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The map label for this gene is lpxA

Identifier: 15606045

GI number: 15606045

Start: 412006

End: 412791

Strand: Direct

Name: lpxA

Synonym: aq_604

Alternate gene names: 15606045

Gene position: 412006-412791 (Clockwise)

Preceding gene: 15606044

Following gene: 15606046

Centisome position: 26.56

GC content: 48.6

Gene sequence:

>786_bases
ATGAAAGTACACTCAAGCGTACTCATAGAAGGAGAGGTTGAAATTCCTGAAGACGTTGAGATAGGAGCTTATACCGTAAT
TCAGGGAAACGTGAAGATAGGGAAGGGGACGAAAATAGGAAACAGGGTAACGATAAAGGGAAACGTAACCATTGGTGAGA
ACTGCAAGATTTTTGACGGAGCGGTTATAGGAGAAGCGCCCCAGCACCTGAAGTACGAAGGGGAAGAAACTTCCGTGGAA
ATAGGGAACAACGTGATAATAAGGGAGTACGTCACCATACACAGGGGAACAAAGCTGGACAAAGGGAAAACGGTTGTCGG
AGATAACGTCATGCTCATGGCATACTCTCACGTTGCGCACGATTGCGTTGTGGGAAACAACGTGATTATGGCAAACTGTG
CAACGCTCGGGGGACACGTTGTCGTCGGAGATTACGCCCTCATAGGTGGTCTTTCCGCGGTTCACCAGTGGGCAAGGGTC
GGAGAACACGCCATGGTGGGCGGTCTTACGGGTGTCTCTTTAGATATACCGCCCTACACGGTAGCCTCGGGTCAGCACGC
AAAGCTTTACGGCATAAACATAATCGGTTTGAGAAGGAGGGGCTTTCCCGAGGAGGTCATTAAAGCCATAAGCAAAGCTT
ACAGGATTATTTTCAGGAGTCCGCTTCCGAGACAAAAAGCCCCTGAGATAGTTTTTCAGGAACTTGGACAGTACGAGGAA
GTGAGGAAAATGGTTGAGTTTATAAAGAGTTCCAAAAGAGGAGTGGCGAGACACCACAAGGACTGA

Upstream 100 bases:

>100_bases
AGAGTTTTACAGGATAGTAGAAAAACTCCTGGAGCACAATTTTTACGTCCCGCTAAGGGCGGTTTAAAATACTTTAAACA
CCTATTTAAAGGAGCAGGGA

Downstream 100 bases:

>100_bases
TAACATAACATTCATGCGTGCTGTAATTCTGGCTGCCGGACTCGGAACGAGGTTCAAGAGCGAAAAACCCAAAGTTCTCC
ACGAAATACTCGGAAAACCG

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MKVHSSVLIEGEVEIPEDVEIGAYTVIQGNVKIGKGTKIGNRVTIKGNVTIGENCKIFDGAVIGEAPQHLKYEGEETSVE
IGNNVIIREYVTIHRGTKLDKGKTVVGDNVMLMAYSHVAHDCVVGNNVIMANCATLGGHVVVGDYALIGGLSAVHQWARV
GEHAMVGGLTGVSLDIPPYTVASGQHAKLYGINIIGLRRRGFPEEVIKAISKAYRIIFRSPLPRQKAPEIVFQELGQYEE
VRKMVEFIKSSKRGVARHHKD

Sequences:

>Translated_261_residues
MKVHSSVLIEGEVEIPEDVEIGAYTVIQGNVKIGKGTKIGNRVTIKGNVTIGENCKIFDGAVIGEAPQHLKYEGEETSVE
IGNNVIIREYVTIHRGTKLDKGKTVVGDNVMLMAYSHVAHDCVVGNNVIMANCATLGGHVVVGDYALIGGLSAVHQWARV
GEHAMVGGLTGVSLDIPPYTVASGQHAKLYGINIIGLRRRGFPEEVIKAISKAYRIIFRSPLPRQKAPEIVFQELGQYEE
VRKMVEFIKSSKRGVARHHKD
>Mature_261_residues
MKVHSSVLIEGEVEIPEDVEIGAYTVIQGNVKIGKGTKIGNRVTIKGNVTIGENCKIFDGAVIGEAPQHLKYEGEETSVE
IGNNVIIREYVTIHRGTKLDKGKTVVGDNVMLMAYSHVAHDCVVGNNVIMANCATLGGHVVVGDYALIGGLSAVHQWARV
GEHAMVGGLTGVSLDIPPYTVASGQHAKLYGINIIGLRRRGFPEEVIKAISKAYRIIFRSPLPRQKAPEIVFQELGQYEE
VRKMVEFIKSSKRGVARHHKD

