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The map label for this gene is nuoL1 [H]

Identifier: 15606524

GI number: 15606524

Start: 933532

End: 935400

Strand: Direct

Name: nuoL1 [H]

Synonym: aq_1320

Alternate gene names: 15606524

Gene position: 933532-935400 (Clockwise)

Preceding gene: 15606523

Following gene: 15606525

Centisome position: 60.18

GC content: 46.6

Gene sequence:

>1869_bases
TTGAGCATGATGGTGGAGTTGGGGGTTATCTTCACACCACTGATAGCATTTTTAATAATATTGCTCTTCGGAAGAAAGAT
AGGAGATTTAGGAAGCGGGATAATAGCGTCAGTAGGAGCAGGACTTACAACTCTTTTCTCCTTGGTAGTCGCCCTCAAAG
CCATTCACTCTCCCGTTCACGTCAAACTCTATGACTTCCTCCCAATTGGCAATTACACACTCTCCCTCGGATTTTACTTT
GACTCACTCTCTTCCTTGATGGCACTTGTCGTCACATTCGTTGCCACTCTCATATTCGTCTACTCAATCGGCTACATGCG
TGACGAGTTCGGCAAATGGGTCTTCAAGTTCTACGCTTACCTATCACTCTTCCTCTTCGCTATGCTCCTTATCGTGCTCT
CGGACAACCTCCTCGGAATCTTCTTCGGCTGGGAAGGTGTGGGACTTGCTTCATACCTCCTTATCGGATACTACCACGAA
CAAAAAAAAGCTACAAAAGCTTCCTTTGAAGCCTTCGTTATGAACAGAATAGGTGACTGGCTCTTTATCTTCGGTATCAT
CTACTCCTTTTATCTCTTCAAAACCTTAGAAATCACTCAAATATTCCCCAAAGTTGAAGAAGTAGACAAGTACGCTCTTG
GCGTTGCCACAATGCTCCTCTTTGGAGGAGCAGTCGGAAAGTCGGGACAATTTCCGCTTCATACGTGGCTACCAAACGCA
ATGGCAGGTCCCACTCCAGTTTCTGCACTCCTTCACGCAGCCACGATGGTAGCAGCTGGTGTCTACATGGTAGCAAGACT
CTATCCCATGTTTGAAGCAACACCTCAAACGCTAAAACTCATAGTGCTTATCGGAGCGATAACCATGACAATGGCAGCAC
TCGCAGGTGCTGTTCACAACGACATAAAGAAGATAATCGCATTTTCAACGATGAGTCAGCTCGGATACATGTTTGTTGCT
CTGGGAGTGGGGGACAAGGGCGGAGCGATGTTCCACCTCACCACTCACGCTTTCTTCAAAGCCCTCCTGTTTTTAGCGGC
TGGTGCTGTAATAACAGCGTTCCACCACCACCTTTACGACATCTTCAAGATGGGAGGGCTAAAGAAGTACATGCCTGTGA
CTTATGTGGCGTTTATGATAGGGGCACTTAGTTTGGCAGGAGTGTTTCCCTTCAGTGGTTTCTGGAGTAAAGACAGGATA
GTGGCGAGCATGTACGAGTGGAGCGGAGTGCTTGGAGTTCTTGGAACGATAGTGGCGTTTATAACTGCATATTACGCGTT
CAGGGAAGGATTTTTGGTGTTTCACGGAAGAGAGAGATGGAGGGAGATATACGATAAAGACGTTCATGAAGTAGAGGGAG
TGATGACGGTACCTATGGGGCTATTAGGATTTTTGACCGTTCTCACAGGGCTATTTGGTCTTTGGCTAGAGCACTGGTAT
GTAGGCTTGATAGGAGGGGAGGAGAAGGGGATACACCTGAGTGTTGCGCTAGTGTCGCTCGGAGTGGCAATAGCTGGGAT
ATGGCTTCCGTGGCCGGTATATGTGAAGAAGGTGATAGATTACAACAAAGCGTATGAATCTTTGAAGTTTATACACACGA
CTTTCAAGGAGCAATTCTTTACTGAAAAGCTCTACCACAACGTTGTTGCGGGTGGGTACCTTACTTACTCAAGGAGTCTG
TATTCCACCGTTGAAAGGCTTTTTATAGACGGTATTGTGAACGCTACGTATCCGATTGTGGAACTCCTGGGAAGTGTGCT
AAAGTTCTTCCAGAACGGAAGGCTCAGCTGGTACGTGATGGGTCTTGCCACGGGATTGACTATAATTGTCCTTATACTTT
TTGCAATAACGATTAGAGGAGGGCTGTAA

