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The map label for this gene is lon

Identifier: 15605788

GI number: 15605788

Start: 151206

End: 153593

Strand: Direct

Name: lon

Synonym: aq_242

Alternate gene names: 15605788

Gene position: 151206-153593 (Clockwise)

Preceding gene: 15605786

Following gene: 15605791

Centisome position: 9.75

GC content: 47.45

Gene sequence:

>2388_bases
GTGAACGAACTATTTCAAACCCCTCAGGTAGAAGCGGGAATTAAAGAATACCCCTTAATGCCTTTAAGGGACATAGTTAT
CTTCCCCACAATGGTTCAGCCTCTCTTTGTAGGAAGGCGTTTCTCAATAAGAGCTATTGAGGAGGCGAACAAAAAGGACA
AACTTATATTCTTAGTTCTTCAAAAGGACAAAGATGTAGAAGAACCTAAGGAAGAGGACATATACAAAGTCGGTGTGGTT
GCCTACATATTAAGAACAGTTCCCATAGAGGACGCAAGAGTAAAGGTTCTCGTTCAGGGATTAAAGAGAGGGGTTATAAA
GAAGCTCGAGTGGAAAGAAGACCACTACGTAGCCCAGGTAGACGTTATAGAGGAAAGGGACATCCCGCCCGAAAGCCAAA
CGATAGAGGACAAAGCCCTCATAAAGGCCGTAAAGGAATCCATAGACAAACTCGTCAGCCTTGGAAAACAGATAATTCCC
GACCTCGTAGTTCTCATAAAGGAACTCGAAGAACCCGGAAAGCTCGCGGATATGGTAGCCTCCATCCTTGATATAAAATC
CTCACAGGCTCAGGAGATACTGGAAACTTTCGACCCCAGAGAAAGACTTAAGAAGGTTTACAAATTCCTACAGGACGAAA
TAGGACTCCTAGAAGTAAAACAAAGGATAAGCGAGATAGCAAGGGAGAGAATGGAAAAGGAACAGAGGGAGTACTACCTC
AGACAGCAACTCAAAGCCATACAGGAGGAACTCGGAGAAGCAGGCGGAATAAAGGCTGAAATAGAGGAGTACACAAAGAA
GTTTGAAGAAGTCAAAGAGTGTATGCCTGAAGAAGGGGTAAAGGAAGTAGAAAAGAACATAAAGAGACTAGAGAGACTGC
ACCCCGAGTCCGCGGAAGCTGGAGTTATAAGAACGTGGCTCGACTGGGTTCTGGACCTTCCCTGGTGTACGAGGACTGAG
GACAATTACGACCTTGAAAGGGCAAGGGAAATTTTAGACAGAGATCACTACGACCTTGAAAAGGTAAAGGACAGGATAAT
AGAGTACCTCGCCATAAGGAAGTTAACTCAAGGTAAAGAAGCCCCAACTCAGATACTTGCCTTTGTAGGACCTCCGGGTG
TAGGTAAGACTTCCCTAGGACGCTCAATAGCGGAGGCCCTCGGAAGGAAGTTCGTAAGGATAGCTTTGGGAGGTATAAGG
GACGAGGCGGAAATCAGGGGACACAGGAGAACTTACGTCGGGGCAATGCCCGGAAGGATTATTCAAGCCATAAAACAGGC
CGGAACGAAAAACCCTGTAATAATGCTGGATGAGATAGACAAGCTCGCCATATCCTTCCAGGGAGACCCCGCGGCTGCAC
TCCTCGAAGTCCTTGATCCGGAGCAAAATAAGAAGTTCACGGACCTCTACATAGGGATTCCCTTTGACCTCTCAGAAGTG
ATATTCATTTGTACGGGAAACAGGGCGGATACTATTCCCACACCGCTCCTCGACAGGATGGAACTCATAATGCTTTCAGG
ATACTCCGAAGAGGAGAAACTCTTCATAGCAAAGAAACACTTGATTCCCAAGTTAATTCCCCTCCACGGCTTTAGCCCGG
AAGAGATCGAGTTTACGGACGAGGCTATTCTGGAGATAATAAGGGGCTACACGAGAGAGGCGGGAGTGAGAAACCTTCAA
AGGCAGATTTCCGCAGTCCTGAGAAAAATAGCTGTAAAGAAACTACAGGGTGAGAAAGGTCCGTTTAATATAACCCCTGA
GCTCGTCAGAAAACTCCTCGGAGTTCCGAGGTACAGACCTGAAAGGGAAAAGAAACCTCTCGTTGGGGTTGCCACAGGAC
TCGCATGGACCGAAGTAGGCGGAGAGATAATGTTCATAGAAGCCACGAAGATGAAGGGGAAAGGCTCGCTTGTTCTCACA
GGTTCACTGGGAGACATAATGAAAGAAAGTGCTCAGGCAGCTCTCTCTTACATCCGCTCAAAGGCGGAAGACTACGGCAT
AGATCCGGATATATTCTCACAGGTTGACGTTCACGTGCACGTTCCCGAGGGAGCGGTTCCGAAGGACGGACCATCCGCGG
GTGTTGCGATAGCGACCGCACTCCTATCTCTGTTTACGGACATTCCCGTGAGGATGGACGTTGCCATGACGGGAGAAATT
ACCTTAAGGGGAAGAGTGCTCCCCGTAGGTGGTCTGAAGGAAAAGATACTCGCGGCAAAGAGAGCGGAAATCTACGAGGT
AATCCTGCCCGCTAAAAACAAAGACGAGGTTATGGAAGAACTCCCAGAGTACGTAAGGGAAAAGATGACTCTACACTTTG
TAGATAACTTAGAAGAAGTGTTCAAGATAGCATTAGTGAGAGAGCCAAAGCCCCTCAAAGAGGCGTGA

