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The map label for this gene is dxr

Identifier: 15605905

GI number: 15605905

Start: 274129

End: 275271

Strand: Direct

Name: dxr

Synonym: aq_404

Alternate gene names: 15605905

Gene position: 274129-275271 (Clockwise)

Preceding gene: 15605904

Following gene: 15605911

Centisome position: 17.67

GC content: 44.01

Gene sequence:

>1143_bases
ATGAAATTAGGAGTTCTCGGTTCTACGGGTTCTGTTGGCTCTCAAACTCTTCAGGTTTACGAGAATTTCAGGGATGAAAT
AGAACTTGTAGGGATACTTGCAAATAGAGCATCGGAAAAGCTTCTCCAGCAGGCAAAAAAGTATAAACCCAAGTACGTGG
TTTCTTACCAGGAGCCTGCAAAGGAGTGGCTGGAGAGTCTGCCCGAAGGCGTTAAATACCTCAAGGGTGACGAAGGACTA
AAAGCGATAATAGAAGAGTCAGAAAGGTTAATGAACGCAATTTCGGGAATTTACGGCATAAAACCCGCCTACGAAGTTAT
AAAGGCTGGAAAAACATTACTCGCCTCCAATAAGGAGTCTATACTCTGTCTGGGTGAGATTATAAGGAAGAACAGGGAAA
GGGTTATTCCCGTGGACAGTGAGCACAACGCCCTGTTTCAGCTTCTTAGTTCTGTCAAAAGGGAAGAAGTAAAGCATGTA
TATCTGACAGCTTCCGGTGGTCCTTTCAAGGACAAAAGCCTTGAGGAACTGAAAACAGCAAGTGTTGAAGAAGCACTAAG
GCACCCCCGCTGGAACATGGGGGCGAAGATAACGATTGACTCTGCAACGCTCATGAACAAAGGTTTTGAAATGCTCGAAG
CCCACTTTTTATTTGACTTTCCCATAGAAAACATAAAGGTGGTTATCCACCCGCAGAGCTTTGTCCACGGGATATTGGAA
CTCATTGACAACAGCTTCCTGATGCACACGTCCCAAACGGACATGAAAATCCCAATAATGCACGCTCTATTTTACCCAAA
GAGGAAAGAGTATCCCTTTAAGAAAGTTTCACTTCTTGAACTATCTCCCATAACCTTTGAGAAGGTTGATACTACAAAGT
TTAAAGCCATTGACTTGGCTAAGTGGGCGGGTTTTATGGGTGGCGTGTACATTCCAGTGCTCGTGGGAGCGGATGAAGAA
GCCGTGAACCTGTTTCTGAATAAGAAAATCGGATTTCTGGACATAGTTGACCTTATAGAGCAGGCTTTAAGTGAGGTTAA
CATCAAAGACCCTCAAAGCGTTGAAGAAATATTGGAAGCGGTTGAGTGGGGAAGACAAAAGGTCAGGGAGATTTACGAGA
GAAAGTATGCAGGTAAAGGATAG

Upstream 100 bases:

>100_bases
TCCCTCGGACTCGAACCTGTGGTATCACCCAACTGTTGTTCTACAGTGTACTCCATGGTTTTCCAAACTATGGAAACTCA
GTGATAAACTTATTCTGGTT

Downstream 100 bases:

>100_bases
AGAGGACGCCCCAAAAGGCAGAGGAAAGCAGTAAGAAGTTGTGAACTATGAAGCCTATCTTGAGTCCTTCCTTTACTTCA
AGACCAAGAAGCTTTAAAGG

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MKLGVLGSTGSVGSQTLQVYENFRDEIELVGILANRASEKLLQQAKKYKPKYVVSYQEPAKEWLESLPEGVKYLKGDEGL
KAIIEESERLMNAISGIYGIKPAYEVIKAGKTLLASNKESILCLGEIIRKNRERVIPVDSEHNALFQLLSSVKREEVKHV
YLTASGGPFKDKSLEELKTASVEEALRHPRWNMGAKITIDSATLMNKGFEMLEAHFLFDFPIENIKVVIHPQSFVHGILE
LIDNSFLMHTSQTDMKIPIMHALFYPKRKEYPFKKVSLLELSPITFEKVDTTKFKAIDLAKWAGFMGGVYIPVLVGADEE
AVNLFLNKKIGFLDIVDLIEQALSEVNIKDPQSVEEILEAVEWGRQKVREIYERKYAGKG

Sequences:

