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The map label for this gene is nuoM1 [H]

Identifier: 15606525

GI number: 15606525

Start: 935400

End: 936875

Strand: Direct

Name: nuoM1 [H]

Synonym: aq_1321

Alternate gene names: 15606525

Gene position: 935400-936875 (Clockwise)

Preceding gene: 15606524

Following gene: 15606526

Centisome position: 60.3

GC content: 45.26

Gene sequence:

>1476_bases
ATGGAAACTCTCTTAAACGTTGCCATATTCCTTCCATTGGTGGGGGCACTGCTTGTCGCCGTAATAAGAAACGAAATTTT
TGCCAAAGTTGCTTCCATACTCATAGGTGCCGTTGTAGCGCTAATATCCCTGGTCCTCTTCGTTAACTTTGATTTCAGTA
AAAAAGGGTTTCAGTTTGAAACATACGTTCCGTGGATAAAGACCTTAGGCATAGGCTACCACGTAGGCGTTGACGGAATG
GCGATAAGCCTTATCCTCATGACTTCCATCCTCTTTCTCGCCGCATATATATGGTCCTGGAAGATAGAAGACAGACCTTC
CCTCTACTTTGCCCTCTTCCTGGCACTGGAAACCGCCTGTATAGGTGTTTTCGCAGCACTGGACTTATTTCTCTTTTACC
TGTTCTGGGAAGGAATGCTCATTCCTATGTACTTCATAATCGGTTTCTGGGGACACGACAGGAAGGTTTACGCGGCTAAT
AAGTTCTTCCTTTACACCTTCTTCGGTTCTCTGTTTCTTCTCCTCGGTATTGCTTCTATACTCGTTTATGGATACTTTGA
AACGGGTAAGATTTCCTTTGATTACTTTTTCCACCTCGGACTTGATTACCCCCTTTGGCTTGAGCTTATAGCTTTCCTGT
TATTCGGTATTGGTTTTGCGGTAAAGATACCCATGTGGCCCTTCCATACATGGCTTCCGGACGCTCACGTTGAAGCTCCT
ACCGCAGGTTCCGTAATACTTGCAGGTGTTCTCCTTAAGATGGGAACTTACGGTTTTGTAAGATTTTCCCTGCCCTTCTT
CCCAGAAGCCTCTAAGTACTATATACCCCTTATATTCACACTCAGCGTAGTTGCAGTTATATACGCTGCCATGATGGCTA
TAGCTCAAACACACATGAAGAGACTCATTGCTTACTCTTCAATATCTCACATGGGACTCGTTACACTCGGAACCTTTGCT
ATGAACAGCGATGCCTTGAACGGTGCGATTTACCTCATGATAGCTCACGGGCTTTCTTCCGCGGCTCTCTTCCTAGGAGC
TGGCTTTATATACGACAGGATACACTCTTACCACATGGATGACCTGGGCGGTCTTGCGAGATACATACCTTACTTTACCT
TTGCCTTCTTTCTTGCGGTTCTTGCCGGTATAGCGTTCCCCGGATTTGCGAGCTTCGTTTCTGAATTCCTTATACTCCTA
GGCATATTTGAAAAGTTCCCCGTATGGGCTTTTGTTGCAGGTATAGGTATGGTTCTGGGAGCGGCATACTCGCTATACAT
GTTCAGAAAGGTAATGCTGGAAGAGGAGAGTATTCCCGAGGAAAGAGTAGAAAAGTGGAAGAAGTTGAAAGACTTGGAAC
TCCACCACGCTATTCCCTTTGCACTGATAATTGGCATGGCTCTCGTTATGGGAATATACCCTTATCCCTTTGTGAAGATA
GTGGAACACACTTCTAAACTCGTGTTCGGAGGTTGA

Upstream 100 bases:

>100_bases
TCCAGAACGGAAGGCTCAGCTGGTACGTGATGGGTCTTGCCACGGGATTGACTATAATTGTCCTTATACTTTTTGCAATA
ACGATTAGAGGAGGGCTGTA

Downstream 100 bases:

