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The map label for this gene is lpxK

Identifier: 15606758

GI number: 15606758

Start: 1159408

End: 1160355

Strand: Direct

Name: lpxK

Synonym: aq_1656

Alternate gene names: 15606758

Gene position: 1159408-1160355 (Clockwise)

Preceding gene: 15606757

Following gene: 15606762

Centisome position: 74.74

GC content: 42.3

Gene sequence:

>948_bases
GTGCTAAGAAGTAGCCTACTTCCCTTTTCGTACTTATACGAAAAAATTATTAACTTCAGAAACACACTTTACGATAAGGG
ATTTTTAAAGATAAAAAAACTTCCCGTTCCCGTGATTTCTGTAGGAAACCTCTCGGTGGGCGGAAGTGGAAAGACCTCCT
TCGTTATGTACCTTGCCGACTTGTTGAAGGATAAAAGGGTTTGTATACTGTCCCGGGGCTACAAGAGAAAGAGTAAAGGT
ACCCTAATCGTTTCGGAGTACGGGAATTTAAAGGTTTCCTGGGAAGAGGCAGGGGACGAGCCCTACCTTATGGCCAAGTT
GCTACCACATGTGAGCGTCGTGGCATCGGAGGACAGGTATAAGGGAGGACTCTTAGCTCTGGAAAAGTTATCTCCCGAGG
TTTTTATTCTTGACGACGGATTTCAACACAGGAAACTCCACAGGGACCTTAATATCTTACTTTTAAAGAAAAAGGATTTG
AAGGACAGGCTTCTCCCCGCCGGAAATCTGAGGGAACCTCTAAAGGAAATAAGGAGGGCAGACGCTTTAGTTCTTACCTA
CCAGGAAGTTGAGCCTTTTGAGTTCTTTACGGGAAAACCCACTTTCAAGATGTTCAGGGAGTTTTGCTGTTTGCTGAACT
CAGACTTTGAAGAAGTGCCTTTTGATATTCTAAAGGAGAGAGAGGTTATAGCTTTCAGCGGACTCGGGGACAACGGACAA
TTCAGGAAAGTTTTGAAAAATTTAGGGATAAAGGTAAAAGAATTTATGTCCTTCCCCGATCACTACGATTACTCGGATTT
CACACCAGAGGAGGGAGAAATTTACTTAACCACTCCAAAGGATCTAATAAAACTGCAGGGTTATGAGAACGTTTTTGCCC
TGAACTTCAAAGTTAAGTTGGAAAGGGAAGAAAAGCTGAAAAAGCTCATTTATAGAATTTTTTACTGA

Upstream 100 bases:

>100_bases
GGATTTCTAAGTGAATTTCTGGAAAAGGACTACGAGGTTAAAGAGGTTCAGTGTCAGGCTCAAGGGTACGAGCAGTGTGT
GTTCAGGATAAGACAAAAGG

Downstream 100 bases:

>100_bases
TTTGGGCTCTCTCTTCACCGCAGTTCACGTCTTCCCTTTCAATGTATTCTTTTAGTTTTTGAACAGCTTCTTCTCCAGTA
ACGAGGTCCTGAAGATCCCT

Product: hypothetical protein

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MLRSSLLPFSYLYEKIINFRNTLYDKGFLKIKKLPVPVISVGNLSVGGSGKTSFVMYLADLLKDKRVCILSRGYKRKSKG
TLIVSEYGNLKVSWEEAGDEPYLMAKLLPHVSVVASEDRYKGGLLALEKLSPEVFILDDGFQHRKLHRDLNILLLKKKDL
KDRLLPAGNLREPLKEIRRADALVLTYQEVEPFEFFTGKPTFKMFREFCCLLNSDFEEVPFDILKEREVIAFSGLGDNGQ
FRKVLKNLGIKVKEFMSFPDHYDYSDFTPEEGEIYLTTPKDLIKLQGYENVFALNFKVKLEREEKLKKLIYRIFY

Sequences:

>Translated_315_residues
MLRSSLLPFSYLYEKIINFRNTLYDKGFLKIKKLPVPVISVGNLSVGGSGKTSFVMYLADLLKDKRVCILSRGYKRKSKG
TLIVSEYGNLKVSWEEAGDEPYLMAKLLPHVSVVASEDRYKGGLLALEKLSPEVFILDDGFQHRKLHRDLNILLLKKKDL
KDRLLPAGNLREPLKEIRRADALVLTYQEVEPFEFFTGKPTFKMFREFCCLLNSDFEEVPFDILKEREVIAFSGLGDNGQ
FRKVLKNLGIKVKEFMSFPDHYDYSDFTPEEGEIYLTTPKDLIKLQGYENVFALNFKVKLEREEKLKKLIYRIFY
>Mature_315_residues
MLRSSLLPFSYLYEKIINFRNTLYDKGFLKIKKLPVPVISVGNLSVGGSGKTSFVMYLADLLKDKRVCILSRGYKRKSKG
TLIVSEYGNLKVSWEEAGDEPYLMAKLLPHVSVVASEDRYKGGLLALEKLSPEVFILDDGFQHRKLHRDLNILLLKKKDL
KDRLLPAGNLREPLKEIRRADALVLTYQEVEPFEFFTGKPTFKMFREFCCLLNSDFEEVPFDILKEREVIAFSGLGDNGQ
FRKVLKNLGIKVKEFMSFPDHYDYSDFTPEEGEIYLTTPKDLIKLQGYENVFALNFKVKLEREEKLKKLIYRIFY

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=322, Percent_Identity=27.639751552795, Blast_Score=110, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_AQUAE (O67572)

Other databases:

- EMBL:   AE000657
- PIR:   C70443
- RefSeq:   NP_214138.1
- GeneID:   1193288
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_1656
- NMPDR:   fig|224324.1.peg.1153
- HOGENOM:   HBG663914
- OMA:   MERIHAR
- PhylomeDB:   O67572
- ProtClustDB:   CLSK2748482
- BioCyc:   AAEO224324:AQ_1656-MONOMER
- BRENDA:   2.7.1.130
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 36542; Mature: 36542

Theoretical pI: Translated: 9.47; Mature: 9.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRSSLLPFSYLYEKIINFRNTLYDKGFLKIKKLPVPVISVGNLSVGGSGKTSFVMYLAD
CCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEECCEEECCCCCHHHHHHHHH
LLKDKRVCILSRGYKRKSKGTLIVSEYGNLKVSWEEAGDEPYLMAKLLPHVSVVASEDRY
HHCCCCEEEEECCCCCCCCCCEEEEECCCEEEEHHCCCCCCHHHHHHHCCCEEEECCCCC
KGGLLALEKLSPEVFILDDGFQHRKLHRDLNILLLKKKDLKDRLLPAGNLREPLKEIRRA
CCCEEEEECCCCEEEEEECCHHHHHHHCCCEEEEEECCCCHHHCCCCCCHHHHHHHHHHC
DALVLTYQEVEPFEFFTGKPTFKMFREFCCLLNSDFEEVPFDILKEREVIAFSGLGDNGQ
CEEEEEECCCCCCEEECCCCHHHHHHHHHHHHCCCHHHCCHHHHCCCCEEEEECCCCCHH
FRKVLKNLGIKVKEFMSFPDHYDYSDFTPEEGEIYLTTPKDLIKLQGYENVFALNFKVKL
HHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCCEEEEECCHHHHEECCCCCEEEEEEEEEE
EREEKLKKLIYRIFY
CHHHHHHHHHHHHCC
>Mature Secondary Structure
MLRSSLLPFSYLYEKIINFRNTLYDKGFLKIKKLPVPVISVGNLSVGGSGKTSFVMYLAD
CCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEECCEEECCCCCHHHHHHHHH
LLKDKRVCILSRGYKRKSKGTLIVSEYGNLKVSWEEAGDEPYLMAKLLPHVSVVASEDRY
HHCCCCEEEEECCCCCCCCCCEEEEECCCEEEEHHCCCCCCHHHHHHHCCCEEEECCCCC
KGGLLALEKLSPEVFILDDGFQHRKLHRDLNILLLKKKDLKDRLLPAGNLREPLKEIRRA
CCCEEEEECCCCEEEEEECCHHHHHHHCCCEEEEEECCCCHHHCCCCCCHHHHHHHHHHC
DALVLTYQEVEPFEFFTGKPTFKMFREFCCLLNSDFEEVPFDILKEREVIAFSGLGDNGQ
CEEEEEECCCCCCEEECCCCHHHHHHHHHHHHCCCHHHCCHHHHCCCCEEEEECCCCCHH
FRKVLKNLGIKVKEFMSFPDHYDYSDFTPEEGEIYLTTPKDLIKLQGYENVFALNFKVKL
HHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCCEEEEECCHHHHEECCCCCEEEEEEEEEE
EREEKLKKLIYRIFY
CHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320