>Translated_380_residues
MKLGVLGSTGSVGSQTLQVYENFRDEIELVGILANRASEKLLQQAKKYKPKYVVSYQEPAKEWLESLPEGVKYLKGDEGL
KAIIEESERLMNAISGIYGIKPAYEVIKAGKTLLASNKESILCLGEIIRKNRERVIPVDSEHNALFQLLSSVKREEVKHV
YLTASGGPFKDKSLEELKTASVEEALRHPRWNMGAKITIDSATLMNKGFEMLEAHFLFDFPIENIKVVIHPQSFVHGILE
LIDNSFLMHTSQTDMKIPIMHALFYPKRKEYPFKKVSLLELSPITFEKVDTTKFKAIDLAKWAGFMGGVYIPVLVGADEE
AVNLFLNKKIGFLDIVDLIEQALSEVNIKDPQSVEEILEAVEWGRQKVREIYERKYAGKG
>Mature_380_residues
MKLGVLGSTGSVGSQTLQVYENFRDEIELVGILANRASEKLLQQAKKYKPKYVVSYQEPAKEWLESLPEGVKYLKGDEGL
KAIIEESERLMNAISGIYGIKPAYEVIKAGKTLLASNKESILCLGEIIRKNRERVIPVDSEHNALFQLLSSVKREEVKHV
YLTASGGPFKDKSLEELKTASVEEALRHPRWNMGAKITIDSATLMNKGFEMLEAHFLFDFPIENIKVVIHPQSFVHGILE
LIDNSFLMHTSQTDMKIPIMHALFYPKRKEYPFKKVSLLELSPITFEKVDTTKFKAIDLAKWAGFMGGVYIPVLVGADEE
AVNLFLNKKIGFLDIVDLIEQALSEVNIKDPQSVEEILEAVEWGRQKVREIYERKYAGKG

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=389, Percent_Identity=33.1619537275064, Blast_Score=240, Evalue=1e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_AQUAE (O66722)

Other databases:

- EMBL:   AE000657
- PIR:   F70336
- RefSeq:   NP_213282.1
- ProteinModelPortal:   O66722
- SMR:   O66722
- GeneID:   1193048
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_404
- NMPDR:   fig|224324.1.peg.297
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- PhylomeDB:   O66722
- ProtClustDB:   PRK05447
- BioCyc:   AAEO224324:AQ_404-MONOMER
- BRENDA:   1.1.1.267
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 42963; Mature: 42963

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: NA

Important sites: BINDING 118-118 BINDING 141-141 BINDING 165-165 BINDING 188-188 BINDING 210-210

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLGVLGSTGSVGSQTLQVYENFRDEIELVGILANRASEKLLQQAKKYKPKYVVSYQEPA
CCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHH
KEWLESLPEGVKYLKGDEGLKAIIEESERLMNAISGIYGIKPAYEVIKAGKTLLASNKES
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHCCCCCCC
ILCLGEIIRKNRERVIPVDSEHNALFQLLSSVKREEVKHVYLTASGGPFKDKSLEELKTA
CHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHH
SVEEALRHPRWNMGAKITIDSATLMNKGFEMLEAHFLFDFPIENIKVVIHPQSFVHGILE
HHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHEECCCCCEEEEECCHHHHHHHHH
LIDNSFLMHTSQTDMKIPIMHALFYPKRKEYPFKKVSLLELSPITFEKVDTTKFKAIDLA
HHCCCCEEECCCCCCCCHHHHHHHCCCCCCCCCCCEEEEEECCCEEECCCCCHHHHHHHH
KWAGFMGGVYIPVLVGADEEAVNLFLNKKIGFLDIVDLIEQALSEVNIKDPQSVEEILEA
HHHHHHCCEEEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
VEWGRQKVREIYERKYAGKG
HHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKLGVLGSTGSVGSQTLQVYENFRDEIELVGILANRASEKLLQQAKKYKPKYVVSYQEPA
CCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHH
KEWLESLPEGVKYLKGDEGLKAIIEESERLMNAISGIYGIKPAYEVIKAGKTLLASNKES
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHCCCCCCC
ILCLGEIIRKNRERVIPVDSEHNALFQLLSSVKREEVKHVYLTASGGPFKDKSLEELKTA
CHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHH
SVEEALRHPRWNMGAKITIDSATLMNKGFEMLEAHFLFDFPIENIKVVIHPQSFVHGILE
HHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHEECCCCCEEEEECCHHHHHHHHH
LIDNSFLMHTSQTDMKIPIMHALFYPKRKEYPFKKVSLLELSPITFEKVDTTKFKAIDLA
HHCCCCEEECCCCCCCCHHHHHHHCCCCCCCCCCCEEEEEECCCEEECCCCCHHHHHHHH
KWAGFMGGVYIPVLVGADEEAVNLFLNKKIGFLDIVDLIEQALSEVNIKDPQSVEEILEA
HHHHHHCCEEEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
VEWGRQKVREIYERKYAGKG
HHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320