Upstream 100 bases:

>100_bases
CGGTGGCTGCGGCGGAAGTTGCGGTAGGGCTTGGTTTAATAGTCGCCATATTCAGGCTCAAAGGTTATGAAGCTTCTCAT
GAGATTTCTCAGTTGAGGGA

Downstream 100 bases:

>100_bases
TGGAAACTCTCTTAAACGTTGCCATATTCCTTCCATTGGTGGGGGCACTGCTTGTCGCCGTAATAAGAAACGAAATTTTT
GCCAAAGTTGCTTCCATACT

Product: NADH dehydrogenase I chain L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 622; Mature: 621

Protein sequence:

>622_residues
MSMMVELGVIFTPLIAFLIILLFGRKIGDLGSGIIASVGAGLTTLFSLVVALKAIHSPVHVKLYDFLPIGNYTLSLGFYF
DSLSSLMALVVTFVATLIFVYSIGYMRDEFGKWVFKFYAYLSLFLFAMLLIVLSDNLLGIFFGWEGVGLASYLLIGYYHE
QKKATKASFEAFVMNRIGDWLFIFGIIYSFYLFKTLEITQIFPKVEEVDKYALGVATMLLFGGAVGKSGQFPLHTWLPNA
MAGPTPVSALLHAATMVAAGVYMVARLYPMFEATPQTLKLIVLIGAITMTMAALAGAVHNDIKKIIAFSTMSQLGYMFVA
LGVGDKGGAMFHLTTHAFFKALLFLAAGAVITAFHHHLYDIFKMGGLKKYMPVTYVAFMIGALSLAGVFPFSGFWSKDRI
VASMYEWSGVLGVLGTIVAFITAYYAFREGFLVFHGRERWREIYDKDVHEVEGVMTVPMGLLGFLTVLTGLFGLWLEHWY
VGLIGGEEKGIHLSVALVSLGVAIAGIWLPWPVYVKKVIDYNKAYESLKFIHTTFKEQFFTEKLYHNVVAGGYLTYSRSL
YSTVERLFIDGIVNATYPIVELLGSVLKFFQNGRLSWYVMGLATGLTIIVLILFAITIRGGL

Sequences:

