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The map label for this gene is trpD2 [C]

Identifier: 15605768

GI number: 15605768

Start: 128584

End: 129513

Strand: Direct

Name: trpD2 [C]

Synonym: aq_209

Alternate gene names: 15605768

Gene position: 128584-129513 (Clockwise)

Preceding gene: 15605767

Following gene: 15605769

Centisome position: 8.29

GC content: 44.73

Gene sequence:

>930_bases
ATGGACATTTTAGAAAGAACTTTCAAAAAATTAACGAGACTTAAGGATAACCTTCAGGACCTTTCTCAGGAAGAAGCCTA
TGAAGTATTTAGGGCTATACTTGAAGGTAAACTCTCAGATATAAAGACAACTGCCTTCCTGACAGCCATGAGGATAAAGG
GGGAAACTTCTGAGGAACTCCTCGGTGTAATTAAGGCAATTAAAGAGAGAATGAATTTTCCGCAGAAGAAAGAGGACGCC
TTAGACCTCGGTCTGAACTATGACGGGAAGAACAGGACCATTTATATCCTTCCCTCTGCCCTGTGGCTCTGTTCAAGACT
CGGTGTAGAGTTCACAAACCACTACGCTCTTGGAGCTCCAACGAAAGAAGGTGTTACCCTCTACGAAGTAGTTAAGGAAC
TTGGTGTAGATATGAACGTATCCTTTGTAGACCAAAAGAATTACGCACCGGAGCTATACAAACTCATGCCTCTGAGAAGA
GAACTCGGTTTCAGGAGCTTGATAAACACGGTAGAAAAGTTTCTAAATCCCTTTCAGACTAAAAAGATTGTCGTTTCTAT
CTTTCACAAGCCGTACTTTGATAAGAACGCAGAGCTTCTTGAGCTCCTCGGGATTGAAGACTACACAATTATCAAGGGGC
TTGAGGGCGGGATTGAGCCTCTCCCTGATAGACCCACGCTCGTAAAGAAGAGAGGGAAGGACATAGAAAGTATAGAACCT
AAATCCCTCGGTCTTGAAATGCCCAAGGATGTTCATTCTGAAAACGTCCTGAGGGATTCGCTTGAGATAAACAGAAAGAT
AATTGATGGTAGAGAGAGGGGAGAGTTCTTCAACTGGGCGCTTTACACGGCGGGGGTATTGCTCTACGCGGCAGGGGAGT
GCGAAAGTGTGGAAGAGGGGGTAGGAAGGGTAGAGAAAGAATCCACCTGA

Upstream 100 bases:

>100_bases
CCGGAGGTAAACCCGCCCGCTGTAATGGTTGTAGGAAAGGTCGTAGAAATAGGAGCAAAAGTCCTATGTGAACGTATAAT
CGGCGTTACACTTTAAAGGA

Downstream 100 bases:

>100_bases
AACAAAAATGTAGCTACAAAATTGTACGCAAAGCGTCTCCACAATCAGAGAAAAGTTTCCAAGAACTGTTAAAACAGAAC
GGGGAGAATTTGGCACGCTT

Product: phosphoribosylanthranilate transferase

Products: anthranilate; 5-phospho-alpha-D-ribose 1-diphosphate

Alternate protein names: NA

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MDILERTFKKLTRLKDNLQDLSQEEAYEVFRAILEGKLSDIKTTAFLTAMRIKGETSEELLGVIKAIKERMNFPQKKEDA
LDLGLNYDGKNRTIYILPSALWLCSRLGVEFTNHYALGAPTKEGVTLYEVVKELGVDMNVSFVDQKNYAPELYKLMPLRR
ELGFRSLINTVEKFLNPFQTKKIVVSIFHKPYFDKNAELLELLGIEDYTIIKGLEGGIEPLPDRPTLVKKRGKDIESIEP
KSLGLEMPKDVHSENVLRDSLEINRKIIDGRERGEFFNWALYTAGVLLYAAGECESVEEGVGRVEKEST

Sequences:

>Translated_309_residues
MDILERTFKKLTRLKDNLQDLSQEEAYEVFRAILEGKLSDIKTTAFLTAMRIKGETSEELLGVIKAIKERMNFPQKKEDA
LDLGLNYDGKNRTIYILPSALWLCSRLGVEFTNHYALGAPTKEGVTLYEVVKELGVDMNVSFVDQKNYAPELYKLMPLRR
ELGFRSLINTVEKFLNPFQTKKIVVSIFHKPYFDKNAELLELLGIEDYTIIKGLEGGIEPLPDRPTLVKKRGKDIESIEP
KSLGLEMPKDVHSENVLRDSLEINRKIIDGRERGEFFNWALYTAGVLLYAAGECESVEEGVGRVEKEST
>Mature_309_residues
MDILERTFKKLTRLKDNLQDLSQEEAYEVFRAILEGKLSDIKTTAFLTAMRIKGETSEELLGVIKAIKERMNFPQKKEDA
LDLGLNYDGKNRTIYILPSALWLCSRLGVEFTNHYALGAPTKEGVTLYEVVKELGVDMNVSFVDQKNYAPELYKLMPLRR
ELGFRSLINTVEKFLNPFQTKKIVVSIFHKPYFDKNAELLELLGIEDYTIIKGLEGGIEPLPDRPTLVKKRGKDIESIEP
KSLGLEMPKDVHSENVLRDSLEINRKIIDGRERGEFFNWALYTAGVLLYAAGECESVEEGVGRVEKEST

Specific function: Tryptophan biosynthesis; first step. Tryptophan biosynthesis; second step. [C]

COG id: COG0547

COG function: function code E; Anthranilate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate phosphoribosyltransferase family

Homologues:

Organism=Escherichia coli, GI1787517, Length=268, Percent_Identity=25, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787019, Length=325, Percent_Identity=22.4615384615385, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: 945 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 900 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): Y209_AQUAE (O66585)

Other databases:

- EMBL:   AE000657
- PIR:   E70319
- RefSeq:   NP_213145.1
- ProteinModelPortal:   O66585
- GeneID:   1192819
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_209
- NMPDR:   fig|224324.1.peg.160
- OMA:   MSREQAT
- PhylomeDB:   O66585
- ProtClustDB:   CLSK2459793
- BioCyc:   AAEO224324:AQ_209-MONOMER
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- Gene3D:   G3DSA:1.20.970.10
- Gene3D:   G3DSA:3.40.1030.10

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; SSF47648 Glyco_trans_3; SSF52418 Glyco_trans_3

EC number: 2.4.2.18

Molecular weight: Translated: 35229; Mature: 35229

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDILERTFKKLTRLKDNLQDLSQEEAYEVFRAILEGKLSDIKTTAFLTAMRIKGETSEEL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCHHHH
LGVIKAIKERMNFPQKKEDALDLGLNYDGKNRTIYILPSALWLCSRLGVEFTNHYALGAP
HHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCEEEECCHHHHHHHHHCCHHHCCEECCCC
TKEGVTLYEVVKELGVDMNVSFVDQKNYAPELYKLMPLRRELGFRSLINTVEKFLNPFQT
CCCCCHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
KKIVVSIFHKPYFDKNAELLELLGIEDYTIIKGLEGGIEPLPDRPTLVKKRGKDIESIEP
HHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCCCC
KSLGLEMPKDVHSENVLRDSLEINRKIIDGRERGEFFNWALYTAGVLLYAAGECESVEEG
HHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHCCCCCHHHHHH
VGRVEKEST
HCCCCCCCC
>Mature Secondary Structure
MDILERTFKKLTRLKDNLQDLSQEEAYEVFRAILEGKLSDIKTTAFLTAMRIKGETSEEL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCHHHH
LGVIKAIKERMNFPQKKEDALDLGLNYDGKNRTIYILPSALWLCSRLGVEFTNHYALGAP
HHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCEEEECCHHHHHHHHHCCHHHCCEECCCC
TKEGVTLYEVVKELGVDMNVSFVDQKNYAPELYKLMPLRRELGFRSLINTVEKFLNPFQT
CCCCCHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
KKIVVSIFHKPYFDKNAELLELLGIEDYTIIKGLEGGIEPLPDRPTLVKKRGKDIESIEP
HHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCCCC
KSLGLEMPKDVHSENVLRDSLEINRKIIDGRERGEFFNWALYTAGVLLYAAGECESVEEG
HHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHCCCCCHHHHHH
VGRVEKEST
HCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-(5-Phospho-D-ribosyl)anthranilate; diphosphate

Specific reaction: N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320