>100_bases
AGCCTTGAACTGGAACGCTATACTTCCCGAAGCCATACTCGCAATAGGAATTCTCACGGTTTTCATACTTGAGCTATTCC
TTGAAAGGAAGCATTACAAG

Product: NADH dehydrogenase I chain M

Products: NA

Alternate protein names: NADH dehydrogenase I, chain 13; NDH-1, chain 13 [H]

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
METLLNVAIFLPLVGALLVAVIRNEIFAKVASILIGAVVALISLVLFVNFDFSKKGFQFETYVPWIKTLGIGYHVGVDGM
AISLILMTSILFLAAYIWSWKIEDRPSLYFALFLALETACIGVFAALDLFLFYLFWEGMLIPMYFIIGFWGHDRKVYAAN
KFFLYTFFGSLFLLLGIASILVYGYFETGKISFDYFFHLGLDYPLWLELIAFLLFGIGFAVKIPMWPFHTWLPDAHVEAP
TAGSVILAGVLLKMGTYGFVRFSLPFFPEASKYYIPLIFTLSVVAVIYAAMMAIAQTHMKRLIAYSSISHMGLVTLGTFA
MNSDALNGAIYLMIAHGLSSAALFLGAGFIYDRIHSYHMDDLGGLARYIPYFTFAFFLAVLAGIAFPGFASFVSEFLILL
GIFEKFPVWAFVAGIGMVLGAAYSLYMFRKVMLEEESIPEERVEKWKKLKDLELHHAIPFALIIGMALVMGIYPYPFVKI
VEHTSKLVFGG

Sequences:

>Translated_491_residues
METLLNVAIFLPLVGALLVAVIRNEIFAKVASILIGAVVALISLVLFVNFDFSKKGFQFETYVPWIKTLGIGYHVGVDGM
AISLILMTSILFLAAYIWSWKIEDRPSLYFALFLALETACIGVFAALDLFLFYLFWEGMLIPMYFIIGFWGHDRKVYAAN
KFFLYTFFGSLFLLLGIASILVYGYFETGKISFDYFFHLGLDYPLWLELIAFLLFGIGFAVKIPMWPFHTWLPDAHVEAP
TAGSVILAGVLLKMGTYGFVRFSLPFFPEASKYYIPLIFTLSVVAVIYAAMMAIAQTHMKRLIAYSSISHMGLVTLGTFA
MNSDALNGAIYLMIAHGLSSAALFLGAGFIYDRIHSYHMDDLGGLARYIPYFTFAFFLAVLAGIAFPGFASFVSEFLILL
GIFEKFPVWAFVAGIGMVLGAAYSLYMFRKVMLEEESIPEERVEKWKKLKDLELHHAIPFALIIGMALVMGIYPYPFVKI
VEHTSKLVFGG
>Mature_491_residues
METLLNVAIFLPLVGALLVAVIRNEIFAKVASILIGAVVALISLVLFVNFDFSKKGFQFETYVPWIKTLGIGYHVGVDGM
AISLILMTSILFLAAYIWSWKIEDRPSLYFALFLALETACIGVFAALDLFLFYLFWEGMLIPMYFIIGFWGHDRKVYAAN
KFFLYTFFGSLFLLLGIASILVYGYFETGKISFDYFFHLGLDYPLWLELIAFLLFGIGFAVKIPMWPFHTWLPDAHVEAP
TAGSVILAGVLLKMGTYGFVRFSLPFFPEASKYYIPLIFTLSVVAVIYAAMMAIAQTHMKRLIAYSSISHMGLVTLGTFA
MNSDALNGAIYLMIAHGLSSAALFLGAGFIYDRIHSYHMDDLGGLARYIPYFTFAFFLAVLAGIAFPGFASFVSEFLILL
GIFEKFPVWAFVAGIGMVLGAAYSLYMFRKVMLEEESIPEERVEKWKKLKDLELHHAIPFALIIGMALVMGIYPYPFVKI
VEHTSKLVFGG

