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The map label for this gene is nuoM2 [H]

Identifier: 15606574

GI number: 15606574

Start: 981656

End: 983161

Strand: Direct

Name: nuoM2 [H]

Synonym: aq_1382

Alternate gene names: 15606574

Gene position: 981656-983161 (Clockwise)

Preceding gene: 15606573

Following gene: 15606575

Centisome position: 63.28

GC content: 42.36

Gene sequence:

>1506_bases
ATGGAAAAGGTGGGGTTTGAGTTTCCCATAATATCCGTTTCCCTGGCTATACCTGCGGTATTTGCCGTTCTCATACTCTT
CTTTAAAGAAAAATTCGCAAAATACATAGCCCTTCTCGGGACGGGACTTACCTTTCTCGTGTCCTTAATAGCACTGTTTA
AGTTTGACTTTGCGAGAGATAATGTAATTCAGTTTTACGAGGAGTACACAATACTCAAGGAACTGGGAGTAAAGCTCTCC
CTCGGTATGGACGGACTCTCGCTCCTTATGTACTTCCTCACCACCTTAGTTTCCCTTATAGCTGTTATATGGTCCATAGG
CGATGAAAAAATAAAGCATAGACTGAAAGAGTACTATATAGCCTTTTTACTTACCGAAAGTTTTGTTATAGGTGTGTTTA
CTACGTTTAACCTCATCGTTTTCTACGTGTTTTACGAACTCACACTCCTTCCCATGCTCTTTGTGATAGGTATCTGGGGA
TATAAGCTCAGGCTTTACTCAGCTTACAAGTTCTTTGTATACATATTTATCTCTTCTTTGTTCTTGCTACTCGGTATAGC
CTCAATATCCACTTACCACTACAAAATGAACGGAAGTTTTACCTTTGAGTACCTTGAGCTCTTAAACTTGAACATTCCAA
ATGGTTTTGAGATCTTCCTATTCTTACTCTTCTTCATAGCTTTTGCGGTAAAGACTCCAATAGTTCCTTTCCACACATGG
CTTCCCGATGCTCACGGTGAGGCTCCCACCGCAGGTTCTGTAGTTCTCGCTGCAATCTTACTTAAGATGGGAACTTACGC
TCTTGTCAGGTTCAACATAGGGCTCTTCCCTGATGCAGCTTTAGAACTTTCTCCCTACCTCGTGGCACTTGGTATTTACT
CCATTATTATGGCTTCATGGATGACAATATCCCAGACGAATATAAAACGTTTCGTCGCTTACTCTTCCGTTTCCCACATG
GGTTTTGTGGTAACCGCGGCATTCCTTCTAAATATGGAAGGTCTCAGGGCGTCAATTATTGAGATGTTTGCTCACGGTCT
TACAAGTGCCGGACTCTTTATGGTTGCCGGATACATATACAACAAGCTCCACACATTTAACTTCGCAAGCTTGAGAGGTG
CTATAAAGTTCATGCCCTTGTTTGCAACCATTACCGCTGCAACAGCCTTTGCCGCCATGGGTCTTCCCGGCGGTTCTTCC
TTCTGGGGTAAGTTCCTCACGATTTTGGCTGCAAGGGAGTACTCAACACCTTTAGCCTTCTTGGTAGTCTTTGCGGCGTT
CTTCAGTGCGGCTTACGTACTTTACTTCTTAAAAACTCTTTATTTGGACGTCAGAGAAGAGAGTGTACTTATTCACTTCA
AGGATGTAAGCGGTTATCCCTTGGTGGCATTTTTGATGATCGTTATTCCTGTTCTATTGGTAGGTTTTGTTCCGTTTATA
TTCTTTGCCTTCTACAACGAGTTCCTTGTGCACTTGTTAAAGTACGTTTTAAAATTGCCGTTTTAG

Upstream 100 bases:

>100_bases
CTGGGCTTGTGAACCACTACATACTGTTTTTGGCCGTAGGATTGACCTTTATCCTTGGAATCATGCTCTATATACTGGAT
AGACTCTAAGGGGTGGTGAT

Downstream 100 bases:

>100_bases
AGGTGAGTAAAAGATGGATTTAAGGGCGTTAATAGGCGTAATAGAGATACCGGATTTAAAGAAATTCCTCCCGGAGTTTA
TACTACTGCTACTTGCCTTT

Product: NADH dehydrogenase I chain M

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M [H]

Number of amino acids: Translated: 501; Mature: 501

Protein sequence:

>501_residues
MEKVGFEFPIISVSLAIPAVFAVLILFFKEKFAKYIALLGTGLTFLVSLIALFKFDFARDNVIQFYEEYTILKELGVKLS
LGMDGLSLLMYFLTTLVSLIAVIWSIGDEKIKHRLKEYYIAFLLTESFVIGVFTTFNLIVFYVFYELTLLPMLFVIGIWG
YKLRLYSAYKFFVYIFISSLFLLLGIASISTYHYKMNGSFTFEYLELLNLNIPNGFEIFLFLLFFIAFAVKTPIVPFHTW
LPDAHGEAPTAGSVVLAAILLKMGTYALVRFNIGLFPDAALELSPYLVALGIYSIIMASWMTISQTNIKRFVAYSSVSHM
GFVVTAAFLLNMEGLRASIIEMFAHGLTSAGLFMVAGYIYNKLHTFNFASLRGAIKFMPLFATITAATAFAAMGLPGGSS
FWGKFLTILAAREYSTPLAFLVVFAAFFSAAYVLYFLKTLYLDVREESVLIHFKDVSGYPLVAFLMIVIPVLLVGFVPFI
FFAFYNEFLVHLLKYVLKLPF

