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The map label for this gene is mutL

Identifier: 15606703

GI number: 15606703

Start: 1113601

End: 1114878

Strand: Direct

Name: mutL

Synonym: aq_1578

Alternate gene names: 15606703

Gene position: 1113601-1114878 (Clockwise)

Preceding gene: 15606702

Following gene: 15606704

Centisome position: 71.78

GC content: 43.74

Gene sequence:

>1278_bases
ATGTTTGTAAAGTTACTTCCTCCTGAAGTAAGAAAGGTAATAGCGGCCGGAGAAGTTATAGAATCTCCTGTTGACGTCGT
AAAGGAACTCGTTGAGAATTCTCTGGACGCAAAGGCGACAAAAGTAGAGGTAGAAATCGTAAAAGGCGGGAAGAGGCTAA
TAAGGGTCAAAGACAACGGTACAGGAATACACCCCGAAGATGTTGAAAAGGTGGTCCTGCAGGGAGCGACGAGTAAGATA
GAGACCGAAAAGGATTTGATGAACATAAGCACTTACGGATTTCGCGGTGAGGCCCTTTACTCCATATCAAGCGTAAGCAA
GTTTAAACTCCGTTCCCGTTTTTTCCAAGAAAAGGAAGGAAAGGAAATAGAAGTAGAAGCGGGAAACATACTCGGGACGA
GAAGAGTGGGAATGCCCGTGGGAACGGAAGTTGAGGTGAGGGATCTCTTTTTCAATCTCCCCGTCAGGAGAAAGTTCTTA
AAAAAGGAGGATACCGAAAGGAGAAAGGTACTGGAACTTATCAAGGAGTACGCCCTCACAAATCCAGAAGTTGAGTTCAC
ACTCTTTTCCGAAGGCAGGGAAACCCTGAAACTGAAAAAGTCAAGTTTAAAGGAAAGAGTTGAGGAAGTTTTCCAGACAA
AAACAGAGGAACTTTACGCAGAGAGAGAAGGAATAACGCTCAGGGCTTTTGTTTCAAGAAACCAAAGACAGGGAAAGTAT
TATGTCTTTATAAACAAAAGACCTATTCAGAATAAGAACTTAAAGGAGTTCCTGAGGAAGGTTTTCGGTTACAAAACTCT
AGTAGTTCTTTACGCAGAGCTCCCTCCCTTTATGGTTGACTTCAACGTCCACCCCAAGAAAAAGGAAGTGAACATACTGA
AGGAGAGAAAGTTCCTTGAACTTGTAAGAGAACTCGCGGGAAAAGAGAAACCTATCGTAGATATTCCCCTCTCTCAACCT
GTGAAAACTTACAAGCCCACATACGAGATACTCGGGCAGATGGACGAGACCTTTATCCTCGTGAAGGATTCCGAATACCT
GTACTTCGTGGACCAGCACCTCCTTGAAGAGAGGATAAACTACGAAAAACTGAAGGACGAAAACTTAGCCTGCAGGATTT
CCGTAAAGGCGGGACAAAAGCTCTCGGAAGAGAAAATCAGAGAACTCATTAAAACCTGGAGAAACTTGGAAAATCCCCAC
GTTTGCCCCCACGGAAGACCCATATACTACAAAATACCCCTGAGGGAAATATACGAAAAAGTAGGCAGGAATTACTGA

Upstream 100 bases:

>100_bases
TTGACGACGTCCAGCAAGTAATAGCCAATTTTGAAATACCCGAAGAAATACTTCAGAAGGTTGGCTAATCCCTCTCTTTT
CCTTAAATTTTCCTTATCCG

Downstream 100 bases:

