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The map label for this gene is gcsP2

Identifier: 15606377

GI number: 15606377

Start: 774618

End: 775937

Strand: Direct

Name: gcsP2

Synonym: aq_1109

Alternate gene names: 15606377

Gene position: 774618-775937 (Clockwise)

Preceding gene: 15606376

Following gene: 15606379

Centisome position: 49.93

GC content: 44.55

Gene sequence:

>1320_bases
ATGAGTTACATTCCTCATTCGGAGGAAGAAACAAAAGAGATACTCTCAAAACTCGGTCTAGAAAGCTTAGAGGATCTCTT
TTCCCACATACCAAAAGAGCTTTTTGCAAAGGATTTTTCCTTTCCCGAACCAAAATCCGAGGAAGAACTCAGGAGAATTT
TTGAAAGAGCCTGTGAAGACACGGAATTACCACTTTACTTTATAGGAGCGGGAGCTTACGACAGAATAATCCCCTCTGTA
ATATGGCAGATACTCAGCAGAGGCGAGTTCCTGACTCCTTACACCCCCTATCAGGCGGAAGCCTCACAGGGAACACTTCA
GGCTATTTTTGAGTACCAATCACTTATATGTGAGCTCACGGGAATGGACGTGGCAAACGCCTCCATGTACGACGGGGCTT
CAGCCCTTGCGGAAGCTGTTTTAATGGCAAGGGCAATAAAAGGTAAGGGGGACACTGTTGTCCTCTCTAAAGCCCTAAAC
CCCCTTTACAGGCGAACCGTAAAAACTTACCTAAGAGGGTATGAGGACAAAATTGTTGAAGTTCCGTACACTGAAGAGGG
AACAACTGACCTGAACAACCTGGAAGAGGTTCTAAAAGAAAGCGAAGTTCACGCCCTTGCGGTTCAGTATCCAAACTTCT
TCGGCTTTGTAGAACCACTAAAGGAAATAGGAGAACTTTGCAAGAAATACGAGGTTCCTTTCGTAGTCTTTGTGGACCCA
ATAGCCCTTTCTATCCTGAAACCTCCCGCGGAGTTTGGAGCGGACATAGTTGTGGGAGAAGGACAGCAGATGGGAATCCC
GCTGTCTTTCGGCGGACCTTATGTGGGATTCTTTGCGACTAAGAAGGAACACGTGAGAAAGATGCCCGGAAGACTCGTGG
GAATGGGAGAGGATATTGAAGGAAAAAGAGCTTTTACCTTGGTTCTCCAGACTAGGGAACAGCACATAAGGAGAGAAAGG
GCAACCTCCAACATATGCACAAACCAGAACTTGATGGCTCTTGCAAACCTCCTTTACATGGTTCTCCTCGGAAAGGAAGG
TATGAAAAAGGTAGCAGTTCAGAGTCTCTCCAAGGCACTTTACTTCAAAAAAGAATTAATGAAAAAGGGATTTGAAGAAG
TCTTTACCGGTAAACACCTCTGGGAATTTCCCTTAAGACACGAAAGCCTAAAGGCTATATACAGGAAACTCTTGAAAGAG
AAAATAGTCCTCGGTCTTCCTCTGGATAGATTTTACGAAGACTTAAAAAACACTACATTAATAGCAGTTACGGAAAAGAG
AACGAAAGAGGAAATAGACTCCGTCTTAGCACTTCTTTAG

Upstream 100 bases:

>100_bases
AGGAAAAGGAAGAAGAAGTTGAAGTAAAAGAAGAGGAATTAATAGAAACCGAGTCCATAGAAGAGTTGTCCGAAGAAGAA
CTCGGATACGAGGAGAATAA

Downstream 100 bases:

>100_bases
GATTTCCCTTAATTTCTTCTCCATCCTTTCAAAGTGCGAACCCTTCCAGAAGACCGCTCCGCACTTGGGACAGAGCGTAA
AGTCCGTAGCCTCTTTATAT

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1

Number of amino acids: Translated: 439; Mature: 438

Protein sequence:

>439_residues
MSYIPHSEEETKEILSKLGLESLEDLFSHIPKELFAKDFSFPEPKSEEELRRIFERACEDTELPLYFIGAGAYDRIIPSV
IWQILSRGEFLTPYTPYQAEASQGTLQAIFEYQSLICELTGMDVANASMYDGASALAEAVLMARAIKGKGDTVVLSKALN
PLYRRTVKTYLRGYEDKIVEVPYTEEGTTDLNNLEEVLKESEVHALAVQYPNFFGFVEPLKEIGELCKKYEVPFVVFVDP
IALSILKPPAEFGADIVVGEGQQMGIPLSFGGPYVGFFATKKEHVRKMPGRLVGMGEDIEGKRAFTLVLQTREQHIRRER
ATSNICTNQNLMALANLLYMVLLGKEGMKKVAVQSLSKALYFKKELMKKGFEEVFTGKHLWEFPLRHESLKAIYRKLLKE
KIVLGLPLDRFYEDLKNTTLIAVTEKRTKEEIDSVLALL

Sequences:

>Translated_439_residues
MSYIPHSEEETKEILSKLGLESLEDLFSHIPKELFAKDFSFPEPKSEEELRRIFERACEDTELPLYFIGAGAYDRIIPSV
IWQILSRGEFLTPYTPYQAEASQGTLQAIFEYQSLICELTGMDVANASMYDGASALAEAVLMARAIKGKGDTVVLSKALN
PLYRRTVKTYLRGYEDKIVEVPYTEEGTTDLNNLEEVLKESEVHALAVQYPNFFGFVEPLKEIGELCKKYEVPFVVFVDP
IALSILKPPAEFGADIVVGEGQQMGIPLSFGGPYVGFFATKKEHVRKMPGRLVGMGEDIEGKRAFTLVLQTREQHIRRER
ATSNICTNQNLMALANLLYMVLLGKEGMKKVAVQSLSKALYFKKELMKKGFEEVFTGKHLWEFPLRHESLKAIYRKLLKE
KIVLGLPLDRFYEDLKNTTLIAVTEKRTKEEIDSVLALL
>Mature_438_residues
SYIPHSEEETKEILSKLGLESLEDLFSHIPKELFAKDFSFPEPKSEEELRRIFERACEDTELPLYFIGAGAYDRIIPSVI
WQILSRGEFLTPYTPYQAEASQGTLQAIFEYQSLICELTGMDVANASMYDGASALAEAVLMARAIKGKGDTVVLSKALNP
LYRRTVKTYLRGYEDKIVEVPYTEEGTTDLNNLEEVLKESEVHALAVQYPNFFGFVEPLKEIGELCKKYEVPFVVFVDPI
ALSILKPPAEFGADIVVGEGQQMGIPLSFGGPYVGFFATKKEHVRKMPGRLVGMGEDIEGKRAFTLVLQTREQHIRRERA
TSNICTNQNLMALANLLYMVLLGKEGMKKVAVQSLSKALYFKKELMKKGFEEVFTGKHLWEFPLRHESLKAIYRKLLKEK
IVLGLPLDRFYEDLKNTTLIAVTEKRTKEEIDSVLALL

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily

Homologues:

Organism=Homo sapiens, GI108773801, Length=445, Percent_Identity=31.0112359550562, Blast_Score=215, Evalue=6e-56,
Organism=Escherichia coli, GI1789269, Length=359, Percent_Identity=33.4261838440111, Blast_Score=176, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI17535605, Length=373, Percent_Identity=35.3887399463807, Blast_Score=207, Evalue=6e-54,
Organism=Saccharomyces cerevisiae, GI6323843, Length=445, Percent_Identity=32.5842696629214, Blast_Score=219, Evalue=6e-58,
Organism=Drosophila melanogaster, GI24645648, Length=429, Percent_Identity=34.965034965035, Blast_Score=243, Evalue=2e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCSPA_AQUAE (O67193)