>Translated_622_residues
MSMMVELGVIFTPLIAFLIILLFGRKIGDLGSGIIASVGAGLTTLFSLVVALKAIHSPVHVKLYDFLPIGNYTLSLGFYF
DSLSSLMALVVTFVATLIFVYSIGYMRDEFGKWVFKFYAYLSLFLFAMLLIVLSDNLLGIFFGWEGVGLASYLLIGYYHE
QKKATKASFEAFVMNRIGDWLFIFGIIYSFYLFKTLEITQIFPKVEEVDKYALGVATMLLFGGAVGKSGQFPLHTWLPNA
MAGPTPVSALLHAATMVAAGVYMVARLYPMFEATPQTLKLIVLIGAITMTMAALAGAVHNDIKKIIAFSTMSQLGYMFVA
LGVGDKGGAMFHLTTHAFFKALLFLAAGAVITAFHHHLYDIFKMGGLKKYMPVTYVAFMIGALSLAGVFPFSGFWSKDRI
VASMYEWSGVLGVLGTIVAFITAYYAFREGFLVFHGRERWREIYDKDVHEVEGVMTVPMGLLGFLTVLTGLFGLWLEHWY
VGLIGGEEKGIHLSVALVSLGVAIAGIWLPWPVYVKKVIDYNKAYESLKFIHTTFKEQFFTEKLYHNVVAGGYLTYSRSL
YSTVERLFIDGIVNATYPIVELLGSVLKFFQNGRLSWYVMGLATGLTIIVLILFAITIRGGL
>Mature_621_residues
SMMVELGVIFTPLIAFLIILLFGRKIGDLGSGIIASVGAGLTTLFSLVVALKAIHSPVHVKLYDFLPIGNYTLSLGFYFD
SLSSLMALVVTFVATLIFVYSIGYMRDEFGKWVFKFYAYLSLFLFAMLLIVLSDNLLGIFFGWEGVGLASYLLIGYYHEQ
KKATKASFEAFVMNRIGDWLFIFGIIYSFYLFKTLEITQIFPKVEEVDKYALGVATMLLFGGAVGKSGQFPLHTWLPNAM
AGPTPVSALLHAATMVAAGVYMVARLYPMFEATPQTLKLIVLIGAITMTMAALAGAVHNDIKKIIAFSTMSQLGYMFVAL
GVGDKGGAMFHLTTHAFFKALLFLAAGAVITAFHHHLYDIFKMGGLKKYMPVTYVAFMIGALSLAGVFPFSGFWSKDRIV
ASMYEWSGVLGVLGTIVAFITAYYAFREGFLVFHGRERWREIYDKDVHEVEGVMTVPMGLLGFLTVLTGLFGLWLEHWYV
GLIGGEEKGIHLSVALVSLGVAIAGIWLPWPVYVKKVIDYNKAYESLKFIHTTFKEQFFTEKLYHNVVAGGYLTYSRSLY
STVERLFIDGIVNATYPIVELLGSVLKFFQNGRLSWYVMGLATGLTIIVLILFAITIRGGL

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=392, Percent_Identity=38.5204081632653, Blast_Score=251, Evalue=2e-66,
Organism=Escherichia coli, GI1788614, Length=611, Percent_Identity=38.7888707037643, Blast_Score=342, Evalue=4e-95,
Organism=Escherichia coli, GI1788829, Length=382, Percent_Identity=34.0314136125654, Blast_Score=156, Evalue=5e-39,
Organism=Escherichia coli, GI1788827, Length=443, Percent_Identity=29.5711060948081, Blast_Score=143, Evalue=4e-35,
Organism=Escherichia coli, GI1788831, Length=340, Percent_Identity=30, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI2367154, Length=335, Percent_Identity=25.9701492537313, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1788613, Length=382, Percent_Identity=23.2984293193717, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI145693160, Length=326, Percent_Identity=24.8466257668712, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR002128
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01010 Oxidored_q1_C; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 68942; Mature: 68811

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SMMVELGVIFTPLIAFLIILLFGRKIGDLGSGIIASVGAGLTTLFSLVVALKAIHSPVH
CHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCE
VKLYDFLPIGNYTLSLGFYFDSLSSLMALVVTFVATLIFVYSIGYMRDEFGKWVFKFYAY
EEEEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSLFLFAMLLIVLSDNLLGIFFGWEGVGLASYLLIGYYHEQKKATKASFEAFVMNRIGDW
HHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFIFGIIYSFYLFKTLEITQIFPKVEEVDKYALGVATMLLFGGAVGKSGQFPLHTWLPNA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCC
MAGPTPVSALLHAATMVAAGVYMVARLYPMFEATPQTLKLIVLIGAITMTMAALAGAVHN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DIKKIIAFSTMSQLGYMFVALGVGDKGGAMFHLTTHAFFKALLFLAAGAVITAFHHHLYD
HHHHHHHHHHHHHHHHHHHEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFKMGGLKKYMPVTYVAFMIGALSLAGVFPFSGFWSKDRIVASMYEWSGVLGVLGTIVAF
HHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ITAYYAFREGFLVFHGRERWREIYDKDVHEVEGVMTVPMGLLGFLTVLTGLFGLWLEHWY
HHHHHHHHCCCEEEECHHHHHHHHHCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGLIGGEEKGIHLSVALVSLGVAIAGIWLPWPVYVKKVIDYNKAYESLKFIHTTFKEQFF
EEEECCCCCCEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TEKLYHNVVAGGYLTYSRSLYSTVERLFIDGIVNATYPIVELLGSVLKFFQNGRLSWYVM
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEHH
GLATGLTIIVLILFAITIRGGL
HHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]