>100_bases
AGGTGGTAAATTAATCCTTGATGAGGATACAAAACTTTTTCTCTCCCAACATTCCCCTGAAAACCACGAGGAAAGAGCAC
ATAAGGGGGGATTTTTACTC

Product: DNA mismatch repair protein MutL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MFVKLLPPEVRKVIAAGEVIESPVDVVKELVENSLDAKATKVEVEIVKGGKRLIRVKDNGTGIHPEDVEKVVLQGATSKI
ETEKDLMNISTYGFRGEALYSISSVSKFKLRSRFFQEKEGKEIEVEAGNILGTRRVGMPVGTEVEVRDLFFNLPVRRKFL
KKEDTERRKVLELIKEYALTNPEVEFTLFSEGRETLKLKKSSLKERVEEVFQTKTEELYAEREGITLRAFVSRNQRQGKY
YVFINKRPIQNKNLKEFLRKVFGYKTLVVLYAELPPFMVDFNVHPKKKEVNILKERKFLELVRELAGKEKPIVDIPLSQP
VKTYKPTYEILGQMDETFILVKDSEYLYFVDQHLLEERINYEKLKDENLACRISVKAGQKLSEEKIRELIKTWRNLENPH
VCPHGRPIYYKIPLREIYEKVGRNY

Sequences:

>Translated_425_residues
MFVKLLPPEVRKVIAAGEVIESPVDVVKELVENSLDAKATKVEVEIVKGGKRLIRVKDNGTGIHPEDVEKVVLQGATSKI
ETEKDLMNISTYGFRGEALYSISSVSKFKLRSRFFQEKEGKEIEVEAGNILGTRRVGMPVGTEVEVRDLFFNLPVRRKFL
KKEDTERRKVLELIKEYALTNPEVEFTLFSEGRETLKLKKSSLKERVEEVFQTKTEELYAEREGITLRAFVSRNQRQGKY
YVFINKRPIQNKNLKEFLRKVFGYKTLVVLYAELPPFMVDFNVHPKKKEVNILKERKFLELVRELAGKEKPIVDIPLSQP
VKTYKPTYEILGQMDETFILVKDSEYLYFVDQHLLEERINYEKLKDENLACRISVKAGQKLSEEKIRELIKTWRNLENPH
VCPHGRPIYYKIPLREIYEKVGRNY
>Mature_425_residues
MFVKLLPPEVRKVIAAGEVIESPVDVVKELVENSLDAKATKVEVEIVKGGKRLIRVKDNGTGIHPEDVEKVVLQGATSKI
ETEKDLMNISTYGFRGEALYSISSVSKFKLRSRFFQEKEGKEIEVEAGNILGTRRVGMPVGTEVEVRDLFFNLPVRRKFL
KKEDTERRKVLELIKEYALTNPEVEFTLFSEGRETLKLKKSSLKERVEEVFQTKTEELYAEREGITLRAFVSRNQRQGKY
YVFINKRPIQNKNLKEFLRKVFGYKTLVVLYAELPPFMVDFNVHPKKKEVNILKERKFLELVRELAGKEKPIVDIPLSQP
VKTYKPTYEILGQMDETFILVKDSEYLYFVDQHLLEERINYEKLKDENLACRISVKAGQKLSEEKIRELIKTWRNLENPH
VCPHGRPIYYKIPLREIYEKVGRNY

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=310, Percent_Identity=33.2258064516129, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI4505911, Length=318, Percent_Identity=30.188679245283, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI189458898, Length=318, Percent_Identity=30.188679245283, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI189458896, Length=301, Percent_Identity=29.9003322259136, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI4505913, Length=327, Percent_Identity=28.7461773700306, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI310128478, Length=327, Percent_Identity=28.7461773700306, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI310128480, Length=291, Percent_Identity=26.4604810996564, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI91992162, Length=276, Percent_Identity=31.5217391304348, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI91992160, Length=276, Percent_Identity=31.5217391304348, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI263191589, Length=227, Percent_Identity=25.9911894273128, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1790612, Length=316, Percent_Identity=37.0253164556962, Blast_Score=198, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI71991825, Length=369, Percent_Identity=30.8943089430894, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17562796, Length=348, Percent_Identity=26.4367816091954, Blast_Score=117, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6323819, Length=351, Percent_Identity=30.7692307692308, Blast_Score=162, Evalue=9e-41,
Organism=Saccharomyces cerevisiae, GI6324247, Length=337, Percent_Identity=28.486646884273, Blast_Score=127, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6325093, Length=205, Percent_Identity=28.2926829268293, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6323063, Length=198, Percent_Identity=31.8181818181818, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17136968, Length=310, Percent_Identity=32.9032258064516, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI17136970, Length=350, Percent_Identity=27.1428571428571, Blast_Score=104, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_AQUAE (O67518)

