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The map label for this gene is nuoH1

Identifier: 15606520

GI number: 15606520

Start: 931120

End: 932130

Strand: Direct

Name: nuoH1

Synonym: aq_1315

Alternate gene names: 15606520

Gene position: 931120-932130 (Clockwise)

Preceding gene: 15606519

Following gene: 15606521

Centisome position: 60.02

GC content: 47.28

Gene sequence:

>1011_bases
ATGGAAGCGATAGCTTACTCTTTAGCCTTTACCTTCTTGAAGATAGTTATAGTCTTTTCCCTGGCTCTCGGTATAGGGGC
TTACCTCACGTGGTTTGAAAGAAAGCTCGCAGGGCACATTCAAAACAGGTTAGGACCAACGGTGGTAGGTAAGTTCGGGA
TACTCCAACCTCTTGCGGACGCCCTAAAGCTCGCAACCAAAGAAGTTATCATCCCTAGAGGAGCGGACAAGCCCGTATAC
TACGCAGCTGTAGTGATGGCTTTAGTTCCGTCCATACTTCTGCTTACGATAATTCCCTTTGGACCGGGTTTTAGAGTGGG
GAATACCTACATAGAGCCCATAATTGCGGACGTGAACATAGCATTACTCCTTGCCTTTGCCTTTGGTTCACTATCGGTTT
ACGGAACAATATTCTCGGGATGGGCTTCAAACTCCAAGTACGCCTTTATAGGTTCACTTAGAAAAGCCGCGGTAGTTATA
GCGTACGAAGTAGTTCTCGGTTTTTCCGTTTTGGGTGTTATTCTTCTTGCGGGTACGCTCAGCACGGTCGGGATAGTTGA
AGCTCAGATACAGAAGGGAGTCTGGTTCATCTTTTACCAGCCTGTGGCTTTTATCCTGTACCTTTTCTGTATGCTTGCTG
AAAGCGGAAGGGTTCCCTTTGACATTCAGGAGGCGGAAGCGGAGCTGGTTACGGGTTACAACGTTGAGTACGGCGGTATG
AAGTTCGGAGCTTTTCCTCTCGCAGAGTGGTACGTAAACGTAATAGCCCTTTCCGCAATAGCTGTAGTTCTCTTCTTCGG
CGGATGGGATGGACCTCACATCTTCGGGCCACTTTCTCCGTACTTCTGGTTCGTGTTCAAGACATTTGCACTGGTTTTCT
TTACTCTATGGCTACACTGGACCTTGCCCAGATTTCAGGCAAAGGACATTACGGAAATTGCCTGGAAGATACTCCTTCCC
ATAGCGATACTTAACGTGATAATTACTGCGGTTGTGGTTTATGCATTTTAG

Upstream 100 bases:

>100_bases
CCCGAAACTCATACAAGGAAGGACGATTGCGGATGCCATAGCACTTCTCGGAAGTCTTGATCCGGTTGTTGGTGAGACGG
ATAGGTAAGGGGGCAAGCGG

Downstream 100 bases:

>100_bases
GAGGATTTAGGATGGGTGTGAAGAAGTTAAGCAGGAAGGATTACTTGAACATACTAGAAAGCATACTTTTTATAGACTTC
CTTAAGGGACTTTCCGTAAC

Product: NADH dehydrogenase I chain H

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MEAIAYSLAFTFLKIVIVFSLALGIGAYLTWFERKLAGHIQNRLGPTVVGKFGILQPLADALKLATKEVIIPRGADKPVY
YAAVVMALVPSILLLTIIPFGPGFRVGNTYIEPIIADVNIALLLAFAFGSLSVYGTIFSGWASNSKYAFIGSLRKAAVVI
AYEVVLGFSVLGVILLAGTLSTVGIVEAQIQKGVWFIFYQPVAFILYLFCMLAESGRVPFDIQEAEAELVTGYNVEYGGM
KFGAFPLAEWYVNVIALSAIAVVLFFGGWDGPHIFGPLSPYFWFVFKTFALVFFTLWLHWTLPRFQAKDITEIAWKILLP
IAILNVIITAVVVYAF

Sequences:

>Translated_336_residues
MEAIAYSLAFTFLKIVIVFSLALGIGAYLTWFERKLAGHIQNRLGPTVVGKFGILQPLADALKLATKEVIIPRGADKPVY
YAAVVMALVPSILLLTIIPFGPGFRVGNTYIEPIIADVNIALLLAFAFGSLSVYGTIFSGWASNSKYAFIGSLRKAAVVI
AYEVVLGFSVLGVILLAGTLSTVGIVEAQIQKGVWFIFYQPVAFILYLFCMLAESGRVPFDIQEAEAELVTGYNVEYGGM
KFGAFPLAEWYVNVIALSAIAVVLFFGGWDGPHIFGPLSPYFWFVFKTFALVFFTLWLHWTLPRFQAKDITEIAWKILLP
IAILNVIITAVVVYAF
>Mature_336_residues
MEAIAYSLAFTFLKIVIVFSLALGIGAYLTWFERKLAGHIQNRLGPTVVGKFGILQPLADALKLATKEVIIPRGADKPVY
YAAVVMALVPSILLLTIIPFGPGFRVGNTYIEPIIADVNIALLLAFAFGSLSVYGTIFSGWASNSKYAFIGSLRKAAVVI
AYEVVLGFSVLGVILLAGTLSTVGIVEAQIQKGVWFIFYQPVAFILYLFCMLAESGRVPFDIQEAEAELVTGYNVEYGGM
KFGAFPLAEWYVNVIALSAIAVVLFFGGWDGPHIFGPLSPYFWFVFKTFALVFFTLWLHWTLPRFQAKDITEIAWKILLP
IAILNVIITAVVVYAF

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=300, Percent_Identity=36.3333333333333, Blast_Score=175, Evalue=6e-44,
Organism=Escherichia coli, GI1788618, Length=323, Percent_Identity=37.7708978328173, Blast_Score=223, Evalue=1e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH_AQUAE (O67336)

Other databases:

- EMBL:   AE000657
- PIR:   E70413
- RefSeq:   NP_213900.1
- GeneID:   1192774
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_1315
- NMPDR:   fig|224324.1.peg.915
- HOGENOM:   HBG727670
- OMA:   MELIVAF
- PhylomeDB:   O67336
- ProtClustDB:   CLSK2299659
- BioCyc:   AAEO224324:AQ_1315-MONOMER
- BRENDA:   1.6.99.5
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 36923; Mature: 36923

Theoretical pI: Translated: 8.33; Mature: 8.33

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xd1b9690)-; HASH(0xd86b8d0)-; HASH(0xd8e2c88)-; HASH(0xcc864a0)-; HASH(0xda2d964)-; HASH(0xdc35094)-; HASH(0xdb6efbc)-; HASH(0x9691ccc)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAIAYSLAFTFLKIVIVFSLALGIGAYLTWFERKLAGHIQNRLGPTVVGKFGILQPLAD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
ALKLATKEVIIPRGADKPVYYAAVVMALVPSILLLTIIPFGPGFRVGNTYIEPIIADVNI
HHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
ALLLAFAFGSLSVYGTIFSGWASNSKYAFIGSLRKAAVVIAYEVVLGFSVLGVILLAGTL
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
STVGIVEAQIQKGVWFIFYQPVAFILYLFCMLAESGRVPFDIQEAEAELVTGYNVEYGGM
HHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEECCE
KFGAFPLAEWYVNVIALSAIAVVLFFGGWDGPHIFGPLSPYFWFVFKTFALVFFTLWLHW
EECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
TLPRFQAKDITEIAWKILLPIAILNVIITAVVVYAF
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure
MEAIAYSLAFTFLKIVIVFSLALGIGAYLTWFERKLAGHIQNRLGPTVVGKFGILQPLAD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
ALKLATKEVIIPRGADKPVYYAAVVMALVPSILLLTIIPFGPGFRVGNTYIEPIIADVNI
HHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
ALLLAFAFGSLSVYGTIFSGWASNSKYAFIGSLRKAAVVIAYEVVLGFSVLGVILLAGTL
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
STVGIVEAQIQKGVWFIFYQPVAFILYLFCMLAESGRVPFDIQEAEAELVTGYNVEYGGM
HHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEECCE
KFGAFPLAEWYVNVIALSAIAVVLFFGGWDGPHIFGPLSPYFWFVFKTFALVFFTLWLHW
EECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
TLPRFQAKDITEIAWKILLPIAILNVIITAVVVYAF
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9537320