Upstream 100 bases:

>100_bases
TTTTTTATAACTTCTTCCTTCCCCTTTATTACTTTCGAGACCTCAGAAATTATGAGGTTTATGTCCATTGGTATAATTTT
AAAAACAAGGAGGAGAAAAG

Downstream 100 bases:

>100_bases
TCTCTATAAGGTAAACCTCTCCCCTGTTCTGTATGGGGATCGTTCCCTTGCTCCCCGTTATTACAAATATCCTTCCTTCG
CTATCCCTTACTATAGCCTG

Product: Lon protease

Products: NA

Alternate protein names: ATP-dependent protease La

Number of amino acids: Translated: 795; Mature: 795

Protein sequence:

>795_residues
MNELFQTPQVEAGIKEYPLMPLRDIVIFPTMVQPLFVGRRFSIRAIEEANKKDKLIFLVLQKDKDVEEPKEEDIYKVGVV
AYILRTVPIEDARVKVLVQGLKRGVIKKLEWKEDHYVAQVDVIEERDIPPESQTIEDKALIKAVKESIDKLVSLGKQIIP
DLVVLIKELEEPGKLADMVASILDIKSSQAQEILETFDPRERLKKVYKFLQDEIGLLEVKQRISEIARERMEKEQREYYL
RQQLKAIQEELGEAGGIKAEIEEYTKKFEEVKECMPEEGVKEVEKNIKRLERLHPESAEAGVIRTWLDWVLDLPWCTRTE
DNYDLERAREILDRDHYDLEKVKDRIIEYLAIRKLTQGKEAPTQILAFVGPPGVGKTSLGRSIAEALGRKFVRIALGGIR
DEAEIRGHRRTYVGAMPGRIIQAIKQAGTKNPVIMLDEIDKLAISFQGDPAAALLEVLDPEQNKKFTDLYIGIPFDLSEV
IFICTGNRADTIPTPLLDRMELIMLSGYSEEEKLFIAKKHLIPKLIPLHGFSPEEIEFTDEAILEIIRGYTREAGVRNLQ
RQISAVLRKIAVKKLQGEKGPFNITPELVRKLLGVPRYRPEREKKPLVGVATGLAWTEVGGEIMFIEATKMKGKGSLVLT
GSLGDIMKESAQAALSYIRSKAEDYGIDPDIFSQVDVHVHVPEGAVPKDGPSAGVAIATALLSLFTDIPVRMDVAMTGEI
TLRGRVLPVGGLKEKILAAKRAEIYEVILPAKNKDEVMEELPEYVREKMTLHFVDNLEEVFKIALVREPKPLKEA