Sequences:

>Translated_501_residues
MEKVGFEFPIISVSLAIPAVFAVLILFFKEKFAKYIALLGTGLTFLVSLIALFKFDFARDNVIQFYEEYTILKELGVKLS
LGMDGLSLLMYFLTTLVSLIAVIWSIGDEKIKHRLKEYYIAFLLTESFVIGVFTTFNLIVFYVFYELTLLPMLFVIGIWG
YKLRLYSAYKFFVYIFISSLFLLLGIASISTYHYKMNGSFTFEYLELLNLNIPNGFEIFLFLLFFIAFAVKTPIVPFHTW
LPDAHGEAPTAGSVVLAAILLKMGTYALVRFNIGLFPDAALELSPYLVALGIYSIIMASWMTISQTNIKRFVAYSSVSHM
GFVVTAAFLLNMEGLRASIIEMFAHGLTSAGLFMVAGYIYNKLHTFNFASLRGAIKFMPLFATITAATAFAAMGLPGGSS
FWGKFLTILAAREYSTPLAFLVVFAAFFSAAYVLYFLKTLYLDVREESVLIHFKDVSGYPLVAFLMIVIPVLLVGFVPFI
FFAFYNEFLVHLLKYVLKLPF
>Mature_501_residues
MEKVGFEFPIISVSLAIPAVFAVLILFFKEKFAKYIALLGTGLTFLVSLIALFKFDFARDNVIQFYEEYTILKELGVKLS
LGMDGLSLLMYFLTTLVSLIAVIWSIGDEKIKHRLKEYYIAFLLTESFVIGVFTTFNLIVFYVFYELTLLPMLFVIGIWG
YKLRLYSAYKFFVYIFISSLFLLLGIASISTYHYKMNGSFTFEYLELLNLNIPNGFEIFLFLLFFIAFAVKTPIVPFHTW
LPDAHGEAPTAGSVVLAAILLKMGTYALVRFNIGLFPDAALELSPYLVALGIYSIIMASWMTISQTNIKRFVAYSSVSHM
GFVVTAAFLLNMEGLRASIIEMFAHGLTSAGLFMVAGYIYNKLHTFNFASLRGAIKFMPLFATITAATAFAAMGLPGGSS
FWGKFLTILAAREYSTPLAFLVVFAAFFSAAYVLYFLKTLYLDVREESVLIHFKDVSGYPLVAFLMIVIPVLLVGFVPFI
FFAFYNEFLVHLLKYVLKLPF

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=270, Percent_Identity=37.4074074074074, Blast_Score=156, Evalue=5e-38,
Organism=Escherichia coli, GI1788613, Length=450, Percent_Identity=36.6666666666667, Blast_Score=284, Evalue=1e-77,
Organism=Escherichia coli, GI1788831, Length=350, Percent_Identity=30, Blast_Score=122, Evalue=7e-29,
Organism=Escherichia coli, GI1788827, Length=242, Percent_Identity=27.2727272727273, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI145693160, Length=405, Percent_Identity=26.9135802469136, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788614, Length=387, Percent_Identity=25.0645994832041, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1788829, Length=407, Percent_Identity=25.7985257985258, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 56526; Mature: 56526

Theoretical pI: Translated: 8.98; Mature: 8.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEKVGFEFPIISVSLAIPAVFAVLILFFKEKFAKYIALLGTGLTFLVSLIALFKFDFARD
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHH
NVIQFYEEYTILKELGVKLSLGMDGLSLLMYFLTTLVSLIAVIWSIGDEKIKHRLKEYYI
HHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
AFLLTESFVIGVFTTFNLIVFYVFYELTLLPMLFVIGIWGYKLRLYSAYKFFVYIFISSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLLLGIASISTYHYKMNGSFTFEYLELLNLNIPNGFEIFLFLLFFIAFAVKTPIVPFHTW
HHHHHHHHHHHEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHC
LPDAHGEAPTAGSVVLAAILLKMGTYALVRFNIGLFPDAALELSPYLVALGIYSIIMASW
CCCCCCCCCCHHHHHHHHHHHHHCCHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
MTISQTNIKRFVAYSSVSHMGFVVTAAFLLNMEGLRASIIEMFAHGLTSAGLFMVAGYIY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
NKLHTFNFASLRGAIKFMPLFATITAATAFAAMGLPGGSSFWGKFLTILAAREYSTPLAF
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHH
LVVFAAFFSAAYVLYFLKTLYLDVREESVLIHFKDVSGYPLVAFLMIVIPVLLVGFVPFI
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
FFAFYNEFLVHLLKYVLKLPF
HHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA