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The map label for this gene is fhp [C]

Identifier: 15605769

GI number: 15605769

Start: 129647

End: 130066

Strand: Direct

Name: fhp [C]

Synonym: aq_211

Alternate gene names: 15605769

Gene position: 129647-130066 (Clockwise)

Preceding gene: 15605768

Following gene: 15605770

Centisome position: 8.36

GC content: 43.1

Gene sequence:

>420_bases
ATGTTGTCCGAGGAGACTATCAGGGTCATTAAGTCAACTGTCCCTCTTCTGAAAGAGCATGGTACGGAGATAACTGCTAG
GATGTACGAATTGCTGTTTTCAAAGTATCCTAAAACTAAGGAGTTATTTGCAGGGGCTTCGGAGGAACAACCAAAGAAGC
TTGCAAACGCCATAATAGCCTACGCTACCTACATTGATAGGCTAGAGGAGCTTGATAACGCTATCTCAACGATAGCCAGG
AGTCATGTGCGAAGAAATGTAAAGCCGGAACATTATCCGCTGGTTAAAGAATGTCTCTTACAGGCAATTGAAGAGGTTTT
AAATCCTGGGGAGGAAGTTCTCAAAGCATGGGAAGAGGCGTACGATTTTCTTGCTAAAACGCTTATAACCCTAGAGAAAA
AACTTTATAGCCAGCCTTAG

Upstream 100 bases:

>100_bases
CGTCTCCACAATCAGAGAAAAGTTTCCAAGAACTGTTAAAACAGAACGGGGAGAATTTGGCACGCTTTTTGCAATTAGTT
TGAGTGAAGGAGGTGAAAAG

Downstream 100 bases:

>100_bases
GGAGGTCTAATTATGAGGAGCGATATAGGAAGGCTCTCTAAGTACTTAATTGAAAGGAAAAAGAATCTTGGTCTTACGTG
GGAAGATGTAAGCAGAAAGC

Product: flavohemoprotein

Products: @TETR01txt*tetrahydropteridine!; NO3-; NAD(P); Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 139; Mature: 139

Protein sequence:

>139_residues
MLSEETIRVIKSTVPLLKEHGTEITARMYELLFSKYPKTKELFAGASEEQPKKLANAIIAYATYIDRLEELDNAISTIAR
SHVRRNVKPEHYPLVKECLLQAIEEVLNPGEEVLKAWEEAYDFLAKTLITLEKKLYSQP

Sequences:

>Translated_139_residues
MLSEETIRVIKSTVPLLKEHGTEITARMYELLFSKYPKTKELFAGASEEQPKKLANAIIAYATYIDRLEELDNAISTIAR
SHVRRNVKPEHYPLVKECLLQAIEEVLNPGEEVLKAWEEAYDFLAKTLITLEKKLYSQP
>Mature_139_residues
MLSEETIRVIKSTVPLLKEHGTEITARMYELLFSKYPKTKELFAGASEEQPKKLANAIIAYATYIDRLEELDNAISTIAR
SHVRRNVKPEHYPLVKECLLQAIEEVLNPGEEVLKAWEEAYDFLAKTLITLEKKLYSQP

Specific function: Possesses Dihydropteridine Reductase Activity. Also Has Nitric Oxide Dioxygenase Activity. Seems To Reduces The Complexed Fe(3+) Iron Of Siderophores To Fe(2+), Thus Releasing It From The Chelator. [C]

COG id: COG1017

COG function: function code C; Hemoglobin-like flavoprotein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the globin family

Homologues:

Organism=Escherichia coli, GI1788903, Length=141, Percent_Identity=40.4255319148936, Blast_Score=111, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6321673, Length=143, Percent_Identity=39.1608391608392, Blast_Score=92, Evalue=3e-20,

Paralogues:

None

Copy number: 100 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): Y211_AQUAE (O66586)

Other databases:

- EMBL:   AE000657
- PIR:   F70319
- RefSeq:   NP_213146.1
- ProteinModelPortal:   O66586
- SMR:   O66586
- GeneID:   1192820
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_211
- NMPDR:   fig|224324.1.peg.161
- HOGENOM:   HBG394659
- OMA:   MAILMAA
- ProtClustDB:   CLSK871657
- BioCyc:   AAEO224324:AQ_211-MONOMER
- InterPro:   IPR012292
- InterPro:   IPR009050
- InterPro:   IPR000971
- Gene3D:   G3DSA:1.10.490.10

Pfam domain/function: PF00042 Globin; SSF46458 Globin_like

EC number: 1.5.1.34 [C]

Molecular weight: Translated: 15965; Mature: 15965

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS01033 GLOBIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSEETIRVIKSTVPLLKEHGTEITARMYELLFSKYPKTKELFAGASEEQPKKLANAIIA
CCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHH
YATYIDRLEELDNAISTIARSHVRRNVKPEHYPLVKECLLQAIEEVLNPGEEVLKAWEEA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHH
YDFLAKTLITLEKKLYSQP
HHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLSEETIRVIKSTVPLLKEHGTEITARMYELLFSKYPKTKELFAGASEEQPKKLANAIIA
CCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHH
YATYIDRLEELDNAISTIARSHVRRNVKPEHYPLVKECLLQAIEEVLNPGEEVLKAWEEA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHH
YDFLAKTLITLEKKLYSQP
HHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: FAD [C]

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: dihydropteridine; 2 nitric oxide; O2; NAD(P)H [C]

Specific reaction: NAD(P)H + dihydropteridine = NAD(P)+ @TETR01.txt*tetrahydropteridine! 2 nitric oxide + 2 O2 + NAD(P)H = 2 NO3- + NAD(P) + Proton [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320