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The map label for this gene is htrA [H]

Identifier: 15606621

GI number: 15606621

Start: 1034952

End: 1036313

Strand: Direct

Name: htrA [H]

Synonym: aq_1450

Alternate gene names: 15606621

Gene position: 1034952-1036313 (Clockwise)

Preceding gene: 15606615

Following gene: 15606622

Centisome position: 66.71

GC content: 45.01

Gene sequence:

>1362_bases
ATGAGAAAGTTCTTACTCCCTTTCCTATTGATAATTTCAGTAACTTTTTCCAGCACCCTAAAAGACCTGGAGGAAGATAT
AGTAAAACTCGTAAACAAGGTAGCTCCCTCGGTAGTGACGATATTCGTTATAAAGGAAGAAAAGAGTATATTCCCCATGC
CTGAGTTTCCCTTTGACTTTCCCTTCAGGTTCAGAGAACCTTTTACGAGAAAGGAACGTTCTCTCGGAAGTGGTGTAATC
GTCAAGTACGACGAAGATAAAAAAGTTGTATACATACTTACAAACGCCCACGTTGTAAAGAACGGAGTGAGGATACTCGT
AAAACTGGACAGGCACACTGAAAAGAAGGGGGAAATAGTAGGGATAGACACGAAAACCGATATAGCCGTGGTGAAAATTT
CTACAAGAGGTATAAACGATATAGAGGATAGGATCGCGAAACTCGGGGATTCGGACAACTTAAAGGTTGGGCAGATAGTT
TTTGCCATAGGAAATCCTTACGGTCTTGAAAGGACGGTAACGATGGGCGTTATATCCGCACTAAGGAGGAGCATAGGGAT
AACCCAGTACGAGAGCTTTATACAGACAGATGCGGCTATAAATCCGGGAAATTCAGGAGGTCCGCTCATAAACGTTGAGG
GAGAAGTCATAGGAATAAACACGGCTATAATAGCCGGTGCTCAGGGACTTGGTTTTGCCATACCCATAAACCTCGCCAAG
TGGGTAATGGAACAGATAATAGAACACGGCAAAGTAATAAGGGGATGGCTCGGTGTTGTTATTCAGGACATAACTCCCGA
CATATCCGAAGCCCTTGGTATTAAGGAAGGTGTCCTAGTTGCACAGGTAGTTCCCGGCAGTCCCGCGGACAAGGCTGGCT
TAAAAGTCGGTGACGTTATAGTGGAGGTAAACGGAAAGAAGATAGAGGACGCGAGGGATCTCCAGTTCACGATTATGAAG
ATGAAACCGGGAACGAAAGCGGTACTCAAAGTAATAAGGAATGGAAAAGAAAAGGAAATTACCGTAATAATAGGTCAGTA
TCCCGAAGAGGGAGTATCCAGAGAGGGTAAGGCGACTCCTGAAAACCTCGGACTCCTTTTAAGGGACCTGACGTTAAAGG
AAAAACAGGAGGCGGGAGTTCCCTACGGAGTGCTCGTTGAGGGAATTTATCCAGACTCCCCCGCGGAGTACAGCGGACTC
CAACCCGGGGACATAATACTTAAGGTAAACAACCGTCCCGTAAGGAGCGTCAGAGAATTTTACGAGATAATTAACAGATT
AAAGGAAATGGGAAGGTCTAAGGCTCTGCTCCTTGTAAGGAGGGGTGACAGAAATATCTTTATAACTCTGGACTTAGAGT
GA

Upstream 100 bases:

>100_bases
GAAATTTTCCCCGTCCCACAGTCTGATAATTACGTCCGTGGCGAGAAGAGGCGTTTTTACGTTAAAGCCCATTTTTATCT
ATTCTATAATCAAAAGTATT

Downstream 100 bases:

>100_bases
GGTAGTAGCCATGATACCAGATACAGAGCAAGAACTTATAAATCAGTACTTGAAGAAAATTTCAAAGATACCGCTCCTCA
CACCGGAAGAGGAGAAGGAG

Product: periplasmic serine protease

Products: NA

Alternate protein names: Antigen htrA [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MRKFLLPFLLIISVTFSSTLKDLEEDIVKLVNKVAPSVVTIFVIKEEKSIFPMPEFPFDFPFRFREPFTRKERSLGSGVI
VKYDEDKKVVYILTNAHVVKNGVRILVKLDRHTEKKGEIVGIDTKTDIAVVKISTRGINDIEDRIAKLGDSDNLKVGQIV
FAIGNPYGLERTVTMGVISALRRSIGITQYESFIQTDAAINPGNSGGPLINVEGEVIGINTAIIAGAQGLGFAIPINLAK
WVMEQIIEHGKVIRGWLGVVIQDITPDISEALGIKEGVLVAQVVPGSPADKAGLKVGDVIVEVNGKKIEDARDLQFTIMK
MKPGTKAVLKVIRNGKEKEITVIIGQYPEEGVSREGKATPENLGLLLRDLTLKEKQEAGVPYGVLVEGIYPDSPAEYSGL
QPGDIILKVNNRPVRSVREFYEIINRLKEMGRSKALLLVRRGDRNIFITLDLE

Sequences:

>Translated_453_residues
MRKFLLPFLLIISVTFSSTLKDLEEDIVKLVNKVAPSVVTIFVIKEEKSIFPMPEFPFDFPFRFREPFTRKERSLGSGVI
VKYDEDKKVVYILTNAHVVKNGVRILVKLDRHTEKKGEIVGIDTKTDIAVVKISTRGINDIEDRIAKLGDSDNLKVGQIV
FAIGNPYGLERTVTMGVISALRRSIGITQYESFIQTDAAINPGNSGGPLINVEGEVIGINTAIIAGAQGLGFAIPINLAK
WVMEQIIEHGKVIRGWLGVVIQDITPDISEALGIKEGVLVAQVVPGSPADKAGLKVGDVIVEVNGKKIEDARDLQFTIMK
MKPGTKAVLKVIRNGKEKEITVIIGQYPEEGVSREGKATPENLGLLLRDLTLKEKQEAGVPYGVLVEGIYPDSPAEYSGL
QPGDIILKVNNRPVRSVREFYEIINRLKEMGRSKALLLVRRGDRNIFITLDLE
>Mature_453_residues
MRKFLLPFLLIISVTFSSTLKDLEEDIVKLVNKVAPSVVTIFVIKEEKSIFPMPEFPFDFPFRFREPFTRKERSLGSGVI
VKYDEDKKVVYILTNAHVVKNGVRILVKLDRHTEKKGEIVGIDTKTDIAVVKISTRGINDIEDRIAKLGDSDNLKVGQIV
FAIGNPYGLERTVTMGVISALRRSIGITQYESFIQTDAAINPGNSGGPLINVEGEVIGINTAIIAGAQGLGFAIPINLAK
WVMEQIIEHGKVIRGWLGVVIQDITPDISEALGIKEGVLVAQVVPGSPADKAGLKVGDVIVEVNGKKIEDARDLQFTIMK
MKPGTKAVLKVIRNGKEKEITVIIGQYPEEGVSREGKATPENLGLLLRDLTLKEKQEAGVPYGVLVEGIYPDSPAEYSGL
QPGDIILKVNNRPVRSVREFYEIINRLKEMGRSKALLLVRRGDRNIFITLDLE

