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The map label for this gene is atpA

Identifier: 15606090

GI number: 15606090

Start: 461663

End: 463174

Strand: Direct

Name: atpA

Synonym: aq_679

Alternate gene names: 15606090

Gene position: 461663-463174 (Clockwise)

Preceding gene: 15606087

Following gene: 15606092

Centisome position: 29.76

GC content: 47.88

Gene sequence:

>1512_bases
ATGGCTACACTGACTTATGAGGAAGCCCTTGAGATACTAAGACAACAGATAAAGGATTTCGAACCTGAAGCCAAAATGGA
AGAAGTAGGTGTAGTTTACTACGTCGGTGATGGTGTAGCAAGGGCTTACGGTCTTGAAAACGTAATGGCGATGGAAATAG
TAGAGTTTCAGGGAGGGCAACAGGGAATAGCCTTCAACCTCGAAGAGGACAACGTTGGTATCATAATCCTCGGTTCTGAA
ACGGGAATAGAAGAAGGGCACATAGTAAAGAGAACGGGCAGGATATTGGACGCTCCCGTTGGAGAAGGACTCGTTGGAAG
GGTTATCGACCCCCTCGGAAACCCCCTCGATGGTAAAGGACCCATTCAGTTTGAATACCGTTCCCCAGTTGAAAAGATCG
CACCCGGTGTTGTAAAGAGAAAACCCGTTCACGAACCCCTTCAAACAGGTATTAAAGCTATAGACGCTATGATTCCAATA
GGAAGGGGACAGAGAGAGCTTATCATCGGTGACAGGGCTACGGGTAAGACCACTGTTGCGATAGACACCATACTCGCTCA
AAAGAACAGTGATGTTTACTGTATTTACGTAGCCGTAGGACAGAAAAGAGCGGCGATAGCGAGACTCATTGAGCTCCTTG
AAAGAGAAGGAGCTATGGAATACACCACAGTTGTTGTAGCTTCAGCATCAGATCCCGCATCACTCCAGTACCTCGCACCC
TTTGTTGGATGTACGATAGGGGAGTACTTCAGAGACAACGGAAAGCACGCACTCATCATATACGACGACCTGTCCAAGCA
CGCGGAAGCTTACAGACAGCTCTCACTCCTCATGAGAAGACCTCCCGGTAGAGAAGCTTACCCCGGTGACGTGTTCTACC
TCCACTCAAGACTCCTTGAAAGAGCTGCAAAACTTAACGACGACCTCGGGGCAGGTTCTCTCACGGCATTGCCCATAATT
GAAACGAAAGCGGGTGACGTCGCGGCTTACATTCCCACGAACGTTATCTCCATTACAGACGGACAGATATACCTCGAAGC
GGACCTCTTCAACAAAGGTATAAGACCTGCTATTAACGTAGGTCTTTCGGTTTCCAGAGTCGGTGGTGCGGCACAGATAA
AGGCTATGAAACAGGTTGCGGGAACCCTCAGACTCGAACTTGCTCAGTTCAGAGAACTTGAAGCTTTCGTTCAGTTCGCT
TCGGAACTTGATAAGGCAACCCAGCAACAAATCAACAGAGGTCTGAGACTCGTAGAACTCCTGAAGCAAGAACCCTACAA
CCCGATACCCGTTGAAAAACAAATCGTTCTCATATACGCCGGAACGCACGGATACCTCGACGACATTCCCGTAGAGTCTG
TAAGAAAGTTTGAAAAGGAACTCTACGCTTACCTAGACAACGAAAGACCGGACATACTCAAGGAGATAAGTGAAAAGAAG
AAACTCGACGAAGAACTAGAGAAGAAGATAAAAGAGGCGCTCGACGCCTTCAAGCAAAAGTTCGTTCCCTAA

Upstream 100 bases:

>100_bases
AGGAAAGGAGTAGTAAGGCTAAGAGTACTATTAACATAAGTTAGATTATAGGTATTTTCTGTGCTACAATAAACCTTTAA
AGAAGGTTAGGAGGTAGAGT

Downstream 100 bases:

>100_bases
CTCTCCCTCCTTCTTTTAACTCATAAATATAAGTATTTCGTCCTTTTCCACCTTTGCCCTTTCGGGCTCTAAATTCCTTA
ACTTCCTAGGAAGCATAACG

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha

Number of amino acids: Translated: 503; Mature: 502

Protein sequence:

>503_residues
MATLTYEEALEILRQQIKDFEPEAKMEEVGVVYYVGDGVARAYGLENVMAMEIVEFQGGQQGIAFNLEEDNVGIIILGSE
TGIEEGHIVKRTGRILDAPVGEGLVGRVIDPLGNPLDGKGPIQFEYRSPVEKIAPGVVKRKPVHEPLQTGIKAIDAMIPI
GRGQRELIIGDRATGKTTVAIDTILAQKNSDVYCIYVAVGQKRAAIARLIELLEREGAMEYTTVVVASASDPASLQYLAP
FVGCTIGEYFRDNGKHALIIYDDLSKHAEAYRQLSLLMRRPPGREAYPGDVFYLHSRLLERAAKLNDDLGAGSLTALPII
ETKAGDVAAYIPTNVISITDGQIYLEADLFNKGIRPAINVGLSVSRVGGAAQIKAMKQVAGTLRLELAQFRELEAFVQFA
SELDKATQQQINRGLRLVELLKQEPYNPIPVEKQIVLIYAGTHGYLDDIPVESVRKFEKELYAYLDNERPDILKEISEKK
KLDEELEKKIKEALDAFKQKFVP