Other databases:

- EMBL:   AE000657
- PIR:   F70395
- RefSeq:   NP_213757.1
- ProteinModelPortal:   O67193
- SMR:   O67193
- GeneID:   1193827
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_1109
- NMPDR:   fig|224324.1.peg.772
- HOGENOM:   HBG288345
- OMA:   VTEKRTK
- ProtClustDB:   PRK00451
- BioCyc:   AAEO224324:AQ_1109-MONOMER
- BRENDA:   1.4.4.2
- HAMAP:   MF_00712
- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11773

Pfam domain/function: PF02347 GDC-P; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =1.4.4.2

Molecular weight: Translated: 49722; Mature: 49591

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYIPHSEEETKEILSKLGLESLEDLFSHIPKELFAKDFSFPEPKSEEELRRIFERACED
CCCCCCCHHHHHHHHHHHCHHHHHHHHHHCCHHHHHHCCCCCCCCCHHHHHHHHHHHCCC
TELPLYFIGAGAYDRIIPSVIWQILSRGEFLTPYTPYQAEASQGTLQAIFEYQSLICELT
CCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
GMDVANASMYDGASALAEAVLMARAIKGKGDTVVLSKALNPLYRRTVKTYLRGYEDKIVE
CCCCCCCHHHCCHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCEEE
VPYTEEGTTDLNNLEEVLKESEVHALAVQYPNFFGFVEPLKEIGELCKKYEVPFVVFVDP
CCCCCCCCCCHHHHHHHHHHCCHHEEEEECCCHHHHHHHHHHHHHHHHHHCCCEEEEEHH
IALSILKPPAEFGADIVVGEGQQMGIPLSFGGPYVGFFATKKEHVRKMPGRLVGMGEDIE
HHHHHHCCHHHHCCCEEEECCCCCCEEEECCCCEEEHHHCCHHHHHHCCCCEECCCCCCC
GKRAFTLVLQTREQHIRRERATSNICTNQNLMALANLLYMVLLGKEGMKKVAVQSLSKAL
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
YFKKELMKKGFEEVFTGKHLWEFPLRHESLKAIYRKLLKEKIVLGLPLDRFYEDLKNTTL
HHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEE
IAVTEKRTKEEIDSVLALL
EEEECHHHHHHHHHHHHHC
>Mature Secondary Structure 
SYIPHSEEETKEILSKLGLESLEDLFSHIPKELFAKDFSFPEPKSEEELRRIFERACED
CCCCCCHHHHHHHHHHHCHHHHHHHHHHCCHHHHHHCCCCCCCCCHHHHHHHHHHHCCC
TELPLYFIGAGAYDRIIPSVIWQILSRGEFLTPYTPYQAEASQGTLQAIFEYQSLICELT
CCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
GMDVANASMYDGASALAEAVLMARAIKGKGDTVVLSKALNPLYRRTVKTYLRGYEDKIVE
CCCCCCCHHHCCHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCEEE
VPYTEEGTTDLNNLEEVLKESEVHALAVQYPNFFGFVEPLKEIGELCKKYEVPFVVFVDP
CCCCCCCCCCHHHHHHHHHHCCHHEEEEECCCHHHHHHHHHHHHHHHHHHCCCEEEEEHH
IALSILKPPAEFGADIVVGEGQQMGIPLSFGGPYVGFFATKKEHVRKMPGRLVGMGEDIE
HHHHHHCCHHHHCCCEEEECCCCCCEEEECCCCEEEHHHCCHHHHHHCCCCEECCCCCCC
GKRAFTLVLQTREQHIRRERATSNICTNQNLMALANLLYMVLLGKEGMKKVAVQSLSKAL
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
YFKKELMKKGFEEVFTGKHLWEFPLRHESLKAIYRKLLKEKIVLGLPLDRFYEDLKNTTL
HHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEE
IAVTEKRTKEEIDSVLALL
EEEECHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320