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The map label for this gene is gcvT [H]

Identifier: 15606626

GI number: 15606626

Start: 1039761

End: 1040666

Strand: Direct

Name: gcvT [H]

Synonym: aq_1458

Alternate gene names: 15606626

Gene position: 1039761-1040666 (Clockwise)

Preceding gene: 15606624

Following gene: 15606628

Centisome position: 67.02

GC content: 43.71

Gene sequence:

>906_bases
GTGTTTGACATCTCCCACATGGGCAGACTACTAATAGAAGACCCTGAGAAAAAACTCCAGTACTTTACCACCAATAACTT
GGATAAACTGAGCGTGGGAAAGGTTCAGTATAACCTCCTTCCAAACGAAAAGGGAGGAATAAAGGACGACGTCACCGTTT
ATATGCTCTCAGAAATTGAGTTCTTTCTCTGCGTGAACGCCGCAAATAGACAGAAGGTAATAAATTGGCTCTCTCCTCAC
TTAAAGTTAAGGGATTTATCTGGTGAACTTGTCCAGATAGCCCTTCAGGGCCCGAAAAGCGAGGAAATAATTTCTAAGTT
TTATCCGGTCTCCGATTTAAAATACTACAGGTTCAAGGTTTTTGATAAAACCATTATTTCAAGAACCGGTTACACGGGTG
AAGATGGATTTGAGATATACGTCTCTCCCGAAGAGGGAAAGGAGTTATTTTTAGAACTCGTAAAACTCGCAAAGCCCTGC
GGACTCGGAGCGAGGGACGTTCTCAGAATAGAAGCGGGACTCCCACTTTACGGAAATGAGCTCTCCGAAGAAATAACGCC
GATAGAGGTAAACCTTGAGAAGTTCGTGGACTTCTCAAAAGAATTCATAGGAAAGGAAGCGATGCTGAAAAAGAAAGTAA
AGAAAAAGCTCTTTGGTCTGGAGCTGACGGAAAAAGGAATACCGAGGAAAGGCTACAGAGTGTTTAAAGGAGATAGAGAA
ATAGGCTGGATTTCGAGCGGTACTTACTCTCCGACGCTTAACAAAGGCATAGCCCTCTGCTTTGTTGATATTGAAGAGAG
GAAAGAAGGCAACGAAGTGGAAATCGAGGTAAGGGGCAGGAGAGTTAGAGGGGTATTGAGAAAGTATCCCTTCGTGAGGA
CACCAGCGGGAAGGTATCAGAAATGA

Upstream 100 bases:

>100_bases
AACACCTGAAGGCAAAGTTCACGAACTTCGCAGGCTGGACAATGCCACTCCAGTACACCTCAATAATAGAAGAAGTAAGG
GCTGTAAGGGAAGAGCCGGA

Downstream 100 bases:

>100_bases
GCAAAGGTAATTAAATCTGATACACTTCCCGCAAAGTGTCCTTCGCTGTCCCCTTTTGGGGAACAGGATTTACTACCCGC
TATCTCCCAAAGAACCGGGA

Product: aminomethyltransferase (glycine cleavage system T protein)

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MFDISHMGRLLIEDPEKKLQYFTTNNLDKLSVGKVQYNLLPNEKGGIKDDVTVYMLSEIEFFLCVNAANRQKVINWLSPH
LKLRDLSGELVQIALQGPKSEEIISKFYPVSDLKYYRFKVFDKTIISRTGYTGEDGFEIYVSPEEGKELFLELVKLAKPC
GLGARDVLRIEAGLPLYGNELSEEITPIEVNLEKFVDFSKEFIGKEAMLKKKVKKKLFGLELTEKGIPRKGYRVFKGDRE
IGWISSGTYSPTLNKGIALCFVDIEERKEGNEVEIEVRGRRVRGVLRKYPFVRTPAGRYQK

Sequences:

>Translated_301_residues
MFDISHMGRLLIEDPEKKLQYFTTNNLDKLSVGKVQYNLLPNEKGGIKDDVTVYMLSEIEFFLCVNAANRQKVINWLSPH
LKLRDLSGELVQIALQGPKSEEIISKFYPVSDLKYYRFKVFDKTIISRTGYTGEDGFEIYVSPEEGKELFLELVKLAKPC
GLGARDVLRIEAGLPLYGNELSEEITPIEVNLEKFVDFSKEFIGKEAMLKKKVKKKLFGLELTEKGIPRKGYRVFKGDRE
IGWISSGTYSPTLNKGIALCFVDIEERKEGNEVEIEVRGRRVRGVLRKYPFVRTPAGRYQK
>Mature_301_residues
MFDISHMGRLLIEDPEKKLQYFTTNNLDKLSVGKVQYNLLPNEKGGIKDDVTVYMLSEIEFFLCVNAANRQKVINWLSPH
LKLRDLSGELVQIALQGPKSEEIISKFYPVSDLKYYRFKVFDKTIISRTGYTGEDGFEIYVSPEEGKELFLELVKLAKPC
GLGARDVLRIEAGLPLYGNELSEEITPIEVNLEKFVDFSKEFIGKEAMLKKKVKKKLFGLELTEKGIPRKGYRVFKGDRE
IGWISSGTYSPTLNKGIALCFVDIEERKEGNEVEIEVRGRRVRGVLRKYPFVRTPAGRYQK

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=323, Percent_Identity=31.2693498452012, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI257796256, Length=313, Percent_Identity=30.6709265175719, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI257796258, Length=306, Percent_Identity=30.3921568627451, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI257796254, Length=221, Percent_Identity=33.9366515837104, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI24797151, Length=324, Percent_Identity=25.3086419753086, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI194306651, Length=331, Percent_Identity=24.1691842900302, Blast_Score=88, Evalue=8e-18,
Organism=Escherichia coli, GI1789272, Length=319, Percent_Identity=35.1097178683386, Blast_Score=167, Evalue=8e-43,
Organism=Caenorhabditis elegans, GI17560118, Length=330, Percent_Identity=32.7272727272727, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI32563613, Length=320, Percent_Identity=25, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71994045, Length=303, Percent_Identity=24.4224422442244, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71994052, Length=303, Percent_Identity=24.4224422442244, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320222, Length=334, Percent_Identity=33.2335329341317, Blast_Score=139, Evalue=8e-34,
Organism=Drosophila melanogaster, GI20129441, Length=327, Percent_Identity=30.5810397553517, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI28571104, Length=218, Percent_Identity=24.3119266055046, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 34507; Mature: 34507

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDISHMGRLLIEDPEKKLQYFTTNNLDKLSVGKVQYNLLPNEKGGIKDDVTVYMLSEIE
CCCHHHHCCEEEECCHHHHEEEECCCCCCEEECEEEEEECCCCCCCCCCCEEEEEEECCE
FFLCVNAANRQKVINWLSPHLKLRDLSGELVQIALQGPKSEEIISKFYPVSDLKYYRFKV
EEEEECCCCHHHHHHHHCCCCEEECCCCEEEEEEECCCCHHHHHHHHCCCCCCCEEEEEH
FDKTIISRTGYTGEDGFEIYVSPEEGKELFLELVKLAKPCGLGARDVLRIEAGLPLYGNE
HHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCHHEEEEECCCCCCCCH
LSEEITPIEVNLEKFVDFSKEFIGKEAMLKKKVKKKLFGLELTEKGIPRKGYRVFKGDRE
HHCCCCCEEECHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCHHCCCCCCCCCEEEECCCC
IGWISSGTYSPTLNKGIALCFVDIEERKEGNEVEIEVRGRRVRGVLRKYPFVRTPAGRYQ
EEEEECCCCCCCCCCCEEEEEEEEHHCCCCCEEEEEECCHHHHHHHHHCCCEECCCCCCC
K
C
>Mature Secondary Structure
MFDISHMGRLLIEDPEKKLQYFTTNNLDKLSVGKVQYNLLPNEKGGIKDDVTVYMLSEIE
CCCHHHHCCEEEECCHHHHEEEECCCCCCEEECEEEEEECCCCCCCCCCCEEEEEEECCE
FFLCVNAANRQKVINWLSPHLKLRDLSGELVQIALQGPKSEEIISKFYPVSDLKYYRFKV
EEEEECCCCHHHHHHHHCCCCEEECCCCEEEEEEECCCCHHHHHHHHCCCCCCCEEEEEH
FDKTIISRTGYTGEDGFEIYVSPEEGKELFLELVKLAKPCGLGARDVLRIEAGLPLYGNE
HHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCHHEEEEECCCCCCCCH
LSEEITPIEVNLEKFVDFSKEFIGKEAMLKKKVKKKLFGLELTEKGIPRKGYRVFKGDRE
HHCCCCCEEECHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCHHCCCCCCCCCEEEECCCC
IGWISSGTYSPTLNKGIALCFVDIEERKEGNEVEIEVRGRRVRGVLRKYPFVRTPAGRYQ
EEEEECCCCCCCCCCCEEEEEEEEHHCCCCCEEEEEECCHHHHHHHHHCCCEECCCCCCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]