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The map label for this gene is hemA

Identifier: 15606498

GI number: 15606498

Start: 904557

End: 905777

Strand: Direct

Name: hemA

Synonym: aq_1279

Alternate gene names: 15606498

Gene position: 904557-905777 (Clockwise)

Preceding gene: 15606496

Following gene: 15606499

Centisome position: 58.31

GC content: 43.33

Gene sequence:

>1221_bases
ATGGGCGAAATATTCGTGGCGGGTGTAAACTTCAAGGTAGCACCCGTAGAGGTAAGGGAAAAACTCGCTTGCTCTCTGGA
AGAAACTAAAAAGGTCTTACCGATTTTAAAGAGGGAAACTCCATTAGAAGAAGTCATGCTCCTCTCAACGTGCAACAGGG
TTGAGGTTTACGCCTATAATTTCGTGGAAAACTCCGAAGATCTAATAAATAAACTTTTAGAGATAAAAAGGTTAAATCCA
AGCTTTAAAAGGTACTTTTTTGTAAAAAGGGGAGAAGAAGCGGTTTACCACATCTTCAAAGTGGCCTCAAGCCTAGACTC
CATGGTTATCGGAGAGCCTCAAATAGTCGCCCAGTTTAAGGAAGCGTACAGAGTTGCAAAGGAAGCTGGAACCGTCGGAA
AGATTTTAAACAGGGTTTACGAGAAAGCTTTAAGGGCTTCCAAAAGGGTTAGGACGGAAACGGGAATAAGCAGGAGTGCG
GTATCCGTAAGTTACGCGGCTGTAGAACTCGCAAAGAAAATTTTCGGAGACTTGAAGGAGGCAAAGGTTCTTTTAATCGG
TGCAGGCGAGATGGGGGAACTCGCTGCAAACTACCTCAGACGCTTTGGAGCAAAACTCCACATAACAAACAGAACCTACG
AAAGGGCTCTTAAACTCGTCAAGGAACTCAGCGGTAATGTTCTGAGATTTGAAGAACTAAAGGAGTACCTTCCCCTGATG
GACATCGTTATCGTCTCAACGGGGGCAAAAGATTACATACTCAAAAGAGAGGATTTTGAACGCTCCGTAAGGGAAAGGCA
TTACGAACCTCAGTTCGTTATAGACATAGCCGTCCCGAGAAACGTTGATCCTGAAGCGGGAAATGTGGAAGGTGTATTCC
TTTACGACATAGACGACCTCAAACAGGTAGTGGAAGAAAACTTAAAGGAGAGGATAAAGGAAGCCCAGAGGGGTGAGATA
ATCCTCTGGGACGAAGTTAAGAAGTTCATGAACTGGTACGAGTCTTTAAAGGCCGAACCCTACATTCTGGAACTAAAAGC
AAGTGTTGAAGGGAAAGAGGTAAGTCCTTACATTAAAAAATTGGTGCACAGGGCTATTAAGGAAATCAAAAGAAATCCCG
AAGTTGCGGATATAATCTTAAGGATATTCAAGGAGGTAGAGAAGAATGAACCCAGAAGAAAGGAATTATCCAATGTCTAT
AACGGAACTCATGGAGCTTGA

Upstream 100 bases:

>100_bases
GTAGCCTTCTGGGCACAGGAGAGTGTGAGGAGAATTATTAAAATTGATAATACCCTTAACATATCCAATATTTTATCAGA
GAGGAATATAATTAACCTTG

Downstream 100 bases:

>100_bases
GTCAGAGTATGCTATAAGGGCGTACATACTAATAAAAGCTGATCCGAGGGAAATTCCCTCAATAATGCTTGCCCTTTCCA
CTTTTGAGGGCGTAAAGACC

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MGEIFVAGVNFKVAPVEVREKLACSLEETKKVLPILKRETPLEEVMLLSTCNRVEVYAYNFVENSEDLINKLLEIKRLNP
SFKRYFFVKRGEEAVYHIFKVASSLDSMVIGEPQIVAQFKEAYRVAKEAGTVGKILNRVYEKALRASKRVRTETGISRSA
VSVSYAAVELAKKIFGDLKEAKVLLIGAGEMGELAANYLRRFGAKLHITNRTYERALKLVKELSGNVLRFEELKEYLPLM
DIVIVSTGAKDYILKREDFERSVRERHYEPQFVIDIAVPRNVDPEAGNVEGVFLYDIDDLKQVVEENLKERIKEAQRGEI
ILWDEVKKFMNWYESLKAEPYILELKASVEGKEVSPYIKKLVHRAIKEIKRNPEVADIILRIFKEVEKNEPRRKELSNVY
NGTHGA

Sequences:

>Translated_406_residues
MGEIFVAGVNFKVAPVEVREKLACSLEETKKVLPILKRETPLEEVMLLSTCNRVEVYAYNFVENSEDLINKLLEIKRLNP
SFKRYFFVKRGEEAVYHIFKVASSLDSMVIGEPQIVAQFKEAYRVAKEAGTVGKILNRVYEKALRASKRVRTETGISRSA
VSVSYAAVELAKKIFGDLKEAKVLLIGAGEMGELAANYLRRFGAKLHITNRTYERALKLVKELSGNVLRFEELKEYLPLM
DIVIVSTGAKDYILKREDFERSVRERHYEPQFVIDIAVPRNVDPEAGNVEGVFLYDIDDLKQVVEENLKERIKEAQRGEI
ILWDEVKKFMNWYESLKAEPYILELKASVEGKEVSPYIKKLVHRAIKEIKRNPEVADIILRIFKEVEKNEPRRKELSNVY
NGTHGA
>Mature_405_residues
GEIFVAGVNFKVAPVEVREKLACSLEETKKVLPILKRETPLEEVMLLSTCNRVEVYAYNFVENSEDLINKLLEIKRLNPS
FKRYFFVKRGEEAVYHIFKVASSLDSMVIGEPQIVAQFKEAYRVAKEAGTVGKILNRVYEKALRASKRVRTETGISRSAV
SVSYAAVELAKKIFGDLKEAKVLLIGAGEMGELAANYLRRFGAKLHITNRTYERALKLVKELSGNVLRFEELKEYLPLMD
IVIVSTGAKDYILKREDFERSVRERHYEPQFVIDIAVPRNVDPEAGNVEGVFLYDIDDLKQVVEENLKERIKEAQRGEII
LWDEVKKFMNWYESLKAEPYILELKASVEGKEVSPYIKKLVHRAIKEIKRNPEVADIILRIFKEVEKNEPRRKELSNVYN
GTHGA

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=351, Percent_Identity=37.037037037037, Blast_Score=216, Evalue=2e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_AQUAE (O67314)

Other databases:

- EMBL:   AE000657
- PIR:   G70410
- RefSeq:   NP_213878.1
- ProteinModelPortal:   O67314
- SMR:   O67314
- GeneID:   1192752
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_1279
- NMPDR:   fig|224324.1.peg.893
- HOGENOM:   HBG732626
- OMA:   GPILNRL
- PhylomeDB:   O67314
- ProtClustDB:   PRK00045
- BioCyc:   AAEO224324:AQ_1279-MONOMER
- BRENDA:   1.2.1.70
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 46649; Mature: 46518

Theoretical pI: Translated: 9.15; Mature: 9.15

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 51-51 BINDING 107-107 BINDING 118-118

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGEIFVAGVNFKVAPVEVREKLACSLEETKKVLPILKRETPLEEVMLLSTCNRVEVYAYN
CCCEEEECCCEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEE
FVENSEDLINKLLEIKRLNPSFKRYFFVKRGEEAVYHIFKVASSLDSMVIGEPQIVAQFK
CCCCCHHHHHHHHHHHHCCCHHHHEEEHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
EAYRVAKEAGTVGKILNRVYEKALRASKRVRTETGISRSAVSVSYAAVELAKKIFGDLKE
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHH
AKVLLIGAGEMGELAANYLRRFGAKLHITNRTYERALKLVKELSGNVLRFEELKEYLPLM
CEEEEEECCCHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHH
DIVIVSTGAKDYILKREDFERSVRERHYEPQFVIDIAVPRNVDPEAGNVEGVFLYDIDDL
HHHEEECCCHHHHCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCEEEEECHHHH
KQVVEENLKERIKEAQRGEIILWDEVKKFMNWYESLKAEPYILELKASVEGKEVSPYIKK
HHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHH
LVHRAIKEIKRNPEVADIILRIFKEVEKNEPRRKELSNVYNGTHGA
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure 
GEIFVAGVNFKVAPVEVREKLACSLEETKKVLPILKRETPLEEVMLLSTCNRVEVYAYN
CCEEEECCCEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEE
FVENSEDLINKLLEIKRLNPSFKRYFFVKRGEEAVYHIFKVASSLDSMVIGEPQIVAQFK
CCCCCHHHHHHHHHHHHCCCHHHHEEEHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
EAYRVAKEAGTVGKILNRVYEKALRASKRVRTETGISRSAVSVSYAAVELAKKIFGDLKE
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHH
AKVLLIGAGEMGELAANYLRRFGAKLHITNRTYERALKLVKELSGNVLRFEELKEYLPLM
CEEEEEECCCHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHH
DIVIVSTGAKDYILKREDFERSVRERHYEPQFVIDIAVPRNVDPEAGNVEGVFLYDIDDL
HHHEEECCCHHHHCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCEEEEECHHHH
KQVVEENLKERIKEAQRGEIILWDEVKKFMNWYESLKAEPYILELKASVEGKEVSPYIKK
HHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHH
LVHRAIKEIKRNPEVADIILRIFKEVEKNEPRRKELSNVYNGTHGA
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320