Sequences:

>Translated_795_residues
MNELFQTPQVEAGIKEYPLMPLRDIVIFPTMVQPLFVGRRFSIRAIEEANKKDKLIFLVLQKDKDVEEPKEEDIYKVGVV
AYILRTVPIEDARVKVLVQGLKRGVIKKLEWKEDHYVAQVDVIEERDIPPESQTIEDKALIKAVKESIDKLVSLGKQIIP
DLVVLIKELEEPGKLADMVASILDIKSSQAQEILETFDPRERLKKVYKFLQDEIGLLEVKQRISEIARERMEKEQREYYL
RQQLKAIQEELGEAGGIKAEIEEYTKKFEEVKECMPEEGVKEVEKNIKRLERLHPESAEAGVIRTWLDWVLDLPWCTRTE
DNYDLERAREILDRDHYDLEKVKDRIIEYLAIRKLTQGKEAPTQILAFVGPPGVGKTSLGRSIAEALGRKFVRIALGGIR
DEAEIRGHRRTYVGAMPGRIIQAIKQAGTKNPVIMLDEIDKLAISFQGDPAAALLEVLDPEQNKKFTDLYIGIPFDLSEV
IFICTGNRADTIPTPLLDRMELIMLSGYSEEEKLFIAKKHLIPKLIPLHGFSPEEIEFTDEAILEIIRGYTREAGVRNLQ
RQISAVLRKIAVKKLQGEKGPFNITPELVRKLLGVPRYRPEREKKPLVGVATGLAWTEVGGEIMFIEATKMKGKGSLVLT
GSLGDIMKESAQAALSYIRSKAEDYGIDPDIFSQVDVHVHVPEGAVPKDGPSAGVAIATALLSLFTDIPVRMDVAMTGEI
TLRGRVLPVGGLKEKILAAKRAEIYEVILPAKNKDEVMEELPEYVREKMTLHFVDNLEEVFKIALVREPKPLKEA
>Mature_795_residues
MNELFQTPQVEAGIKEYPLMPLRDIVIFPTMVQPLFVGRRFSIRAIEEANKKDKLIFLVLQKDKDVEEPKEEDIYKVGVV
AYILRTVPIEDARVKVLVQGLKRGVIKKLEWKEDHYVAQVDVIEERDIPPESQTIEDKALIKAVKESIDKLVSLGKQIIP
DLVVLIKELEEPGKLADMVASILDIKSSQAQEILETFDPRERLKKVYKFLQDEIGLLEVKQRISEIARERMEKEQREYYL
RQQLKAIQEELGEAGGIKAEIEEYTKKFEEVKECMPEEGVKEVEKNIKRLERLHPESAEAGVIRTWLDWVLDLPWCTRTE
DNYDLERAREILDRDHYDLEKVKDRIIEYLAIRKLTQGKEAPTQILAFVGPPGVGKTSLGRSIAEALGRKFVRIALGGIR
DEAEIRGHRRTYVGAMPGRIIQAIKQAGTKNPVIMLDEIDKLAISFQGDPAAALLEVLDPEQNKKFTDLYIGIPFDLSEV
IFICTGNRADTIPTPLLDRMELIMLSGYSEEEKLFIAKKHLIPKLIPLHGFSPEEIEFTDEAILEIIRGYTREAGVRNLQ
RQISAVLRKIAVKKLQGEKGPFNITPELVRKLLGVPRYRPEREKKPLVGVATGLAWTEVGGEIMFIEATKMKGKGSLVLT
GSLGDIMKESAQAALSYIRSKAEDYGIDPDIFSQVDVHVHVPEGAVPKDGPSAGVAIATALLSLFTDIPVRMDVAMTGEI
TLRGRVLPVGGLKEKILAAKRAEIYEVILPAKNKDEVMEELPEYVREKMTLHFVDNLEEVFKIALVREPKPLKEA