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily

Homologues:

Organism=Escherichia coli, GI1786378, Length=257, Percent_Identity=47.0817120622568, Blast_Score=228, Evalue=4e-61,
Organism=Escherichia coli, GI1786376, Length=173, Percent_Identity=29.4797687861272, Blast_Score=76, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXA_AQUAE (O66862)

Other databases:

- EMBL:   AE000657
- PIR:   B70354
- RefSeq:   NP_213422.1
- ProteinModelPortal:   O66862
- SMR:   O66862
- GeneID:   1193924
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_604
- NMPDR:   fig|224324.1.peg.437
- HOGENOM:   HBG659295
- OMA:   DLKYQGE
- PhylomeDB:   O66862
- ProtClustDB:   PRK05289
- BioCyc:   AAEO224324:AQ_604-MONOMER
- BRENDA:   2.3.1.129
- GO:   GO:0005737
- HAMAP:   MF_00387
- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR010137
- InterPro:   IPR011004
- PIRSF:   PIRSF000456
- TIGRFAMs:   TIGR01852

Pfam domain/function: PF00132 Hexapep; SSF51161 Trimer_LpxA_like

EC number: =2.3.1.129

Molecular weight: Translated: 28416; Mature: 28416

Theoretical pI: Translated: 8.75; Mature: 8.75

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVHSSVLIEGEVEIPEDVEIGAYTVIQGNVKIGKGTKIGNRVTIKGNVTIGENCKIFDG
CCCCCEEEEECCCCCCCCCCCCEEEEEECCEEECCCCCCCCEEEEEEEEEECCCCEEECC
AVIGEAPQHLKYEGEETSVEIGNNVIIREYVTIHRGTKLDKGKTVVGDNVMLMAYSHVAH
EEECCCCHHCEECCCCCEEEECCCEEEEEEEEEECCCCCCCCCEEECCCEEEEEEHHHHH
DCVVGNNVIMANCATLGGHVVVGDYALIGGLSAVHQWARVGEHAMVGGLTGVSLDIPPYT
HEEECCCEEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHCCCEEECCCCCEEECCCCEE
VASGQHAKLYGINIIGLRRRGFPEEVIKAISKAYRIIFRSPLPRQKAPEIVFQELGQYEE
ECCCCCEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCHHH
VRKMVEFIKSSKRGVARHHKD
HHHHHHHHHCCCCCCHHCCCC
>Mature Secondary Structure
MKVHSSVLIEGEVEIPEDVEIGAYTVIQGNVKIGKGTKIGNRVTIKGNVTIGENCKIFDG
CCCCCEEEEECCCCCCCCCCCCEEEEEECCEEECCCCCCCCEEEEEEEEEECCCCEEECC
AVIGEAPQHLKYEGEETSVEIGNNVIIREYVTIHRGTKLDKGKTVVGDNVMLMAYSHVAH
EEECCCCHHCEECCCCCEEEECCCEEEEEEEEEECCCCCCCCCEEECCCEEEEEEHHHHH
DCVVGNNVIMANCATLGGHVVVGDYALIGGLSAVHQWARVGEHAMVGGLTGVSLDIPPYT
HEEECCCEEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHCCCEEECCCCCEEECCCCEE
VASGQHAKLYGINIIGLRRRGFPEEVIKAISKAYRIIFRSPLPRQKAPEIVFQELGQYEE
ECCCCCEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCHHH
VRKMVEFIKSSKRGVARHHKD
HHHHHHHHHCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320