Other databases:

- EMBL:   AE000657
- PIR:   D70436
- RefSeq:   NP_214083.1
- ProteinModelPortal:   O67518
- SMR:   O67518
- GeneID:   1193141
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_1578
- NMPDR:   fig|224324.1.peg.1098
- HOGENOM:   HBG520262
- ProtClustDB:   CLSK2748471
- BioCyc:   AAEO224324:AQ_1578-MONOMER
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 49594; Mature: 49594

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVKLLPPEVRKVIAAGEVIESPVDVVKELVENSLDAKATKVEVEIVKGGKRLIRVKDNG
CEEECCCHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCEEEEEEEEECCCEEEEEECCC
TGIHPEDVEKVVLQGATSKIETEKDLMNISTYGFRGEALYSISSVSKFKLRSRFFQEKEG
CCCCHHHHHHHHHHCCCCHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
KEIEVEAGNILGTRRVGMPVGTEVEVRDLFFNLPVRRKFLKKEDTERRKVLELIKEYALT
CEEEEECCCEEEEEECCCCCCCCEEHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHCC
NPEVEFTLFSEGRETLKLKKSSLKERVEEVFQTKTEELYAEREGITLRAFVSRNQRQGKY
CCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCEE
YVFINKRPIQNKNLKEFLRKVFGYKTLVVLYAELPPFMVDFNVHPKKKEVNILKERKFLE
EEEEECCCCCCCCHHHHHHHHHCCCEEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHH
LVRELAGKEKPIVDIPLSQPVKTYKPTYEILGQMDETFILVKDSEYLYFVDQHLLEERIN
HHHHHHCCCCCEEECCCCCCHHHCCCHHHHHCCCCCEEEEEECCCEEEHHHHHHHHHHCC
YEKLKDENLACRISVKAGQKLSEEKIRELIKTWRNLENPHVCPHGRPIYYKIPLREIYEK
HHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCHHHHHHH
VGRNY
HCCCC
>Mature Secondary Structure
MFVKLLPPEVRKVIAAGEVIESPVDVVKELVENSLDAKATKVEVEIVKGGKRLIRVKDNG
CEEECCCHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCEEEEEEEEECCCEEEEEECCC
TGIHPEDVEKVVLQGATSKIETEKDLMNISTYGFRGEALYSISSVSKFKLRSRFFQEKEG
CCCCHHHHHHHHHHCCCCHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
KEIEVEAGNILGTRRVGMPVGTEVEVRDLFFNLPVRRKFLKKEDTERRKVLELIKEYALT
CEEEEECCCEEEEEECCCCCCCCEEHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHCC
NPEVEFTLFSEGRETLKLKKSSLKERVEEVFQTKTEELYAEREGITLRAFVSRNQRQGKY
CCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCEE
YVFINKRPIQNKNLKEFLRKVFGYKTLVVLYAELPPFMVDFNVHPKKKEVNILKERKFLE
EEEEECCCCCCCCHHHHHHHHHCCCEEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHH
LVRELAGKEKPIVDIPLSQPVKTYKPTYEILGQMDETFILVKDSEYLYFVDQHLLEERIN
HHHHHHCCCCCEEECCCCCCHHHCCCHHHHHCCCCCEEEEEECCCEEEHHHHHHHHHHCC
YEKLKDENLACRISVKAGQKLSEEKIRELIKTWRNLENPHVCPHGRPIYYKIPLREIYEK
HHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCHHHHHHH
VGRNY
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320