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The map label for this gene is nuoD2

Identifier: 15606519

GI number: 15606519

Start: 929347

End: 931107

Strand: Direct

Name: nuoD2

Synonym: aq_1314

Alternate gene names: 15606519

Gene position: 929347-931107 (Clockwise)

Preceding gene: 15606518

Following gene: 15606520

Centisome position: 59.91

GC content: 48.32

Gene sequence:

>1761_bases
ATGAAATGGGTCAATAAGGGAACCGTTGAGAGGGTAAAGCAGGAATTTAAGGACGAAGTAAAGTACTACGAGACAAAACA
CACTAAAGGTTTTGAAGTCTCTCACGATTTTCTCAAGCCATTACTTAAGTTCCTGAAAGAAAGGGAGAGGTTCCTTCACT
TCGTTGATATGACCTGTATAGACTTTCCCGAACATCCAAACAGGTTTCAGGGAGTTTACATACTCTATAACCCTGAGGAA
AACGAAAGGGTAATAGTAAAGAGCTGGGCAAAAGATGGGAAACTCCCGACAGTTGAAGATCTGTGGCCCGGTGCAAAGTG
GGCCGAGCGTGAAGCTTACGACATGTTCGGGGTGGTGTTCGAGGGGCACGAAAACCTCAGACGGATGTTCATGTGGGAAG
GCTATGAGCACTACCCCCTAAGGAAAGACTTTCCCCTTCAGGGAATACCTGAAGTAGAACTTCCCTCCCTGACGGAAGTG
CTTCACGGGAGAACGGACCCGCCCTCTCACGACTTTGAACTCGTTCATACAAAGCTTCCCACCTTAGAGGACCTTGAAAG
AACGGAAAAGGCGAGACTCAAGAAGAAGGCAGAACTCGTTCTCAACTGGGGACCACTTCATCCCGGAACCCACGGAACAA
TATGGTTTTTATTTGACCTTGAGGGTGAAAAGGTTGTTCAGAGTGACGTAATTCTCGGACAGCTACACAGGGGAATGGAA
AAGCTTGCGGAAAACTTGCACTACTTCCAGTTCATTCCCTACACGGACCGTATGGACTACATATCCGCTATATGTAACGA
GCTCGCTTACGTGGAGACCGTGGAAAGACTCCTGGGTGTAGAGGTTCCCGAGAAGGCGAGATACATAAGGACGATGTTTG
CGGAACTCCAGAGGATTAACTCCCACCTCCTCTGGCTCGGAACCGGAGCTCTGGACCTCGGAGCACTCACGGTATTCCTT
TACGCTTTCAGGGAAAGGGAAAAGATAATGGACATAATTGAGGGAAATGCGGGTTACAGACTCACGAGCTGCTTCTTAAG
GATAGGAGGGGTTCACTACGACCTCGCGGAAGGCACTCTGGACGTAGTAAAGCACTTTATAAAAGACTTTCCCAACAGAC
TAAAGGAGTATCACACTCTCCTTACGAGGAACAGGATATGGTTAAGGAGAACTAAGGATGTTGGCGTAATAACGAGGGAA
GACGTTCACAATTATGGGCTTTCCGGGCCCGTTGCAAGAGGCTCGGGTGTTCCCTACGACCTGAGAAAACTCCAGCCGTA
CGCCGCTTACGACGAGGTTGAGTTTGATATACCGGTTGGAGAAGTAGGGGACGTTTACGACAGGTACCTTGTGAGAATGG
AAGAAATGGCCCAAAGTGTGAGGATAATTGAGCAGTGTGTTCAGAAGCTTGAAAAACTTCCCAAAGACGCTCCATACCTA
AACAAGGAACACCCTGCGGTAATTCCGCCCAAAGAAGACGTATTCCACGACCTTGAGAGCATGGTAAAGTCCTTTAGAGT
TGTTGTTCACGGTGAAGATGCACCGCCCGGAGAGGTTTACTTTGCCGGTGAAAACCCCAGAGGAGAGCTGGGCTTCTTCA
TCTACTCAAAAGGTGGCGGGAAACCTTACAGAACACGTATACGTTCGGGAGCTCTTTACAACTTATCTATATTCCCGAAA
CTCATACAAGGAAGGACGATTGCGGATGCCATAGCACTTCTCGGAAGTCTTGATCCGGTTGTTGGTGAGACGGATAGGTA
A

Upstream 100 bases:

>100_bases
AGGAATAACAAAGTACGATAAACTCTTCGCAGACTTCAACAGGGAAATAGAGAAGGAAGGTATTTTCGTTCCCAGAGAAC
TAAAGGTGTGAGGATAACTT

Downstream 100 bases:

>100_bases
GGGGGCAAGCGGATGGAAGCGATAGCTTACTCTTTAGCCTTTACCTTCTTGAAGATAGTTATAGTCTTTTCCCTGGCTCT
CGGTATAGGGGCTTACCTCA

Product: NADH dehydrogenase I chain D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit C/D 2; NDH-1 subunit C/D 2

Number of amino acids: Translated: 586; Mature: 586

Protein sequence:

>586_residues
MKWVNKGTVERVKQEFKDEVKYYETKHTKGFEVSHDFLKPLLKFLKERERFLHFVDMTCIDFPEHPNRFQGVYILYNPEE
NERVIVKSWAKDGKLPTVEDLWPGAKWAEREAYDMFGVVFEGHENLRRMFMWEGYEHYPLRKDFPLQGIPEVELPSLTEV
LHGRTDPPSHDFELVHTKLPTLEDLERTEKARLKKKAELVLNWGPLHPGTHGTIWFLFDLEGEKVVQSDVILGQLHRGME
KLAENLHYFQFIPYTDRMDYISAICNELAYVETVERLLGVEVPEKARYIRTMFAELQRINSHLLWLGTGALDLGALTVFL
YAFREREKIMDIIEGNAGYRLTSCFLRIGGVHYDLAEGTLDVVKHFIKDFPNRLKEYHTLLTRNRIWLRRTKDVGVITRE
DVHNYGLSGPVARGSGVPYDLRKLQPYAAYDEVEFDIPVGEVGDVYDRYLVRMEEMAQSVRIIEQCVQKLEKLPKDAPYL
NKEHPAVIPPKEDVFHDLESMVKSFRVVVHGEDAPPGEVYFAGENPRGELGFFIYSKGGGKPYRTRIRSGALYNLSIFPK
LIQGRTIADAIALLGSLDPVVGETDR

Sequences:

>Translated_586_residues
MKWVNKGTVERVKQEFKDEVKYYETKHTKGFEVSHDFLKPLLKFLKERERFLHFVDMTCIDFPEHPNRFQGVYILYNPEE
NERVIVKSWAKDGKLPTVEDLWPGAKWAEREAYDMFGVVFEGHENLRRMFMWEGYEHYPLRKDFPLQGIPEVELPSLTEV
LHGRTDPPSHDFELVHTKLPTLEDLERTEKARLKKKAELVLNWGPLHPGTHGTIWFLFDLEGEKVVQSDVILGQLHRGME
KLAENLHYFQFIPYTDRMDYISAICNELAYVETVERLLGVEVPEKARYIRTMFAELQRINSHLLWLGTGALDLGALTVFL
YAFREREKIMDIIEGNAGYRLTSCFLRIGGVHYDLAEGTLDVVKHFIKDFPNRLKEYHTLLTRNRIWLRRTKDVGVITRE
DVHNYGLSGPVARGSGVPYDLRKLQPYAAYDEVEFDIPVGEVGDVYDRYLVRMEEMAQSVRIIEQCVQKLEKLPKDAPYL
NKEHPAVIPPKEDVFHDLESMVKSFRVVVHGEDAPPGEVYFAGENPRGELGFFIYSKGGGKPYRTRIRSGALYNLSIFPK
LIQGRTIADAIALLGSLDPVVGETDR
>Mature_586_residues
MKWVNKGTVERVKQEFKDEVKYYETKHTKGFEVSHDFLKPLLKFLKERERFLHFVDMTCIDFPEHPNRFQGVYILYNPEE
NERVIVKSWAKDGKLPTVEDLWPGAKWAEREAYDMFGVVFEGHENLRRMFMWEGYEHYPLRKDFPLQGIPEVELPSLTEV
LHGRTDPPSHDFELVHTKLPTLEDLERTEKARLKKKAELVLNWGPLHPGTHGTIWFLFDLEGEKVVQSDVILGQLHRGME
KLAENLHYFQFIPYTDRMDYISAICNELAYVETVERLLGVEVPEKARYIRTMFAELQRINSHLLWLGTGALDLGALTVFL
YAFREREKIMDIIEGNAGYRLTSCFLRIGGVHYDLAEGTLDVVKHFIKDFPNRLKEYHTLLTRNRIWLRRTKDVGVITRE
DVHNYGLSGPVARGSGVPYDLRKLQPYAAYDEVEFDIPVGEVGDVYDRYLVRMEEMAQSVRIIEQCVQKLEKLPKDAPYL
NKEHPAVIPPKEDVFHDLESMVKSFRVVVHGEDAPPGEVYFAGENPRGELGFFIYSKGGGKPYRTRIRSGALYNLSIFPK
LIQGRTIADAIALLGSLDPVVGETDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=415, Percent_Identity=44.0963855421687, Blast_Score=349, Evalue=5e-96,
Organism=Homo sapiens, GI260898743, Length=410, Percent_Identity=43.6585365853659, Blast_Score=339, Evalue=4e-93,
Organism=Homo sapiens, GI4758788, Length=120, Percent_Identity=39.1666666666667, Blast_Score=88, Evalue=2e-17,
Organism=Escherichia coli, GI145693162, Length=532, Percent_Identity=35.1503759398496, Blast_Score=332, Evalue=5e-92,
Organism=Escherichia coli, GI1789076, Length=578, Percent_Identity=26.2975778546713, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1788832, Length=529, Percent_Identity=29.3005671077505, Blast_Score=159, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17568379, Length=407, Percent_Identity=41.2776412776413, Blast_Score=343, Evalue=1e-94,
Organism=Caenorhabditis elegans, GI17555284, Length=407, Percent_Identity=41.5233415233415, Blast_Score=343, Evalue=1e-94,
Organism=Caenorhabditis elegans, GI71990788, Length=127, Percent_Identity=37.7952755905512, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI32563621, Length=127, Percent_Identity=37.7952755905512, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24638644, Length=394, Percent_Identity=44.6700507614213, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI221459469, Length=388, Percent_Identity=43.8144329896907, Blast_Score=344, Evalue=9e-95,
Organism=Drosophila melanogaster, GI24656494, Length=116, Percent_Identity=38.7931034482759, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUCD2_AQUAE (O67335)

Other databases:

- EMBL:   AE000657
- PIR:   D70413
- RefSeq:   NP_213899.1
- HSSP:   Q56220
- ProteinModelPortal:   O67335
- GeneID:   1192773
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_1314
- NMPDR:   fig|224324.1.peg.914
- HOGENOM:   HBG459705
- OMA:   GVFIQGN
- PhylomeDB:   O67335
- ProtClustDB:   CLSK233270
- BioCyc:   AAEO224324:AQ_1314-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01397
- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR001268
- InterPro:   IPR022885
- ProDom:   PD001581
- TIGRFAMs:   TIGR01962

