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The map label for this gene is nuoN2

Identifier: 15606575

GI number: 15606575

Start: 983175

End: 984641

Strand: Direct

Name: nuoN2

Synonym: aq_1383

Alternate gene names: 15606575

Gene position: 983175-984641 (Clockwise)

Preceding gene: 15606574

Following gene: 15606576

Centisome position: 63.38

GC content: 44.92

Gene sequence:

>1467_bases
ATGGATTTAAGGGCGTTAATAGGCGTAATAGAGATACCGGATTTAAAGAAATTCCTCCCGGAGTTTATACTACTGCTACT
TGCCTTTATACTATTCACATTAGAACTCTTCATAAAAGGAAAAGAGCGGAGACTCGTCCTTAACGTTGTGAGTTACGTAG
GGTATTTCTCCGTTTTAATGTCTTTGTTAATTCCTTGGATGTACAAAGGTGACACCTTTTACGGGAACTTTACGAATGAT
CCGTTAGCGGTTACTGTAAAAATATTCGCTGTTTTAATTACTTTAGCTATACTCCCCTTTGCAAGTTCCTACTTCTCCGC
TAAAAAATCCTTCTACGGAGAGTTTTACTACATCCTCGCCTTTACACTTCTTGGGGTATTCGTACTGGCCTCCACTTACA
ACCTCATAATCCTTTACGTGGCTCTGGAGCTCGTATCCGTCGGTTTTTACATATTGACTGCACTCCTGAGAGGCTCTACG
GAAGCGAAAGAGGGAGCGTTTAAGTACTTAATCTTAGGTGGTCTTTCTATAGCTCTCGCCTCTTACGGTGCCGCTTTTAT
GTACATATACTCGGGTAGCCTTGACCTTCGTGAAATACTGACCTATCAGGGGAAAGATATTCACTATCTCGTTCTCGGAC
TCGTTTTCTTCCTTATAGGTCTTGCGGTAAAGATAGGTGCGGTCCCCTTCCACTACTGGGTGCCAGACGCTTACCAAGGT
GCTCCCACGCCTGTTACCGCCCTCATGGCGTCGGTCGGAAAGCTTGCATTCTTCATTCCACTTGTGAGGGTTATGCCTCT
AGTTCAGGAAAAGTTCTCGCTTGTCTGGACAATAACCGTGGGAGTTATAGCGGCACTTACAATGCTCTACGGTAATTTAG
TGGCCCTCGTTCAAAAGGATGTAAAGAGACTGCTCGCTTATTCCTCCATAGCTCACTCAGGTTACATAATGGCAGGTGCT
GCGGTTGCAAAAGTTATAGGTATGAAGGCGGTTATTTACTTCCTCGTGGCTTACGCGGTCATGTCCGCTGGAGCTTTCTT
GGTTTTAGCCCTCATGGAAAAGAATCCGGAATGGCAGAACTACATGGAAAACTTTTACGGACTCAGGTTTAACGCTCCTT
ACATTGCCTTTGCATTCTTCGTTTACATGGTTGCGCTCCTCGGTGTTCCTCCCACGGTAGGTTTTGTAGGAAAGGCTCTG
GTATTTATGGCGCTTTCCTTTGATAAACTCTGGTGGCTTGCCTTTATCATGATACTTTCCGCTGCGATATCCACGGGATA
CTACATAAGACTTGTCGTGGTTATGTACATGCACGAGAGGGAAAAGGAAATACGGTCCGCCCCCTCTCACTTGGGTGAAA
AGTTTTCACTCTTCGCCCTGACACTTGCAAGTGTACTTTTAGGGGTATTACCTTCTTTAGTGTGGTTTCTCATTAAGCAA
TCTGCGGAAAATCTTTTTACGGGGTGA

Upstream 100 bases:

>100_bases
GTAGGTTTTGTTCCGTTTATATTCTTTGCCTTCTACAACGAGTTCCTTGTGCACTTGTTAAAGTACGTTTTAAAATTGCC
GTTTTAGAGGTGAGTAAAAG

Downstream 100 bases:

>100_bases
GAGAGATGGAGTACGTATGGATTTTAGTATTTGCTGGAATTCTCCTCGTTATAGGTCTTGTTATGATATCTCTTAACGCT
CTGCTCGGACCCCGTGAGCC

Product: NADH dehydrogenase I chain N

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N 2; NDH-1 subunit N 2

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MDLRALIGVIEIPDLKKFLPEFILLLLAFILFTLELFIKGKERRLVLNVVSYVGYFSVLMSLLIPWMYKGDTFYGNFTND
PLAVTVKIFAVLITLAILPFASSYFSAKKSFYGEFYYILAFTLLGVFVLASTYNLIILYVALELVSVGFYILTALLRGST
EAKEGAFKYLILGGLSIALASYGAAFMYIYSGSLDLREILTYQGKDIHYLVLGLVFFLIGLAVKIGAVPFHYWVPDAYQG
APTPVTALMASVGKLAFFIPLVRVMPLVQEKFSLVWTITVGVIAALTMLYGNLVALVQKDVKRLLAYSSIAHSGYIMAGA
AVAKVIGMKAVIYFLVAYAVMSAGAFLVLALMEKNPEWQNYMENFYGLRFNAPYIAFAFFVYMVALLGVPPTVGFVGKAL
VFMALSFDKLWWLAFIMILSAAISTGYYIRLVVVMYMHEREKEIRSAPSHLGEKFSLFALTLASVLLGVLPSLVWFLIKQ
SAENLFTG

Sequences:

>Translated_488_residues
MDLRALIGVIEIPDLKKFLPEFILLLLAFILFTLELFIKGKERRLVLNVVSYVGYFSVLMSLLIPWMYKGDTFYGNFTND
PLAVTVKIFAVLITLAILPFASSYFSAKKSFYGEFYYILAFTLLGVFVLASTYNLIILYVALELVSVGFYILTALLRGST
EAKEGAFKYLILGGLSIALASYGAAFMYIYSGSLDLREILTYQGKDIHYLVLGLVFFLIGLAVKIGAVPFHYWVPDAYQG
APTPVTALMASVGKLAFFIPLVRVMPLVQEKFSLVWTITVGVIAALTMLYGNLVALVQKDVKRLLAYSSIAHSGYIMAGA
AVAKVIGMKAVIYFLVAYAVMSAGAFLVLALMEKNPEWQNYMENFYGLRFNAPYIAFAFFVYMVALLGVPPTVGFVGKAL
VFMALSFDKLWWLAFIMILSAAISTGYYIRLVVVMYMHEREKEIRSAPSHLGEKFSLFALTLASVLLGVLPSLVWFLIKQ
SAENLFTG
>Mature_488_residues
MDLRALIGVIEIPDLKKFLPEFILLLLAFILFTLELFIKGKERRLVLNVVSYVGYFSVLMSLLIPWMYKGDTFYGNFTND
PLAVTVKIFAVLITLAILPFASSYFSAKKSFYGEFYYILAFTLLGVFVLASTYNLIILYVALELVSVGFYILTALLRGST
EAKEGAFKYLILGGLSIALASYGAAFMYIYSGSLDLREILTYQGKDIHYLVLGLVFFLIGLAVKIGAVPFHYWVPDAYQG
APTPVTALMASVGKLAFFIPLVRVMPLVQEKFSLVWTITVGVIAALTMLYGNLVALVQKDVKRLLAYSSIAHSGYIMAGA
AVAKVIGMKAVIYFLVAYAVMSAGAFLVLALMEKNPEWQNYMENFYGLRFNAPYIAFAFFVYMVALLGVPPTVGFVGKAL
VFMALSFDKLWWLAFIMILSAAISTGYYIRLVVVMYMHEREKEIRSAPSHLGEKFSLFALTLASVLLGVLPSLVWFLIKQ
SAENLFTG

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1007

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 2 (chain N)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family

Homologues:

Organism=Homo sapiens, GI251831117, Length=351, Percent_Identity=24.2165242165242, Blast_Score=79, Evalue=7e-15,
Organism=Escherichia coli, GI145693160, Length=379, Percent_Identity=32.1899736147757, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI1788831, Length=249, Percent_Identity=26.5060240963855, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788827, Length=319, Percent_Identity=26.9592476489028, Blast_Score=86, Evalue=8e-18,
Organism=Escherichia coli, GI1788614, Length=415, Percent_Identity=25.0602409638554, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1788613, Length=325, Percent_Identity=26.7692307692308, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1788829, Length=256, Percent_Identity=30.46875, Blast_Score=73, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUON2_AQUAE (O67391)

Other databases:

- EMBL:   AE000657
- PIR:   D70420
- RefSeq:   NP_213955.1
- GeneID:   1192921
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_1383
- NMPDR:   fig|224324.1.peg.970
- HOGENOM:   HBG747830
- OMA:   MIMASAI
- PhylomeDB:   O67391
- ProtClustDB:   CLSK2299685
- BioCyc:   AAEO224324:AQ_1383-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_00445
- InterPro:   IPR010096
- InterPro:   IPR001750
- TIGRFAMs:   TIGR01770

Pfam domain/function: PF00361 Oxidored_q1

EC number: =1.6.99.5

Molecular weight: Translated: 54266; Mature: 54266

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xde2cbbc)-; HASH(0xd26d53c)-; HASH(0xd78a4e8)-; HASH(0xddc7340)-; HASH(0xd23e300)-; HASH(0xc80d484)-; HASH(0xde7a180)-; HASH(0xcfa2dbc)-; HASH(0xd693068)-; HASH(0xd551d98)-; HASH(0xc4c24c0)-; HASH(0xde7a288)-; HASH(0xde7a00c)-; HASH(0xd765e40)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLRALIGVIEIPDLKKFLPEFILLLLAFILFTLELFIKGKERRLVLNVVSYVGYFSVLM
CCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
SLLIPWMYKGDTFYGNFTNDPLAVTVKIFAVLITLAILPFASSYFSAKKSFYGEFYYILA
HHHHHHHCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FTLLGVFVLASTYNLIILYVALELVSVGFYILTALLRGSTEAKEGAFKYLILGGLSIALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
SYGAAFMYIYSGSLDLREILTYQGKDIHYLVLGLVFFLIGLAVKIGAVPFHYWVPDAYQG
HHCHHEEEEEECCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCC
APTPVTALMASVGKLAFFIPLVRVMPLVQEKFSLVWTITVGVIAALTMLYGNLVALVQKD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKRLLAYSSIAHSGYIMAGAAVAKVIGMKAVIYFLVAYAVMSAGAFLVLALMEKNPEWQN
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHH
YMENFYGLRFNAPYIAFAFFVYMVALLGVPPTVGFVGKALVFMALSFDKLWWLAFIMILS
HHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAISTGYYIRLVVVMYMHEREKEIRSAPSHLGEKFSLFALTLASVLLGVLPSLVWFLIKQ
HHHHCCHHHHHHHHHHHHHHHHHHHHCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SAENLFTG
HHHHCCCH
>Mature Secondary Structure
MDLRALIGVIEIPDLKKFLPEFILLLLAFILFTLELFIKGKERRLVLNVVSYVGYFSVLM
CCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
SLLIPWMYKGDTFYGNFTNDPLAVTVKIFAVLITLAILPFASSYFSAKKSFYGEFYYILA
HHHHHHHCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FTLLGVFVLASTYNLIILYVALELVSVGFYILTALLRGSTEAKEGAFKYLILGGLSIALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
SYGAAFMYIYSGSLDLREILTYQGKDIHYLVLGLVFFLIGLAVKIGAVPFHYWVPDAYQG
HHCHHEEEEEECCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCC
APTPVTALMASVGKLAFFIPLVRVMPLVQEKFSLVWTITVGVIAALTMLYGNLVALVQKD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKRLLAYSSIAHSGYIMAGAAVAKVIGMKAVIYFLVAYAVMSAGAFLVLALMEKNPEWQN
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHH
YMENFYGLRFNAPYIAFAFFVYMVALLGVPPTVGFVGKALVFMALSFDKLWWLAFIMILS
HHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAISTGYYIRLVVVMYMHEREKEIRSAPSHLGEKFSLFALTLASVLLGVLPSLVWFLIKQ
HHHHCCHHHHHHHHHHHHHHHHHHHHCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SAENLFTG
HHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9537320