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain

Homologues:

Organism=Homo sapiens, GI21396489, Length=670, Percent_Identity=43.5820895522388, Blast_Score=539, Evalue=1e-153,
Organism=Homo sapiens, GI31377667, Length=661, Percent_Identity=44.3267776096823, Blast_Score=531, Evalue=1e-150,
Organism=Escherichia coli, GI1786643, Length=783, Percent_Identity=49.1698595146871, Blast_Score=734, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=707, Percent_Identity=38.7553041018388, Blast_Score=471, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI17556486, Length=550, Percent_Identity=42.1818181818182, Blast_Score=451, Evalue=1e-127,
Organism=Saccharomyces cerevisiae, GI6319449, Length=748, Percent_Identity=38.5026737967914, Blast_Score=493, Evalue=1e-140,
Organism=Drosophila melanogaster, GI221513036, Length=686, Percent_Identity=42.2740524781341, Blast_Score=531, Evalue=1e-151,
Organism=Drosophila melanogaster, GI24666867, Length=680, Percent_Identity=42.5, Blast_Score=530, Evalue=1e-150,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): LON_AQUAE (O66605)

Other databases:

- EMBL:   AE000657
- PIR:   A70322
- RefSeq:   NP_213165.1
- ProteinModelPortal:   O66605
- MEROPS:   S16.001
- GeneID:   1192839
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_242
- NMPDR:   fig|224324.1.peg.180
- HOGENOM:   HBG566281
- OMA:   KDAGTIN
- PhylomeDB:   O66605
- ProtClustDB:   CLSK2299336
- BioCyc:   AAEO224324:AQ_242-MONOMER
- BRENDA:   3.4.21.53
- GO:   GO:0005737
- GO:   GO:0006508
- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568
- PRINTS:   PR00830
- SMART:   SM00382
- SMART:   SM00464
- TIGRFAMs:   TIGR00763

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C; SSF88697 PUA-like; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =3.4.21.53