Pfam domain/function: PF00329 Complex1_30kDa; PF00346 Complex1_49kDa

EC number: =1.6.99.5

Molecular weight: Translated: 67894; Mature: 67894

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00542 COMPLEX1_30K; PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKWVNKGTVERVKQEFKDEVKYYETKHTKGFEVSHDFLKPLLKFLKERERFLHFVDMTCI
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
DFPEHPNRFQGVYILYNPEENERVIVKSWAKDGKLPTVEDLWPGAKWAEREAYDMFGVVF
CCCCCCCCCCEEEEEECCCCCCEEEEEECCCCCCCCCHHHHCCCCCHHHHHHHHHHHHEE
EGHENLRRMFMWEGYEHYPLRKDFPLQGIPEVELPSLTEVLHGRTDPPSHDFELVHTKLP
CCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCEEHHHCCC
TLEDLERTEKARLKKKAELVLNWGPLHPGTHGTIWFLFDLEGEKVVQSDVILGQLHRGME
CHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHH
KLAENLHYFQFIPYTDRMDYISAICNELAYVETVERLLGVEVPEKARYIRTMFAELQRIN
HHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHC
SHLLWLGTGALDLGALTVFLYAFREREKIMDIIEGNAGYRLTSCFLRIGGVHYDLAEGTL
CCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCEEEEHHCCHH
DVVKHFIKDFPNRLKEYHTLLTRNRIWLRRTKDVGVITREDVHNYGLSGPVARGSGVPYD
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEHHHHHHCCCCCCCCCCCCCCHH
LRKLQPYAAYDEVEFDIPVGEVGDVYDRYLVRMEEMAQSVRIIEQCVQKLEKLPKDAPYL
HHHCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
NKEHPAVIPPKEDVFHDLESMVKSFRVVVHGEDAPPGEVYFAGENPRGELGFFIYSKGGG
CCCCCCCCCCHHHHHHHHHHHHHHCEEEEECCCCCCCCEEECCCCCCCCEEEEEEECCCC
KPYRTRIRSGALYNLSIFPKLIQGRTIADAIALLGSLDPVVGETDR
CHHHHHHCCCCEEEHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MKWVNKGTVERVKQEFKDEVKYYETKHTKGFEVSHDFLKPLLKFLKERERFLHFVDMTCI
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
DFPEHPNRFQGVYILYNPEENERVIVKSWAKDGKLPTVEDLWPGAKWAEREAYDMFGVVF
CCCCCCCCCCEEEEEECCCCCCEEEEEECCCCCCCCCHHHHCCCCCHHHHHHHHHHHHEE
EGHENLRRMFMWEGYEHYPLRKDFPLQGIPEVELPSLTEVLHGRTDPPSHDFELVHTKLP
CCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCEEHHHCCC
TLEDLERTEKARLKKKAELVLNWGPLHPGTHGTIWFLFDLEGEKVVQSDVILGQLHRGME
CHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHH
KLAENLHYFQFIPYTDRMDYISAICNELAYVETVERLLGVEVPEKARYIRTMFAELQRIN
HHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHC
SHLLWLGTGALDLGALTVFLYAFREREKIMDIIEGNAGYRLTSCFLRIGGVHYDLAEGTL
CCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCEEEEHHCCHH
DVVKHFIKDFPNRLKEYHTLLTRNRIWLRRTKDVGVITREDVHNYGLSGPVARGSGVPYD
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEHHHHHHCCCCCCCCCCCCCCHH
LRKLQPYAAYDEVEFDIPVGEVGDVYDRYLVRMEEMAQSVRIIEQCVQKLEKLPKDAPYL
HHHCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
NKEHPAVIPPKEDVFHDLESMVKSFRVVVHGEDAPPGEVYFAGENPRGELGFFIYSKGGG
CCCCCCCCCCHHHHHHHHHHHHHHCEEEEECCCCCCCCEEECCCCCCCCEEEEEEECCCC
KPYRTRIRSGALYNLSIFPKLIQGRTIADAIALLGSLDPVVGETDR
CHHHHHHCCCCEEEHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9537320