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The map label for this gene is murA

Identifier: 15606499

GI number: 15606499

Start: 906163

End: 907440

Strand: Direct

Name: murA

Synonym: aq_1281

Alternate gene names: 15606499

Gene position: 906163-907440 (Clockwise)

Preceding gene: 15606498

Following gene: 15606507

Centisome position: 58.41

GC content: 46.09

Gene sequence:

>1278_bases
ATGAAGAACACCACATTATATACTTACCGTGATTACTTCGTTATAAGGGGAGGAAAGCCCCTTACCGGGAAGGTAAAAAT
TTCGGGGGCAAAGAACGCTGCCCTCCCCATTATGTTTGCAACGATCCTTACGGAAGAACCCTGCACCATTACAAACGTTC
CGGATCTCCTTGATGTAAGAAATACTCTACTTTTGCTTCGGGAACTTGGAGCAGAGCTTGAGTTTTTAAACAACACCGTT
TTTATAAATCCATCTATTAACTCCTTTATTACAAATCAGGAAATCATAAGGCGCATGCGTGCTTCCGTTTTGAGCCTTGG
TCCCCTTCTCGGGAGATTTGGAAGGGCGGTCGTTGGACTTCCCGGCGGTTGTTCTATAGGAGCGAGACCAATAGACCAGC
ACCTGAAGTTTTTCAAAGAAGCTGGTGCAGATGTAGAGGTCAGGGAGGGGTACGTATACGTAAACTTGAAGGAAAAGAGG
AGAGTTCACTTTAAATTTGACCTCGTTACCGTCACGGGAACTGAAAACGCACTACTTTATCTGGCAAGCGTTCCCGAAGA
GAGCATCCTTGAAAATATTGCCTTAGAACCCGAAGTAATGGATTTAATAGAAGTCTTGAAGAAAATGGGAGCACATGTAA
AAGTTGAAGGGAGGAGTGCTTACGTAAAAGGTTCTGAAAACTTGAAAGGGTTTACTCACTCGGTTATTCCCGACAGGATA
GAGGCTGGCACTTTTATGGTCGGGGCTGTGCTAACGGACGGAGAAATCCTTCTGGAAAACGCGAGAATAAATCACCTCAG
AGCGGTTGTAGAGAAGTTAAAACTTATCGGAGGAGAGGTTGTGGAAGAAAACGGGAACTTGAGGGTATTCAGGAAGGAAA
GTTTAAGGGCTTGTGATATAGAAACTCAGGTTTACCCGGGATTTCCCACGGATATGCAGGCCCAGTTCATGGCACTCCTT
TCGGTAGCAAAGGGGAAATCAAGGATAAAGGAAAACATCTTTGAACACAGGTTTCACCACGCTCAGGAACTGAACAGGCT
CGGGGCAAACATAACCGTGAGGGGAAACACAGCCTACGTTGAGGGGGTAGAAAGGCTCTACGGAAGTGAGGTTTACTCAA
CAGACCTCAGGGCTTCCGCATCTCTCGTGCTCGCGGGTTTGGTCGCCCAAGGGGAAACCGTGGTGAGGGACGTTTACCAC
CTTGACAGGGGTTATGAAAAACTTGAAGAAAAGTTAAAGAAACTCGGAGCCGACATAGAAAGGGTAAGTGAATTATGA

Upstream 100 bases:

>100_bases
GTTTATTCAAACGAAAAGATAGCCTACGTGGAGGAAGATGACGGAGTGCAGATTTTCTACTCCAAAAATTACGACGTTGT
TAAGATAATTATCCCGAAGG

Downstream 100 bases:

>100_bases
ACTTAACTTCTTAGGGGCAGAAAATAAAAGTGGAGATAAAAGAAAGGGATTAGGCAAGTTTTATCTTCTTTTCCTTTTCT
ACGTGAACCTTGGGTATCCT

Product: UDP-N-acetylglucosamine 1-carboxyvinyltransferase

Products: NA

Alternate protein names: Enoylpyruvate transferase; UDP-N-acetylglucosamine enolpyruvyl transferase; EPT

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MKNTTLYTYRDYFVIRGGKPLTGKVKISGAKNAALPIMFATILTEEPCTITNVPDLLDVRNTLLLLRELGAELEFLNNTV
FINPSINSFITNQEIIRRMRASVLSLGPLLGRFGRAVVGLPGGCSIGARPIDQHLKFFKEAGADVEVREGYVYVNLKEKR
RVHFKFDLVTVTGTENALLYLASVPEESILENIALEPEVMDLIEVLKKMGAHVKVEGRSAYVKGSENLKGFTHSVIPDRI
EAGTFMVGAVLTDGEILLENARINHLRAVVEKLKLIGGEVVEENGNLRVFRKESLRACDIETQVYPGFPTDMQAQFMALL
SVAKGKSRIKENIFEHRFHHAQELNRLGANITVRGNTAYVEGVERLYGSEVYSTDLRASASLVLAGLVAQGETVVRDVYH
LDRGYEKLEEKLKKLGADIERVSEL

Sequences:

>Translated_425_residues
MKNTTLYTYRDYFVIRGGKPLTGKVKISGAKNAALPIMFATILTEEPCTITNVPDLLDVRNTLLLLRELGAELEFLNNTV
FINPSINSFITNQEIIRRMRASVLSLGPLLGRFGRAVVGLPGGCSIGARPIDQHLKFFKEAGADVEVREGYVYVNLKEKR
RVHFKFDLVTVTGTENALLYLASVPEESILENIALEPEVMDLIEVLKKMGAHVKVEGRSAYVKGSENLKGFTHSVIPDRI
EAGTFMVGAVLTDGEILLENARINHLRAVVEKLKLIGGEVVEENGNLRVFRKESLRACDIETQVYPGFPTDMQAQFMALL
SVAKGKSRIKENIFEHRFHHAQELNRLGANITVRGNTAYVEGVERLYGSEVYSTDLRASASLVLAGLVAQGETVVRDVYH
LDRGYEKLEEKLKKLGADIERVSEL
>Mature_425_residues
MKNTTLYTYRDYFVIRGGKPLTGKVKISGAKNAALPIMFATILTEEPCTITNVPDLLDVRNTLLLLRELGAELEFLNNTV
FINPSINSFITNQEIIRRMRASVLSLGPLLGRFGRAVVGLPGGCSIGARPIDQHLKFFKEAGADVEVREGYVYVNLKEKR
RVHFKFDLVTVTGTENALLYLASVPEESILENIALEPEVMDLIEVLKKMGAHVKVEGRSAYVKGSENLKGFTHSVIPDRI
EAGTFMVGAVLTDGEILLENARINHLRAVVEKLKLIGGEVVEENGNLRVFRKESLRACDIETQVYPGFPTDMQAQFMALL
SVAKGKSRIKENIFEHRFHHAQELNRLGANITVRGNTAYVEGVERLYGSEVYSTDLRASASLVLAGLVAQGETVVRDVYH
LDRGYEKLEEKLKKLGADIERVSEL

Specific function: Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine

COG id: COG0766

COG function: function code M; UDP-N-acetylglucosamine enolpyruvyl transferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family. MurA subfamily

Homologues:

Organism=Escherichia coli, GI1789580, Length=417, Percent_Identity=45.5635491606715, Blast_Score=351, Evalue=4e-98,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURA_AQUAE (O67315)

Other databases:

- EMBL:   AE000657
- PIR:   H70410
- RefSeq:   NP_213879.1
- PDB:   2YVW
- PDBsum:   2YVW
- ProteinModelPortal:   O67315
- SMR:   O67315
- GeneID:   1192753
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_1281
- NMPDR:   fig|224324.1.peg.894
- HOGENOM:   HBG482701
- OMA:   MVKTMRA
- ProtClustDB:   PRK09369
- BioCyc:   AAEO224324:AQ_1281-MONOMER
- BRENDA:   2.5.1.7
- GO:   GO:0005737
- HAMAP:   MF_00111
- InterPro:   IPR001986
- InterPro:   IPR013792
- InterPro:   IPR005750
- Gene3D:   G3DSA:3.65.10.10
- PANTHER:   PTHR21090:SF4
- TIGRFAMs:   TIGR01072

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.7

Molecular weight: Translated: 47260; Mature: 47260

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: NA

Important sites: ACT_SITE 124-124

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNTTLYTYRDYFVIRGGKPLTGKVKISGAKNAALPIMFATILTEEPCTITNVPDLLDVR
CCCCEEEEEEEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCEECCCCHHHHHH
NTLLLLRELGAELEFLNNTVFINPSINSFITNQEIIRRMRASVLSLGPLLGRFGRAVVGL
HHHHHHHHHCCHHEECCCEEEECCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEC
PGGCSIGARPIDQHLKFFKEAGADVEVREGYVYVNLKEKRRVHFKFDLVTVTGTENALLY
CCCCCCCCCCHHHHHHHHHHCCCCEEEECCEEEEEECCCCEEEEEEEEEEEECCCCEEEE
LASVPEESILENIALEPEVMDLIEVLKKMGAHVKVEGRSAYVKGSENLKGFTHSVIPDRI
EECCCHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEECCEEEEECCCCCCCCHHHCCCCHH
EAGTFMVGAVLTDGEILLENARINHLRAVVEKLKLIGGEVVEENGNLRVFRKESLRACDI
CCCCEEEEEEEECCEEEEECCCHHHHHHHHHHHHHHCCCEEECCCCEEEEECCCCCEECC
ETQVYPGFPTDMQAQFMALLSVAKGKSRIKENIFEHRFHHAQELNRLGANITVRGNTAYV
CCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHH
EGVERLYGSEVYSTDLRASASLVLAGLVAQGETVVRDVYHLDRGYEKLEEKLKKLGADIE
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHCCCHH
RVSEL
HHHCC
>Mature Secondary Structure
MKNTTLYTYRDYFVIRGGKPLTGKVKISGAKNAALPIMFATILTEEPCTITNVPDLLDVR
CCCCEEEEEEEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCEECCCCHHHHHH
NTLLLLRELGAELEFLNNTVFINPSINSFITNQEIIRRMRASVLSLGPLLGRFGRAVVGL
HHHHHHHHHCCHHEECCCEEEECCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEC
PGGCSIGARPIDQHLKFFKEAGADVEVREGYVYVNLKEKRRVHFKFDLVTVTGTENALLY
CCCCCCCCCCHHHHHHHHHHCCCCEEEECCEEEEEECCCCEEEEEEEEEEEECCCCEEEE
LASVPEESILENIALEPEVMDLIEVLKKMGAHVKVEGRSAYVKGSENLKGFTHSVIPDRI
EECCCHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEECCEEEEECCCCCCCCHHHCCCCHH
EAGTFMVGAVLTDGEILLENARINHLRAVVEKLKLIGGEVVEENGNLRVFRKESLRACDI
CCCCEEEEEEEECCEEEEECCCHHHHHHHHHHHHHHCCCEEECCCCEEEEECCCCCEECC
ETQVYPGFPTDMQAQFMALLSVAKGKSRIKENIFEHRFHHAQELNRLGANITVRGNTAYV
CCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHH
EGVERLYGSEVYSTDLRASASLVLAGLVAQGETVVRDVYHLDRGYEKLEEKLKKLGADIE
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHCCCHH
RVSEL
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320