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The map label for this gene is lpxD

Identifier: 15606000

GI number: 15606000

Start: 365636

End: 366295

Strand: Direct

Name: lpxD

Synonym: aq_538

Alternate gene names: 15606000

Gene position: 365636-366295 (Clockwise)

Preceding gene: 15605999

Following gene: 15606001

Centisome position: 23.57

GC content: 44.85

Gene sequence:

>660_bases
ATGGGGAGTTTTATCGGAGACTTTGTCGTGATTGGTAAAAACGTAAAAATAGGAAGGAACGTAAAGATTTATCCCTTTAC
TTACGTAGGAGATAACACCGTTATAGGTGATAACACGGTTATATTCAGCGGAGTGCATATATACAGGAACACGGTTATAG
GCAGAAACGTCAGGATTCACAGCGGGGCTGTTATAGGAGCGGACGGGTTTGGCTACCACATAACTCAGGAGGGGATTAAG
AAAATTCCTCACATAGGCGGTGTGATAATAGAGGACAACGTGGAGATAGGGGCAAACACCACGATAGACAGGGCGTTGAT
AGAAAACACTTTAATCGGTAAAAACACGAAGATTGACAACCTCGTTATGGTGGCTCACAACTGCAAGGTGGGAGAGAATA
ACATACTCGTTTCTCAAGTAGGTCTTTCAGGAAGTGTAAAAACAGGAAAAAACGTAATTCTTGCAGGACAGGTGGGAGTA
GCGGATCACGTGGAGATAGGGGACAACGTCATCGTCACAGCAAAGTCGGGAGTGGCGAACAACCTCGCTCCAAACAAAAC
TTACGGTGCTAACCTGCCGGCAATTGAGTGGAGCAGGTGGAAGAGGATATACGTCTACCTTTTAAGACTTCCAGAACTCT
TCAAGAAGATAACTACCTGA

Upstream 100 bases:

>100_bases
TAAAACTCGCCCTTGCTGAGTTTCTTGAGCACTTCTTTCCAGAAGAGCATCCCTGGGGATTTCTCAGAACGCCAGCATCG
GAGAAGGAGTTGAGATAGGA

Downstream 100 bases:

>100_bases
AATGTTAAGGGCTTACATATTTTACAGGCTTGTAAAGAACACCTTACTGACCGCCTTTATACTTTCCTTAATACTCCTCA
CACTTCAGCTTACCCGTCTT

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 219; Mature: 218

Protein sequence:

>219_residues
MGSFIGDFVVIGKNVKIGRNVKIYPFTYVGDNTVIGDNTVIFSGVHIYRNTVIGRNVRIHSGAVIGADGFGYHITQEGIK
KIPHIGGVIIEDNVEIGANTTIDRALIENTLIGKNTKIDNLVMVAHNCKVGENNILVSQVGLSGSVKTGKNVILAGQVGV
ADHVEIGDNVIVTAKSGVANNLAPNKTYGANLPAIEWSRWKRIYVYLLRLPELFKKITT

Sequences:

>Translated_219_residues
MGSFIGDFVVIGKNVKIGRNVKIYPFTYVGDNTVIGDNTVIFSGVHIYRNTVIGRNVRIHSGAVIGADGFGYHITQEGIK
KIPHIGGVIIEDNVEIGANTTIDRALIENTLIGKNTKIDNLVMVAHNCKVGENNILVSQVGLSGSVKTGKNVILAGQVGV
ADHVEIGDNVIVTAKSGVANNLAPNKTYGANLPAIEWSRWKRIYVYLLRLPELFKKITT
>Mature_218_residues
GSFIGDFVVIGKNVKIGRNVKIYPFTYVGDNTVIGDNTVIFSGVHIYRNTVIGRNVRIHSGAVIGADGFGYHITQEGIKK
IPHIGGVIIEDNVEIGANTTIDRALIENTLIGKNTKIDNLVMVAHNCKVGENNILVSQVGLSGSVKTGKNVILAGQVGVA
DHVEIGDNVIVTAKSGVANNLAPNKTYGANLPAIEWSRWKRIYVYLLRLPELFKKITT

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily

Homologues:

Organism=Escherichia coli, GI1786376, Length=215, Percent_Identity=36.7441860465116, Blast_Score=134, Evalue=4e-33,
Organism=Escherichia coli, GI1786378, Length=221, Percent_Identity=28.9592760180996, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXD_AQUAE (O66817)

Other databases:

- EMBL:   AE000657
- PIR:   E70348
- RefSeq:   NP_213377.1
- ProteinModelPortal:   O66817
- GeneID:   1193235
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_538
- HOGENOM:   HBG469615
- OMA:   TIHASTV
- PhylomeDB:   O66817
- BioCyc:   AAEO224324:AQ_538-MONOMER
- HAMAP:   MF_00523
- InterPro:   IPR001451
- InterPro:   IPR011004
- InterPro:   IPR007691
- TIGRFAMs:   TIGR01853

Pfam domain/function: PF00132 Hexapep; SSF51161 Trimer_LpxA_like

EC number: 2.3.1.-

Molecular weight: Translated: 23649; Mature: 23518

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSFIGDFVVIGKNVKIGRNVKIYPFTYVGDNTVIGDNTVIFSGVHIYRNTVIGRNVRIH
CCCCCCCEEEECCCEEECCCEEEEEEEEECCCEEECCCEEEEECEEEEEEEEECCEEEEE
SGAVIGADGFGYHITQEGIKKIPHIGGVIIEDNVEIGANTTIDRALIENTLIGKNTKIDN
CCEEECCCCCCEEECHHHHHHCCCCCCEEEECCEEECCCCCHHHHHHHHHCCCCCCCCCE
LVMVAHNCKVGENNILVSQVGLSGSVKTGKNVILAGQVGVADHVEIGDNVIVTAKSGVAN
EEEEEECCEECCCCEEEEEECCCCCCCCCCEEEEEECCCCCCEEECCCCEEEEECCCCCC
NLAPNKTYGANLPAIEWSRWKRIYVYLLRLPELFKKITT
CCCCCCCCCCCCCCCCHHHHHEEEHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GSFIGDFVVIGKNVKIGRNVKIYPFTYVGDNTVIGDNTVIFSGVHIYRNTVIGRNVRIH
CCCCCCEEEECCCEEECCCEEEEEEEEECCCEEECCCEEEEECEEEEEEEEECCEEEEE
SGAVIGADGFGYHITQEGIKKIPHIGGVIIEDNVEIGANTTIDRALIENTLIGKNTKIDN
CCEEECCCCCCEEECHHHHHHCCCCCCEEEECCEEECCCCCHHHHHHHHHCCCCCCCCCE
LVMVAHNCKVGENNILVSQVGLSGSVKTGKNVILAGQVGVADHVEIGDNVIVTAKSGVAN
EEEEEECCEECCCCEEEEEECCCCCCCCCCEEEEEECCCCCCEEECCCCEEEEECCCCCC
NLAPNKTYGANLPAIEWSRWKRIYVYLLRLPELFKKITT
CCCCCCCCCCCCCCCCHHHHHEEEHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320