Sequences:

>Translated_503_residues
MATLTYEEALEILRQQIKDFEPEAKMEEVGVVYYVGDGVARAYGLENVMAMEIVEFQGGQQGIAFNLEEDNVGIIILGSE
TGIEEGHIVKRTGRILDAPVGEGLVGRVIDPLGNPLDGKGPIQFEYRSPVEKIAPGVVKRKPVHEPLQTGIKAIDAMIPI
GRGQRELIIGDRATGKTTVAIDTILAQKNSDVYCIYVAVGQKRAAIARLIELLEREGAMEYTTVVVASASDPASLQYLAP
FVGCTIGEYFRDNGKHALIIYDDLSKHAEAYRQLSLLMRRPPGREAYPGDVFYLHSRLLERAAKLNDDLGAGSLTALPII
ETKAGDVAAYIPTNVISITDGQIYLEADLFNKGIRPAINVGLSVSRVGGAAQIKAMKQVAGTLRLELAQFRELEAFVQFA
SELDKATQQQINRGLRLVELLKQEPYNPIPVEKQIVLIYAGTHGYLDDIPVESVRKFEKELYAYLDNERPDILKEISEKK
KLDEELEKKIKEALDAFKQKFVP
>Mature_502_residues
ATLTYEEALEILRQQIKDFEPEAKMEEVGVVYYVGDGVARAYGLENVMAMEIVEFQGGQQGIAFNLEEDNVGIIILGSET
GIEEGHIVKRTGRILDAPVGEGLVGRVIDPLGNPLDGKGPIQFEYRSPVEKIAPGVVKRKPVHEPLQTGIKAIDAMIPIG
RGQRELIIGDRATGKTTVAIDTILAQKNSDVYCIYVAVGQKRAAIARLIELLEREGAMEYTTVVVASASDPASLQYLAPF
VGCTIGEYFRDNGKHALIIYDDLSKHAEAYRQLSLLMRRPPGREAYPGDVFYLHSRLLERAAKLNDDLGAGSLTALPIIE
TKAGDVAAYIPTNVISITDGQIYLEADLFNKGIRPAINVGLSVSRVGGAAQIKAMKQVAGTLRLELAQFRELEAFVQFAS
ELDKATQQQINRGLRLVELLKQEPYNPIPVEKQIVLIYAGTHGYLDDIPVESVRKFEKELYAYLDNERPDILKEISEKKK
LDEELEKKIKEALDAFKQKFVP

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI50345984, Length=502, Percent_Identity=60.7569721115538, Blast_Score=622, Evalue=1e-178,
Organism=Homo sapiens, GI4757810, Length=502, Percent_Identity=60.7569721115538, Blast_Score=622, Evalue=1e-178,
Organism=Homo sapiens, GI19913428, Length=302, Percent_Identity=30.4635761589404, Blast_Score=119, Evalue=8e-27,
Organism=Homo sapiens, GI19913426, Length=393, Percent_Identity=26.4631043256997, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI32189394, Length=417, Percent_Identity=23.9808153477218, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI19913424, Length=253, Percent_Identity=27.6679841897233, Blast_Score=90, Evalue=5e-18,
Organism=Escherichia coli, GI1790172, Length=506, Percent_Identity=54.5454545454545, Blast_Score=567, Evalue=1e-163,
Organism=Escherichia coli, GI1790170, Length=336, Percent_Identity=25.8928571428571, Blast_Score=112, Evalue=7e-26,
Organism=Escherichia coli, GI1788251, Length=298, Percent_Identity=31.5436241610738, Blast_Score=109, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI71988063, Length=511, Percent_Identity=59.8825831702544, Blast_Score=634, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71988080, Length=511, Percent_Identity=59.8825831702544, Blast_Score=632, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71988074, Length=511, Percent_Identity=55.7729941291585, Blast_Score=573, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI17570191, Length=424, Percent_Identity=25.7075471698113, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17510931, Length=391, Percent_Identity=26.3427109974425, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI25144756, Length=416, Percent_Identity=23.0769230769231, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17565854, Length=253, Percent_Identity=28.0632411067194, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17509265, Length=50, Percent_Identity=70, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71988068, Length=80, Percent_Identity=43.75, Blast_Score=76, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6319370, Length=502, Percent_Identity=60.3585657370518, Blast_Score=626, Evalue=1e-180,
Organism=Saccharomyces cerevisiae, GI6319603, Length=332, Percent_Identity=30.1204819277108, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6322581, Length=409, Percent_Identity=24.9388753056235, Blast_Score=109, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6320016, Length=158, Percent_Identity=29.746835443038, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24658560, Length=508, Percent_Identity=58.6614173228346, Blast_Score=612, Evalue=1e-175,
Organism=Drosophila melanogaster, GI281361666, Length=315, Percent_Identity=30.1587301587302, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24646341, Length=315, Percent_Identity=30.1587301587302, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI17136796, Length=315, Percent_Identity=30.1587301587302, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI28574560, Length=409, Percent_Identity=24.4498777506112, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24638766, Length=417, Percent_Identity=24.220623501199, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24583992, Length=330, Percent_Identity=26.969696969697, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI20129479, Length=254, Percent_Identity=28.3464566929134, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24583988, Length=253, Percent_Identity=26.8774703557312, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24583986, Length=253, Percent_Identity=26.8774703557312, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24583984, Length=253, Percent_Identity=26.8774703557312, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): ATPA_AQUAE (O66907)