Molecular weight: Translated: 89973; Mature: 89973

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS01046 LON_SER

Important sites: ACT_SITE 692-692 ACT_SITE 735-735

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNELFQTPQVEAGIKEYPLMPLRDIVIFPTMVQPLFVGRRFSIRAIEEANKKDKLIFLVL
CCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEHHHHHCCCCCCEEEEEE
QKDKDVEEPKEEDIYKVGVVAYILRTVPIEDARVKVLVQGLKRGVIKKLEWKEDHYVAQV
ECCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
DVIEERDIPPESQTIEDKALIKAVKESIDKLVSLGKQIIPDLVVLIKELEEPGKLADMVA
EEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
SILDIKSSQAQEILETFDPRERLKKVYKFLQDEIGLLEVKQRISEIARERMEKEQREYYL
HHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RQQLKAIQEELGEAGGIKAEIEEYTKKFEEVKECMPEEGVKEVEKNIKRLERLHPESAEA
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCC
GVIRTWLDWVLDLPWCTRTEDNYDLERAREILDRDHYDLEKVKDRIIEYLAIRKLTQGKE
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCC
APTQILAFVGPPGVGKTSLGRSIAEALGRKFVRIALGGIRDEAEIRGHRRTYVGAMPGRI
CHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHEECCCCHHH
IQAIKQAGTKNPVIMLDEIDKLAISFQGDPAAALLEVLDPEQNKKFTDLYIGIPFDLSEV
HHHHHHCCCCCCEEEEECCCEEEEEECCCHHHHHHHHHCCCCCCEEEEEEEECCCCCCCE
IFICTGNRADTIPTPLLDRMELIMLSGYSEEEKLFIAKKHLIPKLIPLHGFSPEEIEFTD
EEEEECCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCHHHHCCCCCCCCCCCCCH
EAILEIIRGYTREAGVRNLQRQISAVLRKIAVKKLQGEKGPFNITPELVRKLLGVPRYRP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCC
EREKKPLVGVATGLAWTEVGGEIMFIEATKMKGKGSLVLTGSLGDIMKESAQAALSYIRS
CCCCCCCEEHHHCCHHHHCCCEEEEEEEECCCCCCCEEEECCHHHHHHHHHHHHHHHHHH
KAEDYGIDPDIFSQVDVHVHVPEGAVPKDGPSAGVAIATALLSLFTDIPVRMDVAMTGEI
HHHHCCCCHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECEE
TLRGRVLPVGGLKEKILAAKRAEIYEVILPAKNKDEVMEELPEYVREKMTLHFVDNLEEV
EEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
FKIALVREPKPLKEA
HHHHHHCCCCCCCCC
>Mature Secondary Structure
MNELFQTPQVEAGIKEYPLMPLRDIVIFPTMVQPLFVGRRFSIRAIEEANKKDKLIFLVL
CCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEHHHHHCCCCCCEEEEEE
QKDKDVEEPKEEDIYKVGVVAYILRTVPIEDARVKVLVQGLKRGVIKKLEWKEDHYVAQV
ECCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
DVIEERDIPPESQTIEDKALIKAVKESIDKLVSLGKQIIPDLVVLIKELEEPGKLADMVA
EEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
SILDIKSSQAQEILETFDPRERLKKVYKFLQDEIGLLEVKQRISEIARERMEKEQREYYL
HHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RQQLKAIQEELGEAGGIKAEIEEYTKKFEEVKECMPEEGVKEVEKNIKRLERLHPESAEA
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCC
GVIRTWLDWVLDLPWCTRTEDNYDLERAREILDRDHYDLEKVKDRIIEYLAIRKLTQGKE
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCC
APTQILAFVGPPGVGKTSLGRSIAEALGRKFVRIALGGIRDEAEIRGHRRTYVGAMPGRI
CHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHEECCCCHHH
IQAIKQAGTKNPVIMLDEIDKLAISFQGDPAAALLEVLDPEQNKKFTDLYIGIPFDLSEV
HHHHHHCCCCCCEEEEECCCEEEEEECCCHHHHHHHHHCCCCCCEEEEEEEECCCCCCCE
IFICTGNRADTIPTPLLDRMELIMLSGYSEEEKLFIAKKHLIPKLIPLHGFSPEEIEFTD
EEEEECCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCHHHHCCCCCCCCCCCCCH
EAILEIIRGYTREAGVRNLQRQISAVLRKIAVKKLQGEKGPFNITPELVRKLLGVPRYRP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCC
EREKKPLVGVATGLAWTEVGGEIMFIEATKMKGKGSLVLTGSLGDIMKESAQAALSYIRS
CCCCCCCEEHHHCCHHHHCCCEEEEEEEECCCCCCCEEEECCHHHHHHHHHHHHHHHHHH
KAEDYGIDPDIFSQVDVHVHVPEGAVPKDGPSAGVAIATALLSLFTDIPVRMDVAMTGEI
HHHHCCCCHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECEE
TLRGRVLPVGGLKEKILAAKRAEIYEVILPAKNKDEVMEELPEYVREKMTLHFVDNLEEV
EEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
FKIALVREPKPLKEA
HHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320