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The map label for this gene is gsa

Identifier: 15606182

GI number: 15606182

Start: 562310

End: 563584

Strand: Direct

Name: gsa

Synonym: aq_816

Alternate gene names: 15606182

Gene position: 562310-563584 (Clockwise)

Preceding gene: 15606178

Following gene: 15606183

Centisome position: 36.25

GC content: 48.71

Gene sequence:

>1275_bases
ATGAAGAACGAAAAGTTATACAGAGAAGCCCTTCAGGTAATGCCCGGAGGCGTAAACAGTCCCGTCAGAGCCTTTAAAGC
GGTAGGGGGAAAGCCCATTTTCCTTGTTAAGGGAAGAGGACCAAGAGTCTGGGACGCCGAAGGGAACGAGTACATAGATT
TCCTCGCTTCCTGGGGGGCTATAATCCTCGGACACGCTCCCAAGAAAGTGGTGAAAGCGGTTCAGGAGGAAGCTGAAAAG
GGACTTTCTTTCGGTTTGACAAACCCTCACGAAGTAACACTGGCAAAGCTCGTGGTTGAGATGGTTCCTAGTGTTGAAAA
AGTAAGGTTCGTAAACTCTGGAACTGAAGCCACGATGTCTGCGGTGAGACTCGCAAGGGGAGTCACAGGAAGAAAGTACA
TAGTGAAGTTTGAAGGTTGCTACCACGGTCACTATGATAGCCTCCTCGTGAGTGCGGGTTCGGGCGTGGCTACTTTCGGG
ATCCCTGGAACTCCCGGCATTCCTGAAGAAATAGCGAAGCTCACCATAGTCTTGCCTTACAACGATGTTCAAGCTCTGGA
GGAAGCCTTTAAAGAGTACGGCAGTGAAATAGCGGGAGTTATAGTGGAGCCCATAGCGGGAAATATGGGCGTAGTTCCCC
CAAAGAAGGAATTCCTTATAAGACTCAGGGAACTCACGAAAGAGTACGGAAGCCTCCTTATGTTTGACGAAGTAATTACG
GGTTTTAGACTTTCAAAGGGCGGAGCTCAGGAACTCTTTGGTATAGAGCCCGACATAACATGCCTCGGGAAAATACTCGG
AGGAGGACTGCCCGTAGGTGCTTACGGAGGAAGAAGGGAAATTATGGAAAGGGTAGCTCCCGAGGGTGAAGTGTATCAGG
CCGGAACGCTTGCGGGAAATCCCCTTGCTATGGTTTCGGGTTCTGAAACCTTAAAAGATTTAAGGGACAAAGAACCTTAC
AAGGAACTGGAAGAGAAGATGGAGAAACTTGCCAGAGGCGTTAAGGATATCCTCACCGAAAAGGGAATACAGCACACGAT
AAACAAGGTAGGTTCTATGATGACGGTGTTCTTCACGGATAAGAAAGTTGTGGACTTCCAAACCGCTAAGACTTCGGACA
CAGAGCTGTTCGCAAAGTTCTTCAGAGCACTTTTAAACAAAGGTGTGTTAATTCCGCCCTCTCAATTCGAGGCGTGGTTC
TTAACCACCGCACACGAGGAAGAAGTAATAGACGAAGCCCTTGAAAGAATCCGGGACGCGGTAAAGGAACTGTGA

Upstream 100 bases:

>100_bases
TCCTTTTTAATTCCCTTACGAGTTCACAAACTTTGTAGGAGGCTATTCCTCCGCAAACTCCTATGAGGATATTCATTAAG
TTAAATTTAAAATAACAAGT

Downstream 100 bases:

>100_bases
CGAATGCTTAAAAACCTTATCAGGAGTGTAATAAAGGGTTCTGTGCTCCTCGTTTTTTTTCTCCTCCTCTCTTTCCTCTT
CTTGGCCTACAGGAGCTTTT

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MKNEKLYREALQVMPGGVNSPVRAFKAVGGKPIFLVKGRGPRVWDAEGNEYIDFLASWGAIILGHAPKKVVKAVQEEAEK
GLSFGLTNPHEVTLAKLVVEMVPSVEKVRFVNSGTEATMSAVRLARGVTGRKYIVKFEGCYHGHYDSLLVSAGSGVATFG
IPGTPGIPEEIAKLTIVLPYNDVQALEEAFKEYGSEIAGVIVEPIAGNMGVVPPKKEFLIRLRELTKEYGSLLMFDEVIT
GFRLSKGGAQELFGIEPDITCLGKILGGGLPVGAYGGRREIMERVAPEGEVYQAGTLAGNPLAMVSGSETLKDLRDKEPY
KELEEKMEKLARGVKDILTEKGIQHTINKVGSMMTVFFTDKKVVDFQTAKTSDTELFAKFFRALLNKGVLIPPSQFEAWF
LTTAHEEEVIDEALERIRDAVKEL

Sequences:

>Translated_424_residues
MKNEKLYREALQVMPGGVNSPVRAFKAVGGKPIFLVKGRGPRVWDAEGNEYIDFLASWGAIILGHAPKKVVKAVQEEAEK
GLSFGLTNPHEVTLAKLVVEMVPSVEKVRFVNSGTEATMSAVRLARGVTGRKYIVKFEGCYHGHYDSLLVSAGSGVATFG
IPGTPGIPEEIAKLTIVLPYNDVQALEEAFKEYGSEIAGVIVEPIAGNMGVVPPKKEFLIRLRELTKEYGSLLMFDEVIT
GFRLSKGGAQELFGIEPDITCLGKILGGGLPVGAYGGRREIMERVAPEGEVYQAGTLAGNPLAMVSGSETLKDLRDKEPY
KELEEKMEKLARGVKDILTEKGIQHTINKVGSMMTVFFTDKKVVDFQTAKTSDTELFAKFFRALLNKGVLIPPSQFEAWF
LTTAHEEEVIDEALERIRDAVKEL
>Mature_424_residues
MKNEKLYREALQVMPGGVNSPVRAFKAVGGKPIFLVKGRGPRVWDAEGNEYIDFLASWGAIILGHAPKKVVKAVQEEAEK
GLSFGLTNPHEVTLAKLVVEMVPSVEKVRFVNSGTEATMSAVRLARGVTGRKYIVKFEGCYHGHYDSLLVSAGSGVATFG
IPGTPGIPEEIAKLTIVLPYNDVQALEEAFKEYGSEIAGVIVEPIAGNMGVVPPKKEFLIRLRELTKEYGSLLMFDEVIT
GFRLSKGGAQELFGIEPDITCLGKILGGGLPVGAYGGRREIMERVAPEGEVYQAGTLAGNPLAMVSGSETLKDLRDKEPY
KELEEKMEKLARGVKDILTEKGIQHTINKVGSMMTVFFTDKKVVDFQTAKTSDTELFAKFFRALLNKGVLIPPSQFEAWF
LTTAHEEEVIDEALERIRDAVKEL

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=316, Percent_Identity=33.2278481012658, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI13994255, Length=328, Percent_Identity=28.9634146341463, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI24119277, Length=379, Percent_Identity=27.1767810026385, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI284507298, Length=231, Percent_Identity=34.6320346320346, Blast_Score=86, Evalue=1e-16,
Organism=Escherichia coli, GI1786349, Length=424, Percent_Identity=50.9433962264151, Blast_Score=457, Evalue=1e-130,
Organism=Escherichia coli, GI1789016, Length=413, Percent_Identity=30.5084745762712, Blast_Score=148, Evalue=8e-37,
Organism=Escherichia coli, GI1788044, Length=335, Percent_Identity=32.5373134328358, Blast_Score=141, Evalue=7e-35,
Organism=Escherichia coli, GI145693181, Length=332, Percent_Identity=32.2289156626506, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1789759, Length=328, Percent_Identity=30.4878048780488, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1787560, Length=382, Percent_Identity=29.0575916230367, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1786991, Length=297, Percent_Identity=29.6296296296296, Blast_Score=86, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI25144271, Length=328, Percent_Identity=33.5365853658537, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI71992977, Length=334, Percent_Identity=26.0479041916168, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI25144274, Length=166, Percent_Identity=35.5421686746988, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71981843, Length=166, Percent_Identity=32.5301204819277, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323470, Length=310, Percent_Identity=30.3225806451613, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6324432, Length=326, Percent_Identity=28.5276073619632, Blast_Score=97, Evalue=3e-21,
Organism=Drosophila melanogaster, GI21357415, Length=341, Percent_Identity=30.2052785923754, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI21356575, Length=308, Percent_Identity=26.9480519480519, Blast_Score=93, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GSA_AQUAE (O66998)