Other databases:

- EMBL:   AE000657
- PIR:   G70359
- RefSeq:   NP_213467.1
- ProteinModelPortal:   O66907
- SMR:   O66907
- GeneID:   1193969
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_679
- NMPDR:   fig|224324.1.peg.482
- HOGENOM:   HBG565875
- OMA:   EMALTLW
- PhylomeDB:   O66907
- ProtClustDB:   PRK09281
- BioCyc:   AAEO224324:AQ_679-MONOMER
- BRENDA:   3.6.3.14
- HAMAP:   MF_01346
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- PANTHER:   PTHR15184:SF3
- TIGRFAMs:   TIGR00962

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N; SSF47917 ATPase_a/b_C; SSF50615 ATPase_a/b_N

EC number: =3.6.3.14

Molecular weight: Translated: 55580; Mature: 55449

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATLTYEEALEILRQQIKDFEPEAKMEEVGVVYYVGDGVARAYGLENVMAMEIVEFQGGQ
CCCCCHHHHHHHHHHHHHCCCCCCCHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCC
QGIAFNLEEDNVGIIILGSETGIEEGHIVKRTGRILDAPVGEGLVGRVIDPLGNPLDGKG
CCEEEEECCCCEEEEEECCCCCCCCCCEEECCCCEEECCCCCCHHHHHHHHCCCCCCCCC
PIQFEYRSPVEKIAPGVVKRKPVHEPLQTGIKAIDAMIPIGRGQRELIIGDRATGKTTVA
CEEEECCCCHHHHCCCHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEE
IDTILAQKNSDVYCIYVAVGQKRAAIARLIELLEREGAMEYTTVVVASASDPASLQYLAP
EEHHHHCCCCCEEEEEEEECCHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHH
FVGCTIGEYFRDNGKHALIIYDDLSKHAEAYRQLSLLMRRPPGREAYPGDVFYLHSRLLE
HHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
RAAKLNDDLGAGSLTALPIIETKAGDVAAYIPTNVISITDGQIYLEADLFNKGIRPAINV
HHHHCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEEEEHHHCCCCCHHHHC
GLSVSRVGGAAQIKAMKQVAGTLRLELAQFRELEAFVQFASELDKATQQQINRGLRLVEL
CEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKQEPYNPIPVEKQIVLIYAGTHGYLDDIPVESVRKFEKELYAYLDNERPDILKEISEKK
HHHCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
KLDEELEKKIKEALDAFKQKFVP
HHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ATLTYEEALEILRQQIKDFEPEAKMEEVGVVYYVGDGVARAYGLENVMAMEIVEFQGGQ
CCCCHHHHHHHHHHHHHCCCCCCCHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCC
QGIAFNLEEDNVGIIILGSETGIEEGHIVKRTGRILDAPVGEGLVGRVIDPLGNPLDGKG
CCEEEEECCCCEEEEEECCCCCCCCCCEEECCCCEEECCCCCCHHHHHHHHCCCCCCCCC
PIQFEYRSPVEKIAPGVVKRKPVHEPLQTGIKAIDAMIPIGRGQRELIIGDRATGKTTVA
CEEEECCCCHHHHCCCHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEE
IDTILAQKNSDVYCIYVAVGQKRAAIARLIELLEREGAMEYTTVVVASASDPASLQYLAP
EEHHHHCCCCCEEEEEEEECCHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHH
FVGCTIGEYFRDNGKHALIIYDDLSKHAEAYRQLSLLMRRPPGREAYPGDVFYLHSRLLE
HHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
RAAKLNDDLGAGSLTALPIIETKAGDVAAYIPTNVISITDGQIYLEADLFNKGIRPAINV
HHHHCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEEEEHHHCCCCCHHHHC
GLSVSRVGGAAQIKAMKQVAGTLRLELAQFRELEAFVQFASELDKATQQQINRGLRLVEL
CEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKQEPYNPIPVEKQIVLIYAGTHGYLDDIPVESVRKFEKELYAYLDNERPDILKEISEKK
HHHCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
KLDEELEKKIKEALDAFKQKFVP
HHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9537320