADVIDAGRFLL
CSSKVLPPVNWEEGELKVRKNFYSRYYLRFDVPDKPGVLAKIANVLADYNISIASVLQKEMVCKIAGREGETIVPLVILT
HKAFEEDIQNALKEIQKLPVVVDKPVLIRVEEEAY

Sequences:

>Translated_435_residues
MGFVRVGIIGCGTVGTGTAKLLIQNADLIKKKTGIEFKLVKVADIDWERKREFEVPKELRTTDYKEVIDNSDVVVELVGG
KTFAKKVILEALEAGKCVVTANKHLLAEEGKEIFEEAKKRNLFIGFEASVGGGIPVIKALREGLAGNKILNILGILNGTT
NYILTRMFEENLDFETALKEAKEKGYAEADPSLDIDGWDAAHKIAILAMLAYGGYLDFNDVYVEGIRNVDKLDVELGKEL
GYTLKLLAIAKKVDSEVEVRVHPTFIHSEEALAKVSGVYNAVMIEGDFVGKTMFYGQGAGSHPTASAVVADVIDAGRFLL
CSSKVLPPVNWEEGELKVRKNFYSRYYLRFDVPDKPGVLAKIANVLADYNISIASVLQKEMVCKIAGREGETIVPLVILT
HKAFEEDIQNALKEIQKLPVVVDKPVLIRVEEEAY
>Mature_434_residues
GFVRVGIIGCGTVGTGTAKLLIQNADLIKKKTGIEFKLVKVADIDWERKREFEVPKELRTTDYKEVIDNSDVVVELVGGK
TFAKKVILEALEAGKCVVTANKHLLAEEGKEIFEEAKKRNLFIGFEASVGGGIPVIKALREGLAGNKILNILGILNGTTN
YILTRMFEENLDFETALKEAKEKGYAEADPSLDIDGWDAAHKIAILAMLAYGGYLDFNDVYVEGIRNVDKLDVELGKELG
YTLKLLAIAKKVDSEVEVRVHPTFIHSEEALAKVSGVYNAVMIEGDFVGKTMFYGQGAGSHPTASAVVADVIDAGRFLLC
SSKVLPPVNWEEGELKVRKNFYSRYYLRFDVPDKPGVLAKIANVLADYNISIASVLQKEMVCKIAGREGETIVPLVILTH
KAFEEDIQNALKEIQKLPVVVDKPVLIRVEEEAY

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790376, Length=357, Percent_Identity=24.9299719887955, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786183, Length=217, Percent_Identity=29.0322580645161, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322599, Length=233, Percent_Identity=29.1845493562232, Blast_Score=74, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 47910; Mature: 47779

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGFVRVGIIGCGTVGTGTAKLLIQNADLIKKKTGIEFKLVKVADIDWERKREFEVPKELR
CCEEEEEEEECCCCCCCCEEEEEECCHHHHHCCCCEEEEEEEECCCCHHCCCCCCCHHHH
TTDYKEVIDNSDVVVELVGGKTFAKKVILEALEAGKCVVTANKHLLAEEGKEIFEEAKKR
CCCHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHC
NLFIGFEASVGGGIPVIKALREGLAGNKILNILGILNGTTNYILTRMFEENLDFETALKE
CEEEEEECCCCCCCHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHH
AKEKGYAEADPSLDIDGWDAAHKIAILAMLAYGGYLDFNDVYVEGIRNVDKLDVELGKEL
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHC
GYTLKLLAIAKKVDSEVEVRVHPTFIHSEEALAKVSGVYNAVMIEGDFVGKTMFYGQGAG
CHHHHHHHHHHHCCCCEEEEEEEEEECCHHHHHHHHCCEEEEEEECCCCCCEEEECCCCC
SHPTASAVVADVIDAGRFLLCSSKVLPPVNWEEGELKVRKNFYSRYYLRFDVPDKPGVLA
CCCHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCHHHEHHCEEEEEEEECCCCCCHHH
KIANVLADYNISIASVLQKEMVCKIAGREGETIVPLVILTHKAFEEDIQNALKEIQKLPV
HHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHCCE
VVDKPVLIRVEEEAY
EECCCEEEEEECCCC
>Mature Secondary Structure 
GFVRVGIIGCGTVGTGTAKLLIQNADLIKKKTGIEFKLVKVADIDWERKREFEVPKELR
CEEEEEEEECCCCCCCCEEEEEECCHHHHHCCCCEEEEEEEECCCCHHCCCCCCCHHHH
TTDYKEVIDNSDVVVELVGGKTFAKKVILEALEAGKCVVTANKHLLAEEGKEIFEEAKKR
CCCHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHC
NLFIGFEASVGGGIPVIKALREGLAGNKILNILGILNGTTNYILTRMFEENLDFETALKE
CEEEEEECCCCCCCHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHH
AKEKGYAEADPSLDIDGWDAAHKIAILAMLAYGGYLDFNDVYVEGIRNVDKLDVELGKEL
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHC
GYTLKLLAIAKKVDSEVEVRVHPTFIHSEEALAKVSGVYNAVMIEGDFVGKTMFYGQGAG
CHHHHHHHHHHHCCCCEEEEEEEEEECCHHHHHHHHCCEEEEEEECCCCCCEEEECCCCC
SHPTASAVVADVIDAGRFLLCSSKVLPPVNWEEGELKVRKNFYSRYYLRFDVPDKPGVLA
CCCHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCHHHEHHCEEEEEEEECCCCCCHHH
KIANVLADYNISIASVLQKEMVCKIAGREGETIVPLVILTHKAFEEDIQNALKEIQKLPV
HHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHCCE
VVDKPVLIRVEEEAY
EECCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]