Other databases:

- EMBL:   AE000657
- PIR:   C70371
- RefSeq:   NP_213559.1
- ProteinModelPortal:   O66998
- SMR:   O66998
- GeneID:   1193448
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_816
- NMPDR:   fig|224324.1.peg.574
- HOGENOM:   HBG725944
- OMA:   VGCFGGK
- PhylomeDB:   O66998
- ProtClustDB:   CLSK2748365
- BioCyc:   AAEO224324:AQ_816-MONOMER
- BRENDA:   5.4.3.8
- GO:   GO:0005737
- HAMAP:   MF_00375
- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- TIGRFAMs:   TIGR00713

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =5.4.3.8

Molecular weight: Translated: 46394; Mature: 46394

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNEKLYREALQVMPGGVNSPVRAFKAVGGKPIFLVKGRGPRVWDAEGNEYIDFLASWGA
CCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEECCCCEEECCCCCHHHHHHHHHHH
IILGHAPKKVVKAVQEEAEKGLSFGLTNPHEVTLAKLVVEMVPSVEKVRFVNSGTEATMS
HEECCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHH
AVRLARGVTGRKYIVKFEGCYHGHYDSLLVSAGSGVATFGIPGTPGIPEEIAKLTIVLPY
HHHHHHCCCCCEEEEEEECEECCCHHHHHEECCCCEEEECCCCCCCCHHHHCEEEEEECC
NDVQALEEAFKEYGSEIAGVIVEPIAGNMGVVPPKKEFLIRLRELTKEYGSLLMFDEVIT
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHH
GFRLSKGGAQELFGIEPDITCLGKILGGGLPVGAYGGRREIMERVAPEGEVYQAGTLAGN
CCCCCCCCHHHHCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCEEECCCCCCC
PLAMVSGSETLKDLRDKEPYKELEEKMEKLARGVKDILTEKGIQHTINKVGSMMTVFFTD
CEEEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEC
KKVVDFQTAKTSDTELFAKFFRALLNKGVLIPPSQFEAWFLTTAHEEEVIDEALERIRDA
CEEEEEECCCCCCHHHHHHHHHHHHHCCEECCCCCCCEEEEECCCHHHHHHHHHHHHHHH
VKEL
HHCC
>Mature Secondary Structure
MKNEKLYREALQVMPGGVNSPVRAFKAVGGKPIFLVKGRGPRVWDAEGNEYIDFLASWGA
CCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEECCCCEEECCCCCHHHHHHHHHHH
IILGHAPKKVVKAVQEEAEKGLSFGLTNPHEVTLAKLVVEMVPSVEKVRFVNSGTEATMS
HEECCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHH
AVRLARGVTGRKYIVKFEGCYHGHYDSLLVSAGSGVATFGIPGTPGIPEEIAKLTIVLPY
HHHHHHCCCCCEEEEEEECEECCCHHHHHEECCCCEEEECCCCCCCCHHHHCEEEEEECC
NDVQALEEAFKEYGSEIAGVIVEPIAGNMGVVPPKKEFLIRLRELTKEYGSLLMFDEVIT
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHH
GFRLSKGGAQELFGIEPDITCLGKILGGGLPVGAYGGRREIMERVAPEGEVYQAGTLAGN
CCCCCCCCHHHHCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCEEECCCCCCC
PLAMVSGSETLKDLRDKEPYKELEEKMEKLARGVKDILTEKGIQHTINKVGSMMTVFFTD
CEEEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEC
KKVVDFQTAKTSDTELFAKFFRALLNKGVLIPPSQFEAWFLTTAHEEEVIDEALERIRDA
CEEEEEECCCCCCHHHHHHHHHHHHHCCEECCCCCCCEEEEECCCHHHHHHHHHHHHHHH
VKEL
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320