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=330, Percent_Identity=36.969696969697, Blast_Score=187, Evalue=2e-47,
Organism=Escherichia coli, GI1788613, Length=500, Percent_Identity=37.4, Blast_Score=291, Evalue=9e-80,
Organism=Escherichia coli, GI1788614, Length=514, Percent_Identity=28.5992217898833, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI1788827, Length=282, Percent_Identity=28.0141843971631, Blast_Score=115, Evalue=7e-27,
Organism=Escherichia coli, GI1788831, Length=378, Percent_Identity=26.1904761904762, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI145693160, Length=435, Percent_Identity=26.4367816091954, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788829, Length=424, Percent_Identity=26.6509433962264, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI2367154, Length=238, Percent_Identity=24.7899159663866, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918
- InterPro:   IPR000260 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01059 Oxidored_q5_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 55034; Mature: 55034

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METLLNVAIFLPLVGALLVAVIRNEIFAKVASILIGAVVALISLVLFVNFDFSKKGFQFE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEH
TYVPWIKTLGIGYHVGVDGMAISLILMTSILFLAAYIWSWKIEDRPSLYFALFLALETAC
HHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
IGVFAALDLFLFYLFWEGMLIPMYFIIGFWGHDRKVYAANKFFLYTFFGSLFLLLGIASI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHH
LVYGYFETGKISFDYFFHLGLDYPLWLELIAFLLFGIGFAVKIPMWPFHTWLPDAHVEAP
HHHHCCCCCCEEEEEHEEECCCCHHHHHHHHHHHHHCCHHEECCCCCCHHCCCCCCCCCC
TAGSVILAGVLLKMGTYGFVRFSLPFFPEASKYYIPLIFTLSVVAVIYAAMMAIAQTHMK
CCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLIAYSSISHMGLVTLGTFAMNSDALNGAIYLMIAHGLSSAALFLGAGFIYDRIHSYHMD
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHCCHHHHHHHHHHHHHHHHHHCCHH
DLGGLARYIPYFTFAFFLAVLAGIAFPGFASFVSEFLILLGIFEKFPVWAFVAGIGMVLG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAYSLYMFRKVMLEEESIPEERVEKWKKLKDLELHHAIPFALIIGMALVMGIYPYPFVKI
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHH
VEHTSKLVFGG
HHHHHHHHCCC
>Mature Secondary Structure
METLLNVAIFLPLVGALLVAVIRNEIFAKVASILIGAVVALISLVLFVNFDFSKKGFQFE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEH
TYVPWIKTLGIGYHVGVDGMAISLILMTSILFLAAYIWSWKIEDRPSLYFALFLALETAC
HHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
IGVFAALDLFLFYLFWEGMLIPMYFIIGFWGHDRKVYAANKFFLYTFFGSLFLLLGIASI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHH
LVYGYFETGKISFDYFFHLGLDYPLWLELIAFLLFGIGFAVKIPMWPFHTWLPDAHVEAP
HHHHCCCCCCEEEEEHEEECCCCHHHHHHHHHHHHHCCHHEECCCCCCHHCCCCCCCCCC
TAGSVILAGVLLKMGTYGFVRFSLPFFPEASKYYIPLIFTLSVVAVIYAAMMAIAQTHMK
CCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLIAYSSISHMGLVTLGTFAMNSDALNGAIYLMIAHGLSSAALFLGAGFIYDRIHSYHMD
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHCCHHHHHHHHHHHHHHHHHHCCHH
DLGGLARYIPYFTFAFFLAVLAGIAFPGFASFVSEFLILLGIFEKFPVWAFVAGIGMVLG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAYSLYMFRKVMLEEESIPEERVEKWKKLKDLELHHAIPFALIIGMALVMGIYPYPFVKI
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHH
VEHTSKLVFGG
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8422400 [H]