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=342, Percent_Identity=33.9181286549708, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI22129776, Length=319, Percent_Identity=33.2288401253918, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI24308541, Length=256, Percent_Identity=36.328125, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI7019477, Length=336, Percent_Identity=32.4404761904762, Blast_Score=129, Evalue=4e-30,
Organism=Escherichia coli, GI1786356, Length=477, Percent_Identity=35.0104821802935, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI1789629, Length=435, Percent_Identity=36.0919540229885, Blast_Score=241, Evalue=5e-65,
Organism=Escherichia coli, GI1789630, Length=292, Percent_Identity=38.6986301369863, Blast_Score=171, Evalue=9e-44,
Organism=Drosophila melanogaster, GI24646839, Length=280, Percent_Identity=34.2857142857143, Blast_Score=139, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 49959; Mature: 49959

Theoretical pI: Translated: 9.26; Mature: 9.26

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKFLLPFLLIISVTFSSTLKDLEEDIVKLVNKVAPSVVTIFVIKEEKSIFPMPEFPFDF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCC
PFRFREPFTRKERSLGSGVIVKYDEDKKVVYILTNAHVVKNGVRILVKLDRHTEKKGEIV
CCCCCCCHHHHHHCCCCCEEEEECCCCEEEEEEECCEEHHCCEEEEEEECCCCCCCCCEE
GIDTKTDIAVVKISTRGINDIEDRIAKLGDSDNLKVGQIVFAIGNPYGLERTVTMGVISA
EECCCCCEEEEEEECCCCCHHHHHHHHCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHH
LRRSIGITQYESFIQTDAAINPGNSGGPLINVEGEVIGINTAIIAGAQGLGFAIPINLAK
HHHHCCHHHHHHHHHHCCCCCCCCCCCCEEEECCCEEEECEEEEECCCCCCEEEEHHHHH
WVMEQIIEHGKVIRGWLGVVIQDITPDISEALGIKEGVLVAQVVPGSPADKAGLKVGDVI
HHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHCCCCCCEEEEEECCCCCCCCCCCEEEEEE
VEVNGKKIEDARDLQFTIMKMKPGTKAVLKVIRNGKEKEITVIIGQYPEEGVSREGKATP
EEECCCCCCCCCCCEEEEEEECCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCH
ENLGLLLRDLTLKEKQEAGVPYGVLVEGIYPDSPAEYSGLQPGDIILKVNNRPVRSVREF
HHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHH
YEIINRLKEMGRSKALLLVRRGDRNIFITLDLE
HHHHHHHHHCCCCEEEEEEEECCCEEEEEEECC
>Mature Secondary Structure
MRKFLLPFLLIISVTFSSTLKDLEEDIVKLVNKVAPSVVTIFVIKEEKSIFPMPEFPFDF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCC
PFRFREPFTRKERSLGSGVIVKYDEDKKVVYILTNAHVVKNGVRILVKLDRHTEKKGEIV
CCCCCCCHHHHHHCCCCCEEEEECCCCEEEEEEECCEEHHCCEEEEEEECCCCCCCCCEE
GIDTKTDIAVVKISTRGINDIEDRIAKLGDSDNLKVGQIVFAIGNPYGLERTVTMGVISA
EECCCCCEEEEEEECCCCCHHHHHHHHCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHH
LRRSIGITQYESFIQTDAAINPGNSGGPLINVEGEVIGINTAIIAGAQGLGFAIPINLAK
HHHHCCHHHHHHHHHHCCCCCCCCCCCCEEEECCCEEEECEEEEECCCCCCEEEEHHHHH
WVMEQIIEHGKVIRGWLGVVIQDITPDISEALGIKEGVLVAQVVPGSPADKAGLKVGDVI
HHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHCCCCCCEEEEEECCCCCCCCCCCEEEEEE
VEVNGKKIEDARDLQFTIMKMKPGTKAVLKVIRNGKEKEITVIIGQYPEEGVSREGKATP
EEECCCCCCCCCCCEEEEEEECCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCH
ENLGLLLRDLTLKEKQEAGVPYGVLVEGIYPDSPAEYSGLQPGDIILKVNNRPVRSVREF
HHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHH
YEIINRLKEMGRSKALLLVRRGDRNIFITLDLE
HHHHHHHHHCCCCEEEEEEEECCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8027347 [H]