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The map label for this gene is moaC

Identifier: 15605993

GI number: 15605993

Start: 357943

End: 358707

Strand: Direct

Name: moaC

Synonym: aq_527

Alternate gene names: 15605993

Gene position: 357943-358707 (Clockwise)

Preceding gene: 15605992

Following gene: 15605994

Centisome position: 23.07

GC content: 44.84

Gene sequence:

>765_bases
ATGAGAACCGTAGACATAACGACGAAGATAGAGACCTTAAGAGAGGCGAAGGCTTACGGCAGGATAAGGTTAAAGCCCGA
AACCGTAAAACTGATTAAGGAAAACAAAGTTCCAAAAGGAAACCTCGTAGAAGCCACAAAACTGAGCGGTATATTCGGGG
CAAAGAAAACGGGAGAACTCCTTCCATTCTGCCACCCTATTCCCTTAGACTTCGTGGCTCTTGAAGTGAAAGTAAACGAA
GATAATCTGGAAGTATTCTCAACGGTAAGAGGGATAGCAAGGACGGGCTACGAGATGGAAGCCCTGACGGCGGTCACAAC
TGCACTTCTTAATGTTTACGATATGTGCAAGGCTCTTGACGACTCCATGGTAATAGAAGAGGTGAAACTCCTCGAAAAGA
GCGGTGGAAAATCTGACTGGTTTAGAAGGCTGGACGGAGTGAAGGTGAACCTTCACGCGGAAAATGAAGGATTAAGGAAA
ATCGCAGAAGACTACCTGAAAGAACTTGGAGCAACCTTTGCCGAAGAGGCAGAACTTTACATCTCCATCGGAGATAATCT
TCCTATAAACAAGGAAATAAGGTCCCTTGAGCGTGTGATTTCCCTTTACGACTTTCGTAGGAATCCGAAAGAGGTGGGAA
AGGAGATAAGAGTAGGGTGGTCCGACGATGCCCTGATAATAATCCTTCCCGAAAGCGAAGAAAAAATCAGGTTCTTCTTT
GAAACCTTCGGAGGTATCATAGGAAATCTTTTATGCAGAAGATAG

Upstream 100 bases:

>100_bases
AGGAAGAACCGAAGGAAGAACCTAAACCTTTATCCGATACGACCTATCTGGAAGAGGAGGAAATACCCGCGGTAATCAGA
AGGAAGAATAAGCGGTTGCT

Downstream 100 bases:

>100_bases
CCCTCTGTATTACGGGTGCAAGCGGAGTAATATACGGGATAAAACTCCTGCAAGTATTGGAGGAGTTAGATTTTTCAGTA
GACTTGGTAATTTCAAGGAA

Product: molybdenum cofactor biosynthesis moaC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MRTVDITTKIETLREAKAYGRIRLKPETVKLIKENKVPKGNLVEATKLSGIFGAKKTGELLPFCHPIPLDFVALEVKVNE
DNLEVFSTVRGIARTGYEMEALTAVTTALLNVYDMCKALDDSMVIEEVKLLEKSGGKSDWFRRLDGVKVNLHAENEGLRK
IAEDYLKELGATFAEEAELYISIGDNLPINKEIRSLERVISLYDFRRNPKEVGKEIRVGWSDDALIIILPESEEKIRFFF
ETFGGIIGNLLCRR

Sequences:

>Translated_254_residues
MRTVDITTKIETLREAKAYGRIRLKPETVKLIKENKVPKGNLVEATKLSGIFGAKKTGELLPFCHPIPLDFVALEVKVNE
DNLEVFSTVRGIARTGYEMEALTAVTTALLNVYDMCKALDDSMVIEEVKLLEKSGGKSDWFRRLDGVKVNLHAENEGLRK
IAEDYLKELGATFAEEAELYISIGDNLPINKEIRSLERVISLYDFRRNPKEVGKEIRVGWSDDALIIILPESEEKIRFFF
ETFGGIIGNLLCRR
>Mature_254_residues
MRTVDITTKIETLREAKAYGRIRLKPETVKLIKENKVPKGNLVEATKLSGIFGAKKTGELLPFCHPIPLDFVALEVKVNE
DNLEVFSTVRGIARTGYEMEALTAVTTALLNVYDMCKALDDSMVIEEVKLLEKSGGKSDWFRRLDGVKVNLHAENEGLRK
IAEDYLKELGATFAEEAELYISIGDNLPINKEIRSLERVISLYDFRRNPKEVGKEIRVGWSDDALIIILPESEEKIRFFF
ETFGGIIGNLLCRR

Specific function: Together with moaA, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z

COG id: COG0315

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the N-terminal section; belongs to the moaC family

Homologues:

Organism=Escherichia coli, GI1787001, Length=141, Percent_Identity=41.1347517730496, Blast_Score=115, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI32566331, Length=141, Percent_Identity=43.2624113475177, Blast_Score=120, Evalue=5e-28,
Organism=Drosophila melanogaster, GI28574492, Length=141, Percent_Identity=43.2624113475177, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI28574490, Length=141, Percent_Identity=43.2624113475177, Blast_Score=120, Evalue=8e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MOAC_AQUAE (O66810)

Other databases:

- EMBL:   AE000657
- PIR:   F70347
- RefSeq:   NP_213370.1
- ProteinModelPortal:   O66810
- SMR:   O66810
- GeneID:   1193228
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_527
- NMPDR:   fig|224324.1.peg.385
- HOGENOM:   HBG289233
- PhylomeDB:   O66810
- ProtClustDB:   CLSK2748321
- BioCyc:   AAEO224324:AQ_527-MONOMER
- HAMAP:   MF_01224_B
- InterPro:   IPR023045
- InterPro:   IPR002820
- Gene3D:   G3DSA:3.30.70.640
- TIGRFAMs:   TIGR00581

Pfam domain/function: PF01967 MoaC; SSF55040 MoaC

EC number: NA

Molecular weight: Translated: 28738; Mature: 28738

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: NA

Important sites: ACT_SITE 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTVDITTKIETLREAKAYGRIRLKPETVKLIKENKVPKGNLVEATKLSGIFGAKKTGEL
CCEEEHHHHHHHHHHHHHHCEEEECHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCC
LPFCHPIPLDFVALEVKVNEDNLEVFSTVRGIARTGYEMEALTAVTTALLNVYDMCKALD
CCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
DSMVIEEVKLLEKSGGKSDWFRRLDGVKVNLHAENEGLRKIAEDYLKELGATFAEEAELY
HHHHHHHHHHHHHCCCHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHHCCHHHCCCEEE
ISIGDNLPINKEIRSLERVISLYDFRRNPKEVGKEIRVGWSDDALIIILPESEEKIRFFF
EEECCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHEECCCCCCEEEEEECCCCHHHHHHH
ETFGGIIGNLLCRR
HHHHHHHHHHHCCC
>Mature Secondary Structure
MRTVDITTKIETLREAKAYGRIRLKPETVKLIKENKVPKGNLVEATKLSGIFGAKKTGEL
CCEEEHHHHHHHHHHHHHHCEEEECHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCC
LPFCHPIPLDFVALEVKVNEDNLEVFSTVRGIARTGYEMEALTAVTTALLNVYDMCKALD
CCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
DSMVIEEVKLLEKSGGKSDWFRRLDGVKVNLHAENEGLRKIAEDYLKELGATFAEEAELY
HHHHHHHHHHHHHCCCHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHHCCHHHCCCEEE
ISIGDNLPINKEIRSLERVISLYDFRRNPKEVGKEIRVGWSDDALIIILPESEEKIRFFF
EEECCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHEECCCCCCEEEEEECCCCHHHHHHH
ETFGGIIGNLLCRR
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Involved in molybdopterin biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320